The spinal microglial IL-10/β-endorphin pathway accounts for cinobufagin-induced mechanical antiallodynia in bone cancer pain following activation of α7-nicotinic acetylcholine receptors

Activation of GPR40 produces mechanical antiallodynia via the spinal glial interleukin-10/β-endorphin pathway

(2019) Xiao-Fang Mao et al.   Journal of Neuroinflammation

Analgesic and toxic effects of venenum bufonis and its constituent compound cinobufagin: A comparative study

(2019) Longsheng Xu et al.   NEUROTOXICOLOGY AND TERATOLOGY

Spinal interleukin-10 produces antinociception in neuropathy through microglial β-endorphin expression, separated from antineuroinflammation

(2018) Hai-Yun Wu et al.   BRAIN BEHAVIOR AND IMMUNITY

Cinobufagin Induces Apoptosis in Osteosarcoma Cells Via the Mitochondria-Mediated Apoptotic Pathway

(2018) Guo Dai et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

The role of alpha7 nicotinic acetylcholine receptors in inflammatory bowel disease: involvement of different cellular pathways

(2018) Mohammad Seyedabadi et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

α7 Nicotinic acetylcholine receptor-mediated anti-inflammatory effect in a chronic migraine rat model via the attenuation of glial cell activation

(2018) Qing Liu et al.   Journal of Pain Research

Alpha 7 nicotinic receptor-targeted cinobufagin induces antinociception and inhibits NF-κB signaling pathway in DRG neurons

(2018) Longsheng Xu et al.   ACS Chemical Neuroscience

The antinociceptive effect of resveratrol in bone cancer pain is inhibited by the Silent Information Regulator 1 inhibitor selisistat

(2018) Sebastian Lux et al.   JOURNAL OF PHARMACY AND PHARMACOLOGY

The Cholinergic Pathways in Inflammation: A Potential Pharmacotherapeutic Target for COPD

(2018) Mitsuhiro Yamada et al.   Frontiers in Pharmacology

IVIg and LPS Co-stimulation Induces IL-10 Production by Human Monocytes, Which Is Compromised by an FcγRIIA Disease-Associated Gene Variant

(2018) Lisa K. Kozicky et al.   Frontiers in Immunology

Nicotinic acetylcholine receptors in neuropathic and inflammatory pain

(2017) Arik J. Hone et al.   FEBS LETTERS

Autocrine Interleukin-10 Mediates Glucagon-Like Peptide-1 Receptor-Induced Spinal Microglial β-Endorphin Expression

(2017) Hai-Yun Wu et al.   JOURNAL OF NEUROSCIENCE

The synergistic antitumor effect of cinobufagin and cisplatin in human osteosarcoma cell line in vitro and in vivo

(2017) Guo Dai et al.   Oncotarget

A G protein-coupled α7 nicotinic receptor regulates signaling and TNF-α release in microglia

(2017) Justin R. King et al.   FEBS Open Bio

Alpha 2 Na+,K+-ATPase silencing induces loss of inflammatory response and ouabain protection in glial cells

(2017) Paula F. Kinoshita et al.   Scientific Reports

MAPK Pathways Are Involved in Neuropathic Pain in Rats with Chronic Compression of the Dorsal Root Ganglion

(2016) Yu-Juan Qu et al.   Evidence-based Complementary and Alternative Medicine

Glial Na+-dependent ion transporters in pathophysiological conditions

(2016) Francesca Boscia et al.   GLIA

Microglial Signaling in Chronic Pain with a Special Focus on Caspase 6, p38 MAP Kinase, and Sex Dependence

(2016) T. Berta et al.   JOURNAL OF DENTAL RESEARCH

Bullatine A stimulates spinal microglial dynorphin A expression to produce anti-hypersensitivity in a variety of rat pain models

(2016) Qian Huang et al.   Journal of Neuroinflammation

The Novel, Nicotinic Alpha7 Receptor Partial Agonist, BMS-933043, Improves Cognition and Sensory Processing in Preclinical Models of Schizophrenia

(2016) Linda J. Bristow et al.   PLoS One

Cinobufagin inhibits tumor growth by inducing intrinsic apoptosis through AKT signaling pathway in human nonsmall cell lung cancer cells

(2016) Guangxin Zhang et al.   Oncotarget

Chinese herb cinobufagin-reduced cancer pain is associated with increased peripheral opioids by invaded CD3/4/8 lymphocytes

(2016) Tao Chen et al.   Oncotarget

The Mitogen-Activated Protein Kinase (MAPK) Pathway: Role in Immune Evasion by Trypanosomatids

(2016) Mercedes Soares-Silva et al.   Frontiers in Microbiology

Ester Hydrolysis Differentially Reduces Aconitine-Induced Anti-hypersensitivity and Acute Neurotoxicity: Involvement of Spinal Microglial Dynorphin Expression and Implications for Aconitum Processing

(2016) Teng-Fei Li et al.   Frontiers in Pharmacology

Cinobufagin Modulates Human Innate Immune Responses and Triggers Antibacterial Activity

(2016) Shanshan Xie et al.   PLoS One

FXYD2, a γ subunit of Na+,K+-ATPase, maintains persistent mechanical allodynia induced by inflammation

(2015) Feng Wang et al.   CELL RESEARCH

Cinobufagin exerts anti-proliferative and pro-apoptotic effects through the modulation ROS-mediated MAPKs signaling pathway

(2015) Seung Ho Baek et al.   IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY

Delayed Activation of Spinal Microglia Contributes to the Maintenance of Bone Cancer Pain in Female Wistar Rats via P2X7 Receptor and IL-18

(2015) Y. Yang et al.   JOURNAL OF NEUROSCIENCE

Peptidic exenatide and herbal catalpol mediate neuroprotection via the hippocampal GLP-1 receptor/β-endorphin pathway

(2015) Yu Jia et al.   PHARMACOLOGICAL RESEARCH

TLR-mediated STAT3 and ERK activation controls IL-10 secretion by human B cells

(2014) Bi-Sheng Liu et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Anti-Inflammatory and Antinociceptive Activities of Bufalin in Rodents

(2014) Lili Wen et al.   MEDIATORS OF INFLAMMATION

Mitogen-activated protein kinase signaling pathways are involved in regulating α7 nicotinic acetylcholine receptor-mediated amyloid-β uptake in SH-SY5Y cells

(2014) W.N. Yang et al.   NEUROSCIENCE

Comparison of toad skins Bufo bufo gargarizans Cantor from different regions for their active constituents content and cytotoxic activity on lung carcinoma cell lines

(2014) Congyan Liu et al.   Pharmacognosy Magazine

Resibufogenin and Cinobufagin Activate Central Neurons through an Ouabain-Like Action

(2014) Ze-Jun Wang et al.   PLoS One

Overactivation of corticotropin-releasing factor receptor type 1 and aquaporin-4 by hypoxia induces cerebral edema

(2014) S.-J. Chen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Functional role of alpha7 nicotinic receptor in chronic neuropathic and inflammatory pain: Studies in transgenic mice

(2013) Shakir D. AlSharari et al.   BIOCHEMICAL PHARMACOLOGY

Neuronal nicotinic receptors as analgesic targets: It's a winding road

(2013) Iboro C. Umana et al.   BIOCHEMICAL PHARMACOLOGY

A new rat model of bone cancer pain produced by rat breast cancer cells implantation of the shaft of femur at the third trochanter level

(2013) Qi Gui et al.   CANCER BIOLOGY & THERAPY

A Study on the Mechanism of Cinobufagin in the Treatment of Paw Cancer Pain by Modulating Localβ-Endorphin ExpressionIn Vivo

(2013) Tao Chen et al.   Evidence-based Complementary and Alternative Medicine

Preparative Isolation of Bufalin and Cinobufagin from Chinese Traditional Medicine ChanSu

(2013) Z. Yang et al.   JOURNAL OF CHROMATOGRAPHIC SCIENCE

The Emerging Role of p38 Mitogen-Activated Protein Kinase in Multiple Sclerosis and Its Models

(2013) D. N. Krementsov et al.   MOLECULAR AND CELLULAR BIOLOGY

Targeting peripheral opioid receptors to promote analgesic and anti-inflammatory actions

(2013) Katerina S. Iwaszkiewicz et al.   Frontiers in Pharmacology

Microglia/Macrophage Polarization Dynamics Reveal Novel Mechanism of Injury Expansion After Focal Cerebral Ischemia

(2012) Xiaoming Hu et al.   STROKE

Induction of interleukin-10 is dependent on p38 mitogen-activated protein kinase pathway in macrophages infected with porcine reproductive and respiratory syndrome virus

(2012) Jun Hou et al.   Virology Journal

Role of the mu-opioid receptor in opioid modulation of immune function

(2011) Jana Ninković et al.   AMINO ACIDS

Immunomodulatory effects of cinobufagin isolated from Chan Su on activation and cytokines secretion of immunocytein vitro

(2011) Xiao-Liang Wang et al.   JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH

Anti-inflammatory and Antinociceptive Activity of Ouabain in Mice

(2011) Danielle Ingrid Bezerra de Vasconcelos et al.   MEDIATORS OF INFLAMMATION

Bone cancer pain

(2010) Juan Miguel Jimenez-Andrade et al.   Annals of the New York Academy of Sciences

α7 nAChR-mediated activation of MAP kinase pathways in PC12 cells

(2010) Earl J. Gubbins et al.   BRAIN RESEARCH

Pre-synaptic nicotinic receptors evoke endogenous glutamate and aspartate release from hippocampal synaptosomes by way of distinct coupling mechanisms

(2010) S Zappettini et al.   BRITISH JOURNAL OF PHARMACOLOGY

Roles of MAPK pathway activation during cytokine induction in BEAS-2B cells exposed to fine World Trade Center (WTC) dust

(2010) Shang Wang et al.   Journal of Immunotoxicology

A p38 Mitogen-Activated Protein Kinase-Dependent Mechanism of Disinhibition in Spinal Synaptic Transmission Induced by Tumor Necrosis Factor- 

(2010) H. Zhang et al.   JOURNAL OF NEUROSCIENCE

Sex, Gender, and Pain: A Review of Recent Clinical and Experimental Findings

(2009) Roger B. Fillingim et al.   JOURNAL OF PAIN

Cathepsin K generates enkephalin from β-endorphin: A new mechanism with possible relevance for schizophrenia

(2009) Uwe Lendeckel et al.   NEUROCHEMISTRY INTERNATIONAL

The β3 subunit of the Na+,K+-ATPase mediates variable nociceptive sensitivity in the formalin test

(2009) Michael L. LaCroix-Fralish et al.   PAIN

The alpha7 nicotinic acetylcholine receptor as a pharmacological target for inflammation

(2007) W J Jonge et al.   BRITISH JOURNAL OF PHARMACOLOGY