Long non-coding RNAs at work on telomeres: Functions and implications in cancer therapy

Oxidative stress induces transcription of telomeric repeat-containing RNA (TERRA) by engaging PKA signaling and cytoskeleton dynamics

(2020) Natalia M. Galigniana et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Non‐coding TERRA inhibits the progression of hepatocellular carcinoma via regulating telomerase‐mediated telomere length

(2020) Haiyan Cao et al.   CANCER SCIENCE

Role of Telomeres and Telomeric Proteins in Human Malignancies and Their Therapeutic Potential

(2020) Stina George Fernandes et al.   Cancers

RAD51-dependent recruitment of TERRA lncRNA to telomeres through R-loops

(2020) Marianna Feretzaki et al.   NATURE

The Emerging Roles of TERRA in Telomere Maintenance and Genome Stability

(2019) Nicole Bettin et al.   Cells

Mitochondrion-processed TERC regulates senescence without affecting telomerase activities

(2019) Qian Zheng et al.   Protein & Cell

SFPQ and NONO suppress RNA:DNA-hybrid-related telomere instability

(2019) Eleonora Petti et al.   Nature Communications

TERC promotes cellular inflammatory response independent of telomerase

(2019) Haiying Liu et al.   NUCLEIC ACIDS RESEARCH

Telomeric Repeat-Containing RNAs (TERRA) Decrease in Squamous Cell Carcinoma of the Head and Neck Is Associated with Worsened Clinical Outcome

(2018) Valerio Vitelli et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Cryo-EM structure of substrate-bound human telomerase holoenzyme

(2018) Thi Hoang Duong Nguyen et al.   NATURE

TRF1 participates in chromosome end protection by averting TRF2-dependent telomeric R loops

(2018) Yong Woo Lee et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

TERRA recruitment of polycomb to telomeres is essential for histone trymethylation marks at telomeric heterochromatin

(2018) Juan J. Montero et al.   Nature Communications

HuR regulates telomerase activity through TERC methylation

(2018) Hao Tang et al.   Nature Communications

TRF1 participates in chromosome end protection by averting TRF2-dependent telomeric R loops

(2018) Yong Woo Lee et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Telomerase RNA Expression and DNA Ploidy as Prognostic Markers of Prostate Carcinomas

(2018) Athanassios Bantis et al.   TUMORI

Mitochondrial Trafficking and Processing of Telomerase RNA TERC

(2018) Ying Cheng et al.   Cell Reports

AGO2 promotes telomerase activity and interaction between the telomerase components TERT and TERC

(2018) Ilaria Laudadio et al.   EMBO REPORTS

The RNA interactome of human telomerase RNA reveals a coding-independent role for a histone mRNA in telomere homeostasis

(2018) Roland Ivanyi-Nagy et al.   eLife

Detection of the alternative lengthening of telomeres pathway in malignant gliomas for improved molecular diagnosis

(2017) Anne Fogli et al.   JOURNAL OF NEURO-ONCOLOGY

MYC drives overexpression of telomerase RNA (hTR /TERC ) in prostate cancer

(2017) Javier A Baena-Del Valle et al.   JOURNAL OF PATHOLOGY

Telomeres in cancer: tumour suppression and genome instability

(2017) John Maciejowski et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Heat shock factor 1 promotes TERRA transcription and telomere protection upon heat stress

(2017) Sivan Koskas et al.   NUCLEIC ACIDS RESEARCH

CTCF driven TERRA transcription facilitates completion of telomere DNA replication

(2017) Kate Beishline et al.   Nature Communications

Genetic variations in TERC and TERT genes are associated with lung cancer risk in a Chinese Han population

(2017) Gang Ye et al.   Oncotarget

R-loop: an emerging regulator of chromatin dynamics: Table 1.

(2016) Qais Al-Hadid et al.   ACTA BIOCHIMICA ET BIOPHYSICA SINICA

Upregulation of long noncoding RNA LOC100507661 promotes tumor aggressiveness in thyroid cancer

(2016) Daham Kim et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Telomeric RNAs are essential to maintain telomeres

(2016) Juan José Montero et al.   Nature Communications

Telomere Transcripts Target Telomerase in Human Cancer Cells

(2016) Theresa Kreilmeier et al.   Genes

MYC and Human Telomerase Gene (TERC) Copy Number Gain in Early-stage Non–small Cell Lung Cancer

(2015) Antonella Flacco et al.   AMERICAN JOURNAL OF CLINICAL ONCOLOGY-CANCER CLINICAL TRIALS

The telomerase inhibitor imetelstat alone, and in combination with trastuzumab, decreases the cancer stem cell population and self-renewal of HER2+ breast cancer cells

(2015) Jillian E. Koziel et al.   BREAST CANCER RESEARCH AND TREATMENT

The HSP90 inhibitor alvespimycin enhances the potency of telomerase inhibition by imetelstat in human osteosarcoma

(2015) Yafang Hu et al.   CANCER BIOLOGY & THERAPY

Subtelomeric p53 binding prevents accumulation of DNA damage at human telomeres

(2015) S. Tutton et al.   EMBO JOURNAL

In-situhybridization-based quantification of hTR: a possible biomarker in malignant melanoma

(2015) Josephine Vagner et al.   HISTOPATHOLOGY

Gain of hTERC: a genetic marker of malignancy in oral potentially malignant lesions

(2015) Tshering Dorji et al.   HUMAN PATHOLOGY

Suppression of the alternative lengthening of telomere pathway by the chromatin remodelling factor ATRX

(2015) David Clynes et al.   Nature Communications

Cancer-associated TERT promoter mutations abrogate telomerase silencing

(2015) Kunitoshi Chiba et al.   eLife

A randomized phase II study of the telomerase inhibitor imetelstat as maintenance therapy for advanced non-small-cell lung cancer

(2014) A. A. Chiappori et al.   ANNALS OF ONCOLOGY

An antiapoptotic role for telomerase RNA in human immune cells independent of telomere integrity or telomerase enzymatic activity

(2014) F. S. Gazzaniga et al.   BLOOD

Bone marrow failure and the telomeropathies

(2014) D. M. Townsley et al.   BLOOD

Telomerase Inhibition Effectively Targets Mouse and Human AML Stem Cells and Delays Relapse following Chemotherapy

(2014) Claudia Bruedigam et al.   Cell Stem Cell

Polycomb Repressive Complex 2 and H3K27me3 Cooperate with H3K9 Methylation To Maintain Heterochromatin Protein 1  at Chromatin

(2014) J. Boros et al.   MOLECULAR AND CELLULAR BIOLOGY

Variants near TERT and TERC influencing telomere length are associated with high-grade glioma risk

(2014) Kyle M Walsh et al.   NATURE GENETICS

Telomeric transcripts stimulate telomere recombination to suppress senescence in cells lacking telomerase

(2014) Tai-Yuan Yu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Expression of Telomeres in Astrocytoma WHO Grade 2 to 4: TERRA Level Correlates with Telomere Length, Telomerase Activity, and Advanced Clinical Grade

(2014) Sandra Sampl et al.   Translational Oncology

Functional characterization of the TERRA transcriptome at damaged telomeres

(2014) Antonio Porro et al.   Nature Communications

RNaseH1 regulates TERRA-telomeric DNA hybrids and telomere maintenance in ALT tumour cells

(2014) Rajika Arora et al.   Nature Communications

TERRA-Reinforced Association of LSD1 with MRE11 Promotes Processing of Uncapped Telomeres

(2014) Antonio Porro et al.   Cell Reports

An evaluation of SOX2 and hTERC gene amplifications as screening markers in oral and oropharyngeal squamous cell carcinomas

(2014) Nadja Kokalj Vokač et al.   Molecular Cytogenetics

Structure of Human Telomeric RNA (TERRA): Stacking of Two G-Quadruplex Blocks in K+ Solution

(2013) Herry Martadinata et al.   BIOCHEMISTRY

Regulation of Telomere Length by G-Quadruplex Telomere DNA- and TERRA-Binding Protein TLS/FUS

(2013) Kentaro Takahama et al.   CHEMISTRY & BIOLOGY

The chromatin remodelling complex NoRC safeguards genome stability by heterochromatin formation at telomeres and centromeres

(2013) Anna Postepska-Igielska et al.   EMBO REPORTS

Quantitative interaction screen of telomeric repeat-containing RNA reveals novel TERRA regulators

(2013) M. Scheibe et al.   GENOME RESEARCH

Telomeric RNA-DNA hybrids affect telomere-length dynamics and senescence

(2013) Bettina Balk et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

TERRA, hnRNP A1, and DNA-PKcs Interactions at Human Telomeres

(2013) Phuong N. Le et al.   Frontiers in Oncology

Significance of Human Telomerase RNA Gene Amplification Detection for Cervical Cancer Screening

(2012) Shao-Min Chen et al.   Asian Pacific Journal of Cancer Prevention

Antitelomerase Therapy Provokes ALT and Mitochondrial Adaptive Mechanisms in Cancer

(2012) Jian Hu et al.   CELL

Human telomerase RNA component (hTERC) gene amplification detected by FISH in precancerous lesions and carcinoma of the larynx

(2012) Yu Liu et al.   Diagnostic Pathology

Genomic Amplification of hTERC in Paraffin-embedded Tissues of Cervical Intraepithelial Neoplasia and Invasive Cancer

(2012) Chunnian He et al.   INTERNATIONAL JOURNAL OF GYNECOLOGICAL PATHOLOGY

An Enhanced H/ACA RNP Assembly Mechanism for Human Telomerase RNA

(2012) E. D. Egan et al.   MOLECULAR AND CELLULAR BIOLOGY

Telomerase inhibition strategies by siRNAs against either hTR or hTERT in oral squamous cell carcinoma

(2011) Y Li et al.   CANCER GENE THERAPY

Telomeres: The silence is broken

(2011) Claus M. Azzalin et al.   CELL CYCLE

TERCpolymorphisms are associated both with susceptibility to colorectal cancer and with longer telomeres

(2011) A M Jones et al.   GUT

Genomic Maps of Long Noncoding RNA Occupancy Reveal Principles of RNA-Chromatin Interactions

(2011) Ci Chu et al.   MOLECULAR CELL

TERRA and hnRNPA1 orchestrate an RPA-to-POT1 switch on telomeric single-stranded DNA

(2011) Rachel Litman Flynn et al.   NATURE

Sizing the ends: Normal length of human telomeres

(2010) Oumar Samassekou et al.   ANNALS OF ANATOMY-ANATOMISCHER ANZEIGER

Effects of combined siRNA-TR and -TERT on telomerase activity and growth of bladder transitional cell cancer BIU-87 cells

(2010) Wen Cheng et al.   Journal of Huazhong University of Science and Technology-Medical Sciences

Detection of TERC Amplification in Cervical Epithelial Cells for the Diagnosis of High-Grade Cervical Lesions and Invasive Cancer

(2010) Jing Jiang et al.   JOURNAL OF MOLECULAR DIAGNOSTICS

Box H/ACA Small Ribonucleoproteins

(2010) Tamás Kiss et al.   MOLECULAR CELL

Structural basis for telomerase catalytic subunit TERT binding to RNA template and telomeric DNA

(2010) Meghan Mitchell et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The non-coding RNA TERRA is a natural ligand and direct inhibitor of human telomerase

(2010) Sophie Redon et al.   NUCLEIC ACIDS RESEARCH

Telomerase: An RNP Enzyme Synthesizes DNA

(2010) E. H. Blackburn et al.   Cold Spring Harbor Perspectives in Biology

TERRA transcripts are bound by a complex array of RNA-binding proteins

(2010) Isabel López de Silanes et al.   Nature Communications

Screening of TERC gene amplification as an additional genetic diagnostic test in detection of cervical preneoplastic lesions

(2009) Nadja Kokalj-Vokač et al.   CANCER GENETICS AND CYTOGENETICS

Anticancer Activity of CX-3543: A Direct Inhibitor of rRNA Biogenesis

(2009) D. Drygin et al.   CANCER RESEARCH

Correlation between morphology and human telomerase gene amplification in bronchial brushing cells for the diagnosis of lung cancer

(2009) Yi-Bo Fan et al.   DIAGNOSTIC CYTOPATHOLOGY

Structure of Long Telomeric RNA Transcripts

(2009) Adrian Randall et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

TERRA RNA Binding to TRF2 Facilitates Heterochromatin Formation and ORC Recruitment at Telomeres

(2009) Zhong Deng et al.   MOLECULAR CELL

Telomerase activity is associated with an increase in DNA methylation at the proximal subtelomere and a reduction in telomeric transcription

(2009) Laura J. Ng et al.   NUCLEIC ACIDS RESEARCH

The human telomerase RNA component, hTR, activates the DNA-dependent protein kinase to phosphorylate heterogeneous nuclear ribonucleoprotein A1

(2009) N. S. Y. Ting et al.   NUCLEIC ACIDS RESEARCH

CpG-island promoters drive transcription of human telomeres

(2009) S. G. Nergadze et al.   RNA

High level of telomerase RNA gene expression is associated with chromatin modification, the ALT phenotype and poor prognosis in liposarcoma

(2008) C J Cairney et al.   BRITISH JOURNAL OF CANCER

G-Quadruplex Formation by Human Telomeric Repeats-Containing RNA in Na+Solution

(2008) Yan Xu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Role of alternative telomere lengthening unmasked in telomerase knock-out mutant plants

(2008) Eva Růčková et al.   PLANT MOLECULAR BIOLOGY