Upregulation of the pathogenic transcription factor SPI1/PU.1 in tuberous sclerosis complex and focal cortical dysplasia by oxidative stress

New insights into a spectrum of developmental malformations related to mTOR dysregulations: challenges and perspectives

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Establishing Cerebral Organoids as Models of Human-Specific Brain Evolution

(2019) Alex A. Pollen et al.   CELL

Targeting oxidative stress improves disease outcomes in a rat model of acquired epilepsy

(2019) Alberto Pauletti et al.   BRAIN

Increased matrix metalloproteinases expression in tuberous sclerosis complex: modulation by microRNA 146a and 147b in vitro

(2019) D. W. M. Broekaart et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

Dissecting the genetic basis of focal cortical dysplasia: a large cohort study

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Inflammation and reactive oxygen species as disease modifiers in epilepsy

(2019) Gaetano Terrone et al.   NEUROPHARMACOLOGY

Chronic activation of anti‐oxidant pathways and iron accumulation in epileptogenic malformations

(2019) T. S. Zimmer et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

KEAP1 inhibition is neuroprotective and suppresses the development of epilepsy

(2018) Tawfeeq Shekh-Ahmad et al.   BRAIN

Microdeletion of 7p12.1p13, including IKZF1 , causes intellectual impairment, overgrowth, and susceptibility to leukaemia

(2018) Tekla Järviaho et al.   BRITISH JOURNAL OF HAEMATOLOGY

The role of gastrulation brain homeobox 2 ( gbx2) in the development of the ventral telencephalon in zebrafish embryos

(2018) Zhe Wang et al.   DIFFERENTIATION

miR147b: A novel key regulator of interleukin 1 beta-mediated inflammation in human astrocytes

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Review: The international consensus classification of Focal Cortical Dysplasia - a critical update 2018

(2018) I. M. Najm et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

Transcription factors Tp73, Cebpd, Pax6, and Spi1 rather than DNA methylation regulate chronic transcriptomics changes after experimental traumatic brain injury

(2018) Anssi Lipponen et al.   Acta Neuropathologica Communications

PU.1 regulates Alzheimer’s disease-associated genes in primary human microglia

(2018) Justin Rustenhoven et al.   Molecular Neurodegeneration

Oxidative stress and inflammation in a spectrum of epileptogenic cortical malformations: molecular insights into their interdependence

(2018) Andrea Arena et al.   BRAIN PATHOLOGY

Recurrent SPI1 (PU.1) fusions in high-risk pediatric T cell acute lymphoblastic leukemia

(2017) Masafumi Seki et al.   NATURE GENETICS

A common haplotype lowers PU.1 expression in myeloid cells and delays onset of Alzheimer's disease

(2017) Kuan-lin Huang et al.   NATURE NEUROSCIENCE

mTOR-related neuropathology in mutant tsc2 zebrafish: Phenotypic, transcriptomic and pharmacological analysis

(2017) Chloë Scheldeman et al.   NEUROBIOLOGY OF DISEASE

The Spi1/PU.1 transcription factor accelerates replication fork progression by increasing PP1 phosphatase in leukemia

(2017) Pauline Rimmelé et al.   Oncotarget

Coding and small non-coding transcriptional landscape of tuberous sclerosis complex cortical tubers: implications for pathophysiology and treatment

(2017) James D. Mills et al.   Scientific Reports

Centre of epileptogenic tubers generate and propagate seizures in tuberous sclerosis

(2016) Lakshminarayanan Kannan et al.   BRAIN

Microglial activation during epileptogenesis in a mouse model of tuberous sclerosis complex

(2016) Bo Zhang et al.   EPILEPSIA

Tuberous sclerosis complex: From molecular biology to novel therapeutic approaches

(2016) Katarzyna Switon et al.   IUBMB LIFE

Promoter-Specific Hypomethylation Correlates with IL-1β Overexpression in Tuberous Sclerosis Complex (TSC)

(2016) A. Fuso et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

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(2016) Guangchuang Yu et al.   Molecular BioSystems

Transcriptional Networks Controlled by NKX2-1 in the Development of Forebrain GABAergic Neurons

(2016) Magnus Sandberg et al.   NEURON

Nrf2 regulates PU.1 expression and activity in the alveolar macrophage

(2015) Bashar S. Staitieh et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Neurological and neuropsychiatric aspects of tuberous sclerosis complex

(2015) Paolo Curatolo et al.   LANCET NEUROLOGY

Blood–brain barrier dysfunction, seizures and epilepsy

(2015) E.A. van Vliet et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Tuberous Sclerosis Complex: new criteria for diagnostic work-up and management

(2015) Sharon Samueli et al.   WIENER KLINISCHE WOCHENSCHRIFT

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(2015) Florent Ginhoux et al.   Cold Spring Harbor Perspectives in Biology

Cortical Tubers: Windows into Dysregulation of Epilepsy Risk and Synaptic Signaling Genes by MicroRNAs

(2014) Alan A. Dombkowski et al.   CEREBRAL CORTEX

Epilepsy Related to Developmental Tumors and Malformations of Cortical Development

(2014) Eleonora Aronica et al.   Neurotherapeutics

Integrated multi-cohort transcriptional meta-analysis of neurodegenerative diseases

(2014) Matthew D Li et al.   Acta Neuropathologica Communications

Evolving neurobiology of tuberous sclerosis complex

(2013) Peter B. Crino   ACTA NEUROPATHOLOGICA

The transcription factor PU.1 is critical for viability and function of human brain microglia

(2013) Amy M. Smith et al.   GLIA

Gbx2 functions as a transcriptional repressor to regulate the specification and morphogenesis of the mid–hindbrain junction in a dosage- and stage-dependent manner

(2013) Yukiko Nakayama et al.   MECHANISMS OF DEVELOPMENT

Microglia emerge from erythromyeloid precursors via Pu.1- and Irf8-dependent pathways

(2013) Katrin Kierdorf et al.   NATURE NEUROSCIENCE

Fetal Brain Lesions in Tuberous Sclerosis Complex: TORC1 Activation and Inflammation

(2012) Avanita S. Prabowo et al.   BRAIN PATHOLOGY

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(2012) Guangchuang Yu et al.   OMICS-A JOURNAL OF INTEGRATIVE BIOLOGY

Zinc Supplementation Restores PU.1 and Nrf2 Nuclear Binding in Alveolar Macrophages and Improves Redox Balance and Bacterial Clearance in the Lungs of Alcohol-Fed Rats

(2011) Ashish J. Mehta et al.   ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH

The Transcription Factor PU.1 is a Critical Regulator of Cellular Communication in the Immune System

(2011) Shereen A. Turkistany et al.   ARCHIVUM IMMUNOLOGIAE ET THERAPIAE EXPERIMENTALIS

Activation of toll-like receptor, RAGE and HMGB1 signalling in malformations of cortical development

(2011) E. Zurolo et al.   BRAIN

Growth controls connect: Interactions between c-myc and the tuberous sclerosis complex-mTOR pathway

(2011) Emmett V. Schmidt et al.   CELL CYCLE

Balloon cells in human cortical dysplasia and tuberous sclerosis: isolation of a pathological progenitor-like cell

(2010) Shireena A. Yasin et al.   ACTA NEUROPATHOLOGICA

Redox Control Systems in the Nucleus: Mechanisms and Functions

(2010) Young-Mi Go et al.   ANTIOXIDANTS & REDOX SIGNALING

ChEA: transcription factor regulation inferred from integrating genome-wide ChIP-X experiments

(2010) Alexander Lachmann et al.   BIOINFORMATICS

The pathophysiology of tuberous sclerosis complex

(2010) Peter B. Crino   EPILEPSIA

The clinicopathologic spectrum of focal cortical dysplasias: A consensus classification proposed by an ad hoc Task Force of the ILAE Diagnostic Methods Commission1

(2010) Ingmar Blümcke et al.   EPILEPSIA

Early microglial colonization of the human forebrain and possible involvement in periventricular white-matter injury of preterm infants

(2010) Catherine Verney et al.   JOURNAL OF ANATOMY

Biallelic TSC gene inactivation in tuberous sclerosis complex

(2010) P. B. Crino et al.   NEUROLOGY

Gene Expression Analysis of Tuberous Sclerosis Complex Cortical Tubers Reveals Increased Expression of Adhesion and Inflammatory Factors

(2009) Karin Boer et al.   BRAIN PATHOLOGY

Tuberous Sclerosis Complex Activity Is Required to Control Neuronal Stress Responses in an mTOR-Dependent Manner

(2009) A. Di Nardo et al.   JOURNAL OF NEUROSCIENCE

Mapping identifiers for the integration of genomic datasets with the R/Bioconductor package biomaRt

(2009) Steffen Durinck et al.   Nature Protocols

Molecular Specification and Patterning of Progenitor Cells in the Lateral and Medial Ganglionic Eminences

(2008) E. S. Tucker et al.   JOURNAL OF NEUROSCIENCE

Tuberous sclerosis

(2008) Paolo Curatolo et al.   LANCET

Outcomes of epilepsy surgery in adults and children

(2008) Susan Spencer et al.   LANCET NEUROLOGY

Clinicopathological and immunohistochemical findings in an autopsy case of tuberous sclerosis complex

(2008) Karin Boer et al.   NEUROPATHOLOGY

Inflammatory processes in cortical tubers and subependymal giant cell tumors of tuberous sclerosis complex

(2007) K. Boer et al.   EPILEPSY RESEARCH