Article
Multidisciplinary Sciences
Ousheng Liu, Junji Xu, Fu Wang, Wenwen Jin, Peter Zanvit, Dandan Wang, Nathan Goldberg, Alexander Cain, Nancy Guo, Yichen Han, Andrew Bynum, Guowu Ma, Songlin Wang, Zhangui Tang, Wanjun Chen
Summary: Research has shown that ADSCs can produce IL-33 in response to stimulation, which alleviates autoimmune diseases by promoting the proliferation of regulatory T cells (Tregs). This previously unrecognized immunoregulatory function of ADSCs through IL-33 production may have potential clinical applications.
Article
Multidisciplinary Sciences
Mikhael Haruo Fernandes de Lima, Caio Cavalcante Machado, Daniele Carvalho Nascimento, Camila Meirelles S. Silva, Juliana Escher Toller-Kawahisa, Tamara Silva Rodrigues, Flavio Protassio Veras, Marjorie Cornejo Pontelli, Italo A. Castro, Dario Simoes Zamboni, Jose-Carlos A. Filho, Thiago M. Cunha, Eurico Arruda, Larissa Dias da Cunha, Rene D. R. Oliveira, Fernando Q. Cunha, Paulo Louzada-Junior
Summary: Expansion of TIGIT(+)Tregs in COVID-19 patients is associated with inflammation, lung dysfunction, bacteremia, and fatal outcome.
SCIENTIFIC REPORTS
(2023)
Article
Biology
Oksana Tsyklauri, Tereza Chadimova, Veronika Niederlova, Jirina Kovarova, Juraj Michalik, Iva Malatova, Sarka Janusova, Olha Ivashchenko, Helene Rossez, Ales Drobek, Hana Vecerova, Virginie Galati, Marek Kovar, Ondrej Stepanek
Summary: In this study, it was identified that Tregs limit the availability of IL-2, thereby suppressing the formation of a previously uncharacterized subset of antigen-stimulated KILR CD8(+) effector T cells. These KILR CD8(+) T cells exhibit superior cell-killing abilities and can be induced by the administration of agonistic IL-2 immunocomplexes. This research has potential implications for immunotherapy targeting these cells in humans.
Article
Immunology
Shanmuga Sundaram Mahalingam, Sangeetha Jayaraman, Adhvika Arunkumar, Holly M. Dudley, Donald D. Anthony, Carey L. Shive, Jeffrey M. Jacobson, Pushpa Pandiyan
Summary: Individuals aged >61 show intrinsic changes in T cell responses during SARS-CoV-2 infection, including reduced cytokine production capacity and increased PD-1(+) cells. These findings may provide insights into dysregulated immune responses in COVID-19 in the elderly.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Immunology
Vusala Abbasova, Ahmet Gul, Guher Saruhan-Direskeneli
Summary: Gamma delta T cells and CD4(+) T cells have complementary roles in cytokine production in Behcet's disease. The higher IFN-gamma production of gamma delta T cells suggests the role of environmental triggers in Behcet's disease pathogenesis, while IL-17 related activity is mainly provided by CD4(+) T cells.
IMMUNOLOGY LETTERS
(2022)
Article
Biology
Jakub Tomala, Petra Weberova, Barbora Tomalova, Zuzana Jiraskova Zakostelska, Ladislav Sivak, Jirina Kovarova, Marek Kovar
Summary: The IL-2 and JES6-1 mAb complexes selectively expand CD25(+) cells and T-reg cells, but also increase sensitivity to LPS shock in mice, potentially raising safety concerns for their use in immunotherapy.
Article
Hematology
Teresa L. Ramos, Sara Bolivar-Wagers, Sujeong Jin, Govindarajan Thangavelu, Federico Simonetta, Po-Yu Lin, Toshihito Hirai, Asim Saha, Brent Koehn, Leon L. Su, Lora K. Picton, Jeanette Baker, Juliane K. Lohmeyer, Megan Riddle, Cindy Eide, Jakub Tolar, Angela Panoskaltsis-Mortari, John E. Wagner, K. Christopher Garcia, Robert S. Nogrin, Bruce R. Blazar
Summary: Expanding regulatory T cells using a novel approach can improve the effectiveness of transplantation and maintain graft-versus-host disease protection and graft-versus-tumor responses.
Article
Microbiology
Liaoxun Lu, Tianhan Li, Xinyu Feng, Zhilong Liu, Yang Liu, Tianzhu Chao, Yanrong Gu, Rong Huang, Fanghui Zhang, Le He, Binhui Zhou, Eryan Kong, Zhuangzhuang Liu, Xugang Wang, Zhijun Chen, Hui Wang, Marie Malissen, Bernard Malissen, Lichen Zhang, Yinming Liang
Summary: Schistosomiasis, a parasitic infection affecting over 200 million people worldwide, can induce the expression of PD-1 in T cells of the liver. Loss of PD-1 leads to an increase in T cell count and a shift in cytokine production in infected mice, but does not result in the eradication of parasites or reduction in pathogen burden.
Article
Immunology
Tej Pratap Singh, Camila Farias Amorim, Victoria M. Lovins, Charles W. Bradley, Lucas P. Carvalho, Edgar M. Carvalho, Elizabeth A. Grice, Phillip Scott
Summary: Cutaneous leishmaniasis leads to changes in the skin microbiota, resulting in immune responses and delayed healing. This study demonstrates that depletion of regulatory T cells contributes to skin inflammation and impaired immunity against Staphylococcus aureus in mice. Similar findings are observed in Leishmania braziliensis-infected mice and patients, suggesting a critical role of these cells in regulating immune balance and disease progression.
JOURNAL OF EXPERIMENTAL MEDICINE
(2023)
Article
Dermatology
Pawit Phadungsaksawasdi, Toshiharu Fujiyama, Kazuo Kurihara, Taisuke Ito, Tetsuya Honda, Yoshiki Tokura
Summary: In human psoriasis, PD-1 expressing CD8(+) CD103(+) T cells in the skin are associated with disease severity and histopathology, indicating a potential pathogenic subset that may play a role in psoriasis pathogenesis.
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2021)
Article
Immunology
Cecile Apert, Ariel O. Galindo-Albarran, Sarah Castan, Claire Detraves, Heloise Michaud, Nicola McJannett, Bart Haegeman, Simon Fillatreau, Bernard Malissen, Georg Hollander, Saulius Zuklys, Jeremy C. Santamaria, Olivier P. Joffre, Paola Romagnoli, Joost P. M. van Meerwijk
Summary: This study reevaluated the role of IL-2 and IL-15 in the development of regulatory T-lymphocytes (Treg) and found that IL-2 and IL-15 play important non-redundant quantitative and qualitative roles in intrathymic Treg development.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Parasitology
Ana Maria Ravena Severino Carvalho, Isabela de Andrade Ferraz, Natalia Satchiko Hojo-Souza, Fernanda Alvarenga Cardoso Medeiros, Laila Almeida Viana, Daniella Castanheira Bartholomeu, Ana Thereza Chaves, Thiago Miranda de Souza, Matheus Fernandes Costa e Silva, Tiago Antonio de Oliveira Mendes, Mariana Costa Duarte, Manoel Otavio da Costa Rocha, Daniel Menezes-Souza
Summary: The pathogenesis of Chronic Chagas Cardiomyopathy (CCC) remains unclear, and the persistence of the parasite in tissues is crucial for the development of heart disease. The study found that monocytes from CCC patients are more susceptible to infection and replication by intracellular amastigotes. Additionally, the stimulation of CD4+ T-cells in CCC patients induces a regulatory response, which may contribute to parasite control inefficiency and the development of severe heart disease.
Editorial Material
Neurosciences
Lisa Johann, Ari Waisman
Summary: The study reveals a novel mechanism by which astrocytes maintain an anti-inflammatory state in the CNS. This mechanism involves IFNg-induced TRAIL expression on astrocytes, leading to effector T cell apoptosis and suppression of inflammation.
Article
Immunology
Matthew T. T. Ollerton, Joy M. M. Folkvord, Andriana La Mantia, David A. A. Parry, Amie L. L. Meditz, Martin D. D. McCarter, Richard T. D'Aquila, Elizabeth Connick
Summary: Follicular helper CD4(+) T cells (TFH) are major sites of HIV replication, but follicular regulatory CD4(+) T cells (TFR) limit HIV replication by suppressing TFH through IL-2 restriction. TFR reduce TFH viability and HIV infected TFH, and IL-2 enhances TFH viability but decreases HIV replication in the presence of TFR.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Li Du, Yaru Nai, Meiying Shen, Tingting Li, Jingjing Huang, Xiaojian Han, Wang Wang, Da Pang, Aishun Jin
Summary: The addition of IL-21 in CAR-T cell preparation was found to improve T cell transfection efficiency, enhance the enrichment and expansion of less differentiated CAR-T cells, and improve CAR-T cell cytotoxicity by promoting the secretion of effector cytokines.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2021)
Article
Immunology
Florencia B. Gonzalez, Silvina R. Villar, Judith Toneatto, Maria F. Pacini, Julia Marquez, Luciano DAttilio, Oscar A. Bottasso, Graciela Piwien-Pilipuk, Ana R. Perez
MEDICAL MICROBIOLOGY AND IMMUNOLOGY
(2019)
Review
Pharmacology & Pharmacy
Adriana Ribeiro Silva, Cassiano Felippe Goncalves-de-Albuquerque, Ana Rosa Perez, Vinicius de Frias Carvalho
EUROPEAN JOURNAL OF PHARMACOLOGY
(2019)
Article
Immunology
Gaelle H. Martin, Nainita Roy, Sohini Chakraborty, Alexis Desrichard, Stephen S. Chung, Caroken M. Woolthuis, Wenhuo Hu, Iryna Berezniuk, Francine E. Garrett-Bakelman, Jorg Hamann, Sean M. Devlin, Timothy A. Chan, Christopher Y. Park
JOURNAL OF EXPERIMENTAL MEDICINE
(2019)
Article
Multidisciplinary Sciences
Robert J. Johnston, Linhui Julie Su, Jason Pinckney, David Critton, Eric Boyer, Arathi Krishnakumar, Martin Corbett, Andrew L. Rankin, Rose Dibella, Lynne Campbell, Gaelle H. Martin, Hadia Lemar, Thomas Cayton, Richard Y. -C. Huang, Xiaodi Deng, Akbar Nayeem, Haibin Chen, Burce Ergel, Joseph M. Rizzo, Aaron P. Yamniuk, Sanjib Dutta, Justine Ngo, Andrea Olga Shorts, Radha Ramakrishnan, Alexander Kozhich, Jim Holloway, Hua Fang, Ying-Kai Wang, Zheng Yang, Kader Thiam, Ginger Rakestraw, Arvind Rajpal, Paul Sheppard, Michael Quigley, Keith S. Bahjat, Alan J. Korman
Article
Immunology
Caroline Pilon, Thomas Stehle, Asma Beldi-Ferchiou, Marie Matignon, Allan Thiolat, Aude Burlion, Cynthia Grondin, Brigitte Birebent, France Pirenne, Helene Rouard, Philippe Lang, Gilles Marodon, Philippe Grimbert, Jose L. Cohen
FRONTIERS IN IMMUNOLOGY
(2019)
Article
Immunology
Caroline Pilon, Jeremy Bigot, Cynthia Grondin, Allan Thiolat, Philippe Lang, Jose L. Cohen, Philippe Grimbert, Marie Matignon
FRONTIERS IN IMMUNOLOGY
(2020)
Article
Cell Biology
Sina Naserian, Mohamed Essameldin Abdelgawad, Mazdak Afshar Bakshloo, Guillaume Ha, Nassim Arouche, Jose L. Cohen, Benoit L. Salomon, Georges Uzan
CELL COMMUNICATION AND SIGNALING
(2020)
Article
Hematology
Laetitia Boucault, Maria-Dolores Lopez Robles, Allan Thiolat, Severine Bezie, Michael Schmueck-Henneresse, Cecile Braudeau, Nadege Vimond, Antoine Freuchet, Elodie Autrusseau, Frederic Charlotte, Rabah Redjoul, Florence Beckerich, Mathieu Leclerc, Eliane Piaggio, Regis Josien, Hans-Dieter Volk, Sebastien Maury, Jose L. Cohen, Ignacio Anegon, Carole Guillonneau
Article
Immunology
Marie-Line Puiffe, Aurelie Dupont, Nouhoum Sako, Jerome Gatineau, Jose L. Cohen, Denis Mestivier, Agnes Lebon, Armelle Prevost-Blondel, Flavia Castellano, Valerie Molinier-Frenkel
FRONTIERS IN IMMUNOLOGY
(2020)
Review
Nanoscience & Nanotechnology
Benedetta Ferrara, Sabrina Belbekhouche, Damien Habert, Claire Houppe, Benoit Vallee, Sandrine Bourgoin-Voillard, Jose L. Cohen, Ilaria Cascone, Jose Courty
Summary: Nanoparticles are being studied as a targeted delivery system for cancer treatment, with nucleolin identified as an interesting therapeutic target. Antagonists of nucleolin from various sources have shown promise as potential anti-cancer agents.
Article
Multidisciplinary Sciences
Emilie Ronin, Charlotte Pouchy, Maryam Khosravi, Morgane Hilaire, Sylvie Gregoire, Armanda Casrouge, Sahar Kassem, David Sleurs, Gaelle H. Martin, Noemie Chanson, Yannis Lombardi, Guilhem Lalle, Harald Wajant, Cedric Auffray, Bruno Lucas, Gilles Marodon, Yenkel Grinberg-Bleyer, Benoit L. Salomon
Summary: The study reveals that TNFR2-expressing Treg cells play a crucial role in suppressing autoimmune diseases in the central nervous system during peak disease, maintaining their functionality and sustained expression of suppressive genes. This late effect also provides insights into the treatment outcomes.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Microbiology
Christophe Rodriguez, Nicolas de Prost, Slim Fourati, Claudie Lamoureux, Guillaume Gricourt, Melissa N'debi, Florence Canoui-Poitrine, Isaac Desveaux, Oriane Picard, Vanessa Demontant, Elisabeth Trawinski, Raphael Lepeule, Laure Surgers, William Vindrios, Jean-Daniel Lelievre, Nicolas Mongardon, Olivier Langeron, Jose L. Cohen, Armand Mekontso-Dessap, Paul-Louis Woerther, Jean-Michel Pawlotsky
Summary: This study utilized shotgun metagenomics and in-depth bioanalysis to investigate the role of viral genomics, microorganism metagenomics, and host transcriptomics in the severity of COVID-19. Severe COVID-19 pneumonia was associated with overexpression of cytokine transcripts activating the CXCR2 pathway, while patients with benign disease presented with a specific T cell profile and a lower mortality rate. Excess neutrophil infiltration leading to enhanced inflammatory response and prolonged tissue damage was identified as a key factor in the most severe cases of COVID-19. The study suggests that CXCR2 antagonists, especially IL-8 antagonists, could be promising candidates for treating severe COVID-19 patients.
Review
Cell Biology
Audrey Moatti, Jose L. Cohen
Summary: Newly discovered anti-cancer immunotherapies focus on stimulating anti-tumor T cell responses, but a significant proportion of patients do not respond. A novel approach proposes targeting the suppressive action of Tregs on anti-tumoral responses. TNFR2 has emerged as a legitimate target for anti-cancer immune checkpoint therapy, showing potential in overcoming the immune suppression in cancer patients.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Oncology
Matteo Ponzo, Anais Debesset, Melissande Cossutta, Mounira Chalabi-Dchar, Claire Houppe, Caroline Pilon, Alba Nicolas-Boluda, Sylvain Meunier, Fabio Raineri, Allan Thiolat, Remy Nicolle, Federica Maione, Serena Brundu, Carina Florina Cojocaru, Philippe Bouvet, Corinne Bousquet, Florence Gazeau, Christophe Tournigand, Jose Courty, Enrico Giraudo, Jose L. Cohen, Ilaria Cascone
Summary: This study explores the effects of a selective inhibitor of nucleolin (NCL) on the immune microenvironment of pancreatic ductal adenocarcinoma (PDAC), and highlights a new therapeutic strategy to restrain immunosuppressive cells, promote T-cell recruitment and activation, and re-program the tumor stroma of PDAC.
Article
Oncology
Flavia Castellano, Armelle Prevost-Blondel, Jose L. Cohen, Valerie Molinier-Frenkel
Summary: Although IL4I1 has emerged as a relevant therapeutic target for cancer, its precise role remains poorly understood. IL4I1 inhibits TCR signaling, modulates T cell differentiation, limits T cell proliferation, and shapes the tumor microenvironment in a way that impairs the antitumor immune response. The production of new IL4I1 metabolites may play a role in activating the aryl-hydrocarbon receptor (AHR), but the correlation between IL4I1 expression and AHR activation in human cancers is weak.
Letter
Immunology
Wan-Ju Cheng, Hong-Mo Shih, Kuan-Pin Su, Po-Ren Hsueh
BRAIN BEHAVIOR AND IMMUNITY
(2024)
Article
Immunology
Felipe Kenji Sudo, Talita P. Pinto, Fernanda G. Q. Barros-Aragao, Ivanei Bramati, Theo F. Marins, Marina Monteiro, Fernanda Meireles, Rejane Soares, Pilar Erthal, Victor Calil, Naima Assuncao, Natalia Oliveira, Joana Bondarovsky, Camila Lima, Beatriz Chagas, Alana Batista, Julia Lins, Thais L. Pinheiro, Felippe Mendonca, Andrea Silveira de Souza, Fernanda C. Rodrigues, Gabriel R. de Freitas, Pedro Kurtz, Paulo Mattos, Erika C. Rodrigues, Fernanda G. De Felice, Fernanda Tovar-Moll
Summary: Post-COVID-19 Condition (PCC) is a multisystemic syndrome that persists for months after SARS-CoV-2 infection, affecting cognitive function and neuropsychiatric features. A study on COVID-19 survivors in Brazil found that these patients experienced significant difficulties in overall cognition, memory, working memory, and inhibitory control, as well as fatigue, anxiety, and depressive symptoms. In addition, elevated levels of inflammatory markers in the blood were associated with brain microstructural damage and cognitive impairments.
BRAIN BEHAVIOR AND IMMUNITY
(2024)
Letter
Immunology
Tieh-Cheng Fu, Juei-Chao Chen, Ching-Mao Chang
BRAIN BEHAVIOR AND IMMUNITY
(2024)
Article
Immunology
Aastha Dheer, Dale B. Bosco, Jiaying Zheng, Lingxiao Wang, Shunyi Zhao, Koichiro Haruwaka, Min-Hee Yi, Abhijeet Barath, Dai-Shi Tian, Long-Jun Wu
Summary: Microglial activation plays a crucial role in the pathology of epilepsy, with both acute and prolonged activation affecting seizure severity and neuronal loss.
BRAIN BEHAVIOR AND IMMUNITY
(2024)
Article
Immunology
Julie B. Rosenberg, Jens Richardt Mollegaard Jepsen, Parisa Mohammadzadeh, Astrid Sevelsted, Rebecca Vinding, Mikkel E. Sorensen, David Horner, Kristina Aagaard, Birgitte Fagerlund, Susanne Brix, Nilofar Folsgaard, Ann -Marie M. Schoos, Jakob Stokholm, Bo Chawes, Christos Pantelis, Soren Dalsgaard, Birte Y. Glenthoj, Niels Bilenberg, Klaus Bonnelykke, Bjorn H. Ebdrup
Summary: Clinical data demonstrates a strong association between prenatal maternal inflammation assessed by hs-CRP and a diagnosis of ADHD by age 10. Maternal inflammation is also associated with ADHD symptom load in the entire cohort.
BRAIN BEHAVIOR AND IMMUNITY
(2024)
Article
Immunology
Suzanne M. Green-Fulgham, Michael J. Lacagnina, Kendal F. Willcox, Jiahe Li, Michael E. Harland, Adriano Polican Ciena, Igor R. Correia Rocha, Jayson B. Ball, Renee A. Dreher, Younus A. Zuberi, Joseph M. Dragavon, Marucia Chacur, Steven F. Maier, Linda R. Watkins, Peter M. Grace
Summary: Regular aerobic activity, specifically voluntary wheel running, can reduce the risk of chronic pain by inhibiting MAC and preserving myelin integrity at the site of peripheral nerve injury.
BRAIN BEHAVIOR AND IMMUNITY
(2024)
Article
Immunology
India Boyton, Stella M. Valenzuela, Lyndsey E. Collins-Praino, Andrew Care
Summary: Neuronanomedicine is a multidisciplinary field that aims to develop innovative nanotechnologies for the treatment of neurodegenerative disorders. Nanoparticles are an important component of neuronanomedicine, as they can improve drug properties and enhance safety and delivery across the blood-brain barrier. However, a major challenge for neuronanomedicine translation is the poor understanding of bio-nano interactions, partly due to inconsistent reporting in published works. This review provides specific recommendations to guide researchers in harnessing the unique properties of nanoparticles for breakthrough treatments of Alzheimer's and Parkinson's disease.
BRAIN BEHAVIOR AND IMMUNITY
(2024)
Article
Immunology
Celine De Looze, Cathal McCrory, Aisling O'Halloran, Silvia Polidoro, Rose Anne Kenny, Joanne Feeney
Summary: Our study found that subjective measures of stress and biological metrics may be independently associated with cognitive function over time in older adults, hinting at potential different underlying mechanisms.
BRAIN BEHAVIOR AND IMMUNITY
(2024)
Article
Immunology
Beatrice Bravi, Elisa Maria Teresa Melloni, Marco Paolini, Mariagrazia Palladini, Federico Calesella, Laura Servidio, Elena Agnoletto, Sara Poletti, Cristina Lorenzi, Cristina Colombo, Francesco Benedetti
Summary: Depressed patients show changes in immune-inflammatory markers in their blood and cerebrospinal fluid. The Choroid Plexus, located at the base of the brain ventricles, plays a key role in regulating the exchange of substances between the brain and immune cells. Patients with bipolar disorder or major depressive disorder have larger Choroid Plexus volumes compared to healthy controls. Age and levels of circulating cytokines are associated with Choroid Plexus volumes in the clinical groups.
BRAIN BEHAVIOR AND IMMUNITY
(2024)
Article
Immunology
Mingxuan Zheng, Huaiyu Ye, Xiaoying Yang, Lijun Shen, Xuemei Dang, Xiaoli Liu, Yuying Gong, Qingyuan Wu, Li Wang, Xing Ge, Xiaoli Fang, Benchi Hou, Peng Zhang, Renxian Tang, Kuiyang Zheng, Xu-Feng Huang, Yinghua Yu
Summary: Obesity is linked to cognitive dysfunction and neurodegenerative disease. The connection between the gut microbiota and the brain is altered in obesity. The probiotic Clostridium butyricum can improve cognitive impairment caused by obesity and prevent gut microbiota dysbiosis and inflammation.
BRAIN BEHAVIOR AND IMMUNITY
(2024)
Article
Immunology
Edward Drydale, Phalguni Rath, Katie Holden, Gregory Holt, Laurissa Havins, Thomas Johnson, James Bancroft, Lahiru Handunnetthi
Summary: This study created a novel three-dimensional neurosphere assay using induced pluripotent stem cell differentiation and live cell imaging techniques to investigate the effect of a simulated viral infection on cortical development. The findings demonstrated that the infection led to reduced radial glial growth and neural migration.
BRAIN BEHAVIOR AND IMMUNITY
(2024)
Article
Immunology
Yuancheng Weng, Ningting Chen, Rui Zhang, Jian He, Xukai Ding, Guo Cheng, Qianqian Bi, Ying-mei Lu, Xiao Z. Shen, Shu Wan, Peng Shi
Summary: This study reveals that microglia is the primary cellular source of PDGFB in adults, and microglial PDGFB is crucial for maintaining BBB integrity in adult mice.
BRAIN BEHAVIOR AND IMMUNITY
(2024)
Article
Immunology
Evan A. Bordt, Haley A. Moya, Young Chan Jo, Caitlin T. Ravichandran, Izabella M. Bankowski, Alexis M. Ceasrine, Christopher J. Mcdougle, William A. Carlezon Jr, Staci D. Bilbo
Summary: There is a strong male bias in many neurodevelopmental disorders such as autism spectrum disorder, but the mechanisms behind this bias are unknown. Infection during the perinatal period increases the risk of neurodevelopmental disorders. Using a mouse model, researchers found that early-life immune activation only induced deficits in social behaviors in male mice. These behavioral changes were associated with alterations in microglial immune signaling, mitochondrial morphology, gene expression, and function specifically in microglia, the brain's innate immune cells. Furthermore, the vulnerability to early-life immune activation and its effects on behavior and microglial mitochondria were programmed by the male-typical perinatal gonadal hormone surge. These findings highlight the role of microglia-specific mechanisms shaped by early developmental events in regulating male social behavior throughout lifespan.
BRAIN BEHAVIOR AND IMMUNITY
(2024)
Article
Immunology
Maria Amalia Di Castro, Stefano Garofalo, Alessandro Mormino, Laura Carbonari, Erika Di Pietro, Eleonora De Felice, Myriam Catalano, Laura Maggi, Cristina Limatola
Summary: Cytokines, such as interleukin-15 (IL-15), play important roles in modulating the central nervous system (CNS). In this study, the authors found that exposure to IL-15 enhances GABA release and reduces glutamatergic currents in hippocampal slices. Chronic treatment with IL-15 has negative effects on memory formation. Serotonin is involved in mediating these effects, as a selective 5-HT3A receptor antagonist prevents the effects on inhibitory neurotransmission and improves performance in a memory test.
BRAIN BEHAVIOR AND IMMUNITY
(2024)
Article
Immunology
Nikhitha Sreenivas, Michael Maes, Hansashree Padmanabha, Apoorva Dharmendra, Priyanka Chakkera, Saptamita Paul Choudhury, Fazal Abdul, Thrinath Mullapudi, Vykuntaraju K. Gowda, Michael Berk, John Vijay Sagar Kommu, Monojit Debnath
Summary: Neurodevelopmental disorders (NDDs) are a spectrum of conditions with both common and differing characteristics in terms of phenome, symptomatome, neuropathology, risk factors and underlying mechanisms. This study investigates the possibility of a shared immune etiology among three early-onset NDDs, namely Autism Spectrum Disorder (ASD), Attention Deficit Hyperactivity Disorder (ADHD) and Intellectual Disability Disorder (IDD).
BRAIN BEHAVIOR AND IMMUNITY
(2024)