Molecular structure and the role of high‐temperature requirement protein 1 in skeletal disorders and cancers

Understanding chondrodysplasia ( cho ): A comprehensive review of cho as an animal model of birth defects, disorders, and molecular mechanisms

(2019) Robert E. Seegmiller et al.   Birth Defects Research

High-Temperature Requirement A1 Protease as a Rate-Limiting Factor in the Development of Osteoarthritis

(2019) Peter H. Chen et al.   AMERICAN JOURNAL OF PATHOLOGY

Review: Targeting the Transforming Growth Factor-Beta Pathway in Ovarian Cancer

(2019) Brandon M. Roane et al.   Cancers

HTRA1 promotes transdifferentiation of normal fibroblasts to cancer-associated fibroblasts through activation of the NF-κB/bFGF signaling pathway in gastric cancer

(2019) Hongxue Wu et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Inactivation of the serine protease HTRA1 inhibits tumor growth by deregulating angiogenesis

(2018) Ralph Klose et al.   ONCOGENE

HtrA1 expression and the prognosis of high-grade serous ovarian carcinoma: a cohort study using digital analysis

(2018) Andréanne Gagné et al.   Diagnostic Pathology

HGF-mediated crosstalk between cancer-associated fibroblasts and MET-unamplified gastric cancer cells activates coordinated tumorigenesis and metastasis

(2018) Xusheng Ding et al.   Cell Death & Disease

Role of HTRA1 in bone formation and regeneration: In vitro and in vivo evaluation

(2017) Gladys Filliat et al.   PLoS One

Lysyl oxidase drives tumour progression by trapping EGF receptors at the cell surface

(2017) HaoRan Tang et al.   Nature Communications

High-Temperature Requirement A1 (Htra1) - A Novel Regulator of Canonical Wnt Signaling

(2017) Oriane Globus et al.   Scientific Reports

Osteoarthritis: toward a comprehensive understanding of pathological mechanism

(2017) Di Chen et al.   Bone Research

HtrA1 activation is driven by an allosteric mechanism of inter-monomer communication

(2017) Alvaro Cortes Cabrera et al.   Scientific Reports

Discoidin Domain Receptor 2 as a Potential Therapeutic Target for Development of Disease-Modifying Osteoarthritis Drugs

(2016) Lauren B. Manning et al.   AMERICAN JOURNAL OF PATHOLOGY

The differential role of HTRA1 in HPV-positive and HPV-negative cervical cell line proliferation

(2016) Bruna Stuqui et al.   BMC CANCER

PITPNC1 Recruits RAB1B to the Golgi Network to Drive Malignant Secretion

(2016) Nils Halberg et al.   CANCER CELL

Fibrotic-like changes in degenerate human intervertebral discs revealed by quantitative proteomic analysis

(2016) A. Yee et al.   OSTEOARTHRITIS AND CARTILAGE

Loss-of-Function of HtrA1 Abrogates All-TransRetinoic Acid-Induced Osteogenic Differentiation of Mouse Adipose-Derived Stromal Cells Through Deficiencies in p70S6K Activation

(2016) Stephan Glanz et al.   STEM CELLS AND DEVELOPMENT

Tumor Vessel Up-Regulation of INSR Revealed by Single-Cell Expression Analysis of the Tyrosine Kinome and Phosphatome in Human Cancers

(2015) Sara Kiflemariam et al.   AMERICAN JOURNAL OF PATHOLOGY

HtrA1 regulates epithelial–mesenchymal transition in hepatocellular carcinoma

(2015) Feng Zhu et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

HtrA1 resensitizes multidrug-resistant hepatocellular carcinoma cells by targeting XIAP

(2015) Wanyuan Bao et al.   BIOMEDICINE & PHARMACOTHERAPY

HtrA1 may regulate the osteogenic differentiation of human periodontal ligament cells by TGF-β1

(2015) Ran Li et al.   JOURNAL OF MOLECULAR HISTOLOGY

Determinants of amyloid fibril degradation by the PDZ protease HTRA1

(2015) Simon Poepsel et al.   Nature Chemical Biology

The Autolysis of Human HtrA1 Is Governed by the Redox State of Its N-Terminal Domain

(2014) Michael W. Risør et al.   BIOCHEMISTRY

The Inhibitory Effect of IFN-  on Protease HTRA1 Expression in Rheumatoid Arthritis

(2014) Y. Hou et al.   JOURNAL OF IMMUNOLOGY

Cerebral small vessel disease-related protease HtrA1 processes latent TGF-β binding protein 1 and facilitates TGF-β signaling

(2014) Nathalie Beaufort et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

HtrA1 is upregulated during RANKL-induced osteoclastogenesis, and negatively regulates osteoblast differentiation and BMP2-induced Smad1/5/8, ERK and p38 phosphorylation

(2013) Xinghuo Wu et al.   FEBS LETTERS

Chondroadherin Fragmentation Mediated by the Protease HTRA1 Distinguishes Human Intervertebral Disc Degeneration from Normal Aging

(2013) Bashar Akhatib et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Serine Protease HTRA1 Antagonizes Transforming Growth Factor-β Signaling by Cleaving Its Receptors and Loss of HTRA1 In Vivo Enhances Bone Formation

(2013) Julie R. Graham et al.   PLoS One

Assessment of the Matrix Degenerative Effects of MMP-3, ADAMTS-4, and HTRA1, Injected Into a Bovine Intervertebral Disc Organ Culture Model

(2013) Tina Furtwängler et al.   SPINE

An overview of the regulation of bone remodelling at the cellular level

(2012) Jasreen Kular et al.   CLINICAL BIOCHEMISTRY

Detrimental Role for Human High Temperature Requirement Serine Protease A1 (HTRA1) in the Pathogenesis of Intervertebral Disc (IVD) Degeneration

(2012) André N. Tiaden et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

HtrA1 Is a Novel Antagonist Controlling Fibroblast Growth Factor (FGF) Signaling via Cleavage of FGF8

(2012) G.-Y. Kim et al.   MOLECULAR AND CELLULAR BIOLOGY

Changes in expression of human serine protease HtrA1, HtrA2 and HtrA3 genes in benign and malignant thyroid tumors

(2012) DOROTA ZURAWA-JANICKA et al.   ONCOLOGY REPORTS

Down-Regulation of HtrA1 Activates the Epithelial-Mesenchymal Transition and ATM DNA Damage Response Pathways

(2012) Ning Wang et al.   PLoS One

Human Serine Protease HTRA1 Positively Regulates Osteogenesis of Human Bone Marrow-derived Mesenchymal Stem Cells and Mineralization of Differentiating Bone-forming Cells Through the Modulation of Extracellular Matrix Protein

(2012) André N. Tiaden et al.   STEM CELLS

Structural and Functional Analysis of HtrA1 and Its Subdomains

(2012) Charles Eigenbrot et al.   STRUCTURE

HtrA1 sensitizes ovarian cancer cells to cisplatin-induced cytotoxicity by targeting XIAP for degradation

(2011) Xiaoping He et al.   INTERNATIONAL JOURNAL OF CANCER

Substrate-induced remodeling of the active site regulates human HTRA1 activity

(2011) Linda Truebestein et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Osteoarthritis-like changes in the heterozygous sedc mouse associated with the HtrA1–Ddr2–Mmp-13 degradative pathway: a new model of osteoarthritis

(2011) D.W. Holt et al.   OSTEOARTHRITIS AND CARTILAGE

Downregulation of HtrA1 Promotes Resistance to Anoikis and Peritoneal Dissemination of Ovarian Cancer Cells

(2010) X. He et al.   CANCER RESEARCH

Expression and Functional Significance of HtrA1 Loss in Endometrial Cancer

(2010) S. A. Mullany et al.   CLINICAL CANCER RESEARCH

Determinants of structural and functional plasticity of a widely conserved protease chaperone complex

(2010) Melisa Merdanovic et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Critical roles of the TGF-β type I receptor ALK5 in perichondrial formation and function, cartilage integrity, and osteoblast differentiation during growth plate development

(2009) Tomoya Matsunobu et al.   DEVELOPMENTAL BIOLOGY

Identification of tubulins as substrates of serine protease HtrA1 by mixture-based oriented peptide library screening

(2009) Jeremy Chien et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Serine Protease HtrA1 Associates with Microtubules and Inhibits Cell Migration

(2009) J. Chien et al.   MOLECULAR AND CELLULAR BIOLOGY

Changes in mRNA and protein levels of human HtrA1, HtrA2 and HtrA3 in ovarian cancer

(2008) Joanna Narkiewicz et al.   CLINICAL BIOCHEMISTRY

Intracellular localization of the tumor suppressor HtrA1/Prss11 and its association with HPV16 E6 and E7 proteins

(2008) Gary A. Clawson et al.   JOURNAL OF CELLULAR BIOCHEMISTRY