Hyperoside attenuates non-alcoholic fatty liver disease through targeting Nr4A1 in macrophages

The Role of Innate Immune Cells in Nonalcoholic Steatohepatitis

(2019) Jingjing Cai et al.   HEPATOLOGY

Innate Immune Signaling in Nonalcoholic Fatty Liver Disease and Cardiovascular Diseases

(2018) Jingjing Cai et al.   Annual Review of Pathology-Mechanisms of Disease

Dual-specificity Phosphatase 9 Protects Against Non-alcoholic Fatty Liver Disease in Mice via ASK1 Suppression

(2018) Ping Ye et al.   HEPATOLOGY

A spotlight on pathogenesis, interactions and novel therapeutic options in NAFLD

(2018) Ramy Younes et al.   Nature Reviews Gastroenterology & Hepatology

The epidemiology of non-alcoholic fatty liver disease

(2017) Stefano Bellentani   LIVER INTERNATIONAL

Hyperoside inhibits the effects induced by oxidized low-density lipoprotein in vascular smooth muscle cells via oxLDL-LOX-1-ERK pathway

(2017) Zhengyu Zhang et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Current and upcoming pharmacotherapy for non-alcoholic fatty liver disease

(2016) Yaron Rotman et al.   GUT

Deleting an Nr4a1 Super-Enhancer Subdomain Ablates Ly6C low Monocytes while Preserving Macrophage Gene Function

(2016) Graham D. Thomas et al.   IMMUNITY

Quercetin ameliorates dysregulation of lipid metabolism genes via the PI3K/AKT pathway in a diet-induced mouse model of nonalcoholic fatty liver disease

(2015) Sandra Pisonero-Vaquero et al.   MOLECULAR NUTRITION & FOOD RESEARCH

The transcription factor NR4A1 is essential for the development of a novel macrophage subset in the thymus

(2015) Robert Tacke et al.   Scientific Reports

Induction of Nur77 by hyperoside inhibits vascular smooth muscle cell proliferation and neointimal formation

(2014) Yan Huo et al.   BIOCHEMICAL PHARMACOLOGY

Ly-6C high Monocytes Depend on Nr4a1 to Balance Both Inflammatory and Reparative Phases in the Infarcted Myocardium

(2014) Ingo Hilgendorf et al.   CIRCULATION RESEARCH

Hyperoside Inhibits High-Glucose-Induced Vascular Inflammation In Vitro and In Vivo

(2014) Sae-Kwang Ku et al.   INFLAMMATION

The pan-caspase inhibitor Emricasan (IDN-6556) decreases liver injury and fibrosis in a murine model of non-alcoholic steatohepatitis

(2014) Fernando J. Barreyro et al.   LIVER INTERNATIONAL

Correction for Chatzigeorgiou et al., Blocking CD40-TRAF6 signaling is a therapeutic target in obesity-associated insulin resistance

(2014)   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Complement Anaphylatoxin C5a Receptor Contributes to Obese Adipose Tissue Inflammation and Insulin Resistance

(2013) J. Phieler et al.   JOURNAL OF IMMUNOLOGY

The cellular and signaling networks linking the immune system and metabolism in disease

(2012) Olivia Osborn et al.   NATURE MEDICINE

Anti-Inflammatory Activity of Hyperoside Through the Suppression of Nuclear Factor-κB Activation in Mouse Peritoneal Macrophages

(2011) Su-Jin Kim et al.   AMERICAN JOURNAL OF CHINESE MEDICINE

Hyperoside attenuates hydrogen peroxide-induced L02 cell damage via MAPK-dependent Keap1–Nrf2–ARE signaling pathway

(2011) Hai-Yan Xing et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

NR4A1 (Nur77) Deletion Polarizes Macrophages Toward an Inflammatory Phenotype and Increases Atherosclerosis

(2011) Richard N. Hanna et al.   CIRCULATION RESEARCH

Hyperoside protects primary rat cortical neurons from neurotoxicity induced by amyloid β-protein via the PI3K/Akt/Bad/BclXL-regulated mitochondrial apoptotic pathway

(2011) Ke-Wu Zeng et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Inflammatory links between obesity and metabolic disease

(2011) Carey N. Lumeng et al.   JOURNAL OF CLINICAL INVESTIGATION

Protective Effects of Hyperoside against Carbon Tetrachloride-Induced Liver Damage in Mice

(2011) Jun-Ho Choi et al.   JOURNAL OF NATURAL PRODUCTS

The transcription factor NR4A1 (Nur77) controls bone marrow differentiation and the survival of Ly6C− monocytes

(2011) Richard N Hanna et al.   NATURE IMMUNOLOGY

Insulin Resistance and Altered Systemic Glucose Metabolism in Mice Lacking Nur77

(2009) Lily C. Chao et al.   DIABETES

Hepatic recruitment of the inflammatory Gr1+monocyte subset upon liver injury promotes hepatic fibrosis

(2009) Karlin Raja Karlmark et al.   HEPATOLOGY