期刊
CANCER LETTERS
卷 502, 期 -, 页码 120-132出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.canlet.2020.12.036
关键词
Telomere; TERC; TERRA; Telomerase; Alternative lengthening of telomeres
类别
资金
- Department of Biotechnology [BT/RLF/Re-entry/06/2015]
- Department of Science and Technology [ECR/2018/002117]
- NMIMS [IO 401405]
Long non-coding RNAs (lncRNAs) play a significant role in telomere length maintenance in cancer, with TERC and TERRA being crucial lncRNAs involved in this process. TERC and TERRA regulate telomere length by interacting with telomerase, having implications in precision oncology.
Long non-coding RNAs (lncRNAs) are known to regulate various biological processes including cancer. Cancer cells possess limitless replicative potential which is attained by telomere length maintenance while normal somatic cells have a limited lifespan because their telomeres shorten with every cell division ultimately triggering replicative senescence. Two lncRNAs have been observed to play a key role in telomere length maintenance. First is the lncRNA TERC (telomerase RNA component) which functions as a template for telomeric DNA synthesis in association with telomerase reverse transcriptase (TERT) which serves as the catalytic component. Together they constitute the telomerase complex which functions as a reverse transcriptase to elongate telomeres. Second lncRNA that helps in regulating telomere length is the telomeric repeat-containing RNA (TERRA) which is transcribed from the subtelomeric region and extends to the telomeric region. TERC and TERRA exhibit important functions in cancer with implications in precision oncology. In this review, we discuss various aspects of these important lncRNAs in humans and their role in cancer along with recent advancements in their anticancer therapeutic application.
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