Forcing dividing cancer cells to die; low‐dose drug combinations to prevent spindle pole clustering

Optimized low‐dose combinatorial drug treatment boosts selectivity and efficacy of colorectal carcinoma treatment

(2020) Marloes Zoetemelk et al.   Molecular Oncology

Anti-angiogenic effects of crenolanib are mediated by mitotic modulation independently of PDGFR expression

(2019) Robert H. Berndsen et al.   BRITISH JOURNAL OF CANCER

Identification of a Synergistic Multi-Drug Combination Active in Cancer Cells via the Prevention of Spindle Pole Clustering

(2019) Andrea Weiss et al.   Cancers

Centrosome amplification arises before neoplasia and increases upon p53 loss in tumorigenesis

(2018) Carla A.M. Lopes et al.   JOURNAL OF CELL BIOLOGY

Clinically Applicable Inhibitors Impacting Genome Stability

(2018) Anu Prakash et al.   MOLECULES

Microtubule-Targeting Agents: Strategies To Hijack the Cytoskeleton

(2018) Michel O. Steinmetz et al.   TRENDS IN CELL BIOLOGY

Over-elongation of centrioles in cancer promotes centriole amplification and chromosome missegregation

(2018) Gaëlle Marteil et al.   Nature Communications

Pharmacological Inhibition of Centrosome Clustering by Slingshot-Mediated Cofilin Activation and Actin Cortex Destabilization

(2016) Gleb Konotop et al.   CANCER RESEARCH

Optimization of drug combinations using Feedback System Control

(2016) Patrycja Nowak-Sliwinska et al.   Nature Protocols

Dosing de novo combinations of two targeted drugs: Towards a customized precision medicine approach to advanced cancers

(2016) Sariah Liu et al.   Oncotarget

A strategy to combine pathway-targeted low toxicity drugs in ovarian cancer

(2015) Joe R Delaney et al.   Oncotarget

A streamlined search technology for identification of synergistic drug combinations

(2015) Andrea Weiss et al.   Scientific Reports

How Taxol/paclitaxel kills cancer cells

(2014) Beth A. Weaver   MOLECULAR BIOLOGY OF THE CELL

Cytotoxicity of Paclitaxel in Breast Cancer Is due to Chromosome Missegregation on Multipolar Spindles

(2014) L. M. Zasadil et al.   Science Translational Medicine

Centrosome-declustering drugs mediate a two-pronged attack on interphase and mitosis in supercentrosomal cancer cells

(2014) V Pannu et al.   Cell Death & Disease

Mitosis and apoptosis: how is the balance set?

(2013) Caroline H Topham et al.   CURRENT OPINION IN CELL BIOLOGY

Inhibitors Targeting Mitosis: Tales of How Great Drugs against a Promising Target Were Brought Down by a Flawed Rationale

(2012) E. Komlodi-Pasztor et al.   CLINICAL CANCER RESEARCH

Chromosomal instability and aneuploidy in cancer: from yeast to man

(2012) Sarah J Pfau et al.   EMBO REPORTS

Merlin/ERM proteins establish cortical asymmetry and centrosome position

(2012) A. M. Hebert et al.   GENES & DEVELOPMENT

Microtubule attachment and spindle assembly checkpoint signalling at the kinetochore

(2012) Emily A. Foley et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Mitosis-targeted anti-cancer therapies: where they stand

(2012) K-S Chan et al.   Cell Death & Disease

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

Mechanisms of chromosome behaviour during mitosis

(2010) Claire E. Walczak et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

A mechanism linking extra centrosomes to chromosomal instability

(2009) Neil J. Ganem et al.   NATURE

Synergistic drug combinations tend to improve therapeutically relevant selectivity

(2009) Joseph Lehár et al.   NATURE BIOTECHNOLOGY

Merotelic kinetochore orientation, aneuploidy, and cancer

(2008) Daniela Cimini   BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER

Mechanisms to suppress multipolar divisions in cancer cells with extra centrosomes

(2008) M. Kwon et al.   GENES & DEVELOPMENT