Dexmedetomidine exerts a protective effect on ischemic brain injury by inhibiting the P2X7R/NLRP3/Caspase-1 signaling pathway

CELSR1 Promotes Neuroprotection in Cerebral Ischemic Injury Mainly through the Wnt/PKC Signaling Pathway

(2020) Li-Hong Wang et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Spinal P2X7R contributes to streptozotocin-induced mechanical allodynia in mice

(2020) Cheng-ming Ni et al.   Journal of Zhejiang University-SCIENCE B

Dexmedetomidine Post-Conditioning Alleviates Cerebral Ischemia-Reperfusion Injury in Rats by Inhibiting High Mobility Group Protein B1 Group (HMGB1)/Toll-Like Receptor 4 (TLR4)/Nuclear Factor kappa B (NF-κB) Signaling Pathway

(2020) Yongyi Zhai et al.   MEDICAL SCIENCE MONITOR

The combination of Panax ginseng and Angelica sinensis alleviates ischemia brain injury by suppressing NLRP3 inflammasome activation and microglial pyroptosis

(2020) Jia Hu et al.   PHYTOMEDICINE

NF-κB Inhibitors Attenuate MCAO Induced Neurodegeneration and Oxidative Stress—A Reprofiling Approach

(2020) Awais Ali et al.   Frontiers in Molecular Neuroscience

Restoration of L-OPA1 alleviates acute ischemic stroke injury in rats via inhibiting neuronal apoptosis and preserving mitochondrial function

(2020) Yongxing Lai et al.   Redox Biology

Post-Treatment of Synthetic Polyphenolic 1,3,4 Oxadiazole Compound A3, Attenuated Ischemic Stroke-Induced Neuroinflammation and Neurodegeneration

(2020) Arooj Mohsin Alvi et al.   Biomolecules

Phthalide derivative CD21 ameliorates ischemic brain injury in a mouse model of global cerebral ischemia: involvement of inhibition of NLRP3

(2020) Xin Li et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Dexmedetomidine inhibits astrocyte pyroptosis and subsequently protects the brain in in vitro and in vivo models of sepsis

(2019) Yi-Bing Sun et al.   Cell Death & Disease

Dexmedetomidine protects against high mobility group box 1‐induced cellular injury by inhibiting pyroptosis

(2019) Xuexia Ji et al.   CELL BIOLOGY INTERNATIONAL

Protective effect of dexmedetomidine against diabetic hyperglycemia-exacerbated cerebral ischemia/reperfusion injury: An in vivo and in vitro study

(2019) Lingyang Chen et al.   LIFE SCIENCES

Silencing of Long Noncoding RNA Nespas Aggravates Microglial Cell Death and Neuroinflammation in Ischemic Stroke

(2019) Yiming Deng et al.   STROKE

Hispidulin exhibits neuroprotective activities against cerebral ischemia reperfusion injury through suppressing NLRP3-mediated pyroptosis

(2019) Pengpeng An et al.   LIFE SCIENCES

Dexmedetomidine protects hippocampal neurons against hypoxia/reoxygenation-induced apoptosis through activation HIF-1α/p53 signaling

(2019) Yan Gao et al.   LIFE SCIENCES

UFL1 modulates NLRP3 inflammasome activation and protects against pyroptosis in LPS-stimulated bovine mammary epithelial cells

(2019) Chengmin Li et al.   MOLECULAR IMMUNOLOGY

Dexmedetomidine inhibits neuronal apoptosis by inducing Sigma-1 receptor signaling in cerebral ischemia-reperfusion injury

(2019) Meili Zhai et al.   Aging-US

BRD4 suppression alleviates cerebral ischemia-induced brain injury by blocking glial activation via the inhibition of inflammatory response and pyroptosis

(2019) Yi Zhou et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The role of microglia mediated pyroptosis in neonatal hypoxic-ischemic brain damage

(2019) Yuan Lv et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Acacetin Alleviates Hepatitis Following Renal Ischemia–Reperfusion in Male Balb/C Mice by Antioxidants Regulation and Inflammatory Markers Suppression

(2019) Cyrus Jalili et al.   JOURNAL OF INVESTIGATIVE SURGERY

The role of Wnt/β-catenin pathway in the protection process by dexmedetomidine against cerebral ischemia/reperfusion injury in rats

(2019) Ping Li et al.   LIFE SCIENCES

Caspase‐7 mediates caspase‐1‐induced apoptosis independently of Bid

(2019) Mamunur Rashid Mahib et al.   MICROBIOLOGY AND IMMUNOLOGY

Dexmedetomidine Protects Against Oxygen–Glucose Deprivation-Induced Injury Through Inducing Astrocytes Autophagy via TSC2/mTOR Pathway

(2019) Chen Zhu et al.   NEUROMOLECULAR MEDICINE

The administration of dexmedetomidine changes microRNA expression profiling of rat hearts

(2019) Lingyan Wang et al.   BIOMEDICINE & PHARMACOTHERAPY

A new research hot spot: The role of NLRP3 inflammasome activation, a key step in pyroptosis, in diabetes and diabetic complications

(2019) Zi-Wei Yu et al.   LIFE SCIENCES

MicroRNA-381 Favors Repair of Nerve Injury Through Regulation of the SDF-1/CXCR4 Signaling Pathway via LRRC4 in Acute Cerebral Ischemia after Cerebral Lymphatic Blockage

(2018) Jian-Min Piao et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Down-regulation of Long Noncoding RNA MALAT1 Protects Hippocampal Neurons Against Excessive Autophagy and Apoptosis via the PI3K/Akt Signaling Pathway in Rats with Epilepsy

(2018) Qiang Wu et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Brain Ischemia Induces Diversified Neuroantigen-Specific T-Cell Responses That Exacerbate Brain Injury

(2018) Wei-Na Jin et al.   STROKE

NOD-Like Receptor Protein 3 Inflammasome-Dependent IL-1β Accelerated ConA-Induced Hepatitis

(2018) Jingyun Luan et al.   Frontiers in Immunology

Administration of Dexmedetomidine inhibited NLRP3 inflammasome and microglial cell activities in hippocampus of traumatic brain injury rats

(2018) Bin Zheng et al.   BIOSCIENCE REPORTS

Evidence that NLRC4 Inflammasome Mediates Apoptotic and Pyroptotic Microglial Death Following Ischemic Stroke

(2018) Luting Poh et al.   BRAIN BEHAVIOR AND IMMUNITY

Dexmedetomidine Attenuates Neuropathic Pain by Inhibiting P2X7R Expression and ERK Phosphorylation in Rats

(2018) Jia-Piao Lin et al.   Experimental Neurobiology

NLRP3/Caspase-1 Pathway-Induced Pyroptosis Mediated Cognitive Deficits in a Mouse Model of Sepsis-Associated Encephalopathy

(2018) Qun Fu et al.   INFLAMMATION

Neuroprotective and Neurological/Cognitive Enhancement Effects of Curcumin after Brain Ischemia Injury with Alzheimer’s Disease Phenotype

(2018) Ryszard Pluta et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The mechanisms of NLRP3 inflammasome/pyroptosis activation and their role in Parkinson's disease

(2018) Shuo Wang et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Purinergic 2X7 receptor/NLRP3 pathway triggers neuronal apoptosis after ischemic stroke in the mouse

(2017) Xinchun Ye et al.   EXPERIMENTAL NEUROLOGY

Sulforaphane improves outcomes and slows cerebral ischemic/reperfusion injury via inhibition of NLRP3 inflammasome activation in rats

(2017) Chang Yu et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Vascular endothelial growth factor is neuroprotective against ischemic brain injury by inhibiting scavenger receptor A expression on microglia

(2017) Zheng Xu et al.   JOURNAL OF NEUROCHEMISTRY

Effects and mechanism of dexmedetomidine on neuronal cell injury induced by hypoxia-ischemia

(2017) Ya-Jun Liu et al.   BMC Anesthesiology

Dexmedetomidine Postconditioning Reduces Brain Injury after Brain Hypoxia-Ischemia in Neonatal Rats

(2016) Xiaoyan Ren et al.   Journal of Neuroimmune Pharmacology

Intranasal Delivery of a Caspase-1 Inhibitor in the Treatment of Global Cerebral Ischemia

(2016) Ningjun Zhao et al.   MOLECULAR NEUROBIOLOGY

LncRNA-N1LR Enhances Neuroprotection Against Ischemic Stroke Probably by Inhibiting p53 Phosphorylation

(2016) Zhuomin Wu et al.   MOLECULAR NEUROBIOLOGY

The Inflammasomes and Autoinflammatory Syndromes

(2015) Lori Broderick et al.   Annual Review of Pathology-Mechanisms of Disease

The contribution of astrocytes and microglia to traumatic brain injury

(2015) Ila P Karve et al.   BRITISH JOURNAL OF PHARMACOLOGY

Inflammasomes: mechanism of action, role in disease and therapeutics

(2015) Haitao Guo et al.   NATURE MEDICINE

Oligodendrocyte Pathophysiology and Treatment Strategies in Cerebral Ischemia

(2014) Gabriella Mifsud et al.   CNS Neuroscience & Therapeutics

Ionic Transporter Activity in Astrocytes, Microglia, and Oligodendrocytes During Brain Ischemia

(2013) Lucio Annunziato et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Parthenolide Is Neuroprotective in Rat Experimental Stroke Model: Downregulating NF-κB, Phospho-p38MAPK, and Caspase-1 and Ameliorating BBB Permeability

(2013) Lipeng Dong et al.   MEDIATORS OF INFLAMMATION

Tetrahydrocurcumin Ameliorates Homocysteinylated Cytochrome-c Mediated Autophagy in Hyperhomocysteinemia Mice after Cerebral Ischemia

(2012) Neetu Tyagi et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

The NALP3 inflammasome is involved in the innate immune response to amyloid-β

(2008) Annett Halle et al.   NATURE IMMUNOLOGY