15-Deoxy-∆-12,14-Prostaglandin J2 (15d-PGJ2), an Endogenous Ligand of PPAR-γ: Function and Mechanism

The Role of Prostaglandins in Disrupted Gastric Motor Activity Associated with Type 2 Diabetes

(2019) Peter J. Blair et al.   DIABETES

Epithelial cell–derived prostaglandin D2 inhibits chronic allergic lung inflammation in mice

(2019) Toko Maehara et al.   FASEB JOURNAL

Role of prostaglandins in tumor microenvironment

(2018) Koji Kobayashi et al.   CANCER AND METASTASIS REVIEWS

New insights into TGF-β/Smad signaling in tissue fibrosis

(2018) He-He Hu et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Cellular and molecular mechanisms of kidney fibrosis

(2018) Sonja Djudjaj et al.   MOLECULAR ASPECTS OF MEDICINE

Organ and tissue fibrosis: Molecular signals, cellular mechanisms and translational implications

(2018) Ralf Weiskirchen et al.   MOLECULAR ASPECTS OF MEDICINE

Peroxisome Proliferator-Activated Receptor γ and PGC-1α in Cancer: Dual Actions as Tumor Promoter and Suppressor

(2018) Seong-Hoon Yun et al.   PPAR Research

Novel SIRT1 inhibitor 15-deoxy-Δ12,14-prostaglandin J2 and its derivatives exhibit anticancer activity through apoptotic or autophagic cell death pathways in SKOV3 cells

(2018) In Hwan Tae et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Biotin and chromium histidinate improve glucose metabolism and proteins expression levels of IRS-1, PPAR-γ, and NF-κB in exercise-trained rats

(2018) Mine Turgut et al.   Journal of the International Society of Sports Nutrition

Prostaglandins in asthma and allergic diseases

(2018) R. Stokes Peebles   PHARMACOLOGY & THERAPEUTICS

15d-PGJ2-loaded nanocapsules ameliorate experimental gout arthritis by reducing pain and inflammation in a PPAR-gamma-sensitive manner in mice

(2018) Kenji W. Ruiz-Miyazawa et al.   Scientific Reports

Identification and Molecular Characterization of Peroxisome Proliferator-Activated Receptor δ as a Novel Target for Covalent Modification by 15-Deoxy-Δ12,14-prostaglandin J2

(2018) Aravind T. Reddy et al.   ACS Chemical Biology

Effects of Flavored Nonalcoholic Beverages on Transcriptional Activities of Nuclear and Steroid Hormone Receptors: Proof of Concept for Novel Reporter Cell Line PAZ-PPARg

(2018) Peter Illés et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Galectin-3 deficiency protects lipopolysaccharide-induced chondrocytes injury via regulation of TLR4 and PPAR-γ-mediated NF-κB signaling pathway

(2018) Jian-sheng Wang et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Hydroxysafflor Yellow A Shows Protection against PPARγ Inactivation in Nitrosative Neurons

(2018) Li Sun et al.   Oxidative Medicine and Cellular Longevity

miR-27b-3p, miR-181a-1-3p, and miR-326-5p are involved in the inhibition of macrophage activation in chronic liver injury

(2017) Weiyang Li et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Alliin, a garlic organosulfur compound, ameliorates gut inflammation through MAPK-NF-κB/AP-1/STAT-1 inactivation and PPAR-γ activation

(2017) Limin Shi et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Recent advances in asymmetric total synthesis of prostaglandins

(2017) Haihui Peng et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

The Interplay between Metabolism, PPAR Signaling Pathway, and Cancer

(2017) Daniele Fanale et al.   PPAR Research

New Transcriptional Reporters to Quantify and Monitor PPARγ Activity

(2017) Séverine A. Degrelle et al.   PPAR Research

M2 microglia promotes neurogenesis and oligodendrogenesis from neural stem/progenitor cells via the PPARγ signaling pathway

(2017) Jichao Yuan et al.   Oncotarget

Nimesulide, a cyclooxygenase-2 selective inhibitor, suppresses obesity-related non-alcoholic fatty liver disease and hepatic insulin resistance through the regulation of peroxisome proliferator-activated receptor γ

(2016) Shunsuke Tsujimoto et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Bone-marrow-derived mesenchymal stem cells inhibit gastric aspiration lung injury and inflammation in rats

(2016) Jing Zhou et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Implications of the endogenous PPAR-gamma ligand, 15-deoxy-delta-12, 14-prostaglandin J2, in diabetic retinopathy

(2016) Tapan Behl et al.   LIFE SCIENCES

Therapeutic Treatment of Arthritic Mice with 15-Deoxy Δ12,14-Prostaglandin J2(15d-PGJ2) Ameliorates Disease through the Suppression of Th17 Cells and the Induction of CD4+CD25−FOXP3+Cells

(2016) Vanessa Carregaro et al.   MEDIATORS OF INFLAMMATION

TGF-β: the master regulator of fibrosis

(2016) Xiao-ming Meng et al.   Nature Reviews Nephrology

PPARγ-induced upregulation of CD36 enhances hematoma resolution and attenuates long-term neurological deficits after germinal matrix hemorrhage in neonatal rats

(2016) Jerry J. Flores et al.   NEUROBIOLOGY OF DISEASE

Renal tubular epithelium-targeted peroxisome proliferator-activated receptor-γ maintains the epithelial phenotype and antagonizes renal fibrogenesis

(2016) Min Zhao et al.   Oncotarget

15-Deoxy-Δ12,14-Prostaglandin J2 Modifies Components of the Proteasome and Inhibits Inflammatory Responses in Human Endothelial Cells

(2016) Simone Marcone et al.   Frontiers in Immunology

The Anti-Inflammatory Effects of Prostaglandins

(2016) Jose U. Scher et al.   JOURNAL OF INVESTIGATIVE MEDICINE

Angiotensin II-Induced Egr-1 Expression is Suppressed by Peroxisome Proliferator- Activated Receptor-γ Ligand 15d-PGJ2 in Macrophages

(2015) Yan Meng et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Inhibitory effects of PPARγ ligands on TGF-β1-induced CTGF expression in cat corneal fibroblasts

(2015) Kye-Im Jeon et al.   EXPERIMENTAL EYE RESEARCH

15-Deoxy-prostaglandin J2 anti-inflammation in a rat model of chronic obstructive pulmonary disease and human bronchial epithelial cells via Nrf2 activation

(2015) X.Y. Li et al.   GENETICS AND MOLECULAR RESEARCH

Cross-talk between TLR4 and PPARγ pathways in the arachidonic acid-induced inflammatory response in pancreatic acini

(2015) A. Mateu et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Possible involvement of 15-deoxy-Δ12,14-prostaglandin J2in the development of leptin resistance

(2015) Toru Hosoi et al.   JOURNAL OF NEUROCHEMISTRY

PPAR-γ Ameliorates Neuronal Apoptosis and Ischemic Brain Injury via Suppressing NF-κB-Driven p22phox Transcription

(2015) Jui-Sheng Wu et al.   MOLECULAR NEUROBIOLOGY

15-Deoxy-Δ12,14-Prostaglandin J2Inhibits Homing of Bone Marrow-Derived Mesenchymal Stem Cells Triggered by Chronic Liver Injury via Redox Pathway

(2015) Xin Liu et al.   PPAR Research

15d-PGJ2 Reduced Microglia Activation and Alleviated Neurological Deficit of Ischemic Reperfusion in Diabetic Rat Model

(2015) Lihong Huang et al.   Biomed Research International

Rosiglitzone Suppresses Angiotensin II-Induced Production of KLF5 and Cell Proliferation in Rat Vascular Smooth Muscle Cells

(2015) Dengfeng Gao et al.   PLoS One

Oxidative stress-induced expression of HSP70 contributes to the inhibitory effect of 15d-PGJ2 on inducible prostaglandin pathway in chondrocytes

(2014) A. Bianchi et al.   FREE RADICAL BIOLOGY AND MEDICINE

Attenuation of IFN-γ-induced B7-H1 expression by 15-deoxy-delta12,14-prostaglandin J2 via downregulation of the Jak/STAT/IRF-1 signaling pathway

(2014) Su-Kil Seo et al.   LIFE SCIENCES

15-Deoxy-γ12,14-prostaglandin J2 Reduces Liver Impairment in a Model of ConA-Induced Acute Hepatic Inflammation by Activation of PPARγand Reduction in NF-κB Activity

(2014) Kan Chen et al.   PPAR Research

Inhibition of Transglutaminase 2, a Novel Target for Pulmonary Fibrosis, by Two Small Electrophilic Molecules

(2013) Keith C. Olsen et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Low doses of 15d-PGJ2 induce osteoblast activity in a PPAR-gamma independent manner

(2013) Marcelo Henrique Napimoga et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

The 15-deoxy-δ12,14-prostaglandin J2 inhibits LPS-stimulated inflammation via enhancement of the platelet-activating factor acetylhydrolase activity in human retinal pigment epithelial cells

(2013) WON-KYO JUNG et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

15-Deoxy-Δ12,14-prostaglandin J2 induces growth inhibition, cell cycle arrest and apoptosis in human endometrial cancer cell lines

(2013) HAILI LI et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

15-Deoxy-∆12,14-PGJ2, by Activating Peroxisome Proliferator-Activated Receptor-Gamma, Suppresses p22phox Transcription to Protect Brain Endothelial Cells Against Hypoxia-Induced Apoptosis

(2013) Jui-Sheng Wu et al.   MOLECULAR NEUROBIOLOGY

15-Deoxy-Δ12,14-Prostaglandin J2Modulates Lipopolysaccharide-Induced Chemokine Expression by Blocking Nuclear Factor-κB Activation via Peroxisome Proliferator Activated Receptor-γ-Independent Mechanism in Renal Tubular Epithelial Cells

(2013) Ying Lu et al.   NEPHRON EXPERIMENTAL NEPHROLOGY

Peroxisome Proliferator-Activated Receptor-γ Agonist 15d-Prostaglandin J2 Mediates Neuronal Autophagy after Cerebral Ischemia-Reperfusion Injury

(2013) Feng Xu et al.   PLoS One

Identification of 15d-PGJ2 as an antagonist of farnesoid X receptor: Molecular modeling with biological evaluation

(2013) Xing Xu et al.   STEROIDS

15-deoxy-Δ12,14-prostaglandin J2Down-Regulates Activin-Induced Activin Receptor, Smad, and Cytokines Expression via Suppression of NF-κB and MAPK Signaling in HepG2 Cells

(2013) Seung-Won Park et al.   PPAR Research

The Prostanoid 15-Deoxy-Δ12,14-Prostaglandin-J2 Reduces Lung Inflammation and Protects Mice Against Lethal Influenza Infection

(2012) Alexandre Cloutier et al.   JOURNAL OF INFECTIOUS DISEASES

PPAR-γ agonists, mainly 15d-PGJ2, reduce eosinophil recruitment following allergen challenge

(2011) Thais S. Farnesi-de-Assunção et al.   CELLULAR IMMUNOLOGY

Modulation of mammary cancer cell migration by 15-deoxy-Δ12,14-prostaglandin J2: implications for anti-metastatic therapy

(2010) Anne R. Diers et al.   BIOCHEMICAL JOURNAL

15-Deoxi-Δ12,14-prostaglandin J2 is a tubulin-binding agent that destabilizes microtubules and induces mitotic arrest

(2009) Claudia Cocca et al.   BIOCHEMICAL PHARMACOLOGY

15d-PGJ2 Induces Apoptosis by Reactive Oxygen Species-mediated Inactivation of Akt in Leukemia and Colorectal Cancer Cells and Shows In vivo Antitumor Activity

(2009) S.-W. Shin et al.   CLINICAL CANCER RESEARCH

PPARγ ligands inhibit telomerase activity and hTERT expression through modulation of the Myc/Mad/Max network in colon cancer cells

(2009) Cristina Toaldo et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

The 15-Deoxy-Δ12,14-prostaglandin J2 inhibits LPS-stimulated AKT and NF-κB activation and suppresses interleukin-6 in osteoblast-like cells MC3T3E-1

(2009) Won-Kyo Jung et al.   LIFE SCIENCES

PPARγ agonists inhibit growth and expansion of CD133+ brain tumour stem cells

(2008) W Chearwae et al.   BRITISH JOURNAL OF CANCER

15-Deoxy-Δ(12,14)-prostaglandin J2Induces Vascular Endothelial Cell Apoptosis through the Sequential Activation of MAPKS and p53

(2008) Tsung-Chuan Ho et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

15-deoxy-Δ12,14-prostaglandin J2 up-regulates death receptor 5 gene expression in HCT116 cells: involvement of reactive oxygen species and C/EBP homologous transcription factor gene transcription

(2008) Rong-Ying Su et al.   MOLECULAR CANCER THERAPEUTICS

Cellular and molecular mechanisms of fibrosis

(2007) TA Wynn   JOURNAL OF PATHOLOGY