Cardiovascular effects of omega-3 fatty acids: Hope or hype?

Emerging Mechanisms of Cardiovascular Protection for the Omega-3 Fatty Acid Eicosapentaenoic Acid

(2020) R. Preston Mason et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Effect of icosapent ethyl on progression of coronary atherosclerosis in patients with elevated triglycerides on statin therapy: final results of the EVAPORATE trial

(2020) Matthew J Budoff et al.   EUROPEAN HEART JOURNAL

Effect of High-Dose Omega-3 Fatty Acids vs Corn Oil on Major Adverse Cardiovascular Events in Patients at High Cardiovascular Risk

(2020) Stephen J. Nicholls et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Dietary Fats in Relation to Total and Cause-Specific Mortality in a Prospective Cohort of 521,120 Individuals with 16 Years of Follow-Up

(2019) Pan Zhuang et al.   CIRCULATION RESEARCH

New Insights into Mechanisms of Action for Omega-3 Fatty Acids in Atherothrombotic Cardiovascular Disease

(2019) R. Preston Mason   Current Atherosclerosis Reports

The Role of n-3 Fatty Acids in Cardiovascular Disease: Back to the Future

(2019) Pablo Perez-Martinez et al.   ANGIOLOGY

Preferential Incorporation of Administered Eicosapentaenoic Acid Into Thin-Cap Atherosclerotic Plaques

(2019) Tomohito Sato et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Omega-3 Fatty Acids for the Management of Hypertriglyceridemia: A Science Advisory From the American Heart Association

(2019) Ann C. Skulas-Ray et al.   CIRCULATION

Association Between Triglyceride Lowering and Reduction of Cardiovascular Risk Across Multiple Lipid-Lowering Therapeutic Classes: A Systematic Review and Meta-Regression Analysis of Randomized Controlled Trials

(2019) Nicholas A. Marston et al.   CIRCULATION

Strategies to Overcome Residual Risk During Statins Era

(2019) Kyoung Im Cho et al.   CIRCULATION JOURNAL

2019 ESC/EAS Guidelines for the management of dyslipidaemias: lipid modification to reduce cardiovascular risk

(2019) François Mach et al.   EUROPEAN HEART JOURNAL

Omega-3 fatty acids supplementation and oxidative stress parameters: a systematic review and meta-analysis of clinical trials

(2019) Javad Heshmati et al.   PHARMACOLOGICAL RESEARCH

Omega-3, omega-6, and total dietary polyunsaturated fat for prevention and treatment of type 2 diabetes mellitus: systematic review and meta-analysis of randomised controlled trials

(2019) Tracey J Brown et al.   BMJ-British Medical Journal

Eicosapentaenoic acid inhibits oxidation of high density lipoprotein particles in a manner distinct from docosahexaenoic acid

(2018) Samuel C.R. Sherratt et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Eicosapentaenoic acid improves endothelial function and nitric oxide bioavailability in a manner that is enhanced in combination with a statin

(2018) R. Preston Mason et al.   BIOMEDICINE & PHARMACOTHERAPY

Eicosapentaenoic acid and docosahexaenoic acid have distinct membrane locations and lipid interactions as determined by X-ray diffraction

(2018) Samuel C.R. Sherratt et al.   CHEMISTRY AND PHYSICS OF LIPIDS

Eicosapentaenoic Acid-Enriched High-Density Lipoproteins Exhibit Anti-Atherogenic Properties

(2018) Nobuaki Tanaka et al.   CIRCULATION JOURNAL

Effects of EPA and DHA on blood pressure and inflammatory factors: a meta-analysis of randomized controlled trials

(2018) Xiao-fei Guo et al.   CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION

The Differential Effects of Eicosapentaenoic Acid and Docosahexaenoic Acid on Cardiometabolic Risk Factors: A Systematic Review

(2018) Jacqueline Innes et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

High-dose DHA has more profound effects on LDL-related features than high-dose EPA: The ComparED study

(2018) Janie Allaire et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Associations of Omega-3 Fatty Acid Supplement Use With Cardiovascular Disease Risks

(2018) Theingi Aung et al.   JAMA Cardiology

Assessment of omega-3 carboxylic acids in statin-treated patients with high levels of triglycerides and low levels of high-density lipoprotein cholesterol: Rationale and design of the STRENGTH trial

(2018) Stephen J. Nicholls et al.   CLINICAL CARDIOLOGY

Effects of n−3 Fatty Acid Supplements in Diabetes Mellitus

(2018)   NEW ENGLAND JOURNAL OF MEDICINE

Marine n−3 Fatty Acids and Prevention of Cardiovascular Disease and Cancer

(2018) JoAnn E. Manson et al.   NEW ENGLAND JOURNAL OF MEDICINE

Cardiovascular Risk Reduction with Icosapent Ethyl for Hypertriglyceridemia

(2018) Deepak L. Bhatt et al.   NEW ENGLAND JOURNAL OF MEDICINE

A randomized, crossover, head-to-head comparison of eicosapentaenoic acid and docosahexaenoic acid supplementation to reduce inflammation markers in men and women: the Comparing EPA to DHA (ComparED) Study

(2016) Janie Allaire et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Eicosapentaenoic acid reduces membrane fluidity, inhibits cholesterol domain formation, and normalizes bilayer width in atherosclerotic-like model membranes

(2016) R. Preston Mason et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Eicosapentaenoic Acid Inhibits Oxidation of ApoB-containing Lipoprotein Particles of Different Size In Vitro When Administered Alone or in Combination With Atorvastatin Active Metabolite Compared With Other Triglyceride-lowering Agents

(2016) R. Preston Mason et al.   JOURNAL OF CARDIOVASCULAR PHARMACOLOGY

Icosapent ethyl (eicosapentaenoic acid ethyl ester): Effects on plasma apolipoprotein C-III levels in patients from the MARINE and ANCHOR studies

(2016) Christie M. Ballantyne et al.   Journal of Clinical Lipidology

Icosapent ethyl: Eicosapentaenoic acid concentration and triglyceride-lowering effects across clinical studies

(2016) Harold E. Bays et al.   PROSTAGLANDINS & OTHER LIPID MEDIATORS

Biologic plausibility, cellular effects, and molecular mechanisms of eicosapentaenoic acid (EPA) in atherosclerosis

(2015) Kenneth M. Borow et al.   ATHEROSCLEROSIS

Eicosapentaenoic acid inhibits glucose-induced membrane cholesterol crystalline domain formation through a potent antioxidant mechanism

(2015) R. Preston Mason et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Administration of high dose eicosapentaenoic acid enhances anti-inflammatory properties of high-density lipoprotein in Japanese patients with dyslipidemia

(2014) Nobuaki Tanaka et al.   ATHEROSCLEROSIS

Modulation of adiponectin as a potential therapeutic strategy

(2014) Soo Lim et al.   ATHEROSCLEROSIS

Omega-3 fatty acid therapy dose-dependently and significantly decreased triglycerides and improved flow-mediated dilation, however, did not significantly improve insulin sensitivity in patients with hypertriglyceridemia

(2014) Pyung Chun Oh et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

Effects of Extended-Release Niacin with Laropiprant in High-Risk Patients

(2014)   NEW ENGLAND JOURNAL OF MEDICINE

Comparative cardiometabolic effects of fibrates and omega-3 fatty acids

(2013) Seung Hwan Han et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

Efficacy of Omega-3 Fatty Acid Supplements (Eicosapentaenoic Acid and Docosahexaenoic Acid) in the Secondary Prevention of Cardiovascular Disease

(2012) Seung-Kwon Myung   ARCHIVES OF INTERNAL MEDICINE

n–3 Fatty Acids and Cardiovascular Outcomes in Patients with Dysglycemia

(2012)   NEW ENGLAND JOURNAL OF MEDICINE

Dose-dependent effects of omega-3-polyunsaturated fatty acids on systolic left ventricular function, endothelial function, and markers of inflammation in chronic heart failure of nonischemic origin

(2011) Deddo Moertl et al.   AMERICAN HEART JOURNAL

Eicosapentaenoic Acid Ethyl Ester (AMR101) Therapy in Patients With Very High Triglyceride Levels (from the Multi-center, plAcebo-controlled, Randomized, double-blINd, 12-week study with an open-label Extension [MARINE] Trial)

(2011) Harold E. Bays et al.   AMERICAN JOURNAL OF CARDIOLOGY

Significant differential effects of omega-3 fatty acids and fenofibrate in patients with hypertriglyceridemia

(2011) Kwang Kon Koh et al.   ATHEROSCLEROSIS

Fish oil — How does it reduce plasma triglycerides?

(2011) Gregory C. Shearer et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Relationships between Plasma Fatty Acid Composition and Coronary Artery Disease

(2011) Hiroshige Itakura et al.   Journal of Atherosclerosis and Thrombosis

Effects of eicosapentaenoic acid and docosahexaenoic acid on low-density lipoprotein cholesterol and other lipids: A review

(2011) Terry A. Jacobson et al.   Journal of Clinical Lipidology

Docosahexaenoic Acid Supplementation Improved Lipocentric but Not Glucocentric Markers of Insulin Sensitivity in Hypertriglyceridemic Men

(2011) Darshan S. Kelley et al.   Metabolic Syndrome and Related Disorders

Niacin in Patients with Low HDL Cholesterol Levels Receiving Intensive Statin Therapy

(2011)   NEW ENGLAND JOURNAL OF MEDICINE

Dose-dependent decrease of platelet activation and tissue factor by omega-3 polyunsaturated fatty acids in patients with advanced chronic heart failure

(2011) D. Moertl et al.   THROMBOSIS AND HAEMOSTASIS

Dietary omega-3 fatty acids and fish consumption and risk of type 2 diabetes

(2010) Luc Djoussé et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Omega-3 fatty acid supplementation improves vascular function and reduces inflammation in obese adolescents

(2010) Frida Dangardt et al.   ATHEROSCLEROSIS

n–3 Fatty Acids and Cardiovascular Events after Myocardial Infarction

(2010) Daan Kromhout et al.   NEW ENGLAND JOURNAL OF MEDICINE

Gender-specific inhibition of platelet aggregation following omega-3 fatty acid supplementation

(2010) M. Phang et al.   NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES

Long-chain omega-3 fatty acids, fish intake, and the risk of type 2 diabetes mellitus

(2009) Manas Kaushik et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Dietary α-Linolenic Acid, EPA, and DHA Have Differential Effects on LDL Fatty Acid Composition but Similar Effects on Serum Lipid Profiles in Normolipidemic Humans

(2009) Sarah Egert et al.   JOURNAL OF NUTRITION