Therapeutic Potential of Lespedeza bicolor to Prevent Methylglyoxal-Induced Glucotoxicity in Familiar Diabetic Nephropathy

Oxyresveratrol prevents murine H22 hepatocellular carcinoma growth and lymph node metastasis via inhibiting tumor angiogenesis and lymphangiogenesis

(2018) Yuanqi Liu et al.   Journal of Natural Medicines

Diphlorethohydroxycarmalol Attenuates Methylglyoxal-Induced Oxidative Stress and Advanced Glycation End Product Formation in Human Kidney Cells

(2018) Seon-Heui Cha et al.   Oxidative Medicine and Cellular Longevity

Bioactive phytochemicals that regulate the cellular processes involved in diabetic nephropathy

(2018) Amna Parveen et al.   PHYTOMEDICINE

Alteration of oxidative stress and inflammatory cytokines induces apoptosis in diabetic nephropathy

(2017) Jibin Sha et al.   Molecular Medicine Reports

Lespedeza bicolor ameliorates endothelial dysfunction induced by methylglyoxal glucotoxicity

(2017) Moon Ho Do et al.   PHYTOMEDICINE

Methylglyoxal, A Metabolite Increased in Diabetes is Associated with Insulin Resistance, Vascular Dysfunction and Neuropathies

(2016) Yousif A. Shamsaldeen et al.   CURRENT DRUG METABOLISM

Mangiferin Upregulates Glyoxalase 1 Through Activation of Nrf2/ARE Signaling in Central Neurons Cultured with High Glucose

(2016) Yao-Wu Liu et al.   MOLECULAR NEUROBIOLOGY

A potential anti-inflammation activity and depigmentation effect of Lespedeza bicolor extract and its fractions

(2016) Seung Jin Lee et al.   SAUDI JOURNAL OF BIOLOGICAL SCIENCES

Lespedeza davurica(Lax.) Schindl. Extract Protects against Cytokine-Inducedβ-Cell Damage and Streptozotocin-Induced Diabetes

(2015) Bhesh Raj Sharma et al.   Biomed Research International

Low-molecular-weight chitosan scavenges methylglyoxal and N ε-(carboxyethyl)lysine, the major factors contributing to the pathogenesis of nephropathy

(2015) Chu-Kuang Chou et al.   SpringerPlus

Glyoxalases and stress tolerance in plants

(2014) Charanpreet Kaur et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Anti-oxidant and anti-diabetic activities of Lespedeza cuneata water extract

(2014) Raj Sharma Bhesh et al.   Journal of Medicinal Plants Research

Advanced Glycation End Products and Diabetic Complications

(2014) Varun Parkash Singh et al.   KOREAN JOURNAL OF PHYSIOLOGY & PHARMACOLOGY

(+)-Catechin ameliorates diabetic nephropathy by trapping methylglyoxal in type 2 diabetic mice

(2014) Dina Zhu et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Knockdown of Glyoxalase 1 Mimics Diabetic Nephropathy in Nondiabetic Mice

(2013) F. Giacco et al.   DIABETES

The Critical Role of Methylglyoxal and Glyoxalase 1 in Diabetic Nephropathy

(2013) N. Rabbani et al.   DIABETES

Dimerumic acid attenuates receptor for advanced glycation endproducts signal to inhibit inflammation and diabetes mediated by Nrf2 activation and promotes methylglyoxal metabolism into d-lactic acid

(2013) Bao-Hong Lee et al.   FREE RADICAL BIOLOGY AND MEDICINE

Suppression of methylglyoxal hyperactivity by mangiferin can prevent diabetes-associated cognitive decline in rats

(2013) Yao-Wu Liu et al.   PSYCHOPHARMACOLOGY

A novel natural Nrf2 activator with PPARγ-agonist (monascin) attenuates the toxicity of methylglyoxal and hyperglycemia

(2013) Wei-Hsuan Hsu et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Hesperidin and naringin attenuate hyperglycemia-mediated oxidative stress and proinflammatory cytokine production in high fat fed/streptozotocin-induced type 2 diabetic rats

(2012) Ayman M. Mahmoud et al.   JOURNAL OF DIABETES AND ITS COMPLICATIONS

Anti-diabetic functions of soy isoflavone genistein: mechanisms underlying its effects on pancreatic β-cell function

(2012) Elizabeth. R. Gilbert et al.   Food & Function

Transcriptional control of glyoxalase 1 by Nrf2 provides a stress-responsive defence against dicarbonyl glycation

(2011) Mingzhan Xue et al.   BIOCHEMICAL JOURNAL

Potent inhibition of bacterial neuraminidase activity by pterocarpans isolated from the roots of Lespedeza bicolor

(2011) Hyun Sim Woo et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Chronic Methylglyoxal Infusion by Minipump Causes Pancreatic β-Cell Dysfunction and Induces Type 2 Diabetes in Sprague-Dawley Rats

(2011) Arti Dhar et al.   DIABETES

Nrf2 Activators as Attractive Therapeutics for Diabetic Nephropathy: FIG. 1.

(2011) Judy B. de Haan   DIABETES

Vascular relaxation induced by aqueous extract of Lespedeza cuneata via the NO-cGMP pathway

(2011) Jun Kyoung Lee et al.   Journal of Natural Medicines

Two new dihydrofuranoisoflavanones from the leaves of Lespedeza maximowiczi and their inhibitory effect on the formation of advanced glycation end products

(2010) Hyun Young Park et al.   ARCHIVES OF PHARMACAL RESEARCH

The RAGE Axis

(2010) Shi Fang Yan et al.   CIRCULATION RESEARCH

Increased plasma methylglyoxal level, inflammation, and vascular endothelial dysfunction in diabetic nephropathy

(2010) Jianxin Lu et al.   CLINICAL BIOCHEMISTRY

RAGE: A Multi-Ligand Receptor Unveiling Novel Insights in Health and Disease

(2010) P. Alexiou et al.   CURRENT MEDICINAL CHEMISTRY

Overexpression of Glyoxalase-I Reduces Hyperglycemia-induced Levels of Advanced Glycation End Products and Oxidative Stress in Diabetic Rats

(2010) Olaf Brouwers et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Methylglyoxal, protein binding and biological samples: Are we getting the true measure?

(2009) Arti Dhar et al.   JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES

Melanin Synthesis Inhibitors fromLespedeza floribunda

(2009) Maya Mori-Hongo et al.   JOURNAL OF NATURAL PRODUCTS