USP3 promotes breast cancer cell proliferation by deubiquitinating KLF5

Cancer statistics, 2018

(2018) Rebecca L. Siegel et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Enzalutamide for the Treatment of Androgen Receptor–Expressing Triple-Negative Breast Cancer

(2018) Tiffany A. Traina et al.   JOURNAL OF CLINICAL ONCOLOGY

Deubiquitinating enzyme USP3 controls CHK1 chromatin association and activation

(2018) Yu-Che Cheng et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mithramycin A suppresses basal triple-negative breast cancer cell survival partially via down-regulating Krüppel-like factor 5 transcription by Sp1

(2018) Rong Liu et al.   Scientific Reports

Ubiquitin-specific protease 3 overexpression promotes gastric carcinogenesis and is predictive of poor patient prognosis

(2018) Chia-Lang Fang et al.   CANCER SCIENCE

Krüpple-like factor 5 is essential for mammary gland development and tumorigenesis

(2018) Rong Liu et al.   JOURNAL OF PATHOLOGY

Atezolizumab and Nab-Paclitaxel in Advanced Triple-Negative Breast Cancer

(2018) Peter Schmid et al.   NEW ENGLAND JOURNAL OF MEDICINE

Ipatasertib plus paclitaxel versus placebo plus paclitaxel as first-line therapy for metastatic triple-negative breast cancer (LOTUS): a multicentre, randomised, double-blind, placebo-controlled, phase 2 trial

(2017) Sung-Bae Kim et al.   LANCET ONCOLOGY

Olaparib for Metastatic Breast Cancer in Patients with a Germline BRCA Mutation

(2017) Mark Robson et al.   NEW ENGLAND JOURNAL OF MEDICINE

Somatic Superenhancer Duplications and Hotspot Mutations Lead to Oncogenic Activation of the KLF5 Transcription Factor

(2017) Xiaoyang Zhang et al.   Cancer Discovery

Potential therapeutic targets of triple-negative breast cancer based on its intrinsic subtype

(2017) Fangyuan Shao et al.   Oncotarget

Novel therapeutic strategies in the treatment of triple-negative breast cancer

(2017) Karima Oualla et al.   Therapeutic Advances in Medical Oncology

Metformin suppresses triple-negative breast cancer stem cells by targeting KLF5 for degradation

(2017) Peiguo Shi et al.   Cell Discovery

Mifepristone Suppresses Basal Triple-Negative Breast Cancer Stem Cells by Down-regulating KLF5 Expression

(2016) Rong Liu et al.   Theranostics

Targeting Kruppel-Like Factor 5 (KLF5) for Cancer Therapy

(2015) Yu Gao et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

KLF5 promotes breast cancer proliferation, migration and invasion in part by upregulating the transcription of TNFAIP2

(2015) L Jia et al.   ONCOGENE

BAP1 promotes breast cancer cell proliferation and metastasis by deubiquitinating KLF5

(2015) Junying Qin et al.   Nature Communications

Ataxin-3 like (ATXN3L), a member of the Josephin family of deubiquitinating enzymes, promotes breast cancer proliferation by deubiquitinating Krüppel-like factor 5 (KLF5)

(2015) Fei Ge et al.   Oncotarget

Abstract 1785: Ubiquitin specific protease 3 is a regulator of histone ubiquitination required for maintenance of genomic stability.

(2014) Nidhi Sharma et al.   CANCER RESEARCH

Tight regulation of ubiquitin-mediated DNA damage response by USP3 preserves the functional integrity of hematopoietic stem cells

(2014) Cesare Lancini et al.   JOURNAL OF EXPERIMENTAL MEDICINE

USP3 controls BRCA1 “foci”

(2013) Pradip Raychaudhuri   CELL CYCLE

USP3 counteracts RNF168 via deubiquitinating H2A and γH2AX at lysine 13 and 15

(2013) Nidhi Sharma et al.   CELL CYCLE

Krüppel-like Factor 5 Transcription Factor Promotes Microsomal Prostaglandin E2Synthase 1 Gene Transcription in Breast Cancer

(2013) Houjun Xia et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

YAP Promotes Breast Cell Proliferation and Survival Partially through Stabilizing the KLF5 Transcription Factor

(2012) Xu Zhi et al.   AMERICAN JOURNAL OF PATHOLOGY

PAM50 Breast Cancer Subtyping by RT-qPCR and Concordance with Standard Clinical Molecular Markers

(2012) Roy RL Bastien et al.   BMC Medical Genomics

Krüppel-like factor 5 in human breast carcinoma: a potent prognostic factor induced by androgens

(2012) Kiyoshi Takagi et al.   ENDOCRINE-RELATED CANCER

Oestrogen causes degradation of KLF5 by inducing the E3 ubiquitin ligase EFP in ER-positive breast cancer cells

(2011) Ke-Wen Zhao et al.   BIOCHEMICAL JOURNAL

TAZ antagonizes the WWP1-mediated KLF5 degradation and promotes breast cell proliferation and tumorigenesis

(2011) Dong Zhao et al.   CARCINOGENESIS

The E3 Ubiquitin Ligase SMAD Ubiquitination Regulatory Factor 2 Negatively Regulates Krüppel-like Factor 5 Protein

(2011) James X. Du et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Induction of KLF5 Transcription Factor by Progesterone Contributes to Progesterone-Induced Breast Cancer Cell Proliferation and Dedifferentiation

(2011) Rong Liu et al.   MOLECULAR ENDOCRINOLOGY

Triple-Negative Breast Cancer

(2010) Anthony D. Elias   AMERICAN JOURNAL OF CLINICAL ONCOLOGY-CANCER CLINICAL TRIALS

The Fbw7/Human CDC4 Tumor Suppressor Targets Proproliferative Factor KLF5 for Ubiquitination and Degradation through Multiple Phosphodegron Motifs

(2010) Ning Liu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

What’s positive about ‘triple-negative’ breast cancer?

(2009) Sara A Hurvitz et al.   Future Oncology

Krüppel-like factor 5 promotes breast cell proliferation partially through upregulating the transcription of fibroblast growth factor binding protein 1

(2009) H -Q Zheng et al.   ONCOGENE

An embryonic stem cell–like gene expression signature in poorly differentiated aggressive human tumors

(2008) Ittai Ben-Porath et al.   NATURE GENETICS