Biogenesis, physiological functions and potential applications of extracellular vesicles in substance use disorders

Alcohol-and-HIV-Induced Lysosomal Dysfunction Regulates Extracellular Vesicles Secretion in Vitro and in Liver-Humanized Mice

(2021) Raghubendra Singh Dagur et al.   Biology-Basel

Electronic cigarettes containing nicotine increase endothelial and platelet derived extracellular vesicles in healthy volunteers

(2020) Fariborz Mobarrez et al.   ATHEROSCLEROSIS

Cocaine Self-administration and Extinction Inversely Alter Neuron to Glia Exosomal Dynamics in the Nucleus Accumbens

(2020) Rachel Jarvis et al.   Frontiers in Cellular Neuroscience

Altered serum microRNA expression profile in subjects with heroin and methamphetamine use disorder

(2020) Wan-Jian Gu et al.   BIOMEDICINE & PHARMACOTHERAPY

Differential packaging of inflammatory cytokines/ chemokines and oxidative stress modulators in U937 and U1 macrophages-derived extracellular vesicles upon exposure to tobacco constituents

(2020) Sanjana Haque et al.   PLoS One

Circulatory Astrocyte and Neuronal EVs as Potential Biomarkers of Neurological Dysfunction in HIV-Infected Subjects and Alcohol/Tobacco Users

(2020) Sunitha Kodidela et al.   Diagnostics

Role of Extracellular Vesicles in Substance Abuse and HIV-Related Neurological Pathologies

(2020) Katherine E. Odegaard et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Plasma neuronal exosomes serve as biomarkers of cognitive impairment in HIV infection and Alzheimer’s disease

(2019) Lynn Pulliam et al.   JOURNAL OF NEUROVIROLOGY

Dysregulated autophagy and lysosome function are linked to exosome production via miR‐155 in alcoholic liver disease

(2019) Mrigya Babuta et al.   HEPATOLOGY

Cardioprotective role of extracellular vesicles: A highlight on exosome beneficial effects in cardiovascular diseases

(2019) Jafar Rezaie et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Proteomic Profiling of Exosomes Derived from Plasma of HIV-Infected Alcohol Drinkers and Cigarette Smokers

(2019) Sunitha Kodidela et al.   Journal of Neuroimmune Pharmacology

Extracellular Vesicles: Intercellular Mediators in Alcohol-Induced Pathologies

(2019) Mohammad A. Rahman et al.   Journal of Neuroimmune Pharmacology

TLR4 participates in the transmission of ethanol-induced neuroinflammation via astrocyte-derived extracellular vesicles

(2019) Francesc Ibáñez et al.   Journal of Neuroinflammation

Plasma exosomes exacerbate alcohol- and acetaminophen-induced toxicity via CYP2E1 pathway

(2019) Mohammad A. Rahman et al.   Scientific Reports

Strategies for the use of Extracellular Vesicles for the Delivery of Therapeutics

(2019) Susmita Sil et al.   Journal of Neuroimmune Pharmacology

Human Immunodeficiency Virus (HIV) Infection and Use of Illicit Substances Promote Secretion of Semen Exosomes that Enhance Monocyte Adhesion and Induce Actin Reorganization and Chemotactic Migration

(2019) Lyu et al.   Cells

Cocaine-induced endocannabinoid signaling mediated by sigma-1 receptors and extracellular vesicle secretion

(2019) Yoki Nakamura et al.   eLife

Extracellular vesicles and chronic inflammation during HIV infection

(2019) Paula Soledad Pérez et al.   Journal of Extracellular Vesicles

Heroin Abuse and/or HIV Infection Dysregulate Plasma Exosomal miRNAs

(2019) Xu Wang et al.   Journal of Neuroimmune Pharmacology

Neuronal-derived extracellular vesicles are enriched in the brain and serum of HIV-1 transgenic rats

(2019) Raghubendra Singh Dagur et al.   Journal of Extracellular Vesicles

Rational incorporation of molecular adjuvants into a hybrid nanoparticle-based nicotine vaccine for immunotherapy against nicotine addiction

(2018) Zongmin Zhao et al.   BIOMATERIALS

Effect of methamphetamine exposure on the plasma levels of endothelial-derived microparticles

(2018) Azadeh Nazari et al.   DRUG AND ALCOHOL DEPENDENCE

Expression of miRNAs in Serum Exosomes versus Hippocampus in Methamphetamine-Induced Rats and Intervention of Rhynchophylline

(2018) Han-cheng Li et al.   Evidence-based Complementary and Alternative Medicine

Potential neuroprotective role of astroglial exosomes against smoking-induced oxidative stress and HIV-1 replication in the central nervous system

(2018) Sabina Ranjit et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Macrophage-derived extracellular vesicles mediates smooth muscle hyperplasia: role of altered miRNA cargo in response to HIV-infection and substance abuse

(2018) Himanshu Sharma et al.   FASEB JOURNAL

Extracellular vesicles from mice with alcoholic liver disease carry a distinct protein cargo and induce macrophage activation through heat shock protein 90

(2018) Banishree Saha et al.   HEPATOLOGY

Extracellular vesicles characteristics and emerging roles in atherosclerotic cardiovascular disease

(2018) Anouar Hafiane et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

The impact of oncogenic EGFRvIII on the proteome of extracellular vesicles released from glioblastoma cells

(2018) Dongsic Choi et al.   MOLECULAR & CELLULAR PROTEOMICS

Morphine-Mediated Brain Region-Specific Astrocytosis Involves the ER Stress-Autophagy Axis

(2018) Susmita Sil et al.   MOLECULAR NEUROBIOLOGY

Extracellular vesicles as potential biomarkers for alcohol- and drug-induced liver injury and their therapeutic applications

(2018) Young-Eun Cho et al.   PHARMACOLOGY & THERAPEUTICS

Nef Secretion into Extracellular Vesicles or Exosomes Is Conserved across Human and Simian Immunodeficiency Viruses

(2018) Ryan P. McNamara et al.   mBio

Exosome-Mimetic Nanovesicles from Hepatocytes promote hepatocyte proliferation in vitro and liver regeneration in vivo

(2018) Jun-Yi Wu et al.   Scientific Reports

Antiretroviral Drugs Alter the Content of Extracellular Vesicles from HIV-1-Infected Cells

(2018) Catherine DeMarino et al.   Scientific Reports

Intranasal delivery of mesenchymal stem cell-derived exosomes reduces oxidative stress and markedly inhibits ethanol consumption and post-deprivation relapse drinking.

(2018) Fernando Ezquer et al.   ADDICTION BIOLOGY

Sinomenine Protects Against Morphine Dependence through the NMDAR1/CAMKII/CREB Pathway: A Possible Role of Astrocyte-Derived Exosomes

(2018) Jinying Ou et al.   MOLECULES

Cytokine profiling of exosomes derived from the plasma of HIV-infected alcohol drinkers and cigarette smokers

(2018) Sunitha Kodidela et al.   PLoS One

Benzo(a)pyrene in Cigarette Smoke Enhances HIV-1 Replication through NF-κB Activation via CYP-Mediated Oxidative Stress Pathway

(2018) Sabina Ranjit et al.   Scientific Reports

Cannabidiol (CBD) Is a Novel Inhibitor for Exosome and Microvesicle (EMV) Release in Cancer

(2018) Uchini S. Kosgodage et al.   Frontiers in Pharmacology

Astrocyte EV-induced lincRNA-Cox2 regulates microglial phagocytosis: Implications for morphine-mediated potentiation of neurodegeneration

(2018) Guoku Hu et al.   Molecular Therapy-Nucleic Acids

Urinary exosomal expression of long non-coding RNAs as diagnostic marker in bladder cancer

(2018) Fatemeh Yazarlou et al.   Cancer Management and Research

Cannabidiol Affects Extracellular Vesicle Release, miR21 and miR126, and Reduces Prohibitin Protein in Glioblastoma Multiforme Cells

(2018) Uchini S. Kosgodage et al.   Translational Oncology

MicroRNAs regulate synaptic plasticity underlying drug addiction

(2017) A. C. W. Smith et al.   GENES BRAIN AND BEHAVIOR

Methamphetamine increases HIV infectivity in neural progenitor cells

(2017) Marta Skowronska et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Proceedings of the 2017 ISEV symposium on “HIV, NeuroHIV, drug abuse, & EVs”

(2017) Guoku Hu et al.   JOURNAL OF NEUROVIROLOGY

Cocaine-Mediated Downregulation of miR-124 Activates Microglia by Targeting KLF4 and TLR4 Signaling

(2017) Palsamy Periyasamy et al.   MOLECULAR NEUROBIOLOGY

hucMSC Exosome-Derived GPX1 Is Required for the Recovery of Hepatic Oxidant Injury

(2017) Yongmin Yan et al.   MOLECULAR THERAPY

Extracellular vesicles in liver disease and potential as biomarkers and therapeutic targets

(2017) Gyongyi Szabo et al.   Nature Reviews Gastroenterology & Hepatology

Extracellular Vesicles: Unique Intercellular Delivery Vehicles

(2017) Sybren L.N. Maas et al.   TRENDS IN CELL BIOLOGY

HIV-1 Nef is released in extracellular vesicles derived from astrocytes: evidence for Nef-mediated neurotoxicity

(2017) A Sami Saribas et al.   Cell Death & Disease

MiR-218 targets MeCP2 and inhibits heroin seeking behavior

(2017) Biao Yan et al.   Scientific Reports

Monocyte-derived exosomes upon exposure to cigarette smoke condensate alter their characteristics and show protective effect against cytotoxicity and HIV-1 replication

(2017) Sanjana Haque et al.   Scientific Reports

Extracellular Vesicles in Brain Tumor Progression

(2016) Esterina D’Asti et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

MicroRNAs as regulators of drug abuse and immunity

(2016) Kai Zhang et al.   Central European Journal of Immunology

Infection and Alcoholic Liver Disease

(2016) Christine Chan et al.   Clinics in Liver Disease

Cocaine-mediated downregulation of microglial miR-124 expression involves promoter DNA methylation

(2016) Ming-Lei Guo et al.   Epigenetics

Extracellular vesicles released by hepatocytes from gastric infusion model of alcoholic liver disease contain a MicroRNA barcode that can be detected in blood

(2016) Akiko Eguchi et al.   HEPATOLOGY

Extracellular vesicles and intercellular communication within the nervous system

(2016) Valentina Zappulli et al.   JOURNAL OF CLINICAL INVESTIGATION

Exosomes as therapeutics: The implications of molecular composition and exosomal heterogeneity

(2016) Scott W. Ferguson et al.   JOURNAL OF CONTROLLED RELEASE

Hepatocyte exosomes mediate liver repair and regeneration via sphingosine-1-phosphate

(2016) Hiroyuki Nojima et al.   JOURNAL OF HEPATOLOGY

Alcohol stimulates macrophage activation through caspase-dependent hepatocyte derived release of CD40L containing extracellular vesicles

(2016) Vikas K. Verma et al.   JOURNAL OF HEPATOLOGY

Extracellular vesicles in cardiovascular disease: are they Jedi or Sith?

(2016) Xabier Osteikoetxea et al.   JOURNAL OF PHYSIOLOGY-LONDON

Prolonged Induction of miR-212/132 and REST Expression in Rat Striatum Following Cocaine Self-Administration

(2016) Anna Sadakierska-Chudy et al.   MOLECULAR NEUROBIOLOGY

MicroRNA let-7d is a target of cannabinoid CB 1 receptor and controls cannabinoid signaling

(2016) Anna Chiarlone et al.   NEUROPHARMACOLOGY

Substance Abuse Screening and Treatment

(2016) Johnny C. Tenegra et al.   PRIMARY CARE

Proteomic comparison defines novel markers to characterize heterogeneous populations of extracellular vesicle subtypes

(2016) Joanna Kowal et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Infected erythrocyte-derived extracellular vesicles alter vascular function via regulatory Ago2-miRNA complexes in malaria

(2016) Pierre-Yves Mantel et al.   Nature Communications

KRAS-MEK Signaling Controls Ago2 Sorting into Exosomes

(2016) Andrew J. McKenzie et al.   Cell Reports

MicroRNAs Are Involved in the Development of Morphine-Induced Analgesic Tolerance and Regulate Functionally Relevant Changes in Serpini1

(2016) Jenica D. Tapocik et al.   Frontiers in Molecular Neuroscience

Extracellular Vesicles: Composition, Biological Relevance, and Methods of Study

(2015) MikoŁaj P. Zaborowski et al.   BIOSCIENCE

MicroRNAs: Emerging Role in the Endogenous μ Opioid System

(2015) Massmo Barbierato et al.   CNS & Neurological Disorders-Drug Targets

ESCRTs are everywhere

(2015) J. H. Hurley   EMBO JOURNAL

Active endocannabinoids are secreted on extracellular membrane vesicles

(2015) M. Gabrielli et al.   EMBO REPORTS

NAc Shell Arc/Arg3.1 Protein Mediates Reconsolidation of Morphine CPP by Increased GluR1 Cell Surface Expression: Activation of ERK-Coupled CREB is Required

(2015) Xiu-Fang Lv et al.   INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY

MicroRNA Cargo of Extracellular Vesicles from Alcohol-exposed Monocytes Signals Naive Monocytes to Differentiate into M2 Macrophages

(2015) Banishree Saha et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Exosomes from HIV-1-infected Cells Stimulate Production of Pro-inflammatory Cytokines through Trans-activating Response (TAR) RNA

(2015) Gavin C. Sampey et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Increased number of circulating exosomes and their microRNA cargos are potential novel biomarkers in alcoholic hepatitis

(2015) Fatemeh Momen-Heravi et al.   Journal of Translational Medicine

Ceftriaxone attenuates ethanol drinking and restores extracellular glutamate concentration through normalization of GLT-1 in nucleus accumbens of male alcohol-preferring rats

(2015) Sujan C. Das et al.   NEUROPHARMACOLOGY

Effects of ceftriaxone on GLT1 isoforms, xCT and associated signaling pathways in P rats exposed to ethanol

(2015) P. S. S. Rao et al.   PSYCHOPHARMACOLOGY

Targeted exosome-mediated delivery of opioid receptor Mu siRNA for the treatment of morphine relapse

(2015) Yuchen Liu et al.   Scientific Reports

Integrated miRNA-mRNA analysis in the habenula nuclei of mice intravenously self-administering nicotine

(2015) Sangjoon Lee et al.   Scientific Reports

Exosomes derived from alcohol-treated hepatocytes horizontally transfer liver specific miRNA-122 and sensitize monocytes to LPS

(2015) Fatemeh Momen-Heravi et al.   Scientific Reports

HIV-1, methamphetamine and astrocytes at neuroinflammatory Crossroads

(2015) Kathleen Borgmann et al.   Frontiers in Microbiology

Distinct miRNA expression in dorsal striatal subregions is associated with risk for addiction in rats

(2015) R K Quinn et al.   Translational Psychiatry

Dorsal hippocampal NMDA receptor blockade impairs extinction of naloxone-precipitated conditioned place aversion in acute morphine-treated rats by suppressing ERK and CREB phosphorylation in the basolateral amygdala

(2014) Wei-Sheng Wang et al.   BRITISH JOURNAL OF PHARMACOLOGY

Cancer Exosomes Perform Cell-Independent MicroRNA Biogenesis and Promote Tumorigenesis

(2014) Sonia A. Melo et al.   CANCER CELL

In Vitro Effects of Cocaine on Tunneling Nanotube Formation and Extracellular Vesicle Release in Glioblastoma Cell Cultures

(2014) Chiara Carone et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

microRNA-206 in Rat Medial Prefrontal Cortex Regulates BDNF Expression and Alcohol Drinking

(2014) J. D. Tapocik et al.   JOURNAL OF NEUROSCIENCE

Proteomic Analysis of Saliva in HIV-Positive Heroin Addicts Reveals Proteins Correlated with Cognition

(2014) Stephen S. Dominy et al.   PLoS One

miRNAome analysis of the mammalian neuronal nicotinic acetylcholine receptor gene family

(2014) Eric M. Hogan et al.   RNA

Syntenin-ALIX exosome biogenesis and budding into multivesicular bodies are controlled by ARF6 and PLD2

(2014) Rania Ghossoub et al.   Nature Communications

Mesenchymal stem cell-derived exosomes promote hepatic regeneration in drug-induced liver injury models

(2014) Cheau Tan et al.   Stem Cell Research & Therapy

Exosomes from Hepatitis C Infected Patients Transmit HCV Infection and Contain Replication Competent Viral RNA in Complex with Ago2-miR122-HSP90

(2014) Terence N. Bukong et al.   PLoS Pathogens

Characterization of human plasma-derived exosomal RNAs by deep sequencing

(2013) Xiaoyi Huang et al.   BMC GENOMICS

Alcoholism and its Effects on the Central Nervous System

(2013) Sukhes Mukherjee   CURRENT NEUROVASCULAR RESEARCH

Neuroimmune signaling: a key component of alcohol abuse

(2013) Jody Mayfield et al.   CURRENT OPINION IN NEUROBIOLOGY

Striatal modulation of BDNF expression using microRNA124a-expressing lentiviral vectors impairs ethanol-induced conditioned-place preference and voluntary alcohol consumption

(2013) Amine Bahi et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Epigenetic regulation of connective tissue growth factor by MicroRNA-214 delivery in exosomes from mouse or human hepatic stellate cells

(2013) Li Chen et al.   HEPATOLOGY

Exosomes: Looking back three decades and into the future

(2013) Clifford V. Harding et al.   JOURNAL OF CELL BIOLOGY

Alcohol and toxicity

(2013) Ivan Rusyn et al.   JOURNAL OF HEPATOLOGY

Disruption of alcohol-related memories by mTORC1 inhibition prevents relapse

(2013) Segev Barak et al.   NATURE NEUROSCIENCE

Hrs- and CD63-Dependent Competing Mechanisms Make Different Sized Endosomal Intraluminal Vesicles

(2013) James R. Edgar et al.   TRAFFIC

Exosomes: Current knowledge of their composition, biological functions, and diagnostic and therapeutic potentials

(2012) Alexander V. Vlassov et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Regulation of hepatic stellate cells by connective tissue growth factor

(2012) Guangcun Huang   Frontiers in Bioscience-Landmark

Circulating microRNAs in exosomes indicate hepatocyte injury and inflammation in alcoholic, drug-induced, and inflammatory liver diseases

(2012) Shashi Bala et al.   HEPATOLOGY

Exosome-mediated shuttling of microRNA-29 regulates HIV Tat and morphine-mediated Neuronal dysfunction

(2012) G Hu et al.   Cell Death & Disease

Up-Regulation of MicroRNAs in Brain of Human Alcoholics

(2011) Joanne M. Lewohl et al.   ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH

Monocytic microparticles activate endothelial cells in an IL-1 -dependent manner

(2011) J.-G. Wang et al.   BLOOD

The Tetraspanin CD63 Regulates ESCRT-Independent and -Dependent Endosomal Sorting during Melanogenesis

(2011) Guillaume van Niel et al.   DEVELOPMENTAL CELL

Dopamine receptor D3 genetic polymorphism (rs6280TC) is associated with rates of cognitive impairment in methamphetamine-dependent men with HIV: preliminary findings

(2011) Saurabh Gupta et al.   JOURNAL OF NEUROVIROLOGY

Cerium Oxide Nanoparticles Inhibits Oxidative Stress and Nuclear Factor- B Activation in H9c2 Cardiomyocytes Exposed to Cigarette Smoke Extract

(2011) J. Niu et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Regulation of MiR-124, Let-7d and MiR-181a in the Accumbens Affects the Expression, Extinction and Reinstatement of Cocaine-Induced Conditioned Place Preference

(2011) Vijay Chandrasekar et al.   NEUROPSYCHOPHARMACOLOGY

Characterization of extracellular circulating microRNA

(2011) Andrey Turchinovich et al.   NUCLEIC ACIDS RESEARCH

Microvesicles as mediators of intercellular communication in cancer—the emerging science of cellular ‘debris’

(2011) Tae Hoon Lee et al.   Seminars in Immunopathology

Suppression of activity-regulated cytoskeleton-associated gene expression in the dorsal striatum attenuates extinction of cocaine-seeking

(2010) Matthew C. Hearing et al.   INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY

Yin Yang 1 Phosphorylation Contributes to the Differential Effects of μ-Opioid Receptor Agonists on MicroRNA-190 Expression

(2010) Hui Zheng et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Regulation of Opioid Tolerance by let-7 Family MicroRNA Targeting the   Opioid Receptor

(2010) Y. He et al.   JOURNAL OF NEUROSCIENCE

Striatal microRNA controls cocaine intake through CREB signalling

(2010) Jonathan A. Hollander et al.   NATURE

Differential Allelic Expression of Dopamine D1 Receptor Gene (DRD1) Is Modulated by microRNA miR-504

(2009) Weihua Huang et al.   BIOLOGICAL PSYCHIATRY

Neuronal activity rapidly induces transcription of the CREB-regulated microRNA-132, in vivo

(2009) Aaron S. Nudelman et al.   HIPPOCAMPUS

microRNAs miR-124, let-7d and miR-181a regulate Cocaine-induced Plasticity

(2009) Vijay Chandrasekar et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

The glutamate homeostasis hypothesis of addiction

(2009) Peter W. Kalivas   NATURE REVIEWS NEUROSCIENCE

Nicotine modulates expression of miR-140*, which targets the 3′-untranslated region of dynamin 1 gene (Dnm1)

(2008) Weihua Huang et al.   INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY

Posttranscriptional Regulation of BK Channel Splice Variant Stability by miR-9 Underlies Neuroadaptation to Alcohol

(2008) Andrzej Z. Pietrzykowski et al.   NEURON

Ceramide Triggers Budding of Exosome Vesicles into Multivesicular Endosomes

(2008) K. Trajkovic et al.   SCIENCE