Chromosomal instability and aneuploidy in cancer: from yeast to man

Genome Sequencing of Pediatric Medulloblastoma Links Catastrophic DNA Rearrangements with TP53 Mutations

(2012) Tobias Rausch et al.   CELL

A unique role of cohesin-SA1 in gene regulation and development

(2012) Silvia Remeseiro et al.   EMBO JOURNAL

DNA breaks and chromosome pulverization from errors in mitosis

(2012) Karen Crasta et al.   NATURE

Tumor Heterogeneity and Personalized Medicine

(2012) Dan L. Longo   NEW ENGLAND JOURNAL OF MEDICINE

Increased Survival following Tumorigenesis in Ts65Dn Mice That Model Down Syndrome

(2011) A. Yang et al.   CANCER RESEARCH

Massive Genomic Rearrangement Acquired in a Single Catastrophic Event during Cancer Development

(2011) Philip J. Stephens et al.   CELL

Identification of Aneuploidy-Selective Antiproliferation Compounds

(2011) Yun-Chi Tang et al.   CELL

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

Bub1 overexpression induces aneuploidy and tumor formation through Aurora B kinase hyperactivation

(2011) Robin M. Ricke et al.   JOURNAL OF CELL BIOLOGY

Mutations in CEP57 cause mosaic variegated aneuploidy syndrome

(2011) Katie Snape et al.   NATURE GENETICS

Dysregulation of Gene Expression in the Artificial Human Trisomy Cells of Chromosome 8 Associated with Transformed Cell Phenotypes

(2011) Hisakatsu Nawata et al.   PLoS One

Chromosome Segregation Errors as a Cause of DNA Damage and Structural Chromosome Aberrations

(2011) A. Janssen et al.   SCIENCE

Aneuploidy Drives Genomic Instability in Yeast

(2011) J. M. Sheltzer et al.   SCIENCE

Mutational Inactivation of STAG2 Causes Aneuploidy in Human Cancer

(2011) D. A. Solomon et al.   SCIENCE

Aneuploidy and tumorigenesis

(2011) Xiao Fang et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Large-scale analysis of chromosomal aberrations in cancer karyotypes reveals two distinct paths to aneuploidy

(2011) Michal Ozery-Flato et al.   GENOME BIOLOGY

Identification of Aneuploidy-Tolerating Mutations

(2010) Eduardo M. Torres et al.   CELL

Overexpression of the E2 ubiquitin–conjugating enzyme UbcH10 causes chromosome missegregation and tumor formation

(2010) Janine H. van Ree et al.   JOURNAL OF CELL BIOLOGY

Proliferation of aneuploid human cells is limited by a p53-dependent mechanism

(2010) Sarah L. Thompson et al.   JOURNAL OF CELL BIOLOGY

Neuronal DNA content variation (DCV) with regional and individual differences in the human brain

(2010) Jurjen W. Westra et al.   JOURNAL OF COMPARATIVE NEUROLOGY

A general lack of compensation for gene dosage in yeast

(2010) Michael Springer et al.   Molecular Systems Biology

Tumour angiogenesis is reduced in the Tc1 mouse model of Down’s syndrome

(2010) Louise E. Reynolds et al.   NATURE

Mad2-induced chromosome instability leads to lung tumour relapse after oncogene withdrawal

(2010) Rocio Sotillo et al.   NATURE

The ploidy conveyor of mature hepatocytes as a source of genetic variation

(2010) Andrew W. Duncan et al.   NATURE

Aneuploidy confers quantitative proteome changes and phenotypic variation in budding yeast

(2010) Norman Pavelka et al.   NATURE

p53 suppresses structural chromosome instability after mitotic arrest in human cells

(2010) W B Dalton et al.   ONCOGENE

The ATM-p53 pathway suppresses aneuploidy-induced tumorigenesis

(2010) M. Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

ATM Activation by Oxidative Stress

(2010) Z. Guo et al.   SCIENCE

Cohesin: Its Roles and Mechanisms

(2009) Kim Nasmyth et al.   Annual Review of Genetics

Constitutional aneuploidy and cancer predisposition

(2009) I. Ganmore et al.   HUMAN MOLECULAR GENETICS

Loss of spindle assembly checkpoint–mediated inhibition of Cdc20 promotes tumorigenesis in mice

(2009) Min Li et al.   JOURNAL OF CELL BIOLOGY

Down's syndrome suppression of tumour growth and the role of the calcineurin inhibitor DSCR1

(2009) Kwan-Hyuck Baek et al.   NATURE

The genetic architecture of Down syndrome phenotypes revealed by high-resolution analysis of human segmental trisomies

(2009) J. O. Korbel et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Ploidy Reductions in Murine Fusion-Derived Hepatocytes

(2009) Andrew W. Duncan et al.   PLoS Genetics

Trisomy 21 in patients with acute leukemia

(2008) Yizhi Cheng et al.   AMERICAN JOURNAL OF HEMATOLOGY

Sister Chromatid Cohesion: A Simple Concept with a Complex Reality

(2008) Itay Onn et al.   Annual Review of Cell and Developmental Biology

Acute megakaryoblastic leukaemia (AMKL) in children: a comparison of AMKL with and without Down syndrome

(2008) Asahito Hama et al.   BRITISH JOURNAL OF HAEMATOLOGY

Targeted Deletion of the Calcineurin Inhibitor DSCR1 Suppresses Tumor Growth

(2008) Sandra Ryeom et al.   CANCER CELL

Aneuploidy Underlies Rapid Adaptive Evolution of Yeast Cells Deprived of a Conserved Cytokinesis Motor

(2008) Giulia Rancati et al.   CELL

Phase II Trial of 17-Allylamino-17-Demethoxygeldanamycin in Patients with Metastatic Melanoma

(2008) D. B. Solit et al.   CLINICAL CANCER RESEARCH

A Phase II Trial of 17-Allylamino-17-Demethoxygeldanamycin in Patients with Hormone-Refractory Metastatic Prostate Cancer

(2008) E. I. Heath et al.   CLINICAL CANCER RESEARCH

Chromosome-Scale Genetic Mapping Using a Set of 16 Conditionally Stable Saccharomyces cerevisiae Chromosomes

(2008) R. J. D. Reid et al.   GENETICS

Aneuploidy: Cells Losing Their Balance

(2008) Eduardo M. Torres et al.   GENETICS

Comprehensive molecular cytogenetic analysis of the human blastocyst stage

(2008) E. Fragouli et al.   HUMAN REPRODUCTION

Examining the link between chromosomal instability and aneuploidy in human cells

(2008) Sarah L. Thompson et al.   JOURNAL OF CELL BIOLOGY

Aneuploid mosaicism in the developing and adult cerebellar cortex

(2008) Jurjen W. Westra et al.   JOURNAL OF COMPARATIVE NEUROLOGY

Trisomy represses Apc Min -mediated tumours in mouse models of Down’s syndrome

(2008) Thomas E. Sussan et al.   NATURE

Hec1 overexpression hyperactivates the mitotic checkpoint and induces tumor formation in vivo

(2008) E. Diaz-Rodriguez et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

An Oncogene-Induced DNA Damage Model for Cancer Development

(2008) T. D. Halazonetis et al.   SCIENCE

Aneuploidy Affects Proliferation and Spontaneous Immortalization in Mammalian Cells

(2008) B. R. Williams et al.   SCIENCE

Whole chromosome instability and cancer: a complex relationship

(2008) Robin M. Ricke et al.   TRENDS IN GENETICS

Defining ‘chromosomal instability’

(2008) Jochen B. Geigl et al.   TRENDS IN GENETICS