Review
Medicine, Research & Experimental
Shan Wang, Mao Yang, Ruiying Li, Jie Bai
Summary: Oral squamous cell carcinoma (OSCC), a common type of cancer, is primarily diagnosed through tissue biopsy. However, there is a growing focus on more rapid, economical, and noninvasive screening methods due to the tumor heterogeneity and drawbacks of biopsy procedures. Liquid biopsy, optical detection systems, oral brush cytology, microfluidic detection, and artificial intelligence auxiliary diagnosis are examples of such methods, each with its own advantages and limitations. Extensive research is being conducted on liquid biopsy biomarkers such as novel microbiome components, noncoding RNAs, extracellular vesicles, and circulating tumor DNA, which have shown promising clinical outcomes in early OSCC detection. This review summarizes OSCC screening methods and provides new guiding strategies for diagnosis.
EUROPEAN JOURNAL OF MEDICAL RESEARCH
(2023)
Article
Medicine, General & Internal
Weiping Jie, Jiaying Bai, Jing Yan, Yanting Chi, Bin-bin Li
Summary: This study demonstrated the advantages of MSTS in reflecting the morphological and molecular characteristics of OSCC and OPSCC. MSTS was found to be more representative compared to RP and can compensate for the limitations in ITH detection, especially in large tumors.
FRONTIERS IN MEDICINE
(2021)
Article
Oncology
Ioannis A. Voutsadakis
Summary: Amplification of the 3q26 locus is a prevalent molecular lesion in cervical squamous cell carcinomas, leading to over-expression of several cancer-related genes. Differences exist between 3q26-amplified cases and PIK3CA mutant cases, with potentially relevant therapeutic targets identified in the former.
Article
Dentistry, Oral Surgery & Medicine
S. Y. Yang, S. H. Li, J. L. Liu, X. Q. Sun, Y. Y. Cen, R. Y. Ren, S. C. Ying, Y. Chen, Z. H. Zhao, W. Liao
Summary: This study developed a deep learning model to assist pathologists in diagnosing oral squamous cell carcinoma (OSCC), demonstrating improved diagnostic accuracy and speed in both junior and senior pathologists.
JOURNAL OF DENTAL RESEARCH
(2022)
Editorial Material
Oncology
Todd Lambert, Jason Tasoulas, Melissa Flores, Siddharth Sheth, Samip N. Patel
Summary: HPV testing is mandatory for newly diagnosed OPSCC in order to assist in treatment decisions and prognosis. FNA is commonly used for OPSCC but can yield indeterminate results for HPV testing. In this study, we propose the use of ctHPVDNA to determine HPV status in cases with indeterminate FNA results. We report three cases where ctHPVDNA successfully confirmed HPV status. If validated, this non-invasive assay could eliminate the need for repeat FNAs or biopsies solely for determining HPV status.
Article
Medicine, General & Internal
Galinos Fanourakis, Efthymios Kyrodimos, Vasileios Papanikolaou, Aristeidis Chrysovergis, Georgia Kafiri, Nikolaos Papanikolaou, Mihalis Verykokakis, Konstantinos Tosios, Heleni Vastardis
Summary: The enzymatic activity of APOBEC3B has been implicated as a main cause of mutagenesis in head and neck squamous cell carcinoma. The expression of PKC alpha and NF-kappa B p65 has been linked to the upregulation of A3B. The study evaluated the expression of PKC alpha, NF-kappa B p65, and A3B in non-HPV related oral and oropharyngeal squamous cell carcinomas and found that A3B expression is associated with PKC alpha/NF-kappa B p65 expression, suggesting a potential role for the PKC/NF-kappa B signaling pathway in the development of oral and oropharyngeal cancer.
Article
Otorhinolaryngology
Robbie S. R. Woods, Deirdre Callanan, Hadeel Jawad, Peter Molony, Reiltin Werner, Cynthia Heffron, Linda Feeley, Patrick Sheahan
Summary: This study investigated the interaction between HPV and specific cytokeratins in crypt epithelium and found higher expression of CK7 and CK19 in HPV-positive OPSCC compared to HPV-negative disease. These findings support a potential role for these cytokeratins in the etiopathogenesis of HPV-related OPSCC.
EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY
(2022)
Article
Immunology
Wen-Jie Wu, Qian Liu, Pu-Gen An, Lin Wang, Jian-Yun Zhang, Yan Chen, Tong Zhang, Jie Zhang
Summary: This retrospective study analyzed the clinical data of 33 patients with locally advanced oral or oropharyngeal squamous cell carcinoma (LAOOPSCC) who received neoadjuvant PD-1 inhibitors and chemotherapy followed by surgery. The results showed a high pathological response rate and possible organ preservation with neoadjuvant therapy. Patients who achieved major pathological response had longer overall survival and disease-free survival. However, further studies are needed to evaluate the survival benefits of the treatment.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Microbiology
Paola Zanetta, Diletta Francesca Squarzanti, Rita Sorrentino, Roberta Rolla, Paolo Aluffi Valletti, Massimiliano Garzaro, Valeria Dell'Era, Angela Amoruso, Barbara Azzimonti
Summary: The oral microbiota and vitamin D play significant roles in the pathogenesis of oropharyngeal squamous cell carcinoma (OPSCC). Further investigations are needed to fully understand their relationship and potential for specific prevention and treatment strategies.
CRITICAL REVIEWS IN MICROBIOLOGY
(2021)
Review
Oncology
Krishnakumar Thankappan, Azhar Jan Battoo, Sivakumar Vidhyadharan, Akshay Kudpaje, Deepak Balasubramanian, Subramania Iyer
Summary: Trans-oral robotic surgery (TORS) and primary radiotherapy are two modalities used to treat early T stage oropharyngeal squamous cell carcinoma (OPSCC). Economic evaluations suggest that TORS may be a cost-effective strategy in certain scenarios, but the need for adjuvant therapy can impact cost-effectiveness.
Article
Dentistry, Oral Surgery & Medicine
Jan-Michael Hirsch, Ronak Sandy, Bengt Hasseus, Joakim Lindblad
Summary: Oral squamous cell carcinoma (OSCC) is a widespread disease with low survival rates. Non-invasive brush biopsies, deep learning, and genomic analysis offer potential methods for early detection and prediction of malignant transformation.
JOURNAL OF ORAL PATHOLOGY & MEDICINE
(2023)
Article
Health Care Sciences & Services
Cosmin Ioan Faur, Cristian Dinu, Valentin Toma, Anca Jurj, Radu Marginean, Anca Onaciu, Rares Calin Roman, Carina Culic, Magdalena Chirila, Horatiu Rotar, Alexandra Falamas, Gabriela Fabiola Stiufiuc, Mihaela Hedesiu, Oana Almasan, Rares Ionut Stiufiuc
Summary: Raman spectroscopy is a non-invasive, rapid, and reliable method for cancer detection, and it has recently shown great potential in identifying disease-specific markers. In this study, vibrational spectra of salivary exosomes from oral and oropharyngeal squamous cell carcinoma patients and healthy controls were recorded using surface enhancement Raman spectroscopy (SERS). The method's ability to discriminate between malignant and non-malignant samples was assessed using chemometric analysis, with a discrimination sensitivity of up to 79.3%.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Simona Fontana, Rodolfo Mauceri, Maria Eugenia Novara, Riccardo Alessandro, Giuseppina Campisi
Summary: This pilot study utilized proteomic and bioinformatic strategies to analyze saliva small extracellular vesicles (S/SEVs) from oral squamous cell carcinoma (OSCC) patients, identifying 365 proteins that could potentially serve as novel biomarkers for early OSCC diagnosis. The analysis also revealed specific cluster of enriched functional network terms associated with each group of S/SEVs, indicating their potential value in predicting OSCC.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Dentistry, Oral Surgery & Medicine
Zhou Jiang, Chenzhou Wu, Shoushan Hu, Nailin Liao, Yingzhao Huang, Haoran Ding, Ruohan Li, Yi Li
Summary: Neck dissection for oral squamous-cell carcinoma is a clinically controversial issue, with research mainly focused on the field of Otorhinolaryngology. The study identified depth of invasion and management of N0 OSCC as research frontiers in this area, and found Memorial Sloan Kettering Cancer Center in the USA to be the most active institution in related research.
INTERNATIONAL JOURNAL OF ORAL SCIENCE
(2021)
Article
Oncology
Vera Panzarella, Fortunato Buttacavoli, Alessio Gambino, Giorgia Capocasale, Olga Di Fede, Rodolfo Mauceri, Vito Rodolico, Giuseppina Campisi
Summary: Optical Coherence Tomography (OCT) is a promising non-invasive method for oral diagnostics. However, there is a lack of systematic comparisons between clinical/histological and OCT parameters, especially in reference to the anatomical site-codification of the oral mucosa. In this study, suspected OSCCs were evaluated using both in vivo OCT and histological investigations, with the OCT images of the same site-coded healthy mucosa as references. The results revealed site-specific OCT patterns in OSCCs, indicating potential for the reliable use of OCT in oral cancer diagnosis.