Chemogenetic approaches reveal dual functions of microglia in seizures

Microglia play beneficial roles in multiple experimental seizure models

(2023) Synphane Gibbs‐Shelton et al.   GLIA

Bridging the Gap: The Importance of TUBA1A α-Tubulin in Forming Midline Commissures

(2022) Georgia Buscaglia et al.   Frontiers in Cell and Developmental Biology

Astrocytes in the initiation and progression of epilepsy

(2022) Annamaria Vezzani et al.   Nature Reviews Neurology

Microglia proliferation plays distinct roles in acquired epilepsy depending on disease stages

(2021) Martina Di Nunzio et al.   EPILEPSIA

Microglial TREM2 in amyotrophic lateral sclerosis

(2021) Manling Xie et al.   Developmental Neurobiology

Chronic hM3Dq signaling in microglia ameliorates neuroinflammation in male mice

(2020) William Binning et al.   BRAIN BEHAVIOR AND IMMUNITY

Microglial depletion aggravates the severity of acute and chronic seizures in mice

(2020) Wenning Wu et al.   BRAIN BEHAVIOR AND IMMUNITY

Deschloroclozapine, a potent and selective chemogenetic actuator enables rapid neuronal and behavioral modulations in mice and monkeys

(2020) Yuji Nagai et al.   NATURE NEUROSCIENCE

Negative feedback control of neuronal activity by microglia

(2020) Ana Badimon et al.   NATURE

Microglial Gi-dependent dynamics regulate brain network hyperexcitability

(2020) Mario Merlini et al.   NATURE NEUROSCIENCE

Microglial proliferation and monocyte infiltration contribute to microgliosis following status epilepticus

(2019) Lijie Feng et al.   GLIA

Off-Target Effects of Clozapine-N-Oxide on the Chemosensory Reflex Are Masked by High Stress Levels

(2019) Vena K. Martinez et al.   Frontiers in Physiology

Graph-based genome alignment and genotyping with HISAT2 and HISAT-genotype

(2019) Daehwan Kim et al.   NATURE BIOTECHNOLOGY

Microglial P2Y12 receptor regulates ventral hippocampal CA1 neuronal excitability and innate fear in mice

(2019) Jiyun Peng et al.   Molecular Brain

Microglial P2Y12 Receptor Regulates Seizure-Induced Neurogenesis and Immature Neuronal Projections

(2019) Mingshu Mo et al.   JOURNAL OF NEUROSCIENCE

Microglia monitor and protect neuronal function through specialized somatic purinergic junctions

(2019) Csaba Cserép et al.   SCIENCE

DREADDed microglia in pain: Implications for spinal inflammatory signaling in male rats

(2018) Peter M. Grace et al.   EXPERIMENTAL NEUROLOGY

CNO Evil? Considerations for the Use of DREADDs in Behavioral Neuroscience

(2018) Stephen V Mahler et al.   NEUROPSYCHOPHARMACOLOGY

The GluN2A Subunit Regulates Neuronal NMDA receptor-Induced Microglia-Neuron Physical Interactions

(2018) Ukpong B. Eyo et al.   Scientific Reports

RNAseq analysis of hippocampal microglia after kainic acid-induced seizures

(2018) Dale B. Bosco et al.   Molecular Brain

Structure of the adenosine-bound human adenosine A1 receptor–Gi complex

(2018) Christopher J. Draper-Joyce et al.   NATURE

Behavioral Effects of Acute Systemic Low-Dose Clozapine in Wild-Type Rats: Implications for the Use of DREADDs in Behavioral Neuroscience

(2018) Ann-Kathrin Ilg et al.   Frontiers in Behavioral Neuroscience

Microglial phenotypes in the human epileptic temporal lobe

(2018) Mélanie Morin-Brureau et al.   BRAIN

Chemokine CCL2–CCR2 Signaling Induces Neuronal Cell Death via STAT3 Activation and IL-1β Production after Status Epilepticus

(2017) Dai-Shi Tian et al.   JOURNAL OF NEUROSCIENCE

Neurotoxic reactive astrocytes are induced by activated microglia

(2017) Shane A. Liddelow et al.   NATURE

Inhibition of microglial activation with minocycline at the intrathecal level attenuates sympathoexcitatory and proarrhythmogenic changes in rats with chronic temporal lobe epilepsy

(2017) Amol M. Bhandare et al.   NEUROSCIENCE

Chemogenetics revealed: DREADD occupancy and activation via converted clozapine

(2017) Juan L. Gomez et al.   SCIENCE

SOAPnuke: a MapReduce acceleration-supported software for integrated quality control and preprocessing of high-throughput sequencing data

(2017) Yuxin Chen et al.   GigaScience

Chemogenetic silencing of GABAergic dorsal horn interneurons induces morphine-resistant spontaneous nocifensive behaviours

(2017) Keisuke Koga et al.   Scientific Reports

Cre-dependent DREADD (Designer Receptors Exclusively Activated by Designer Drugs) mice

(2016) Hu Zhu et al.   GENESIS

Microglia are less pro-inflammatory than myeloid infiltrates in the hippocampus of mice exposed to status epilepticus

(2016) Jonathan Vinet et al.   GLIA

Microglia engulf viable newborn cells in the epileptic dentate gyrus

(2016) Cong Luo et al.   GLIA

Microglia-Neuron Communication in Epilepsy

(2016) Ukpong B. Eyo et al.   GLIA

Gi-DREADD Expression in Peripheral Nerves Produces Ligand-Dependent Analgesia, as well as Ligand-Independent Functional Changes in Sensory Neurons

(2016) Jami L. Saloman et al.   JOURNAL OF NEUROSCIENCE

Interleukin 1α and the inflammatory process

(2016) Nelson C Di Paolo et al.   NATURE IMMUNOLOGY

DREADDs for Neuroscientists

(2016) Bryan L. Roth   NEURON

Infiltrating monocytes promote brain inflammation and exacerbate neuronal damage after status epilepticus

(2016) Nicholas H. Varvel et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

DREADDs (Designer Receptors Exclusively Activated by Designer Drugs): Chemogenetic Tools with Therapeutic Utility

(2015) Daniel J. Urban et al.   Annual Review of Pharmacology and Toxicology

Minocycline inhibits brain inflammation and attenuates spontaneous recurrent seizures following pilocarpine-induced status epilepticus

(2015) N. Wang et al.   NEUROSCIENCE

TLR9 signalling in microglia attenuates seizure-induced aberrant neurogenesis in the adult hippocampus

(2015) Taito Matsuda et al.   Nature Communications

circlize implements and enhances circular visualization in R

(2014) Zuguang Gu et al.   BIOINFORMATICS

Neuronal Hyperactivity Recruits Microglial Processes via Neuronal NMDA Receptors and Microglial P2Y12 Receptors after Status Epilepticus

(2014) U. B. Eyo et al.   JOURNAL OF NEUROSCIENCE

Aging-induced type I interferon response at the choroid plexus negatively affects brain function

(2014) K. Baruch et al.   SCIENCE

Microglia Promote Learning-Dependent Synapse Formation through Brain-Derived Neurotrophic Factor

(2013) Christopher N. Parkhurst et al.   CELL

Reciprocal Regulation between Resting Microglial Dynamics and Neuronal Activity In Vivo

(2012) Ying Li et al.   DEVELOPMENTAL CELL

Fast gapped-read alignment with Bowtie 2

(2012) Ben Langmead et al.   NATURE METHODS

Reorganization of the actin cytoskeleton upon G-protein coupled receptor signaling

(2011) Sourav Ganguly et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Activation of serotonin receptors promotes microglial injury-induced motility but attenuates phagocytic activity

(2011) Grietje Krabbe et al.   BRAIN BEHAVIOR AND IMMUNITY

Standards for epidemiologic studies and surveillance of epilepsy

(2011) David J. Thurman et al.   EPILEPSIA

The interferon beta therapies for treatment of relapsing–remitting multiple sclerosis: are they equally efficacious? A comparative review of open-label studies evaluating the efficacy, safety, or dosing of different interferon beta formulations alone or in combination

(2011) Volker Limmroth et al.   Therapeutic Advances in Neurological Disorders

The role of inflammation in epilepsy

(2010) Annamaria Vezzani et al.   Nature Reviews Neurology

Microglial Physiology: Unique Stimuli, Specialized Responses

(2009) Richard M. Ransohoff et al.   Annual Review of Immunology

Remote Control of Neuronal Activity in Transgenic Mice Expressing Evolved G Protein-Coupled Receptors

(2009) Georgia M. Alexander et al.   NEURON

Control of neuronal polarity and plasticity – a renaissance for microtubules?

(2009) Casper C. Hoogenraad et al.   TRENDS IN CELL BIOLOGY

Status Epilepticus Induces a Particular Microglial Activation State Characterized by Enhanced Purinergic Signaling

(2008) E. Avignone et al.   JOURNAL OF NEUROSCIENCE