Cynandione A Alleviates Neuropathic Pain Through α7-nAChR-Dependent IL-10/β-Endorphin Signaling Complexes

The spinal microglial IL-10/β-endorphin pathway accounts for cinobufagin-induced mechanical antiallodynia in bone cancer pain following activation of α7-nicotinic acetylcholine receptors

(2020) Evhy Apryani et al.   Journal of Neuroinflammation

Lemairamin, isolated from the Zanthoxylum plants, alleviates pain hypersensitivity via spinal α7 nicotinic acetylcholine receptors

(2020) Zi-Ying Wang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Low frequency electroacupuncture alleviates neuropathic pain by activation of spinal microglial IL-10/β-endorphin pathway

(2020) Usman Ali et al.   BIOMEDICINE & PHARMACOTHERAPY

Activation of α7‐nAChRs protects SH‐SY5Y cells from 1‐methyl‐4‐phenylpyridinium‐induced apoptotic cell death via ERK/p53 signaling pathway

(2019) Shi Xu et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Perioperative activation of spinal α7 nAChR promotes recovery from preoperative stress-induced prolongation of postsurgical pain

(2019) Rao Sun et al.   BRAIN BEHAVIOR AND IMMUNITY

Activation of GPR40 produces mechanical antiallodynia via the spinal glial interleukin-10/β-endorphin pathway

(2019) Xiao-Fang Mao et al.   Journal of Neuroinflammation

Activation of alpha7 acetylcholine receptors reduces neuropathic pain by decreasing dynorphin A release from microglia

(2019) Liu Ji et al.   BRAIN RESEARCH

IL-10 and CXCL2 in trigeminal ganglia in neuropathic pain

(2019) Takuma Iwasa et al.   NEUROSCIENCE LETTERS

Antagonizing α7 nicotinic receptors with methyllycaconitine (MLA) potentiates receptor activity and memory acquisition

(2019) Nick P. van Goethem et al.   CELLULAR SIGNALLING

Spinal interleukin-10 produces antinociception in neuropathy through microglial β-endorphin expression, separated from antineuroinflammation

(2018) Hai-Yun Wu et al.   BRAIN BEHAVIOR AND IMMUNITY

Involvement of α7nAChR in electroacupuncture relieving neuropathic pain in the spinal cord of rat with spared nerve injury

(2018) Ying Wang et al.   BRAIN RESEARCH BULLETIN

Both classic Gs-cAMP/PKA/CREB and alternative Gs-cAMP/PKA/p38β/CREB signal pathways mediate exenatide-stimulated expression of M2 microglial markers

(2018) Hai-Yun Wu et al.   JOURNAL OF NEUROIMMUNOLOGY

β-Cell mass restoration by α7 nicotinic acetylcholine receptor activation

(2018) Dhananjay Gupta et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Exogenous (Pomegranate Juice) or Endogenous (Paraoxonase1) Antioxidants Decrease Triacylglycerol Accumulation in Mouse Cardiovascular Disease-Related Tissues

(2018) Oren Rom et al.   LIPIDS

Autocrine Interleukin-10 Mediates Glucagon-Like Peptide-1 Receptor-Induced Spinal Microglial β-Endorphin Expression

(2017) Hai-Yun Wu et al.   JOURNAL OF NEUROSCIENCE

p38 β Mitogen-Activated Protein Kinase Signaling Mediates Exenatide-Stimulated Microglial β -Endorphin Expression

(2017) Hai-Yun Wu et al.   MOLECULAR PHARMACOLOGY

A G protein-coupled α7 nicotinic receptor regulates signaling and TNF-α release in microglia

(2017) Justin R. King et al.   FEBS Open Bio

Dezocine exhibits antihypersensitivity activities in neuropathy through spinal μ-opioid receptor activation and norepinephrine reuptake inhibition

(2017) Yong-Xiang Wang et al.   Scientific Reports

Molecular signaling underlying bulleyaconitine A (BAA)-induced microglial expression of prodynorphin

(2017) Teng-Fei Li et al.   Scientific Reports

The α7 nicotinic receptor dual allosteric agonist and positive allosteric modulator GAT107 reverses nociception in mouse models of inflammatory and neuropathic pain

(2016) Deniz Bagdas et al.   BRITISH JOURNAL OF PHARMACOLOGY

Antinociception of spirocyclopiperazinium salt compound LXM-10-M targeting α7 nicotinic receptor and M4 muscarinic receptor and inhibiting CaMKIIα/CREB/CGRP signaling pathway in mice

(2016) Dan Wan et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Gx-50 Inhibits Neuroinflammation via α7 nAChR Activation of the JAK2/STAT3 and PI3K/AKT Pathways

(2016) Shi Shi et al.   JOURNAL OF ALZHEIMERS DISEASE

Bullatine A stimulates spinal microglial dynorphin A expression to produce anti-hypersensitivity in a variety of rat pain models

(2016) Qian Huang et al.   Journal of Neuroinflammation

Stimulation of α7 nicotinic acetylcholine receptor regulates glutamate transporter GLAST via basic fibroblast growth factor production in cultured cortical microglia

(2015) Norimitsu Morioka et al.   BRAIN RESEARCH

An ethanol root extract of Cynanchum wilfordii containing acetophenones suppresses the expression of VCAM-1 and ICAM-1 in TNF-α-stimulated human aortic smooth muscle cells through the NF-κB pathway

(2015) HYUN JUNG KOO et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Activation of α7 nicotinic acetylcholine receptors protects astrocytes against oxidative stress-induced apoptosis: Implications for Parkinson's disease

(2015) Yuan Liu et al.   NEUROPHARMACOLOGY

Nicotinic acetylcholine receptor α7 subunit is involved in the cobratoxin-induced antinociception in an animal model of neuropathic pain

(2015) Shan Gong et al.   TOXICON

Cynandione A from Cynanchum wilfordii Attenuates the Production of Inflammatory Mediators in LPS-Induced BV-2 Microglial Cells via NF-κB Inactivation

(2014) Seung Bo Yang et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Cynandione A attenuates lipopolysaccharide-induced production of inflammatory mediators via MAPK inhibition and NF-κB inactivation in RAW264.7 macrophages and protects mice against endotoxin shock

(2014) Sung Hwan Kim et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Improving peripheral nerve regeneration: From molecular mechanisms to potential therapeutic targets

(2014) K. Ming Chan et al.   EXPERIMENTAL NEUROLOGY

Cytokine pathways regulating glial and leukocyte function after spinal cord and peripheral nerve injury

(2014) Dominic Bastien et al.   EXPERIMENTAL NEUROLOGY

Activation of Spinal Glucagon-Like Peptide-1 Receptors Specifically Suppresses Pain Hypersensitivity

(2014) N. Gong et al.   JOURNAL OF NEUROSCIENCE

Pain-Related Depression of the Mesolimbic Dopamine System in Rats: Expression, Blockade by Analgesics and Role of Endogenous κ-opioids

(2013) Michael D Leitl et al.   NEUROPSYCHOPHARMACOLOGY

Contributions of spinal d-amino acid oxidase to bone cancer pain

(2012) Jin-Lu Huang et al.   AMINO ACIDS

Effects of IFN-γ, TNF-α, IL-10 and TGF-β on Neospora caninum infection in rat glial cells

(2012) E.E.V. Jesus et al.   EXPERIMENTAL PARASITOLOGY

Cynandione A mitigates ischemic injuries in rats with cerebral ischemia

(2012) Rongcai Yue et al.   JOURNAL OF NEUROCHEMISTRY

JAK-STAT1/3-Induced Expression of Signal Sequence-Encoding Proopiomelanocortin mRNA in Lymphocytes Reduces Inflammatory Pain in Rats

(2012) Melanie Busch-Dienstfertig et al.   Molecular Pain

Activation of nicotinic acetylcholine receptors on bone marrow-derived cells relieves neuropathic pain accompanied by peripheral neuroinflammation

(2012) Norikazu Kiguchi et al.   NEUROCHEMISTRY INTERNATIONAL

The antihyperalgesic effect of cytidine-5′-diphosphate-choline in neuropathic and inflammatory pain models

(2011) Deniz Bagdas et al.   BEHAVIOURAL PHARMACOLOGY

Research update: Alpha7 nicotinic acetylcholine receptor mechanisms in Alzheimer's disease

(2011) H. Rheinallt Parri et al.   BIOCHEMICAL PHARMACOLOGY

Cyclic AMP response element-binding protein (CREB) phosphorylation: A mechanistic marker in the development of memory enhancing Alzheimer's disease therapeutics

(2011) R. Scott Bitner   BIOCHEMICAL PHARMACOLOGY

The Physiology, Signaling, and Pharmacology of Dopamine Receptors

(2011) J.-M. Beaulieu et al.   PHARMACOLOGICAL REVIEWS

Biology of interleukin-10

(2010) Robert Sabat et al.   CYTOKINE & GROWTH FACTOR REVIEWS

IL-10 production by CD4+ effector T cells: a mechanism for self-regulation

(2010) D Jankovic et al.   Mucosal Immunology

Mammalian Nicotinic Acetylcholine Receptors: From Structure to Function

(2009) Edson X. Albuquerque et al.   PHYSIOLOGICAL REVIEWS