Crosstalk between PPARs and gut microbiota in NAFLD

Bergenin Attenuates Hepatic Fibrosis by Regulating Autophagy Mediated by the PPAR-γ/TGF-β Pathway

(2021) Yujing Xia et al.   PPAR Research

Epidemiological feature of NAFLD from 1999 to 2018 in China

(2020) Jianghua Zhou et al.   HEPATOLOGY

Therapeutic potential of PPARγ natural agonists in liver diseases

(2020) Liwei Wu et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Simvastatin re-sensitizes hepatocellular carcinoma cells to sorafenib by inhibiting HIF-1α/PPAR-γ/PKM2-mediated glycolysis

(2020) Jiao Feng et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

PPARs and the Development of Type 1 Diabetes

(2020) Laurits J. Holm et al.   PPAR Research

Adenosine Receptor A1-A2a Heteromers Regulate EAAT2 Expression and Glutamate Uptake via YY1-Induced Repression of PPARγ Transcription

(2020) Xianhua Hou et al.   PPAR Research

Bergenin Exerts Hepatoprotective Effects by Inhibiting the Release of Inflammatory Factors, Apoptosis and Autophagy via the PPAR-γ Pathway

(2020) Shihao Xiang et al.   Drug Design Development and Therapy

Seabuckthorn (Hippophaë rhamnoides) Freeze-Dried Powder Protects against High-Fat Diet-Induced Obesity, Lipid Metabolism Disorders by Modulating the Gut Microbiota of Mice

(2020) Caixia Guo et al.   Nutrients

Lactobacillus plantarum FRT10 alleviated high-fat diet–induced obesity in mice through regulating the PPARα signal pathway and gut microbiota

(2020) Hongying Cai et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Gut microbiota and human NAFLD: disentangling microbial signatures from metabolic disorders

(2020) Judith Aron-Wisnewsky et al.   Nature Reviews Gastroenterology & Hepatology

Loss of Hepatocyte-Specific PPARγ Expression Ameliorates Early Events of Steatohepatitis in Mice Fed the Methionine and Choline-Deficient Diet

(2020) Jose Cordoba-Chacon   PPAR Research

Weaning Alters Intestinal Gene Expression Involved in Nutrient Metabolism by Shaping Gut Microbiota in Pigs

(2020) Qingwei Meng et al.   Frontiers in Microbiology

Cafestol preconditioning attenuates apoptosis and autophagy during hepatic ischemia-reperfusion injury by inhibiting ERK/PPARγ pathway

(2020) Jie Ji et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Garcinol Promotes Hepatic Gluconeogenesis by Inhibiting P300/CBP-Associated Factor in Late Pregnant Sows

(2020) Weilei Yao et al.   BRITISH JOURNAL OF NUTRITION

The gut microbiome-bile acid axis in hepatocarcinogenesis

(2020) Liwei Wu et al.   BIOMEDICINE & PHARMACOTHERAPY

MicroRNA-21 Contributes to Acute Liver Injury in LPS-Induced Sepsis Mice by Inhibiting PPARα Expression

(2020) Xianjin Du et al.   PPAR Research

The PPAR–microbiota–metabolic organ trilogy to fine-tune physiology

(2019) Hui Yun Penny Oh et al.   FASEB JOURNAL

Gut microbiota determines the prevention effects of Luffa cylindrica (L.) Roem supplementation against obesity and associated metabolic disorders induced by high-fat diet

(2019) Lu Zhang et al.   FASEB JOURNAL

Mussel polysaccharide α-D-glucan (MP-A) protects against non-alcoholic fatty liver disease via maintaining the homeostasis of gut microbiota and regulating related gut-liver axis signaling pathways

(2019) Jixu Wu et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

15-Deoxy-∆-12,14-Prostaglandin J2 (15d-PGJ2), an Endogenous Ligand of PPAR-γ: Function and Mechanism

(2019) Jingjing Li et al.   PPAR Research

Short-Term Activation of Peroxisome Proliferator-Activated Receptors α and γ Induces Tissue-Specific Effects on Lipid Metabolism and Fatty Acid Composition in Male Wistar Rats

(2019) Elin Strand et al.   PPAR Research

Flos Abelmoschus manihot extract attenuates DSS-induced colitis by regulating gut microbiota and Th17/Treg balance

(2019) Wei Zhang et al.   BIOMEDICINE & PHARMACOTHERAPY

Butyrolactone-I, an efficient α-glucosidase inhibitor, improves type 2 diabetes with potent TNF-α–lowering properties through modulating gut microbiota in db/db mice

(2019) Wei Wu et al.   FASEB JOURNAL

Xiexin Tang ameliorates dyslipidemia in high-fat diet-induced obese rats via elevating gut microbiota-derived short chain fatty acids production and adjusting energy metabolism

(2019) Suwei Xiao et al.   JOURNAL OF ETHNOPHARMACOLOGY

A sea cucumber (Holothuria leucospilota) polysaccharide improves the gut microbiome to alleviate the symptoms of type 2 diabetes mellitus in Goto-Kakizaki rats

(2019) Fuqiang Zhao et al.   FOOD AND CHEMICAL TOXICOLOGY

Exploration and Development of PPAR Modulators in Health and Disease: An Update of Clinical Evidence

(2019) Cheng et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The Gut Microbiota in Women Suffering from Gestational Diabetes Mellitus with the Failure of Glycemic Control by Lifestyle Modification

(2019) Guangyong Ye et al.   Journal of Diabetes Research

Gut microbiota in non‐alcoholic fatty liver disease and alcohol‐related liver disease: Current concepts and perspectives

(2019) Juan P. Arab et al.   HEPATOLOGY RESEARCH

Polysaccharide from Rosa roxburghii Tratt Fruit Attenuates Hyperglycemia and Hyperlipidemia and Regulates Colon Microbiota in Diabetic db/db Mice

(2019) Lei Wang et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Effect of okra fruit powder supplementation on metabolic syndrome and gut microbiota diversity in high fat diet-induced obese mice

(2019) Jin Zhang et al.   FOOD RESEARCH INTERNATIONAL

Dietary α-cyclodextrin modifies gut microbiota and reduces fat accumulation in high-fat-diet-fed obese mice

(2018) Nanako Nihei et al.   BIOFACTORS

Marine polysaccharides attenuate metabolic syndrome by fermentation products and altering gut microbiota: An overview

(2018) Xueliang Wang et al.   CARBOHYDRATE POLYMERS

Role of peroxisome proliferator-activated receptors in non-alcoholic fatty liver disease inflammation

(2018) Amanda Karolina Soares Silva et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Hepatocellular carcinoma is associated with gut microbiota profile and inflammation in nonalcoholic fatty liver disease

(2018) Francesca Romana Ponziani et al.   HEPATOLOGY

The Role of PPAR and Its Cross-Talk with CAR and LXR in Obesity and Atherosclerosis

(2018) Pengfei Xu et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Insights into the Role of PPARβ/δ in NAFLD

(2018) Jiapeng Chen et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Honokiol attenuates diet-induced non-alcoholic steatohepatitis by regulating macrophage polarization through activating peroxisome proliferator-activated receptor γ

(2018) Xueqing Zhong et al.   JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY

Modeling NAFLD disease burden in China, France, Germany, Italy, Japan, Spain, United Kingdom, and United States for the period 2016–2030

(2018) Chris Estes et al.   JOURNAL OF HEPATOLOGY

Increased butyrate priming in the gut stalls microbiome associated-gastrointestinal inflammation and hepatic metabolic reprogramming in a mouse model of Gulf War Illness

(2018) Ratanesh Kumar Seth et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Personalized Gut Mucosal Colonization Resistance to Empiric Probiotics Is Associated with Unique Host and Microbiome Features

(2018) Niv Zmora et al.   CELL

Global Perspectives on Non-alcoholic Fatty Liver Disease and Non-alcoholic Steatohepatitis

(2018) Zobair Younossi et al.   HEPATOLOGY

The role of the microbiome in NAFLD and NASH

(2018) Aleksandra A Kolodziejczyk et al.   EMBO Molecular Medicine

Kiwifruit seed oil prevents obesity by regulating inflammation, thermogenesis, and gut microbiota in high-fat diet-induced obese C57BL/6 mice

(2018) Linlin Qu et al.   FOOD AND CHEMICAL TOXICOLOGY

Modeling the epidemic of nonalcoholic fatty liver disease demonstrates an exponential increase in burden of disease

(2017) Chris Estes et al.   HEPATOLOGY

Distinct but complementary contributions of PPAR isotypes to energy homeostasis

(2017) Vanessa Dubois et al.   JOURNAL OF CLINICAL INVESTIGATION

Alliin, a garlic organosulfur compound, ameliorates gut inflammation through MAPK-NF-κB/AP-1/STAT-1 inactivation and PPAR-γ activation

(2017) Limin Shi et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Nonalcoholic Fatty Liver Disease Is Exacerbated in High-Fat Diet-Fed Gnotobiotic Mice by Colonization with the Gut Microbiota from Patients with Nonalcoholic Steatohepatitis

(2017) Chien-Chao Chiu et al.   Nutrients

Effect of modulation of PPAR-γ activity on Kupffer cells M1/M2 polarization in the development of non-alcoholic fatty liver disease

(2017) Wenjing Luo et al.   Scientific Reports

Total fecal microbiota transplantation alleviates high-fat diet-induced steatohepatitis in mice via beneficial regulation of gut microbiota

(2017) Da Zhou et al.   Scientific Reports

Nuclear receptors and nonalcoholic fatty liver disease 1 1This article is part of a Special Issue entitled: Xenobiotic nuclear receptors: New Tricks for An Old Dog, edited by Dr. Wen Xie.

(2016) Matthew C. Cave et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Extrahepatic Complications of Nonalcoholic Fatty Liver Disease

(2016) Kristina R. Chacko et al.   Clinics in Liver Disease

Nonalcoholic steatohepatitis and the intestinal microbiota

(2016) David B. Haslam   HEPATOLOGY

Bile acids and nonalcoholic fatty liver disease: Molecular insights and therapeutic perspectives

(2016) Juan P. Arab et al.   HEPATOLOGY

Global epidemiology of nonalcoholic fatty liver disease-Meta-analytic assessment of prevalence, incidence, and outcomes

(2016) Zobair M. Younossi et al.   HEPATOLOGY

The severity of nonalcoholic fatty liver disease is associated with gut dysbiosis and shift in the metabolic function of the gut microbiota

(2016) Jérôme Boursier et al.   HEPATOLOGY

Homeostatic PPARα Signaling Limits Inflammatory Responses to Commensal Microbiota in the Intestine

(2016) Indumathi Manoharan et al.   JOURNAL OF IMMUNOLOGY

Obesity: An overview of possible role(s) of gut hormones, lipid sensing and gut microbiota

(2016) Alok Kumar Mishra et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

PPARs in obesity-induced T2DM, dyslipidaemia and NAFLD

(2016) Barbara Gross et al.   Nature Reviews Endocrinology

Dual-specificity phosphatase 6 deficiency regulates gut microbiome and transcriptome response against diet-induced obesity in mice

(2016) Jhen-Wei Ruan et al.   Nature Microbiology

Efficacy of rifaximin on circulating endotoxins and cytokines in patients with nonalcoholic fatty liver disease

(2015) Venkatanarayana Gangarapu et al.   EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY

Early investigational drugs targeting PPAR-α for the treatment of metabolic disease

(2015) Zhong-Min Liu et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

PPARα gene expression correlates with severity and histological treatment response in patients with non-alcoholic steatohepatitis

(2015) Sven Francque et al.   JOURNAL OF HEPATOLOGY

LPSF/GQ-02 Inhibits the Development of Hepatic Steatosis and Inflammation in a Mouse Model of Non-Alcoholic Fatty Liver Disease (NAFLD)

(2015) Amanda Karolina Soares e Silva et al.   PLoS One

Role of ultrasound in the diagnosis and treatment of nonalcoholic fatty liver disease and its complications

(2015) Stefano Ballestri et al.   Expert Review of Gastroenterology & Hepatology

Abrogating Monoacylglycerol Acyltransferase Activity in Liver Improves Glucose Tolerance and Hepatic Insulin Signaling in Obese Mice

(2014) A. M. Hall et al.   DIABETES

Effects of resveratrol on gut microbiota and fat storage in a mouse model with high-fat-induced obesity

(2014) Yi Qiao et al.   Food & Function

Fatty Liver Accompanies an Increase in Lactobacillus Species in the Hind Gut of C57BL/6 Mice Fed a High-Fat Diet

(2013) Huawei Zeng et al.   JOURNAL OF NUTRITION

Nutritional protective mechanisms against gut inflammation

(2013) Monica Viladomiu et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Gut Microbiota from Twins Discordant for Obesity Modulate Metabolism in Mice

(2013) V. K. Ridaura et al.   SCIENCE

Peroxisome proliferator-activated receptor δ agonist attenuates hepatic steatosis by anti-inflammatory mechanism

(2012) Mi Young Lee et al.   EXPERIMENTAL AND MOLECULAR MEDICINE

Intestinal microbiota determines development of non-alcoholic fatty liver disease in mice

(2012) Tiphaine Le Roy et al.   GUT

Characterization of gut microbiomes in nonalcoholic steatohepatitis (NASH) patients: A connection between endogenous alcohol and NASH

(2012) Lixin Zhu et al.   HEPATOLOGY

The Gut Microbiota and Human Health with an Emphasis on the Use of Microencapsulated Bacterial Cells

(2012) Satya Prakash et al.   JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY

Lactobacillus casei Shirota protects from fructose-induced liver steatosis: A mouse model

(2012) Sabine Wagnerberger et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Gut–liver axis: The impact of gut microbiota on non alcoholic fatty liver disease

(2012) D. Compare et al.   NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES

Probiotic Bacteria Produce Conjugated Linoleic Acid Locally in the Gut That Targets Macrophage PPAR γ to Suppress Colitis

(2012) Josep Bassaganya-Riera et al.   PLoS One

Misregulation of PPAR Functioning and Its Pathogenic Consequences Associated with Nonalcoholic Fatty Liver Disease in Human Obesity

(2012) Luis A. Videla et al.   PPAR Research

Causative role of gut microbiota in non-alcoholic fatty liver disease pathogenesis

(2012) Anna Alisi et al.   Frontiers in Cellular and Infection Microbiology

Energy-balance studies reveal associations between gut microbes, caloric load, and nutrient absorption in humans

(2011) Reiner Jumpertz et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Roles of PPARs in NAFLD: Potential therapeutic targets

(2011) Anne Tailleux et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

The PPARβ/δ Activator GW501516 Prevents the Down-Regulation of AMPK Caused by a High-Fat Diet in Liver and Amplifies the PGC-1α-Lipin 1-PPARα Pathway Leading to Increased Fatty Acid Oxidation

(2011) Emma Barroso et al.   ENDOCRINOLOGY

Role for PPARγ in obesity-induced hepatic steatosis as determined by hepatocyte- and macrophage-specific conditional knockouts

(2011) Eva Morán-Salvador et al.   FASEB JOURNAL

Up-Regulation of PPAR-γ mRNA Expression in the Liver of Obese Patients: an Additional Reinforcing Lipogenic Mechanism to SREBP-1c Induction

(2011) Paulina Pettinelli et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

PPARα Expression Protects Male Mice from High Fat–Induced Nonalcoholic Fatty Liver

(2011) Mohamed A. Abdelmegeed et al.   JOURNAL OF NUTRITION

An evaluation of the effects of Lactobacillus ingluviei on body weight, the intestinal microbiome and metabolism in mice

(2011) Emmanouil Angelakis et al.   MICROBIAL PATHOGENESIS

Association Between Composition of the Human Gastrointestinal Microbiome and Development of Fatty Liver With Choline Deficiency

(2010) Melanie D. Spencer et al.   GASTROENTEROLOGY

Elevated endotoxin levels in non-alcoholic fatty liver disease

(2010) Alison L Harte et al.   Journal of Inflammation-London

GW0742, a selective PPAR- /  agonist, contributes to the resolution of inflammation after gut ischemia/reperfusion injury

(2010) R. Di Paola et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Adenovirus-mediated peroxisome proliferator activated receptor gamma overexpression prevents nutritional fibrotic steatohepatitis in mice

(2010) Yue-Min Nan et al.   SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY

Acetic Acid Upregulates the Expression of Genes for Fatty Acid Oxidation Enzymes in Liver To Suppress Body Fat Accumulation

(2009) Tomoo Kondo et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Kupffer cells in non-alcoholic fatty liver disease: The emerging view

(2009) György Baffy   JOURNAL OF HEPATOLOGY

Regulation of myocardial ketone body metabolism by the gut microbiota during nutrient deprivation

(2009) P. A. Crawford et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

THE ROLE OF ENDOGENOUS AND EXOGENOUS LIGANDS FOR THE PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR ALPHA (PPAR-α) IN THE REGULATION OF INFLAMMATION IN MACROPHAGES

(2009) Concetta Crisafulli et al.   SHOCK

Role of PPARs in Radiation-Induced Brain Injury

(2009) Sriram Ramanan et al.   PPAR Research

Pioglitazone retrieves hepatic antioxidant DNA repair in a mice model of high fat diet

(2008) Pi-Jung Hsiao et al.   BMC MOLECULAR BIOLOGY

Rosiglitazone for Nonalcoholic Steatohepatitis: One-Year Results of the Randomized Placebo-Controlled Fatty Liver Improvement With Rosiglitazone Therapy (FLIRT) Trial

(2008) Vlad Ratziu et al.   GASTROENTEROLOGY

Randomized, Placebo-Controlled Trial of Pioglitazone in Nondiabetic Subjects With Nonalcoholic Steatohepatitis

(2008) Guruprasad P. Aithal et al.   GASTROENTEROLOGY

Rosiglitazone prevents nutritional fibrosis and steatohepatitis in mice

(2008) Yue-Min Nan et al.   SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY