Chemo‐Enzymatic Modification of the 5′ Cap Maintains Translation and Increases Immunogenic Properties of mRNA
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Title
Chemo‐Enzymatic Modification of the 5′ Cap Maintains Translation and Increases Immunogenic Properties of mRNA
Authors
Keywords
-
Journal
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
Volume -, Issue -, Pages -
Publisher
Wiley
Online
2021-03-23
DOI
10.1002/anie.202100352
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Note: Only part of the references are listed.- The identity and methylation status of the first transcribed nucleotide in eukaryotic mRNA 5′ cap modulates protein expression in living cells
- (2020) Pawel J Sikorski et al. NUCLEIC ACIDS RESEARCH
- CAP-MAP: cap analysis protocol with minimal analyte processing, a rapid and sensitive approach to analysing mRNA cap structures
- (2020) Alison Galloway et al. Open Biology
- mRNA Therapies: New Hope in the Fight against Melanoma
- (2020) Melissa van Dülmen et al. BIOCHEMISTRY
- The mRNA Cap 2′-O-Methyltransferase CMTR1 Regulates the Expression of Certain Interferon-Stimulated Genes
- (2020) Graham D. Williams et al. mSphere
- Phosphorothioate Modification of mRNA Accelerates the Rate of Translation Initiation to Provide More Efficient Protein Synthesis
- (2020) Daisuke Kawaguchi et al. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
- Immune Sensing Mechanisms that Discriminate Self from Altered Self and Foreign Nucleic Acids
- (2020) Eva Bartok et al. IMMUNITY
- Phase 1/2 study of COVID-19 RNA vaccine BNT162b1 in adults
- (2020) Mark J. Mulligan et al. NATURE
- An mRNA Vaccine against SARS-CoV-2 — Preliminary Report
- (2020) Lisa A. Jackson et al. NEW ENGLAND JOURNAL OF MEDICINE
- Impact of mRNA chemistry and manufacturing process on innate immune activation
- (2020) Jennifer Nelson et al. Science Advances
- Tag‐free internal RNA labeling and photocaging based on mRNA methyltransferases
- (2020) Anna Ovcharenko et al. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
- SARS-CoV-2 vaccines in development
- (2020) Florian Krammer NATURE
- COVID-19 vaccine BNT162b1 elicits human antibody and TH1 T cell responses
- (2020) Ugur Sahin et al. NATURE
- Safety and Immunogenicity of Two RNA-Based Covid-19 Vaccine Candidates
- (2020) Edward E. Walsh et al. NEW ENGLAND JOURNAL OF MEDICINE
- Phosphodiester modifications in mRNA polyA tail prevent deadenylation without compromising protein expression
- (2020) Dominika Strzelecka et al. RNA
- The Mammalian Cap-Specific m6Am RNA Methyltransferase PCIF1 Regulates Transcript Levels in Mouse Tissues
- (2020) Radha Raman Pandey et al. Cell Reports
- Immunization with the receptor-binding domain of SARS-CoV-2 elicits antibodies cross-neutralizing SARS-CoV-2 and SARS-CoV without antibody-dependent enhancement
- (2020) Jinkai Zang et al. Cell Discovery
- Efficacy and Safety of the mRNA-1273 SARS-CoV-2 Vaccine
- (2020) Lindsey R. Baden et al. NEW ENGLAND JOURNAL OF MEDICINE
- Safety and Efficacy of the BNT162b2 mRNA Covid-19 Vaccine
- (2020) Fernando P. Polack et al. NEW ENGLAND JOURNAL OF MEDICINE
- Multiple covalent fluorescence labeling of eukaryotic mRNA at the poly(A) tail enhances translation and can be performed in living cells
- (2019) Lea Anhäuser et al. NUCLEIC ACIDS RESEARCH
- FTO controls reversible m6Am RNA methylation during snRNA biogenesis
- (2019) Jan Mauer et al. Nature Chemical Biology
- Identification of the m6Am Methyltransferase PCIF1 Reveals the Location and Functions of m6Am in the Transcriptome
- (2019) Konstantinos Boulias et al. MOLECULAR CELL
- PCIF1 Catalyzes m6Am mRNA Methylation to Regulate Gene Expression
- (2019) Erdem Sendinc et al. MOLECULAR CELL
- Quantifying the RNA cap epitranscriptome reveals novel caps in cellular and viral RNA
- (2019) Jin Wang et al. NUCLEIC ACIDS RESEARCH
- Tailoring mRNA Vaccine to Balance Innate/Adaptive Immune Response
- (2019) Sergio Linares-Fernández et al. TRENDS IN MOLECULAR MEDICINE
- Reversible modification of DNA by methyltransferase-catalyzed transfer and light-triggered removal of photo-caging groups
- (2018) Lea Anhäuser et al. CHEMICAL COMMUNICATIONS
- 5′-Phosphorothiolate Dinucleotide Cap Analogues: Reagents for Messenger RNA Modification and Potent Small-Molecular Inhibitors of Decapping Enzymes
- (2018) Blazej A. Wojtczak et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- mRNA vaccines — a new era in vaccinology
- (2018) Norbert Pardi et al. NATURE REVIEWS DRUG DISCOVERY
- mRNA cap regulation in mammalian cell function and fate
- (2018) Alison Galloway et al. Biochimica et Biophysica Acta-Gene Regulatory Mechanisms
- Cap-specific, terminal N6-methylation by a mammalian m6Am methyltransferase
- (2018) Hanxiao Sun et al. CELL RESEARCH
- Cap-specific terminal N6-methylation of RNA by an RNA polymerase II–associated methyltransferase
- (2018) Shinichiro Akichika et al. SCIENCE
- Structure of human IFIT1 with capped RNA reveals adaptable mRNA binding and mechanisms for sensing N1 and N2 ribose 2′-O methylations
- (2017) Yazan M. Abbas et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Modifying the 5′-Cap for Click Reactions of Eukaryotic mRNA and To Tune Translation Efficiency in Living Cells
- (2016) Josephin M. Holstein et al. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
- When your cap matters: structural insights into self vs non-self recognition of 5′ RNA by immunomodulatory host proteins
- (2016) Daisy W Leung et al. CURRENT OPINION IN STRUCTURAL BIOLOGY
- Analysis of RNA modifications by liquid chromatography–tandem mass spectrometry
- (2016) Kathrin Thüring et al. METHODS
- Structural basis for m7G recognition and 2′-O-methyl discrimination in capped RNAs by the innate immune receptor RIG-I
- (2016) Swapnil C. Devarkar et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- RNAs Containing Modified Nucleotides Fail To Trigger RIG-I Conformational Changes for Innate Immune Signaling
- (2016) Ann Fiegen Durbin et al. mBio
- mRNA-based therapeutics — developing a new class of drugs
- (2014) Ugur Sahin et al. NATURE REVIEWS DRUG DISCOVERY
- Large-Scale, Protection-Free Synthesis of Se-Adenosyl-l-selenomethionine Analogues and Their Application as Cofactor Surrogates of Methyltransferases
- (2014) Ian R. Bothwell et al. ORGANIC LETTERS
- How cells get the message: dynamic assembly and function of mRNA–protein complexes
- (2013) Michaela Müller-McNicoll et al. NATURE REVIEWS GENETICS
- A Selenium-Based Click AdoMet Analogue for Versatile Substrate Labeling with Wild-Type Protein Methyltransferases
- (2012) Sophie Willnow et al. CHEMBIOCHEM
- Bioorthogonal Profiling of Protein Methylation Using Azido Derivative of S-Adenosyl-l-methionine
- (2012) Kabirul Islam et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Programmable sequence-specific click-labeling of RNA using archaeal box C/D RNP methyltransferases
- (2012) Miglė Tomkuvienė et al. NUCLEIC ACIDS RESEARCH
- Expanding Cofactor Repertoire of Protein Lysine Methyltransferase for Substrate Labeling
- (2011) Kabirul Islam et al. ACS Chemical Biology
- Detection of prokaryotic mRNA signifies microbial viability and promotes immunity
- (2011) Leif E. Sander et al. NATURE
- Regulation of Translation Initiation in Eukaryotes: Mechanisms and Biological Targets
- (2009) Nahum Sonenberg et al. CELL
- Mechanism-Based Small Molecule Probes for Labeling CD38 on Live Cells
- (2009) Hong Jiang et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
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