CISD2 maintains cellular homeostasis

The ageing epigenome and its rejuvenation

(2020) Weiqi Zhang et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Epigenetic changes during ageing and their underlying mechanisms

(2020) Deisi L. Braga et al.   BIOGERONTOLOGY

Benefits of Metformin in Attenuating the Hallmarks of Aging

(2020) Ameya S. Kulkarni et al.   Cell Metabolism

Cisd2: a promising new target in Alzheimer's disease †

(2020) Annalisa Nobili et al.   JOURNAL OF PATHOLOGY

SIRT7: an influence factor in healthy aging and the development of age-dependent myeloid stem-cell disorders

(2020) Alexander Kaiser et al.   LEUKEMIA

Mitochondrial ROS-Modulated mtDNA: A Potential Target for Cardiac Aging

(2020) Yue Quan et al.   Oxidative Medicine and Cellular Longevity

Loss of glutathione peroxidase 3 induces ROS and contributes to prostatic hyperplasia in Nkx3.1 knockout mice

(2020) Ukjin Kim et al.   Andrology

Aging is associated with a decline in Atg9b‐mediated autophagosome formation and appearance of enlarged mitochondria in the heart

(2020) Wenjing Liang et al.   AGING CELL

Pro‐inflammatory role of cell‐free mitochondrial DNA in cardiovascular diseases

(2020) Shu Nie et al.   IUBMB LIFE

Calpain inhibitor and ibudilast rescue β cell functions in a cellular model of Wolfram syndrome

(2020) Lien D. Nguyen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

NAF-1 Inhibition by Resveratrol Suppresses Cancer Stem Cell-Like Properties and the Invasion of Pancreatic Cancer

(2020) Tao Qin et al.   Frontiers in Oncology

Targeting metabolic pathways for extension of lifespan and healthspan across multiple species

(2020) Andrey A. Parkhitko et al.   AGEING RESEARCH REVIEWS

Consequences of compromised mitochondrial genome integrity

(2020) Margaret A. Gustafson et al.   DNA REPAIR

Mitochondrial biogenesis in organismal senescence and neurodegeneration

(2020) Ioanna Daskalaki et al.   MECHANISMS OF AGEING AND DEVELOPMENT

Function of WFS1 and WFS2 in the Central Nervous System: Implications for Wolfram Syndrome and Alzheimer’s Disease

(2020) Liangping Li et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Systematic Surveys of Iron Homeostasis Mechanisms Reveal Ferritin Superfamily and Nucleotide Surveillance Regulation to be Modified by PINK1 Absence

(2020) Jana Key et al.   Cells

Defining the Functional Targets of Cap‘n’collar Transcription Factors NRF1, NRF2, and NRF3

(2020) Lara Ibrahim et al.   Antioxidants

Mitochondria and Calcium Homeostasis: Cisd2 as a Big Player in Cardiac Ageing

(2020) Chi-Hsiao Yeh et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Exercise and the Cisd2 Prolongevity Gene: Two Promising Strategies to Delay the Aging of Skeletal Muscle

(2020) Yuan-Chi Teng et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Mitochondria and cellular redox state on the route from ageing to Alzheimer’s disease

(2020) G. Abate et al.   MECHANISMS OF AGEING AND DEVELOPMENT

Redox regulation by NRF2 in aging and disease

(2019) Cody J. Schmidlin et al.   FREE RADICAL BIOLOGY AND MEDICINE

Mitochondrial DNA Integrity: Role in Health and Disease

(2019) Priyanka Sharma et al.   Cells

Protective Effects of CISD2 and Influence of Curcumin on CISD2 Expression in Aged Animals and Inflammatory Cell Model

(2019) Chai-Ching Lin et al.   Nutrients

Mechanisms of Mitochondrial DNA Deletion Formation

(2019) Nadee Nissanka et al.   TRENDS IN GENETICS

MicroRNAs as modulators of longevity and the aging process

(2019) Holly E. Kinser et al.   HUMAN GENETICS

From discoveries in ageing research to therapeutics for healthy ageing

(2019) Judith Campisi et al.   NATURE

Reduced NRF2 expression suppresses endothelial progenitor cell function and induces senescence during aging

(2019) Ruiyun Wang et al.   Aging-US

Mitochondria as multifaceted regulators of cell death

(2019) Florian J. Bock et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

CDGSH Iron Sulfur Domain 2 Deficiency Inhibits Cell Proliferation and Induces Cell Differentiation of Neuroblastoma

(2019) Jia Li et al.   PATHOLOGY & ONCOLOGY RESEARCH

Cisd2 is essential to delaying cardiac aging and to maintaining heart functions

(2019) Chi-Hsiao Yeh et al.   PLOS BIOLOGY

A meta-analysis of genome-wide association studies of epigenetic age acceleration

(2019) Jude Gibson et al.   PLoS Genetics

Aberrant mitochondrial function in ageing and cancer

(2019) Julia C. Whitehall et al.   BIOGERONTOLOGY

Upregulation of Cisd2 attenuates Alzheimer's‐related neuronal loss in mice

(2019) Yi‐Fan Chen et al.   JOURNAL OF PATHOLOGY

NEET Proteins: A New Link Between Iron Metabolism, Reactive Oxygen Species, and Cancer

(2018) Ron Mittler et al.   ANTIOXIDANTS & REDOX SIGNALING

CISD2 inhibition overcomes resistance to sulfasalazine-induced ferroptotic cell death in head and neck cancer

(2018) Eun Hye Kim et al.   CANCER LETTERS

A Reassessment of Genes Modulating Aging in Mice Using Demographic Measurements of the Rate of Aging

(2018) João Pedro de Magalhães et al.   GENETICS

Mitochondria-associated membranes (MAMs) and inflammation

(2018) Sonia Missiroli et al.   Cell Death & Disease

A Reassessment of Genes Modulating Aging in Mice Using Demographic Measurements of the Rate of Aging

(2018) João Pedro de Magalhães et al.   GENETICS

Mouse Models to Disentangle the Hallmarks of Human Aging

(2018) Alicia R. Folgueras et al.   CIRCULATION RESEARCH

A young testicular microenvironment protects Leydig cells against age-related dysfunction in a mouse model of premature aging

(2018) Michael Curley et al.   FASEB JOURNAL

Autophagy-dependent cell death – where, how and why a cell eats itself to death

(2018) Shani Bialik et al.   JOURNAL OF CELL SCIENCE

Exercise training increases CISD family protein expression in murine skeletal muscle and white adipose tissue

(2018) Takumi Yokokawa et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Cause or casualty: The role of mitochondrial DNA in aging and age-associated disease

(2018) E. Sandra Chocron et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

DNA damage related crosstalk between the nucleus and mitochondria

(2017) Mohammad Saki et al.   FREE RADICAL BIOLOGY AND MEDICINE

The mitochondrial outer membrane protein mitoNEET is a redox enzyme catalyzing electron transfer from FMNH2to oxygen or ubiquinone

(2017) Yiming Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Intracellular Ca 2+ Sensing: Its Role in Calcium Homeostasis and Signaling

(2017) Rafaela Bagur et al.   MOLECULAR CELL

CISD2 promotes the proliferation of glioma cells via suppressing beclin-1-mediated autophagy and is targeted by microRNA-449a

(2017) Ai-Gang Sun et al.   Molecular Medicine Reports

CDGSH Iron Sulfur Domain 2 Activates Proliferation and EMT of Pancreatic Cancer Cells via Wnt/β-Catenin Pathway and Has Prognostic Value in Human Pancreatic Cancer

(2017) Yang Yang et al.   ONCOLOGY RESEARCH

CISD2 Haploinsufficiency Disrupts Calcium Homeostasis, Causes Nonalcoholic Fatty Liver Disease, and Promotes Hepatocellular Carcinoma

(2017) Zhao-Qing Shen et al.   Cell Reports

Sirtuins and DNA damage repair: SIRT7 comes to play

(2017) Berta N. Vazquez et al.   Nucleus

CISD2 enhances the chemosensitivity of gastric cancer through the enhancement of 5-FU-induced apoptosis and the inhibition of autophagy by AKT/mTOR pathway

(2017) Yi Sun et al.   Cancer Medicine

Sirtuins and DNA damage repair: SIRT7 comes to play

(2017) Berta N. Vazquez et al.   Nucleus

Association of Mitochondrial DNA Copy Number With Cardiovascular Disease

(2017) Foram N. Ashar et al.   JAMA Cardiology

Upregulation of CISD2 augments ROS homeostasis and contributes to tumorigenesis and poor prognosis of lung adenocarcinoma

(2017) Shih-Miao Li et al.   Scientific Reports

Hypoxia tolerance, longevity and cancer-resistance in the mole rat Spalax – a liver transcriptomics approach

(2017) Hanno Schmidt et al.   Scientific Reports

Recovery of oxidative stress-induced damage in Cisd2-deficient cardiomyocytes by sustained release of ferulic acid from injectable hydrogel

(2016) Yung-Hsin Cheng et al.   BIOMATERIALS

Epigenetic Mechanisms of Longevity and Aging

(2016) Payel Sen et al.   CELL

Exercise Promotes Healthy Aging of Skeletal Muscle

(2016) Gregory D. Cartee et al.   Cell Metabolism

Alterations of calcium homeostasis in cancer cells

(2016) Saverio Marchi et al.   CURRENT OPINION IN PHARMACOLOGY

SIRT7 promotes genome integrity and modulates non‐homologous end joining DNA repair

(2016) Berta N Vazquez et al.   EMBO JOURNAL

GLP-1-RA Corrects Mitochondrial Labile Iron Accumulation and Improves β-Cell Function in Type 2 Wolfram Syndrome

(2016) Liron Danielpur et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Bcl-2 proteins and calcium signaling: complexity beneath the surface

(2016) T Vervliet et al.   ONCOGENE

A novel prognostic score model incorporating CDGSH iron sulfur domain2 (CISD2) predicts risk of disease progression in laryngeal squamous cell carcinoma

(2016) Lin Yang et al.   Oncotarget

Mitochondria-Associated Membranes: Composition, Molecular Mechanisms, and Physiopathological Implications

(2015) Carlotta Giorgi et al.   ANTIOXIDANTS & REDOX SIGNALING

NAF-1 antagonizes starvation-induced autophagy through AMPK signaling pathway in cardiomyocytes

(2015) Xiaohong Du et al.   CELL BIOLOGY INTERNATIONAL

Reduction of mitochondrial protein mitoNEET [2Fe–2S] clusters by human glutathione reductase

(2015) Aaron P. Landry et al.   FREE RADICAL BIOLOGY AND MEDICINE

Oxidative stress response and Nrf2 signaling in aging

(2015) Hongqiao Zhang et al.   FREE RADICAL BIOLOGY AND MEDICINE

Age-Related Changes in Sirtuin 7 Expression in Calorie-Restricted and Refed Rats

(2015) Agata Wronska et al.   GERONTOLOGY

Activation of apoptosis in NAF-1-deficient human epithelial breast cancer cells

(2015) Sarah H. Holt et al.   JOURNAL OF CELL SCIENCE

A transcriptional signature of “exercise resistance” in skeletal muscle of individuals with type 2 diabetes mellitus

(2015) Natalie A. Stephens et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Dysregulation of Mitochondrial Functions and Osteogenic Differentiation in Cisd2-Deficient Murine Induced Pluripotent Stem Cells

(2015) Ping-Hsing Tsai et al.   STEM CELLS AND DEVELOPMENT

Overexpressed CISD2 has prognostic value in human gastric cancer and promotes gastric cancer cell proliferation and tumorigenesis via AKT signaling pathway

(2015) Lan Wang et al.   Oncotarget

DNA Damage, DNA Repair, Aging, and Neurodegeneration

(2015) Scott Maynard et al.   Cold Spring Harbor Perspectives in Medicine

A SIRT7-Dependent Acetylation Switch of GABPβ1 Controls Mitochondrial Function

(2014) Dongryeol Ryu et al.   Cell Metabolism

Cisd2 mediates lifespan: is there an interconnection among Ca2+homeostasis, autophagy, and lifespan?

(2014) C.-H. Wang et al.   FREE RADICAL RESEARCH

Cisd2 modulates the differentiation and functioning of adipocytes by regulating intracellular Ca2+ homeostasis

(2014) Chih-Hao Wang et al.   HUMAN MOLECULAR GENETICS

CISD2 expression is a novel marker correlating with pelvic lymph node metastasis and prognosis in patients with early-stage cervical cancer

(2014) Luxin Liu et al.   MEDICAL ONCOLOGY

Susceptibility of Nrf2-Null Mice to Steatohepatitis and Cirrhosis upon Consumption of a High-Fat Diet Is Associated with Oxidative Stress, Perturbation of the Unfolded Protein Response, and Disturbance in the Expression of Metabolic Enzymes but Not with Insulin Resistance

(2014) P. J. Meakin et al.   MOLECULAR AND CELLULAR BIOLOGY

Integrated strategy reveals the protein interface between cancer targets Bcl-2 and NAF-1

(2014) S. Tamir et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A calcium-dependent protease as a potential therapeutic target for Wolfram syndrome

(2014) Simin Lu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Hallmarks of Aging

(2013) Carlos López-Otín et al.   CELL

Mitochondrial DNA Damage Can Promote Atherosclerosis Independently of Reactive Oxygen Species Through Effects on Smooth Muscle Cells and Monocytes and Correlates With Higher-Risk Plaques in Humans

(2013) Emma Yu et al.   CIRCULATION

Wolfram Syndrome protein, Miner1, regulates sulphydryl redox status, the unfolded protein response, and Ca2+homeostasis

(2013) Sandra E. Wiley et al.   EMBO Molecular Medicine

In-depth proteomic analysis of mammalian mitochondria-associated membranes (MAM)

(2013) Chloe N. Poston et al.   Journal of Proteomics

Aging and Calorie Restriction Oppositely Affect Mitochondrial Biogenesis through TFAM Binding at Both Origins of Mitochondrial DNA Replication in Rat Liver

(2013) Anna Picca et al.   PLoS One

NAF-1 and mitoNEET are central to human breast cancer proliferation by maintaining mitochondrial homeostasis and promoting tumor growth

(2013) Yang-Sung Sohn et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Oxidant stress in mitochondrial DNA damage, autophagy and inflammation in atherosclerosis

(2013) Zufeng Ding et al.   Scientific Reports

Mitochondrial DNA Damage Patterns and Aging: Revising the Evidences for Humans and Mice

(2013) Nadiya Kazachkova   Aging and Disease

BCL2-CISD2

(2012) Natasha C. Chang et al.   Autophagy

Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death

(2012) Scott J. Dixon et al.   CELL

Mitochondria and Cardiovascular Aging

(2012) Dao-Fu Dai et al.   CIRCULATION RESEARCH

A persistent level of Cisd2 extends healthy lifespan and delays aging in mice

(2012) Chia-Yu Wu et al.   HUMAN MOLECULAR GENETICS

Bcl-2-associated autophagy regulator Naf-1 required for maintenance of skeletal muscle

(2012) N. C. Chang et al.   HUMAN MOLECULAR GENETICS

MicroRNAs and their roles in aging

(2012) T. Smith-Vikos et al.   JOURNAL OF CELL SCIENCE

MicroRNAs as a novel cellular senescence regulator

(2011) Feng-Jiao Liu et al.   AGEING RESEARCH REVIEWS

Calcium signaling around Mitochondria Associated Membranes (MAMs)

(2011) Simone Patergnani et al.   Cell Communication and Signaling

Signal transduction by reactive oxygen species

(2011) Toren Finkel   JOURNAL OF CELL BIOLOGY

Deep Sequencing Reveals Novel MicroRNAs and Regulation of MicroRNA Expression during Cell Senescence

(2011) Joseph M. Dhahbi et al.   PLoS One

A role for the CISD2 gene in lifespan control and human disease

(2010) Yi-Fan Chen et al.   Annals of the New York Academy of Sciences

The ER and ageing II: Calcium homeostasis

(2009) Monika Puzianowska-Kuznicka et al.   AGEING RESEARCH REVIEWS

Cisd2 mediates mitochondrial integrity and life span in mammals

(2009) Yi-Fan Chen et al.   Autophagy

Antagonism of Beclin 1-dependent autophagy by BCL-2 at the endoplasmic reticulum requires NAF-1

(2009) Natasha C Chang et al.   EMBO JOURNAL

Mitochondria and reactive oxygen species

(2009) Alicia J. Kowaltowski et al.   FREE RADICAL BIOLOGY AND MEDICINE

Cisd2 deficiency drives premature aging and causes mitochondria-mediated defects in mice

(2009) Y.-F. Chen et al.   GENES & DEVELOPMENT

Sirt7 Increases Stress Resistance of Cardiomyocytes and Prevents Apoptosis and Inflammatory Cardiomyopathy in Mice

(2008) Olesya Vakhrusheva et al.   CIRCULATION RESEARCH

DNA deletions and clonal mutations drive premature aging in mitochondrial mutator mice

(2008) Marc Vermulst et al.   NATURE GENETICS

Loss of the Calmodulin-Dependent Inhibition of the RyR1 Calcium Release Channel upon Oxidation of Methionines in Calmodulin†

(2007) Curt B. Boschek et al.   BIOCHEMISTRY