Nitric Oxide as a Target for Phytochemicals in Anti-Neuroinflammatory Prevention Therapy

A New Oleanane Type Saponin from the Aerial Parts of Nigella sativa with Anti-Oxidant and Anti-Diabetic Potential

(2020) Amna Parveen et al.   MOLECULES

Antineurodegenerative Labdane Diterpenoid Glycosides from the Twigs of Pinus koraiensis

(2020) Kyoung Jin Park et al.   JOURNAL OF NATURAL PRODUCTS

Sphingosine 1-Phosphate Receptors in Cerebral Ischemia

(2020) Bhakta Prasad Gaire et al.   NEUROMOLECULAR MEDICINE

Sulforaphane Inhibits MGO-AGE-Mediated Neuroinflammation by Suppressing NF-κB, MAPK, and AGE–RAGE Signaling Pathways in Microglial Cells

(2020) Lalita Subedi et al.   Antioxidants

Trifostigmanoside I, an Active Compound from Sweet Potato, Restores the Activity of MUC2 and Protects the Tight Junctions through PKCα/β to Maintain Intestinal Barrier Function

(2020) Amna Parveen et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Three New Lignan Glycosides from the Firmiana simplex

(2019) Kyeong Wan Woo et al.   CHEMICAL & PHARMACEUTICAL BULLETIN

Anti-Inflammatory Effect of Sulforaphane on LPS-Activated Microglia Potentially through JNK/AP-1/NF-κB Inhibition and Nrf2/HO-1 Activation

(2019) Lalita Subedi et al.   Cells

Sulforaphane-Enriched Broccoli Sprouts Pretreated by Pulsed Electric Fields Reduces Neuroinflammation and Ameliorates Scopolamine-Induced Amnesia in Mouse Brain through Its Antioxidant Ability via Nrf2-HO-1 Activation

(2019) Lalita Subedi et al.   Oxidative Medicine and Cellular Longevity

Phytochemicals Targeting VEGF and VEGF-Related Multifactors as Anticancer Therapy

(2019) Amna Parveen et al.   Journal of Clinical Medicine

Therapeutic Potential of Lespedeza bicolor to Prevent Methylglyoxal-Induced Glucotoxicity in Familiar Diabetic Nephropathy

(2019) Moon Ho Do et al.   Journal of Clinical Medicine

Chemical constituents of the root bark of Ulmus davidiana var. japonica and their potential biological activities

(2019) Hae Min So et al.   BIOORGANIC CHEMISTRY

Phenolic constituents from the twigs of Betula schmidtii collected in Goesan, Korea

(2019) Kyoung Jin Park et al.   PHYTOCHEMISTRY

Bioactive triterpenoids from twigs of Betula schmidtii

(2018) Kyoung Jin Park et al.   BIOORGANIC CHEMISTRY

Secoiridoid Glycosides from the Twigs of Ligustrum obtusifolium Possess Anti-inflammatory and Neuroprotective Effects

(2018) Won Se Suh et al.   CHEMICAL & PHARMACEUTICAL BULLETIN

Herbal Medicine in Ischemic Stroke: Challenges and Prospective

(2018) Bhakta Prasad Gaire   Chinese Journal of Integrative Medicine

Phytochemicals: Target-Based Therapeutic Strategies for Diabetic Retinopathy

(2018) Amna Parveen et al.   MOLECULES

Anti-neuroinflammatory effects of cudraflavanone A isolated from the chloroform fraction of Cudrania tricuspidata root bark

(2018) Kwan-Woo Kim et al.   PHARMACEUTICAL BIOLOGY

Bioactive phytochemicals that regulate the cellular processes involved in diabetic nephropathy

(2018) Amna Parveen et al.   PHYTOMEDICINE

Two New Phenolic Glycosides from Sorbus commixta

(2018) Chung Sub Kim et al.   CHEMICAL & PHARMACEUTICAL BULLETIN

Synthesis and anti-neuroinflammatory activity of N-heterocyclic analogs based on natural biphenyl-neolignan honokiol

(2018) Yue Yuan et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Neuroprotective and Anti-Inflammatory Activities of Allyl Isothiocyanate through Attenuation of JNK/NF-κB/TNF-α Signaling

(2017) et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Iridoid Glycosides from the Twigs of Sambucus williamsii var. coreana and Their Biological Activities

(2017) Won Se Suh et al.   JOURNAL OF NATURAL PRODUCTS

Anti-Neurodegenerative Biflavonoid Glycosides from Impatiens balsamina

(2017) Chung Sub Kim et al.   JOURNAL OF NATURAL PRODUCTS

Bioactive Triterpenoids from the Twigs of Chaenomeles sinensis

(2017) Chung Sub Kim et al.   JOURNAL OF NATURAL PRODUCTS

Anti-inflammatory effect of oleuropein on microglia through regulation of Drp1-dependent mitochondrial fission

(2017) Junghyung Park et al.   JOURNAL OF NEUROIMMUNOLOGY

Phenolic Glycosides from Capsella bursa-pastoris (L.) Medik and Their Anti-Inflammatory Activity

(2017) Joon Cha et al.   MOLECULES

Insights in pathogenesis of multiple sclerosis: nitric oxide may induce mitochondrial dysfunction of oligodendrocytes

(2017) Minghong Lan et al.   REVIEWS IN THE NEUROSCIENCES

Equol, a Dietary Daidzein Gut Metabolite Attenuates Microglial Activation and Potentiates Neuroprotection In Vitro

(2017) Lalita Subedi et al.   Nutrients

Regulation of neuroinflammation by matrix metalloproteinase-8 inhibitor derivatives in activated microglia and astrocytes

(2017) Eun-Jung Lee et al.   Oncotarget

6-Shogaol attenuates LPS-induced inflammation in BV2 microglia cells by activating PPAR-γ

(2017) Qinghe Han et al.   Oncotarget

Holophyllane A: A Triterpenoid Possessing an Unprecedented B-nor-3,4-seco-17,14-friedo-lanostane Architecture from Abies holophylla

(2017) Chung Sub Kim et al.   Scientific Reports

Eupatilin exerts neuroprotective effects in mice with transient focal cerebral ischemia by reducing microglial activation

(2017) Arjun Sapkota et al.   PLoS One

A new rearranged eudesmane sesquiterpene and bioactive sesquiterpenes from the twigs of Lindera glauca (Sieb. et Zucc.) Blume

(2016) Jae Sik Yu et al.   ARCHIVES OF PHARMACAL RESEARCH

Isolation of bioactive biphenyl compounds from the twigs of Chaenomeles sinensis

(2016) Chung Sub Kim et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Oxidative Stress and Nitric Oxide in Autism Spectrum Disorder and Other Neuropsychiatric Disorders

(2016) Kunio Yui et al.   CNS & Neurological Disorders-Drug Targets

Zingerone ameliorates lipopolysaccharide-induced acute kidney injury by inhibiting Toll-like receptor 4 signaling pathway

(2016) Jie Song et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Neuroprotective Fatty Acids from the Stem Bark of Sorbus commixta

(2016) Chung Sub Kim et al.   LIPIDS

Anti-Inflammatory Chemical Profiling of the Australian Rainforest Tree Alphitonia petriei (Rhamnaceae)

(2016) Ritesh Raju et al.   MOLECULES

Anti-Inflammatory Effects and Mechanisms of Action of Coussaric and Betulinic Acids Isolated from Diospyros kaki in Lipopolysaccharide-Stimulated RAW 264.7 Macrophages

(2016) Kyoung-Su Kim et al.   MOLECULES

Getting to NO Alzheimer’s Disease: Neuroprotection versus Neurotoxicity Mediated by Nitric Oxide

(2016) Rachelle Balez et al.   Oxidative Medicine and Cellular Longevity

(7R,8S)-9-Acetyl-dehydrodiconiferyl alcohol inhibits inflammation and migration in lipopolysaccharide-stimulated macrophages

(2016) Li-Long Pan et al.   PHYTOMEDICINE

Anti-neuroinflammatory and neuroprotective effects of the Lindera neesiana fruit in vitro

(2016) Lalita Subedi et al.   PHYTOMEDICINE

Anti-neuroinflammatory effect of Sophoraflavanone G from Sophora alopecuroides in LPS-activated BV2 microglia by MAPK, JAK/STAT and Nrf2/HO-1 signaling pathways

(2016) Chao Guo et al.   PHYTOMEDICINE

Suppression of Cartilage Degradation by Zingerone Involving the p38 and JNK MAPK Signaling Pathway

(2016) Jetsada Ruangsuriya et al.   PLANTA MEDICA

Investigating the Role of TNF-α and IFN-γ Activation on the Dynamics of iNOS Gene Expression in LPS Stimulated Macrophages

(2016) Taha Salim et al.   PLoS One

Antineuroinflammatory and Antiproliferative Activities of Constituents from Tilia amurensis

(2015) Ki Hyun Kim et al.   CHEMICAL & PHARMACEUTICAL BULLETIN

Salicin derivatives from Salix glandulosa and their biological activities

(2015) Chung Sub Kim et al.   FITOTERAPIA

Phenolic Derivatives from the Stems of Lagerstroemia indica and Their Biological Activity

(2015) Kang Ro Lee et al.   HETEROCYCLES

Ethanol extract of Bupleurum falcatum and saikosaponins inhibit neuroinflammation via inhibition of NF-κB

(2015) Wook Ha Park et al.   JOURNAL OF ETHNOPHARMACOLOGY

Anti-inflammatory activity of a new cyclic peptide, citrusin XI, isolated from the fruits of Citrus unshiu

(2015) Hyung Jun Noh et al.   JOURNAL OF ETHNOPHARMACOLOGY

Identification of cytotoxic and anti-inflammatory constituents from the bark of Toxicodendron vernicifluum (Stokes) F.A. Barkley

(2015) Ki Hyun Kim et al.   JOURNAL OF ETHNOPHARMACOLOGY

Lignan Glycosides from the Twigs of Chaenomeles sinensis and Their Biological Activities

(2015) Chung Sub Kim et al.   JOURNAL OF NATURAL PRODUCTS

Blood-Brain Barrier Breakdown in the Aging Human Hippocampus

(2015) Axel Montagne et al.   NEURON

Neuroprotective Effect of 6-Paradol in Focal Cerebral Ischemia Involves the Attenuation of Neuroinflammatory Responses in Activated Microglia

(2015) Bhakta Prasad Gaire et al.   PLoS One

Anti-inflammatory lignanamides from the roots of Solanum melongena L.

(2014) Jing Sun et al.   FITOTERAPIA

Tangeretin exerts anti-neuroinflammatory effects via NF-κB modulation in lipopolysaccharide-stimulated microglial cells

(2014) Zunpeng Shu et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Say “no” to spinal cord injury: is nitric oxide an option for therapeutic strategies?

(2014) Valentina Tardivo et al.   INTERNATIONAL JOURNAL OF NEUROSCIENCE

Lignans from the stems of Clematis armandii (“Chuan-Mu-Tong”) and their anti-neuroinflammatory activities

(2014) Juan Xiong et al.   JOURNAL OF ETHNOPHARMACOLOGY

Anti-inflammatory activity of omphalocarpin isolated from Radix Toddaliae Asiaticae

(2014) Ling Tong et al.   JOURNAL OF ETHNOPHARMACOLOGY

Ginger components as new leads for the design and development of novel multi-targeted anti-Alzheimer’s drugs: a computational investigation

(2014) Faizul Azam et al.   Drug Design Development and Therapy

Potential role of nitric oxide synthase isoforms in pathophysiology of neuropathic pain

(2014) Abhilasha Ahlawat et al.   INFLAMMOPHARMACOLOGY

Anti-neuroinflammatory diarylheptanoids from the rhizomes of Dioscorea nipponica

(2013) Kyeong Wan Woo et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Anti-neuroinflammatory capacity of fresh ginger is attributed mainly to 10-gingerol

(2013) Su-Chen Ho et al.   FOOD CHEMISTRY

4-Methylthio-butanyl derivatives from the seeds of Raphanus sativus and their biological evaluation on anti-inflammatory and antitumor activities

(2013) Ki Hyun Kim et al.   JOURNAL OF ETHNOPHARMACOLOGY

Endothelial nitric oxide deficiency promotes Alzheimer's disease pathology

(2013) Susan A. Austin et al.   JOURNAL OF NEUROCHEMISTRY

Sesquiterpene dimer (DSF-52) from Artemisia argyi inhibits microglia-mediated neuroinflammation via suppression of NF-κB, JNK/p38 MAPKs and Jak2/Stat3 signaling pathways

(2013) Ke-Wu Zeng et al.   PHYTOMEDICINE

Genistein Suppresses LPS-Induced Inflammatory Response through Inhibiting NF-κB following AMP Kinase Activation in RAW 264.7 Macrophages

(2013) Guiyuan Ji et al.   PLoS One

Microglia Play a Role in Ethanol-Induced Oxidative Stress and Apoptosis in Developing Hypothalamic Neurons

(2012) Nadka I. Boyadjieva et al.   ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH

Rutin prevents cognitive impairments by ameliorating oxidative stress and neuroinflammation in rat model of sporadic dementia of Alzheimer type

(2012) H. Javed et al.   NEUROSCIENCE

Anti-Inflammatory Role of the Isoflavone Diadzein in Lipopolysaccharide-Stimulated Microglia: Implications for Parkinson’s Disease

(2012) Shankar J. Chinta et al.   NEUROTOXICITY RESEARCH

Nitric oxide synthases: regulation and function

(2011) U. Forstermann et al.   EUROPEAN HEART JOURNAL

Chemical Mediators of Migraine: Preclinical and Clinical Observations

(2011) Saurabh Gupta et al.   HEADACHE

Neuropeptide Y Modulation of Interleukin-1β (IL-1β)-induced Nitric Oxide Production in Microglia

(2010) Raquel Ferreira et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Nitric Oxide Signaling in Brain Function, Dysfunction, and Dementia

(2010) Joern R. Steinert et al.   NEUROSCIENTIST

Phytochemical and pharmacological potential ofMedicago sativa: A review

(2010) Kundan Singh Bora et al.   PHARMACEUTICAL BIOLOGY

Cerebral blood flow regulation by nitric oxide in neurological disorders

(2009) Noboru Toda et al.   CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY

Regulation of nitric oxide production in health and disease

(2009) Yvette C Luiking et al.   CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE

Role of nitric oxide, superoxide, peroxynitrite and PARP in diabetic retinopathy

(2009) Ling Zheng   Frontiers in Bioscience-Landmark

Inducible Nitric Oxide Synthase-Nitric Oxide Plays an Important Role in Acute and Severe Hypoxic Injury to Pancreatic Beta Cells

(2009) Seung-Hyun Ko et al.   TRANSPLANTATION

Targets for neuroprotection in Parkinson's disease

(2008) Talene A. Yacoubian et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Concepts of neural nitric oxide-mediated transmission

(2008) John Garthwaite   EUROPEAN JOURNAL OF NEUROSCIENCE

Role of Nitric Oxide Synthases in Parkinson’s Disease: A Review on the Antioxidant and Anti-inflammatory Activity of Polyphenols

(2008) Katia Aquilano et al.   NEUROCHEMICAL RESEARCH

The role of nitric oxide (NO) in migraine, tension-type headache and cluster headache

(2008) J OLESEN   PHARMACOLOGY & THERAPEUTICS

Antiinflammatory activity ofLindera erythrocarpa fruits

(2007) Sheng-Yang Wang et al.   PHYTOTHERAPY RESEARCH