β2-Adrenergic Receptor-Mediated HIF-1α Upregulation Mediates Blood Brain Barrier Damage in Acute Cerebral Ischemia

Sodium Tanshinone IIA Sulfonate Enhances Effectiveness Rt-PA Treatment in Acute Ischemic Stroke Patients Associated with Ameliorating Blood-Brain Barrier Damage

(2017) Biying Ji et al.   Translational Stroke Research

Blood brain barrier breakdown was found in non-infarcted area after 2-h MCAO

(2016) Xiaona Wang et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

Normobaric Hyperoxia Extends Neuro- and Vaso-Protection of N-Acetylcysteine in Transient Focal Ischemia

(2016) Yushan Liu et al.   MOLECULAR NEUROBIOLOGY

Role of Hypoxia Inducible Factor 1 in Hyperglycemia-Exacerbated Blood-Brain Barrier Disruption in Ischemic Stroke

(2016) Ziyan Zhang et al.   NEUROBIOLOGY OF DISEASE

Pretreatment blood–brain barrier disruption and post-endovascular intracranial hemorrhage

(2016) Richard Leigh et al.   NEUROLOGY

Hydrogen Sulfide Attenuates Tissue Plasminogen Activator-Induced Cerebral Hemorrhage Following Experimental Stroke

(2016) Hui Liu et al.   Translational Stroke Research

Translational Stroke Research on Blood-Brain Barrier Damage: Challenges, Perspectives, and Goals

(2016) Yejie Shi et al.   Translational Stroke Research

Cerebral Microvascular Endothelial Cell Apoptosis after Ischemia: Role of Enolase-Phosphatase 1 Activation and Aci-Reductone Dioxygenase 1 Translocation

(2016) Yuan Zhang et al.   Frontiers in Molecular Neuroscience

Activation of matrix metalloproteinase in dorsal hippocampus drives improvement in spatial working memory after intra-VTA nicotine infusion in rats

(2015) Hui Shu et al.   JOURNAL OF NEUROCHEMISTRY

Caveolin-1 mediates tissue plasminogen activator-induced MMP-9 up-regulation in cultured brain microvascular endothelial cells

(2015) Xinchun Jin et al.   JOURNAL OF NEUROCHEMISTRY

Nitric Oxide Interacts with Caveolin-1 to Facilitate Autophagy-Lysosome-Mediated Claudin-5 Degradation in Oxygen-Glucose Deprivation-Treated Endothelial Cells

(2015) Jie Liu et al.   MOLECULAR NEUROBIOLOGY

β2-adrenogenic signaling regulates NNK-induced pancreatic cancer progression via upregulation of HIF-1α

(2015) Dong Zhang et al.   Oncotarget

Early Ischemic Blood Brain Barrier Damage: A Potential Indicator for Hemorrhagic Transformation Following Tissue Plasminogen Activator (tPA) Thrombolysis?

(2014) Xinchun Jin et al.   CURRENT NEUROVASCULAR RESEARCH

Hemorrhagic Transformation after Tissue Plasminogen Activator Reperfusion Therapy for Ischemic Stroke: Mechanisms, Models, and Biomarkers

(2014) Wei Wang et al.   MOLECULAR NEUROBIOLOGY

Pretreatment Blood–Brain Barrier Damage and Post-Treatment Intracranial Hemorrhage in Patients Receiving Intravenous Tissue-Type Plasminogen Activator

(2014) Richard Leigh et al.   STROKE

Hyperglycemia, Acute Ischemic Stroke, and Thrombolytic Therapy

(2014) Sherif Hafez et al.   Translational Stroke Research

Ischemia induces different levels of hypoxia inducible factor-1α protein expression in interneurons and pyramidal neurons

(2014) Prabhu Ramamoorthy et al.   Acta Neuropathologica Communications

Oxygen Sensing, Hypoxia-Inducible Factors, and Disease Pathophysiology

(2013) Gregg L. Semenza   Annual Review of Pathology-Mechanisms of Disease

Cell-specific blood-brain barrier regulation in health and disease: a focus on hypoxia

(2013) S Engelhardt et al.   BRITISH JOURNAL OF PHARMACOLOGY

β2-AR-HIF-1α: A Novel Regulatory Axis for Stress-Induced Pancreatic Tumor Growth and Angiogenesis

(2013) T. Shan et al.   CURRENT MOLECULAR MEDICINE

VEGF Secreted by Hypoxic Muller Cells Induces MMP-2 Expression and Activity in Endothelial Cells to Promote Retinal Neovascularization in Proliferative Diabetic Retinopathy

(2013) M. Rodrigues et al.   DIABETES

Hypoxia-inducible factor 1 contributes to N-acetylcysteine’s protection in stroke

(2013) Ziyan Zhang et al.   FREE RADICAL BIOLOGY AND MEDICINE

Ischemic neurons activate astrocytes to disrupt endothelial barrier via increasing VEGF expression

(2013) Ying-Na Li et al.   JOURNAL OF NEUROCHEMISTRY

Normobaric hyperoxia combined with minocycline provides greater neuroprotection than either alone in transient focal cerebral ischemia

(2012) Xinchun Jin et al.   EXPERIMENTAL NEUROLOGY

Matrix Metalloproteinase-2-Mediated Occludin Degradation and Caveolin-1-Mediated Claudin-5 Redistribution Contribute to Blood-Brain Barrier Damage in Early Ischemic Stroke Stage

(2012) J. Liu et al.   JOURNAL OF NEUROSCIENCE

Spatiotemporal evolution of blood brain barrier damage and tissue infarction within the first 3h after ischemia onset

(2012) Xinchun Jin et al.   NEUROBIOLOGY OF DISEASE

Differential Effects of HIF-1 Inhibition by YC-1 on the Overall Outcome and Blood-Brain Barrier Damage in a Rat Model of Ischemic Stroke

(2011) Jingqi Yan et al.   PLoS One

Oxygen Therapy Reduces Secondary Hemorrhage after Thrombolysis in Thromboembolic Cerebral Ischemia

(2010) Li Sun et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Suppression of hypoxia-inducible factor-1α and its downstream genes reduces acute hyperglycemia-enhanced hemorrhagic transformation in a rat model of cerebral ischemia

(2010) Chunhua Chen et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Experimental Models for Assaying Microvascular Endothelial Cell Pathophysiology in Stroke

(2010) Susanna Camós et al.   MOLECULES

Hypoxia Inducible Factor 1 as a Therapeutic Target in Ischemic Stroke

(2009) Honglian Shi   CURRENT MEDICINAL CHEMISTRY

Early inhibition of HIF-1α with small interfering RNA reduces ischemic–reperfused brain injury in rats

(2009) Chunhua Chen et al.   NEUROBIOLOGY OF DISEASE

Astrocyte responses to injury: VEGF simultaneously modulates cell death and proliferation

(2008) Nicole Schmid-Brunclik et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

β1- and β2-Adrenoceptors in basolateral nucleus of amygdala and their roles in consolidation of fear memory in rats

(2008) Li-Li Qu et al.   HIPPOCAMPUS

The Good, the Bad, and the Cell Type-Specific Roles of Hypoxia Inducible Factor-1  in Neurons and Astrocytes

(2008) G. Vangeison et al.   JOURNAL OF NEUROSCIENCE

Reactive Oxygen Species Regulate Hypoxia-Inducible Factor 1  Differentially in Cancer and Ischemia

(2008) A. A. Qutub et al.   MOLECULAR AND CELLULAR BIOLOGY

Thrombolysis with Alteplase 3 to 4.5 Hours after Acute Ischemic Stroke

(2008) Werner Hacke et al.   NEW ENGLAND JOURNAL OF MEDICINE

Early Disruption of the Blood–Brain Barrier After Thrombolytic Therapy Predicts Hemorrhage in Patients With Acute Stroke

(2008) Andreas Kastrup et al.   STROKE