Arginine methyltransferase PRMT5 methylates and stabilizes KLF5 via decreasing its phosphorylation and ubiquitination to promote basal-like breast cancer

Cancer statistics, 2020

(2020) Rebecca L. Siegel et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Recent insight into the role of FBXW7 as a tumor suppressor

(2020) Kanae Yumimoto et al.   SEMINARS IN CANCER BIOLOGY

PRMT5 control of cGAS/STING and NLRC5 pathways defines melanoma response to antitumor immunity

(2020) Hyungsoo Kim et al.   Science Translational Medicine

PRMT5 inhibition modulates E2F1 methylation and gene regulatory networks leading to therapeutic efficacy in JAK2V617F mutant MPN

(2020) Friederike Pastore et al.   Cancer Discovery

PRMT5 Modulates Splicing for Genome Integrity and Preserves Proteostasis of Hematopoietic Stem Cells

(2019) Darren Qiancheng Tan et al.   Cell Reports

The arginine methyltransferase PRMT5 and PRMT1 distinctly regulate the degradation of anti-apoptotic protein CFLARL in human lung cancer cells

(2019) Mingyue Li et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

PRMT5 enhances tumorigenicity and glycolysis in pancreatic cancer via the FBW7/cMyc axis

(2019) Yi Qin et al.   Cell Communication and Signaling

Genomic and Transcriptomic Landscape of Triple-Negative Breast Cancers: Subtypes and Treatment Strategies

(2019) Yi-Zhou Jiang et al.   CANCER CELL

Protein arginine methyltransferase 5: A novel therapeutic target for triple‐negative breast cancers

(2019) Mathilde Vinet et al.   Cancer Medicine

Targeting mRNA processing as an anticancer strategy

(2019) Joana Desterro et al.   NATURE REVIEWS DRUG DISCOVERY

Regulation of PRMT5–MDM4 axis is critical in the response to CDK4/6 inhibitors in melanoma

(2019) Shatha AbuHammad et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

USP3 promotes breast cancer cell proliferation by deubiquitinating KLF5

(2019) Yingying Wu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

PRMT5 methylome profiling uncovers a direct link to splicing regulation in acute myeloid leukemia

(2019) Aliaksandra Radzisheuskaya et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

PRMT5 promotes epithelial‐mesenchymal transition via EGFR‐β‐catenin axis in pancreatic cancer cells

(2019) Lu Ge et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Crosstalk between lysine methylation and phosphorylation of ATG16L1 dictates the apoptosis of hypoxia/reoxygenation-induced cardiomyocytes

(2018) Huiwen Song et al.   Autophagy

Protein Arginine Methyltransferase 5 (PRMT5) as an Anticancer Target and Its Inhibitor Discovery

(2018) Yuanxiang Wang et al.   JOURNAL OF MEDICINAL CHEMISTRY

The LINC01138 drives malignancies via activating arginine methyltransferase 5 in hepatocellular carcinoma

(2018) Zhe Li et al.   Nature Communications

PRMT5-mediated regulation of developmental myelination

(2018) Antonella Scaglione et al.   Nature Communications

Abstract 4859: JNJ-64619178, a selective and pseudo-irreversible PRMT5 inhibitor with potentin vitroandin vivoactivity, demonstrated in several lung cancer models

(2018) Tongfei Wu et al.   CANCER RESEARCH

Krüpple-like factor 5 is essential for mammary gland development and tumorigenesis

(2018) Rong Liu et al.   JOURNAL OF PATHOLOGY

Transposable elements are regulated by context-specific patterns of chromatin marks in mouse embryonic stem cells

(2018) Jiangping He et al.   Nature Communications

Arginine Methylation: The Coming of Age

(2017) Roméo S. Blanc et al.   MOLECULAR CELL

The PRMT5/WDR77 complex regulates alternative splicing through ZNF326 in breast cancer

(2017) Madhumitha Rengasamy et al.   NUCLEIC ACIDS RESEARCH

Elevated expression of protein arginine methyltransferase 5 predicts the poor prognosis of breast cancer

(2017) Ying Wu et al.   TUMOR BIOLOGY

PRMT5 Is a Critical Regulator of Breast Cancer Stem Cell Function via Histone Methylation and FOXP1 Expression

(2017) Kelly Chiang et al.   Cell Reports

Metformin suppresses triple-negative breast cancer stem cells by targeting KLF5 for degradation

(2017) Peiguo Shi et al.   Cell Discovery

Targeting methyltransferase PRMT5 eliminates leukemia stem cells in chronic myelogenous leukemia

(2016) Yanli Jin et al.   JOURNAL OF CLINICAL INVESTIGATION

GLI pathogenesis-related 1 functions as a tumor-suppressor in lung cancer

(2016) Xiumei Sheng et al.   Molecular Cancer

Mifepristone Suppresses Basal Triple-Negative Breast Cancer Stem Cells by Down-regulating KLF5 Expression

(2016) Rong Liu et al.   Theranostics

Therapeutic Implications of Cellular Heterogeneity and Plasticity in Breast Cancer

(2015) Michael D. Brooks et al.   Cell Stem Cell

A selective inhibitor of PRMT5 with in vivo and in vitro potency in MCL models

(2015) Elayne Chan-Penebre et al.   Nature Chemical Biology

BAP1 promotes breast cancer cell proliferation and metastasis by deubiquitinating KLF5

(2015) Junying Qin et al.   Nature Communications

Interplay between arginine methylation and ubiquitylation regulates KLF4-mediated genome stability and carcinogenesis

(2015) Dong Hu et al.   Nature Communications

Ataxin-3 like (ATXN3L), a member of the Josephin family of deubiquitinating enzymes, promotes breast cancer proliferation by deubiquitinating Krüppel-like factor 5 (KLF5)

(2015) Fei Ge et al.   Oncotarget

Inactivation of Klf5 by zinc finger nuclease downregulates expression of pluripotent genes and attenuates colony formation in embryonic stem cells

(2013) Xilin Long et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Comprehensive molecular portraits of human breast tumours

(2012) Daniel C. Koboldt et al.   NATURE

Crystal structure of the human PRMT5:MEP50 complex

(2012) S. Antonysamy et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

TAZ antagonizes the WWP1-mediated KLF5 degradation and promotes breast cell proliferation and tumorigenesis

(2011) Dong Zhao et al.   CARCINOGENESIS

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

The E3 Ubiquitin Ligase SMAD Ubiquitination Regulatory Factor 2 Negatively Regulates Krüppel-like Factor 5 Protein

(2011) James X. Du et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Nuclear Cyclin D1/CDK4 Kinase Regulates CUL4 Expression and Triggers Neoplastic Growth via Activation of the PRMT5 Methyltransferase

(2010) Priya Aggarwal et al.   CANCER CELL

The Fbw7 Tumor Suppressor Targets KLF5 for Ubiquitin-Mediated Degradation and Suppresses Breast Cell Proliferation

(2010) Dong Zhao et al.   CANCER RESEARCH

Prmt5 is essential for early mouse development and acts in the cytoplasm to maintain ES cell pluripotency

(2010) W.-W. Tee et al.   GENES & DEVELOPMENT

The Fbw7/Human CDC4 Tumor Suppressor Targets Proproliferative Factor KLF5 for Ubiquitination and Degradation through Multiple Phosphodegron Motifs

(2010) Ning Liu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

KLF5 Promotes Breast Cell Survival Partially through Fibroblast Growth Factor-binding Protein 1-pERK-mediated Dual Specificity MKP-1 Protein Phosphorylation and Stabilization

(2009) Rong Liu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Protein Arginine Methylation in Mammals: Who, What, and Why

(2009) Mark T. Bedford et al.   MOLECULAR CELL

Krüppel-like factor 5 promotes breast cell proliferation partially through upregulating the transcription of fibroblast growth factor binding protein 1

(2009) H -Q Zheng et al.   ONCOGENE

Klf5 is involved in self-renewal of mouse embryonic stem cells

(2008) S. Parisi et al.   JOURNAL OF CELL SCIENCE