Cynandione A and PHA-543613 inhibit inflammation and stimulate macrophageal IL-10 expression following α7 nAChR activation

Cynandione A Alleviates Neuropathic Pain Through α7-nAChR-Dependent IL-10/β-Endorphin Signaling Complexes

(2021) Qiao-Qiao Han et al.   Frontiers in Pharmacology

Activation of α7 nAChR by PNU-282987 improves synaptic and cognitive functions through restoring the expression of synaptic-associated proteins and the CaM-CaMKII-CREB signaling pathway

(2020) Xiao-Ling Wang et al.   Aging-US

The spinal microglial IL-10/β-endorphin pathway accounts for cinobufagin-induced mechanical antiallodynia in bone cancer pain following activation of α7-nicotinic acetylcholine receptors

(2020) Evhy Apryani et al.   Journal of Neuroinflammation

Small interfering RNA targeting alpha7 nicotinic acetylcholine receptor sensitizes hepatocellular carcinoma cells to sorafenib

(2020) Khalil Hajiasgharzadeh et al.   LIFE SCIENCES

Activation of α7 Nicotinic Acetylcholine Receptor Upregulates HLA-DR and Macrophage Receptors: Potential Role in Adaptive Immunity and in Preventing Immunosuppression

(2020) Andrei E. Siniavin et al.   Biomolecules

Activation of α7‐nAChRs protects SH‐SY5Y cells from 1‐methyl‐4‐phenylpyridinium‐induced apoptotic cell death via ERK/p53 signaling pathway

(2019) Shi Xu et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Activation of alpha7 acetylcholine receptors reduces neuropathic pain by decreasing dynorphin A release from microglia

(2019) Liu Ji et al.   BRAIN RESEARCH

IL-10/STAT3/SOCS3 Axis Is Involved in the Anti-inflammatory Effect of Benznidazole

(2019) Ágata C. Cevey et al.   Frontiers in Immunology

Dexmedetomidine ameliorates LPS induced acute lung injury via GSK-3β/STAT3-NF-κB signaling pathway in rats

(2019) Huayun Zhang et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Effect of Vitamin C Infusion on Organ Failure and Biomarkers of Inflammation and Vascular Injury in Patients With Sepsis and Severe Acute Respiratory Failure

(2019) Alpha A. Fowler et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Antagonizing α7 nicotinic receptors with methyllycaconitine (MLA) potentiates receptor activity and memory acquisition

(2019) Nick P. van Goethem et al.   CELLULAR SIGNALLING

Nicotinic Mitigation of Neuroinflammation and Oxidative Stress After Chronic Sleep Deprivation

(2019) Rong Xue et al.   Frontiers in Immunology

Loss of IL-10 signaling in macrophages limits bacterial killing driven by prostaglandin E2

(2019) Subhankar Mukhopadhyay et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Spinal interleukin-10 produces antinociception in neuropathy through microglial β-endorphin expression, separated from antineuroinflammation

(2018) Hai-Yun Wu et al.   BRAIN BEHAVIOR AND IMMUNITY

IL-10-STAT3-Galectin-3 Axis is Essential for Osteopontin-Producing Reparative Macrophage Polarization After Myocardial Infarction

(2018) Kohsuke Shirakawa et al.   CIRCULATION

A Placebo-Controlled Phase II Study of Ruxolitinib in Combination With Pemetrexed and Cisplatin for First-Line Treatment of Patients With Advanced Nonsquamous Non–Small-Cell Lung Cancer and Systemic Inflammation

(2018) Giuseppe Giaccone et al.   Clinical Lung Cancer

Additive counteraction by α7 and α4β2-nAChRs of the hypotension and cardiac sympathovagal imbalance evoked by endotoxemia in male rats

(2018) Marwa Y. Sallam et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

The Cholinergic Anti-Inflammatory Response and the Role of Macrophages in HIV-Induced Inflammation

(2018) Manuel Delgado-Vélez et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The Role of Inflammation in the Pain, Fatigue, and Sleep Disturbance Symptom Cluster in Advanced Cancer

(2018) Kristine L. Kwekkeboom et al.   JOURNAL OF PAIN AND SYMPTOM MANAGEMENT

Effect of Eicosapentaenoic Acid on Body Composition and Inflammation Markers in Patients with Head and Neck Squamous Cell Cancer from a Public Hospital in Mexico

(2018) Obed Solís-Martínez et al.   NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL

Immunological and clinical effects of low-dose interleukin-2 across 11 autoimmune diseases in a single, open clinical trial

(2018) Michelle Rosenzwajg et al.   ANNALS OF THE RHEUMATIC DISEASES

Resveratrol regulates neuro-inflammation and induces adaptive immunity in Alzheimer’s disease

(2017) Charbel Moussa et al.   Journal of Neuroinflammation

Autocrine Interleukin-10 Mediates Glucagon-Like Peptide-1 Receptor-Induced Spinal Microglial β-Endorphin Expression

(2017) Hai-Yun Wu et al.   JOURNAL OF NEUROSCIENCE

Neuroprotective effect of the alpha 7 nicotinic receptor agonist PHA 543613 in an in vivo excitotoxic adult rat model

(2017) Laura Foucault-Fruchard et al.   NEUROSCIENCE

Association Between Dietary Inflammation Index and The Risk of Colorectal Cancer: A Meta-Analysis

(2017) Caixia Zhang et al.   NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL

Effects of dietary weight loss with and without exercise on interstitial matrix turnover and tissue inflammation biomarkers in adults with knee osteoarthritis: the Intensive Diet and Exercise for Arthritis trial (IDEA)

(2017) R.F. Loeser et al.   OSTEOARTHRITIS AND CARTILAGE

α7 Nicotinic Acetylcholine Receptor Stimulation Attenuates Neuroinflammation through JAK2-STAT3 Activation in Murine Models of Intracerebral Hemorrhage

(2017) Paul R. Krafft et al.   Biomed Research International

Expression and Function of the Cholinergic System in Immune Cells

(2017) Takeshi Fujii et al.   Frontiers in Immunology

Alpha-7 nicotinic acetylcholine receptor (nAChR) agonist inhibits the development of endometriosis by regulating inflammation

(2016) Kaori Yamada-Nomoto et al.   AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY

Alcohol and dietary factors associate with gut integrity and inflammation in HIV-infected adults

(2016) AR Webel et al.   HIV MEDICINE

Nicotinic Acetylcholine Receptors Modulate Bone Marrow-Derived Pro-Inflammatory Monocyte Production and Survival

(2016) Stéphanie St-Pierre et al.   PLoS One

Acetylcholine Inhibits LPS-Induced MMP-9 Production and Cell Migration via the a7 nAChR-JAK2/STAT3 Pathway in RAW264.7 Cells

(2015) Yong-Hua Yang et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Regulatory B Cells: Origin, Phenotype, and Function

(2015) Elizabeth C. Rosser et al.   IMMUNITY

A Jekyll and Hyde Profile: Type 1 Interferon Signaling Plays a Prominent Role in the Initiation and Maintenance of a Persistent Virus Infection

(2015) Michael B. A. Oldstone   JOURNAL OF INFECTIOUS DISEASES

Activation of α7 nicotinic acetylcholine receptors protects astrocytes against oxidative stress-induced apoptosis: Implications for Parkinson's disease

(2015) Yuan Liu et al.   NEUROPHARMACOLOGY

Cynandione A from Cynanchum wilfordii Attenuates the Production of Inflammatory Mediators in LPS-Induced BV-2 Microglial Cells via NF-κB Inactivation

(2014) Seung Bo Yang et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Cynandione A attenuates lipopolysaccharide-induced production of inflammatory mediators via MAPK inhibition and NF-κB inactivation in RAW264.7 macrophages and protects mice against endotoxin shock

(2014) Sung Hwan Kim et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Activation of Spinal Glucagon-Like Peptide-1 Receptors Specifically Suppresses Pain Hypersensitivity

(2014) N. Gong et al.   JOURNAL OF NEUROSCIENCE

Upregulating Nonneuronal Cholinergic Activity Decreases TNF Release from Lipopolysaccharide-Stimulated RAW264.7 Cells

(2014) Yi Lv et al.   MEDIATORS OF INFLAMMATION

STAT3 inhibitor NSC74859 radiosensitizes esophageal cancer via the downregulation of HIF-1α

(2014) Chi Zhang et al.   TUMOR BIOLOGY

Host innate immune responses to sepsis

(2013) Willem Joost Wiersinga et al.   Virulence

Alpha7 Nicotinic Acetylcholine Receptor Is a Target in Pharmacology and Toxicology

(2012) Miroslav Pohanka   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Cynandione A mitigates ischemic injuries in rats with cerebral ischemia

(2012) Rongcai Yue et al.   JOURNAL OF NEUROCHEMISTRY

MyD88 signalling in colonic mononuclear phagocytes drives colitis in IL-10-deficient mice

(2012) Namiko Hoshi et al.   Nature Communications

Cynanchum wilfordiiameliorates hypertension and endothelial dysfunction in rats fed with high fat/cholesterol diets

(2011) Deok Ho Choi et al.   IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY

The role of IL-10 in immune regulation during M. tuberculosis infection

(2011) P S Redford et al.   Mucosal Immunology

EVP-6124, a novel and selective α7 nicotinic acetylcholine receptor partial agonist, improves memory performance by potentiating the acetylcholine response of α7 nicotinic acetylcholine receptors

(2011) Jos Prickaerts et al.   NEUROPHARMACOLOGY

Neuronal nicotinic alpha7 receptors modulate early neutrophil infiltration to sites of skin inflammation

(2010) Lorise C Gahring et al.   Journal of Neuroinflammation

GTS-21 inhibits pro-inflammatory cytokine release independent of the Toll-like receptor stimulated via a transcriptional mechanism involving JAK2 activation

(2009) Matthijs Kox et al.   BIOCHEMICAL PHARMACOLOGY

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(2009) Mauricio Rosas-Ballina et al.   MOLECULAR MEDICINE

Discovery of N-[(3R,5R)-1-azabicyclo[3.2.1]oct-3-yl]furo[2,3-c]pyridine-5-carboxamide as an agonist of the α7 nicotinic acetylcholine receptor: In vitro and in vivo activity

(2008) Brad A. Acker et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

LPS/TLR4 signal transduction pathway

(2008) Yong-Chen Lu et al.   CYTOKINE

The alpha7 nicotinic acetylcholine receptor as a pharmacological target for inflammation

(2007) W J Jonge et al.   BRITISH JOURNAL OF PHARMACOLOGY