Loss of IL-10 signaling in macrophages limits bacterial killing driven by prostaglandin E2

Interleukin-22 promotes phagolysosomal fusion to induce protection against Salmonella enterica Typhimurium in human epithelial cells

(2018) Jessica L. Forbester et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mitochondrial Membrane Potential Regulates Nuclear Gene Expression in Macrophages Exposed to Prostaglandin E2

(2018) David E. Sanin et al.   IMMUNITY

Autocrine–paracrine prostaglandin E2 signaling restricts TLR4 internalization and TRIF signaling

(2018) Darren J. Perkins et al.   NATURE IMMUNOLOGY

Eros is a novel transmembrane protein that controls the phagocyte respiratory burst and is essential for innate immunity

(2017) David C. Thomas et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Inhibition of Inflammatory Gene Transcription by IL-10 Is Associated with Rapid Suppression of Lipopolysaccharide-Induced Enhancer Activation

(2017) Evan A. Conaway et al.   JOURNAL OF IMMUNOLOGY

Prostaglandin E-major Urinary Metabolite as a Biomarker for Pediatric Ulcerative Colitis Activity

(2017) Shin-ichiro Hagiwara et al.   JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION

Elevated prostaglandin E2 post–bone marrow transplant mediates interleukin-1β-related lung injury

(2017) G J Martínez-Colón et al.   Mucosal Immunology

Corrigendum: Common genetic variation drives molecular heterogeneity in human iPSCs

(2017) Helena Kilpinen et al.   NATURE

Fine-mapping inflammatory bowel disease loci to single-variant resolution

(2017) Hailiang Huang et al.   NATURE

Genome-wide association study implicates immune activation of multiple integrin genes in inflammatory bowel disease

(2017) Katrina M de Lange et al.   NATURE GENETICS

Anti-inflammatory effect of IL-10 mediated by metabolic reprogramming of macrophages

(2017) W. K. Eddie Ip et al.   SCIENCE

Exploiting induced pluripotent stem cell-derived macrophages to unravel host factors influencing Chlamydia trachomatis pathogenesis

(2017) Amy T. Y. Yeung et al.   Nature Communications

Macrophage dysfunction initiates colitis during weaning of infant mice lacking the interleukin-10 receptor

(2017) Naresh S Redhu et al.   eLife

Interleukin-10 and prostaglandin E2 have complementary but distinct suppressive effects on Toll-like receptor-mediated dendritic cell activation in ovarian carcinoma

(2017) Eva Brencicova et al.   PLoS One

Opposing roles of IL-10 in acute bacterial infection

(2016) Hernán F. Peñaloza et al.   CYTOKINE & GROWTH FACTOR REVIEWS

Alterations to chromatin in intestinal macrophages link IL-10 deficiency to inappropriate inflammatory responses

(2016) Jeremy M. Simon et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Human knockouts ofPLA2G4Aphenocopy NSAID-induced gastrointestinal and renal toxicity

(2016) Sateesh Maddirevula et al.   GUT

The macrophage IRF8/IRF1 regulome is required for protection against infections and is associated with chronic inflammation

(2016) David Langlais et al.   JOURNAL OF EXPERIMENTAL MEDICINE

MARCH1 E3 Ubiquitin Ligase Dampens the Innate Inflammatory Response by Modulating Monocyte Functions in Mice

(2016) Tristan Galbas et al.   JOURNAL OF IMMUNOLOGY

Analysis of five chronic inflammatory diseases identifies 27 new associations and highlights disease-specific patterns at shared loci

(2016) David Ellinghaus et al.   NATURE GENETICS

Mechanism and regulation of the nonsense-mediated decay pathway

(2016) Nele Hug et al.   NUCLEIC ACIDS RESEARCH

IL-21/IL-21R signaling suppresses intestinal inflammation induced by DSS through regulation of Th responses in lamina propria in mice

(2016) Yuanyuan Wang et al.   Scientific Reports

CRISPR-mediated genotypic and phenotypic correction of a chronic granulomatous disease mutation in human iPS cells

(2015) Rowan Flynn et al.   EXPERIMENTAL HEMATOLOGY

Interleukin 10 (IL-10)-mediated Immunosuppression

(2015) Sharad K. Mittal et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Association analyses identify 38 susceptibility loci for inflammatory bowel disease and highlight shared genetic risk across populations

(2015) Jimmy Z Liu et al.   NATURE GENETICS

Transcriptional profiling of macrophages derived from monocytes and iPS cells identifies a conserved response to LPS and novel alternative transcription

(2015) Kaur Alasoo et al.   Scientific Reports

Successful Generation of Human Induced Pluripotent Stem Cell Lines from Blood Samples Held at Room Temperature for up to 48 hr

(2015) Chukwuma A. Agu et al.   Stem Cell Reports

Induced Pluripotent Stem Cell Derived Macrophages as a Cellular System to Study Salmonella and Other Pathogens

(2015) Christine Hale et al.   PLoS One

IL-21 Is a Major Negative Regulator of IRF4-Dependent Lipolysis Affecting Tregs in Adipose Tissue and Systemic Insulin Sensitivity

(2014) Marta Fabrizi et al.   DIABETES

Interleukin-10 Receptor Signaling in Innate Immune Cells Regulates Mucosal Immune Tolerance and Anti-Inflammatory Macrophage Function

(2014) Dror S. Shouval et al.   IMMUNITY

Macrophage-Restricted Interleukin-10 Receptor Deficiency, but Not IL-10 Deficiency, Causes Severe Spontaneous Colitis

(2014) Ehud Zigmond et al.   IMMUNITY

Prostaglandin E–Major Urinary Metabolite as a Reliable Surrogate Marker for Mucosal Inflammation in Ulcerative Colitis

(2014) Yoshinori Arai et al.   INFLAMMATORY BOWEL DISEASES

IL-10: The Master Regulator of Immunity to Infection

(2014) Kevin N. Couper et al.   JOURNAL OF IMMUNOLOGY

Immunosuppression in acutely decompensated cirrhosis is mediated by prostaglandin E2

(2014) Alastair J O'Brien et al.   NATURE MEDICINE

NetworkAnalyst - integrative approaches for protein–protein interaction network analysis and visual exploration

(2014) Jianguo Xia et al.   NUCLEIC ACIDS RESEARCH

EP4 and EP2 Receptor Activation of Protein Kinase A by Prostaglandin E2Impairs Macrophage Phagocytosis ofClostridium sordellii

(2013) Lisa M. Rogers et al.   AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY

featureCounts: an efficient general purpose program for assigning sequence reads to genomic features

(2013) Y. Liao et al.   BIOINFORMATICS

The IL-10/STAT3-mediated anti-inflammatory response: recent developments and future challenges

(2013) A. P. Hutchins et al.   Briefings in Functional Genomics

Human Cytomegalovirus Interleukin-10 Polarizes Monocytes toward a Deactivated M2c Phenotype To Repress Host Immune Responses

(2013) S. Avdic et al.   JOURNAL OF VIROLOGY

MSK1 and MSK2 Inhibit Lipopolysaccharide-Induced Prostaglandin Production via an Interleukin-10 Feedback Loop

(2013) K. F. MacKenzie et al.   MOLECULAR AND CELLULAR BIOLOGY

Inflammatory monocytes regulate pathologic responses to commensals during acute gastrointestinal infection

(2013) John R Grainger et al.   NATURE MEDICINE

PGE2 suppression of innate immunity during mucosal bacterial infection

(2013) Mallory Agard et al.   Frontiers in Cellular and Infection Microbiology

IL-10 and IL-10 receptor defects in humans

(2012) Erik-Oliver Glocker et al.   Annals of the New York Academy of Sciences

Genome-wide analysis of STAT3 binding in vivo predicts effectors of the anti-inflammatory response in macrophages

(2012) A. P. Hutchins et al.   BLOOD

Cryptogenic multifocal ulcerating stenosing enteritis associated with homozygous deletion mutations in cytosolic phospholipase A2-α

(2012) Matthew A Brooke et al.   GUT

Global Effect of Interleukin-10 on the Transcriptional Profile Induced by Neisseria meningitidis in Human Monocytes

(2012) Unni Gopinathan et al.   INFECTION AND IMMUNITY

IL-10R Polymorphisms Are Associated with Very-early-onset Ulcerative Colitis

(2012) Christopher J. Moran et al.   INFLAMMATORY BOWEL DISEASES

Clinical outcome in IL-10– and IL-10 receptor–deficient patients with or without hematopoietic stem cell transplantation

(2012) Karin R. Engelhardt et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

IL-10 Regulates Il12b Expression via Histone Deacetylation: Implications for Intestinal Macrophage Homeostasis

(2012) T. Kobayashi et al.   JOURNAL OF IMMUNOLOGY

Prostaglandin and the Suppression of Phagocyte Innate Immune Responses in Different Organs

(2012) Alexandra Medeiros et al.   MEDIATORS OF INFLAMMATION

Host–microbe interactions have shaped the genetic architecture of inflammatory bowel disease

(2012) Luke Jostins et al.   NATURE

InnateDB: systems biology of innate immunity and beyond—recent updates and continuing curation

(2012) Karin Breuer et al.   NUCLEIC ACIDS RESEARCH

Francisella tularensis Elicits IL-10 via a PGE2-Inducible Factor, to Drive Macrophage MARCH1 Expression and Class II Down-Regulation

(2012) Danielle Hunt et al.   PLoS One

Induced pluripotent stem cell model recapitulates pathologic hallmarks of Gaucher disease

(2012) L. M. Panicker et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

PTEN Directly Activates the Actin Depolymerization Factor Cofilin-1 During PGE2-Mediated Inhibition of Phagocytosis of Fungi

(2012) C. H. Serezani et al.   Science Signaling

MyD88 signalling in colonic mononuclear phagocytes drives colitis in IL-10-deficient mice

(2012) Namiko Hoshi et al.   Nature Communications

IL-10 suppresses bactericidal response of macrophages against Salmonella Typhimurium

(2011) Kyoung-Sun Lee et al.   JOURNAL OF MICROBIOLOGY

Bi-allelic gene targeting in mouse embryonic stem cells

(2011) Peri H. Tate et al.   METHODS

The role of IL-10 in immune regulation during M. tuberculosis infection

(2011) P S Redford et al.   Mucosal Immunology

TLR signalling augments macrophage bactericidal activity through mitochondrial ROS

(2011) A. Phillip West et al.   NATURE

Intestinal homeostasis and its breakdown in inflammatory bowel disease

(2011) Kevin J. Maloy et al.   NATURE

IL-10 administration reduces PGE-2 levels and promotes CR3-mediated clearance ofEscherichia coliK1 by phagocytes in meningitis

(2010) Rahul Mittal et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Inducible Cyclooxygenase Released Prostaglandin E2 Modulates the Severity of Infection Caused by Streptococcus pyogenes

(2010) O. Goldmann et al.   JOURNAL OF IMMUNOLOGY

Infant colitis—it's in the genes

(2010) Erik-Oliver Glocker et al.   LANCET

Nonsteroidal Antiinflammatory Drugs and Cyclooxygenase Inhibition in the Gastrointestinal Tract: A Trip From Peptic Ulcer to Colon Cancer

(2009) Angel Lanas   AMERICAN JOURNAL OF THE MEDICAL SCIENCES

The Induction of IL-10 by Zymosan in Dendritic Cells Depends on CREB Activation by the Coactivators CREB-Binding Protein and TORC2 and Autocrine PGE2

(2009) Y. Alvarez et al.   JOURNAL OF IMMUNOLOGY

Nonsense-mediated mRNA decay (NMD) mechanisms

(2009) Saverio Brogna et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Inflammatory Bowel Disease and Mutations Affecting the Interleukin-10 Receptor

(2009) Erik-Oliver Glocker et al.   NEW ENGLAND JOURNAL OF MEDICINE

Regulation of Gut Inflammation and Th17 Cell Response by Interleukin-21

(2008) Daniele Fina et al.   GASTROENTEROLOGY