Inhibition of hypoxia inducible factor 1 by YC-1 attenuates tissue plasminogen activator induced hemorrhagic transformation by suppressing HMGB1/TLR4/NF-κB mediated neutrophil infiltration in thromboembolic stroke rats

Neuroinflammation in hemorrhagic transformation after tissue plasminogen activator thrombolysis: Potential mechanisms, targets, therapeutic drugs and biomarkers

(2020) Guodong Ma et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Increase in neutrophils after recombinant tissue plasminogen activator thrombolysis predicts poor functional outcome of ischaemic stroke: a longitudinal study

(2018) J. Shi et al.   EUROPEAN JOURNAL OF NEUROLOGY

Pinocembrin Protects Blood-Brain Barrier Function and Expands the Therapeutic Time Window for Tissue-Type Plasminogen Activator Treatment in a Rat Thromboembolic Stroke Model

(2018) YinZhong Ma et al.   Biomed Research International

Neutrophils in tPA-induced hemorrhagic transformations: Main culprit, accomplice or innocent bystander?

(2018) Thavarak Ouk et al.   PHARMACOLOGY & THERAPEUTICS

Hypoxia-independent mechanisms of HIF-1α expression in astrocytes after ischemic preconditioning

(2017) Yuri Hirayama et al.   GLIA

Therapeutic Strategies to Attenuate Hemorrhagic Transformation After Tissue Plasminogen Activator Treatment for Acute Ischemic Stroke

(2017) Masato Kanazawa et al.   Journal of Atherosclerosis and Thrombosis

Treatment and Outcome of Hemorrhagic Transformation After Intravenous Alteplase in Acute Ischemic Stroke: A Scientific Statement for Healthcare Professionals From the American Heart Association/American Stroke Association

(2017) Shadi Yaghi et al.   STROKE

β2-Adrenergic Receptor-Mediated HIF-1α Upregulation Mediates Blood Brain Barrier Damage in Acute Cerebral Ischemia

(2017) Yanyun Sun et al.   Frontiers in Molecular Neuroscience

Neuronal HIF-1α and HIF-2α deficiency improves neuronal survival and sensorimotor function in the early acute phase after ischemic stroke

(2016) Philipp Barteczek et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Dynamic change of neutrophil to lymphocyte ratio and hemorrhagic transformation after thrombolysis in stroke

(2016) Zhiliang Guo et al.   Journal of Neuroinflammation

Thromboinflammation in Stroke Brain Damage

(2016) Simon F. De Meyer et al.   STROKE

A Review of the Mechanisms of Blood-Brain Barrier Permeability by Tissue-Type Plasminogen Activator Treatment for Cerebral Ischemia

(2016) Yasuhiro Suzuki et al.   Frontiers in Cellular Neuroscience

Implications of MMP9 for Blood Brain Barrier Disruption and Hemorrhagic Transformation Following Ischemic Stroke

(2016) Renée J. Turner et al.   Frontiers in Cellular Neuroscience

Crosstalk between the HIF-1 and Toll-like receptor/nuclear factor-κB pathways in the oral squamous cell carcinoma microenvironment

(2016) Shengwei Han et al.   Oncotarget

A novel embolic middle cerebral artery occlusion model induced by thrombus formed in common carotid artery in rat

(2015) Yin-Zhong Ma et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

Treatment with recombinant tissue plasminogen activator (r-TPA) induces neutrophil degranulation in vitro via defined pathways

(2015) Federico Carbone et al.   VASCULAR PHARMACOLOGY

The HIF-1/glial TIM-3 axis controls inflammation-associated brain damage under hypoxia

(2015) Han Seok Koh et al.   Nature Communications

Tissue-type plasminogen activator deficiency delays bone repair: roles of osteoblastic proliferation and vascular endothelial growth factor

(2014) Naoyuki Kawao et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Neutralization of chemokine-like factor 1, a novel C-C chemokine, protects against focal cerebral ischemia by inhibiting neutrophil infiltration via MAPK pathways in rats

(2014) Ling Kong et al.   Journal of Neuroinflammation

Hemorrhagic Transformation after Tissue Plasminogen Activator Reperfusion Therapy for Ischemic Stroke: Mechanisms, Models, and Biomarkers

(2014) Wei Wang et al.   MOLECULAR NEUROBIOLOGY

Delayed Hyperbaric Oxygen Therapy Promotes Neurogenesis Through Reactive Oxygen Species/Hypoxia-Inducible Factor-1α/β-Catenin Pathway in Middle Cerebral Artery Occlusion Rats

(2014) Qin Hu et al.   STROKE

Cell-specific blood-brain barrier regulation in health and disease: a focus on hypoxia

(2013) S Engelhardt et al.   BRITISH JOURNAL OF PHARMACOLOGY

Hyperbaric oxygen preconditioning attenuates hyperglycemia-enhanced hemorrhagic transformation by inhibiting matrix metalloproteinases in focal cerebral ischemia in rats

(2013) Yoshiteru Soejima et al.   EXPERIMENTAL NEUROLOGY

Hypoxia Selectively Disrupts Brain Microvascular Endothelial Tight Junction Complexes Through a Hypoxia-Inducible Factor-1 (HIF-1) Dependent Mechanism

(2013) Sabrina Engelhardt et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Hemorrhagic Transformation after Ischemic Stroke in Animals and Humans

(2013) Glen C Jickling et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Progesterone Attenuates Hemorrhagic Transformation after Delayed tPA Treatment in an Experimental Model of Stroke in Rats: Involvement of the VEGF–MMP Pathway

(2013) Soonmi Won et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Toll-like receptor 4 signaling in intracerebral hemorrhage-induced inflammation and injury

(2013) Huang Fang et al.   Journal of Neuroinflammation

Factors influencing haemorrhagic transformation in ischaemic stroke

(2013) José Álvarez-Sabín et al.   LANCET NEUROLOGY

Matrix Metalloproteinases and Blood-Brain Barrier Disruption in Acute Ischemic Stroke

(2013) Shaheen E. Lakhan et al.   Frontiers in Neurology

Hypoxia Inducible Factor-1: Its Potential Role In Cerebral Ischemia

(2012) Neetu Singh et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

HIF-1 at the Blood-Brain Barrier: A Mediator of Permeability?

(2012) Omolara O. Ogunshola et al.   HIGH ALTITUDE MEDICINE & BIOLOGY

Tissue-Type Plasminogen Activator Regulates the Neuronal Uptake of Glucose in the Ischemic Brain

(2012) F. Wu et al.   JOURNAL OF NEUROSCIENCE

Inhibition of VEGF signaling pathway attenuates hemorrhage after tPA treatment

(2011) Masato Kanazawa et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Differential Effects of HIF-1 Inhibition by YC-1 on the Overall Outcome and Blood-Brain Barrier Damage in a Rat Model of Ischemic Stroke

(2011) Jingqi Yan et al.   PLoS One

Molecular insights and therapeutic targets for blood–brain barrier disruption in ischemic stroke: Critical role of matrix metalloproteinases and tissue-type plasminogen activator

(2010) Rong Jin et al.   NEUROBIOLOGY OF DISEASE

Erythropoietin in Combination of Tissue Plasminogen Activator Exacerbates Brain Hemorrhage When Treatment Is Initiated 6 Hours After Stroke

(2010) Longfei Jia et al.   STROKE

The role and regulation of hypoxia-inducible factor-1α expression in brain development and neonatal hypoxic–ischemic brain injury

(2009) Xiyong Fan et al.   BRAIN RESEARCH REVIEWS

Neutrophils contribute to intracerebral haemorrhages after treatment with recombinant tissue plasminogen activator following cerebral ischaemia

(2009) Sophie Gautier et al.   BRITISH JOURNAL OF PHARMACOLOGY

Tissue plasminogen activator (t-PA) promotes neutrophil degranulation and MMP-9 release

(2008) Eloy Cuadrado et al.   JOURNAL OF LEUKOCYTE BIOLOGY

A novel mode of action of YC-1 in HIF inhibition: stimulation of FIH-dependent p300 dissociation from HIF-1 

(2008) S. H. Li et al.   MOLECULAR CANCER THERAPEUTICS

HIF-1α inhibition ameliorates neonatal brain injury in a rat pup hypoxic–ischemic model

(2008) Wanqiu Chen et al.   NEUROBIOLOGY OF DISEASE

Extension of the Thrombolytic Time Window With Minocycline in Experimental Stroke

(2008) Yoshihiro Murata et al.   STROKE