Chemo‐Enzymatic Modification of the 5′ Cap Maintains Translation and Increases Immunogenic Properties of mRNA

The identity and methylation status of the first transcribed nucleotide in eukaryotic mRNA 5′ cap modulates protein expression in living cells

(2020) Pawel J Sikorski et al.   NUCLEIC ACIDS RESEARCH

CAP-MAP: cap analysis protocol with minimal analyte processing, a rapid and sensitive approach to analysing mRNA cap structures

(2020) Alison Galloway et al.   Open Biology

mRNA Therapies: New Hope in the Fight against Melanoma

(2020) Melissa van Dülmen et al.   BIOCHEMISTRY

The mRNA Cap 2′-O-Methyltransferase CMTR1 Regulates the Expression of Certain Interferon-Stimulated Genes

(2020) Graham D. Williams et al.   mSphere

Phosphorothioate Modification of mRNA Accelerates the Rate of Translation Initiation to Provide More Efficient Protein Synthesis

(2020) Daisuke Kawaguchi et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Immune Sensing Mechanisms that Discriminate Self from Altered Self and Foreign Nucleic Acids

(2020) Eva Bartok et al.   IMMUNITY

Phase 1/2 study of COVID-19 RNA vaccine BNT162b1 in adults

(2020) Mark J. Mulligan et al.   NATURE

An mRNA Vaccine against SARS-CoV-2 — Preliminary Report

(2020) Lisa A. Jackson et al.   NEW ENGLAND JOURNAL OF MEDICINE

Impact of mRNA chemistry and manufacturing process on innate immune activation

(2020) Jennifer Nelson et al.   Science Advances

Tag‐free internal RNA labeling and photocaging based on mRNA methyltransferases

(2020) Anna Ovcharenko et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

SARS-CoV-2 vaccines in development

(2020) Florian Krammer   NATURE

COVID-19 vaccine BNT162b1 elicits human antibody and TH1 T cell responses

(2020) Ugur Sahin et al.   NATURE

Safety and Immunogenicity of Two RNA-Based Covid-19 Vaccine Candidates

(2020) Edward E. Walsh et al.   NEW ENGLAND JOURNAL OF MEDICINE

Phosphodiester modifications in mRNA polyA tail prevent deadenylation without compromising protein expression

(2020) Dominika Strzelecka et al.   RNA

The Mammalian Cap-Specific m6Am RNA Methyltransferase PCIF1 Regulates Transcript Levels in Mouse Tissues

(2020) Radha Raman Pandey et al.   Cell Reports

Immunization with the receptor-binding domain of SARS-CoV-2 elicits antibodies cross-neutralizing SARS-CoV-2 and SARS-CoV without antibody-dependent enhancement

(2020) Jinkai Zang et al.   Cell Discovery

Efficacy and Safety of the mRNA-1273 SARS-CoV-2 Vaccine

(2020) Lindsey R. Baden et al.   NEW ENGLAND JOURNAL OF MEDICINE

Safety and Efficacy of the BNT162b2 mRNA Covid-19 Vaccine

(2020) Fernando P. Polack et al.   NEW ENGLAND JOURNAL OF MEDICINE

Multiple covalent fluorescence labeling of eukaryotic mRNA at the poly(A) tail enhances translation and can be performed in living cells

(2019) Lea Anhäuser et al.   NUCLEIC ACIDS RESEARCH

FTO controls reversible m6Am RNA methylation during snRNA biogenesis

(2019) Jan Mauer et al.   Nature Chemical Biology

Identification of the m6Am Methyltransferase PCIF1 Reveals the Location and Functions of m6Am in the Transcriptome

(2019) Konstantinos Boulias et al.   MOLECULAR CELL

PCIF1 Catalyzes m6Am mRNA Methylation to Regulate Gene Expression

(2019) Erdem Sendinc et al.   MOLECULAR CELL

Quantifying the RNA cap epitranscriptome reveals novel caps in cellular and viral RNA

(2019) Jin Wang et al.   NUCLEIC ACIDS RESEARCH

Tailoring mRNA Vaccine to Balance Innate/Adaptive Immune Response

(2019) Sergio Linares-Fernández et al.   TRENDS IN MOLECULAR MEDICINE

Reversible modification of DNA by methyltransferase-catalyzed transfer and light-triggered removal of photo-caging groups

(2018) Lea Anhäuser et al.   CHEMICAL COMMUNICATIONS

5′-Phosphorothiolate Dinucleotide Cap Analogues: Reagents for Messenger RNA Modification and Potent Small-Molecular Inhibitors of Decapping Enzymes

(2018) Blazej A. Wojtczak et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

mRNA vaccines — a new era in vaccinology

(2018) Norbert Pardi et al.   NATURE REVIEWS DRUG DISCOVERY

mRNA cap regulation in mammalian cell function and fate

(2018) Alison Galloway et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Cap-specific, terminal N6-methylation by a mammalian m6Am methyltransferase

(2018) Hanxiao Sun et al.   CELL RESEARCH

Cap-specific terminal N6-methylation of RNA by an RNA polymerase II–associated methyltransferase

(2018) Shinichiro Akichika et al.   SCIENCE

Structure of human IFIT1 with capped RNA reveals adaptable mRNA binding and mechanisms for sensing N1 and N2 ribose 2′-O methylations

(2017) Yazan M. Abbas et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Modifying the 5′-Cap for Click Reactions of Eukaryotic mRNA and To Tune Translation Efficiency in Living Cells

(2016) Josephin M. Holstein et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

When your cap matters: structural insights into self vs non-self recognition of 5′ RNA by immunomodulatory host proteins

(2016) Daisy W Leung et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Analysis of RNA modifications by liquid chromatography–tandem mass spectrometry

(2016) Kathrin Thüring et al.   METHODS

Structural basis for m7G recognition and 2′-O-methyl discrimination in capped RNAs by the innate immune receptor RIG-I

(2016) Swapnil C. Devarkar et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

RNAs Containing Modified Nucleotides Fail To Trigger RIG-I Conformational Changes for Innate Immune Signaling

(2016) Ann Fiegen Durbin et al.   mBio

mRNA-based therapeutics — developing a new class of drugs

(2014) Ugur Sahin et al.   NATURE REVIEWS DRUG DISCOVERY

Large-Scale, Protection-Free Synthesis of Se-Adenosyl-l-selenomethionine Analogues and Their Application as Cofactor Surrogates of Methyltransferases

(2014) Ian R. Bothwell et al.   ORGANIC LETTERS

How cells get the message: dynamic assembly and function of mRNA–protein complexes

(2013) Michaela Müller-McNicoll et al.   NATURE REVIEWS GENETICS

A Selenium-Based Click AdoMet Analogue for Versatile Substrate Labeling with Wild-Type Protein Methyltransferases

(2012) Sophie Willnow et al.   CHEMBIOCHEM

Bioorthogonal Profiling of Protein Methylation Using Azido Derivative of S-Adenosyl-l-methionine

(2012) Kabirul Islam et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Programmable sequence-specific click-labeling of RNA using archaeal box C/D RNP methyltransferases

(2012) Miglė Tomkuvienė et al.   NUCLEIC ACIDS RESEARCH

Expanding Cofactor Repertoire of Protein Lysine Methyltransferase for Substrate Labeling

(2011) Kabirul Islam et al.   ACS Chemical Biology

Detection of prokaryotic mRNA signifies microbial viability and promotes immunity

(2011) Leif E. Sander et al.   NATURE

Regulation of Translation Initiation in Eukaryotes: Mechanisms and Biological Targets

(2009) Nahum Sonenberg et al.   CELL

Mechanism-Based Small Molecule Probes for Labeling CD38 on Live Cells

(2009) Hong Jiang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY