Article
Biochemistry & Molecular Biology
Dai Sik Ko, Junho Kang, Hye Jin Heo, Eun Kyoung Kim, Kihun Kim, Jin Mo Kang, YunJae Jung, Seung Eun Baek, Yun Hak Kim
Summary: Vascular smooth muscle cell (VSMC) proliferation plays a crucial role in atherosclerosis and restenosis. This study identified PCK2 as a key regulator of VSMC proliferation and suggested targeting PCK2 as a novel therapeutic approach for atherosclerosis.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2022)
Article
Plant Sciences
Guanghong Chen, Honglin Xu, Yuting Wu, Xin Han, Lingpeng Xie, Guoyong Zhang, Bin Liu, YingChun Zhou
Summary: Myricetin inhibits neointimal hyperplasia and VSMC proliferation and migration by suppressing TGFBR1 signaling pathway. This study demonstrates the potential therapeutic value of myricetin for atherosclerosis and vascular restenosis.
Article
Cell Biology
Xueyan Ding, Yan Yan, Chengke Zhang, Xudong Xu, Fan Yang, Yang Liu, Guokun Wang, Yongwen Qin
Summary: In this study, OCT4 was found to enhance neointimal formation in response to vascular injury by promoting VSMCs proliferation and migration via MMP2. Targeting OCT4 in VSMCs could be a novel therapeutic strategy for vascular restenosis.
JOURNAL OF CELLULAR PHYSIOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Dan Shan, Ping Qu, Chao Zhong, Luling He, Qingshan Zhang, Guoyue Zhong, Wenhui Hu, Yulin Feng, Shilin Yang, Xiao-feng Yang, Jun Yu
Summary: This study identified Anemoside B4 as a potential therapeutic agent that regulates vascular smooth muscle cell plasticity and inhibits restenosis after vascular intervention.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Junchul Shin, Svyatoslav Tkachenko, Delphine Gomez, Rupande Tripathi, Gary K. Owens, Olga A. Cherepanova
Summary: OCT4 is quickly activated in SMC after acute vascular injury, inhibiting SMC hyperproliferation and potentially preventing excessive neointima formation.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Chihiro Sakai, Mei Mikawa, Takeshi Yamamoto, Tomoyuki Uchida, Yoshihide Nakamura, Hideaki Akase, Takeshi Suetomi, Naoomi Tominaga, Masako Inamitsu, Tetsuro Oda, Takayuki Okamura, Shigeki Kobayashi, Masafumi Yano
Summary: This study investigated the inhibitory effect of Dantrolene on smooth muscle cell proliferation and migration, and found that Dantrolene effectively suppressed vascular smooth muscle cell proliferation, migration, and neointimal formation.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Article
Hematology
Chien-Jung Lin, Bridget M. Hunkins, Robyn A. Roth, Chieh-Yu Lin, Jessica E. Wagenseil, Robert P. Mecham
Summary: This study investigates the mechanism of neointima formation due to Eln insufficiency in a mouse model, showing that cells from the secondary heart field are significant contributors to intimal hyperplasia. Two unique SMC populations were identified in the neointima of SMC-Eln knockout mice, suggesting shared mechanisms with adult vessel injury models.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Yuichi Kimura, Yasuhiro Izumiya, Satoshi Araki, Satoru Yamamura, Shinsuke Hanatani, Yoshiro Onoue, Toshifumi Ishida, Yuichiro Arima, Taishi Nakamura, Eiichiro Yamamoto, Takafumi Senokuchi, Tatsuya Yoshizawa, Masataka Sata, Shokei Kim-Mitsuyama, Naomi Nakagata, Eva Bober, Thomas Braun, Koichi Kaikita, Kazuya Yamagata, Kenichi Tsujita
Summary: Sirt7 plays a crucial role in neointimal formation after vascular injury, and its deficiency attenuates the formation of neointima. The study revealed that Sirt7(-/-) mice exhibited a significant reduction in neointima and modulation of cyclins and CDK2 in VSMCs when compared to WT mice. These findings suggest that Sirt7 could be a potential target for the treatment of vascular diseases.
CIRCULATION JOURNAL
(2021)
Article
Biochemistry & Molecular Biology
Ya-Ning Shi, Le-Ping Liu, Chang-Feng Deng, Tan-Jun Zhao, Zhe Shi, Jian-Ye Yan, Yong-Zhen Gong, Duan-Fang Liao, Li Qin
Summary: The study found that celastrol effectively inhibited intimal hyperplasia and hyperproliferation of VSMCs by inducing autophagy, suggesting it may be a novel drug with great potential to prevent restenosis. The mechanism behind this effect involves lysosomal degradation of c-MYC and the Wnt5a/PKC/mTOR signaling pathway.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2021)
Article
Multidisciplinary Sciences
Yin Chen, Peng Gao, Lu Huang, Xing Tan, Ningling Zhou, Tong Yang, Hua Qiu, Xin Dai, Sean Michael, Qiufen Tu, Nan Huang, Zhihong Guo, Jianhua Zhou, Zhilu Yang, Hongkai Wu
Summary: Authors have developed a nitric oxide releasing hydrogel that promotes endothelialization of the stent surface and inhibits smooth muscle cell growth, reducing neointimal hyperplasia and thrombosis.
NATURE COMMUNICATIONS
(2021)
Article
Chemistry, Multidisciplinary
Ying-ying Liu, Xiu Liu, Jia-guo Zhou, Si-jia Liang
Summary: MiR-302a exacerbates smooth muscle cell proliferation and restenosis by increasing Akt signaling through targeting PHLPP2.
ACTA PHARMACOLOGICA SINICA
(2021)
Article
Immunology
Yuhan Chen, Yuanyuan Chen, Xueze Jiang, Mengkun Shi, Zhenwei Yang, Zhiyong Chen, Xuesheng Hua, Jie Chen, Yuepeng Wang
Summary: This study demonstrated that FGF10 derived from VAFs promoted the proliferation, migration, and neointima formation of VSMCs, while the FGF10-FGFR2 signaling pathway triggered the activation of the MAPK/PI3K-AKT pathways in VSMCs. Additionally, PDGF synergistically amplified the FGF10 signaling.
JOURNAL OF INFLAMMATION RESEARCH
(2021)
Article
Hematology
Sebastian F. Mause, Elisabeth Ritzel, Annika Deck, Felix Vogt, Elisa A. Liehn
Summary: EPCs stimulate proliferation and migration of SMCs and increase their neointimal accumulation following vascular injury. Furthermore, EPCs context-dependently modify the SMC phenotype with protection from the transformative effect of cholesterol when a direct cell-cell contact is established.
THROMBOSIS AND HAEMOSTASIS
(2022)
Article
Cardiac & Cardiovascular Systems
Jochen Dutzmann, Marco Haertle, Jan-Marcus Daniel, Frederik Kloss, Robert-Jonathan Musmann, Katrin Kalies, Kai Knopp, Claudia Pilowski, Mirja Sirisko, Jan-Thorben Sieweke, Johann Bauersachs, Daniel G. Sedding, Simona Gegel
Summary: Selective inhibition of BET proteins can reduce proliferation and migration of SMCs by regulating FOXO1 transcription factor, leading to cell cycle arrest and prevention of neointima formation. Inhibition of BET epigenetic reader proteins may represent a promising therapeutic strategy to prevent adverse vascular remodeling.
CARDIOVASCULAR RESEARCH
(2021)
Article
Cardiac & Cardiovascular Systems
Yuanjun Tang, Yiting Jia, Linwei Fan, Han Liu, Yuan Zhou, Miao Wang, Yuefeng Liu, Juanjuan Zhu, Wei Pang, Jing Zhou
Summary: Mechanical forces, particularly the downregulation of the protein MFN2, play a significant role in neointimal hyperplasia after vein grafting, by mediating PFK1 degradation and suppressing glycolysis in vascular smooth muscle cells (VSMCs).
CIRCULATION RESEARCH
(2022)
Article
Cardiac & Cardiovascular Systems
Jia Qi, Ping Yang, Bing Yi, Yan Huo, Ming Chen, Jian Zhang, Jianxin Sun
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
(2015)
Article
Hematology
Bing Yi, Maria Ozerova, Guan-Xin Zhang, Guijun Yan, Shengdong Huang, Jianxin Sun
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2015)
Article
Hematology
Ping Yang, Xin Wei, Jian Zhang, Bing Yi, Guan-Xin Zhang, Litian Yin, Xiao-Feng Yang, Jianxin Sun
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2016)
Article
Cardiac & Cardiovascular Systems
Ming Chen, Bing Yi, Ni Zhu, Xin Wei, Guan-Xin Zhang, Shengdong Huang, Jianxin Sun
CARDIOVASCULAR RESEARCH
(2016)
Article
Cell Biology
Melanie Paillard, Gyoergy Csordas, Gergoe Szanda, Tuende Golenar, Valentina Debattisti, Adam Bartok, Nadan Wang, Cynthia Moffat, Erin L. Seifert, Andras Spaet, Gyoergy Hajnoczky
Article
Oncology
Shisuo Du, Lin Zhou, Gregory S. Alexander, Kyewon Park, Lifeng Yang, Nadan Wang, Nicholas G. Zaorsky, Xinliang Ma, Yajing Wang, Adam P. Dicker, Bo Lu
JOURNAL OF THORACIC ONCOLOGY
(2018)
Review
Cell Biology
Hongyu Wang, Huijuan Yao, Bing Yi, Kyosuke Kazama, Yan Liu, Deepak Deshpande, Jian Zhang, Jianxin Sun
JOURNAL OF CELLULAR PHYSIOLOGY
(2019)
Article
Multidisciplinary Sciences
Pawan Sharma, Roslyn Yi, Ajay P. Nayak, Nadan Wang, Francesca Tang, Morgan J. Knight, Shi Pan, Brian Oliver, Deepak A. Deshpande
SCIENTIFIC REPORTS
(2017)
Article
Physiology
Ajay P. Nayak, Tonio Pera, Deepak A. Deshpande, James Michael, Jennifer R. Liberato, Shi Pan, Eric Tompkins, Henry P. Morelli, Roslyn Yi, Nadan Wang, Raymond B. Penn
AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY
(2019)
Article
Cardiac & Cardiovascular Systems
Natasha Fillmore, Kevin M. Casin, Prithvi Sinha, Junhui Sun, Hanley Ma, Jennifer Boylston, Audrey Noguchi, Chengyu Liu, Nadan Wang, Guangshuo Zhou, Mark J. Kohr, Elizabeth Murphy
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
(2019)
Article
Biochemistry & Molecular Biology
Brenal K. Singh, Wen Lu, Amanda M. Schmidt Paustian, Moyar Q. Ge, Cynthia J. Koziol-White, Cameron H. Flayer, Sara S. Killingbeck, Nadan Wang, Xinzhong Dong, Matthew J. Riese, Deepak A. Deshpande, Reynold A. Panettieri, Angela Haczku, Taku Kambayashi
Article
Medicine, General & Internal
Jacopo Agrimi, Arianna Scalco, Julia Agafonova, Larry Williams, Nainika Pansari, Gizem Keceli, Seungho Jun, Nadan Wang, Francesca Mastorci, Crystal Tichnell, Brittney Murray, Cynthia A. James, Hugh Calkins, Tania Zaglia, Nazareno Paolocci, Stephen P. Chelko
JOURNAL OF CLINICAL MEDICINE
(2020)
Article
Physiology
Ajay P. Nayak, Deepak A. Deshpande, Sushrut D. Shah, Dominic R. Villalba, Roslyn Yi, Nadan Wang, Raymond B. Penn
Summary: The study found that OGR1KO mice are resistant to asthma features induced by inhaled allergen. Treatment with Gs-biased OGR1 agonist sulazepam can protect WT mice from allergen-induced AHR and inhibit collagen accumulation in lung tissue.
AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY
(2021)
Retraction
Multidisciplinary Sciences
Dilip Shah, Freddy Romero, Michelle Duong, Nadan Wang, Bishnuhari Paudyal, Benjamin T. Suratt, Caleb B. Kallen, Jianxin Sun, Ying Zhu, Kenneth Walsh, Ross Summer
SCIENTIFIC REPORTS
(2022)
Article
Cardiac & Cardiovascular Systems
Guanxin Zhang, Qing Qin, Chen Zhang, Xiaobo Sun, Kyosuke Kazama, Bing Yi, Fang Cheng, Zhi-Fu Guo, Jianxin Sun
Summary: The study finds that NDRG1 plays an essential role in cell differentiation, proliferation, and stress responses. The expression of NDRG1 significantly increases in cytokine-stimulated endothelial cells and atherosclerotic lesions. Inhibition of NDRG1 not only suppresses the expression of procoagulant molecules but also exerts antithrombotic effects in endothelial cells, highlighting its potential as a therapeutic target for vascular diseases.
CIRCULATION RESEARCH
(2023)
Article
Pharmacology & Pharmacy
Paola Orlandi, Marta Banchi, Francesca Vaglini, Marco Carli, Stefano Aringhieri, Arianna Bandini, Carla Pardini, Cristina Viaggi, Michele Lai, Greta Ali, Alessandra Ottani, Eleonora Vandini, Patrizia Guidi, Margherita Bernardeschi, Veronica La Rocca, Giulio Francia, Gabriella Fontanini, Mauro Pistello, Giada Frenzilli, Daniela Giuliani, Marco Scarselli, Guido Bocci
Summary: This study investigates the role of MC4R in melanoma and the use of the selective antagonist ML in combination with vemurafenib. The results show that ML can inhibit melanoma cell proliferation and induce apoptosis through the inhibition of ERK1/2 phosphorylation and reduction of BCL-XL expression. The combination of vemurafenib and ML exhibits a synergistic effect in vitro and inhibits tumor growth in vivo without causing adverse effects.
BIOCHEMICAL PHARMACOLOGY
(2024)
Article
Pharmacology & Pharmacy
Conor J. Bloxham, Katina D. Hulme, Fabrizio Fierro, Christian Fercher, Cassandra L. Pegg, Shannon L. O'Brien, Simon R. Foster, Kirsty R. Short, Sebastian G. B. Furness, Melissa E. Reichelt, Masha Y. Niv, Walter G. Thomas
Summary: Bitter taste receptors (T2Rs) are a type of G protein-coupled receptors that allow humans to detect aversive and toxic substances. This study characterized the functional properties of previously identified T2Rs in human cardiac tissues and their naturally occurring polymorphisms. The results showed differences in signaling among different T2R variants, and revealed a potential association between the T2R50 Tyr203 variant and cardiovascular disease.
BIOCHEMICAL PHARMACOLOGY
(2024)
Article
Pharmacology & Pharmacy
Lu Chen, Huanying Shi, Wenxin Zhang, Yongjun Zhu, Haifei Chen, Zimei Wu, Huijie Qi, Jiafeng Liu, Mingkang Zhong, Xiaojin Shi, Tianxiao Wang, Qunyi Li
Summary: This study demonstrates that Carfilzomib exhibits potent anti-tumor activity against esophageal squamous cell carcinoma (ESCC) by triggering mitochondrial apoptosis and reprogramming cellular metabolism. It has been identified that activating transcription factor 3 (ATF3) plays a crucial role as a cellular target in ESCC cells treated with Carfilzomib. Overexpression of ATF3 effectively counteracts the effects of Carfilzomib on ESCC cell proliferation, apoptosis, and metabolic reprogramming. Furthermore, ATF3 mediates the anti-tumor activity of Carfilzomib, suggesting its potential as a therapeutic agent for ESCC.
BIOCHEMICAL PHARMACOLOGY
(2024)
Review
Pharmacology & Pharmacy
Xing Zhang, Xiang Li, Ran Xia, Hong-Sheng Zhang
Summary: This review summarizes recent progress on the mechanisms of ferroptosis resistance in cancer and highlights the role of redox status and metabolism. Combination therapy for ferroptosis has great potential in treating resistant malignant tumors.
BIOCHEMICAL PHARMACOLOGY
(2024)