Advances in peptide-mediated cytosolic delivery of proteins

Stimulating Macropinocytosis for Intracellular Nucleic Acid and Protein Delivery: A Combined Strategy with Membrane-Lytic Peptides To Facilitate Endosomal Escape

(2020) Jan Vincent V. Arafiles et al.   BIOCONJUGATE CHEMISTRY

The Pharmaceutical Industry in 2019. An Analysis of FDA Drug Approvals from the Perspective of Molecules

(2020) Beatriz G. de la Torre et al.   MOLECULES

Internalization mechanisms of cell-penetrating peptides

(2020) Ivana Ruseska et al.   Beilstein Journal of Nanotechnology

Photochemical Internalization for Intracellular Drug Delivery. From Basic Mechanisms to Clinical Research

(2020) Waseem Jerjes et al.   Journal of Clinical Medicine

Cellular Uptake and Cytosolic Delivery of a Cyclic Cystine Knot Scaffold

(2020) Huawu Yin et al.   ACS Chemical Biology

Rational Design Principles of Attenuated Cationic Lytic Peptides for Intracellular Delivery of Biomacromolecules

(2020) Naoki Tamemoto et al.   MOLECULAR PHARMACEUTICS

Engineering Cell-Permeable Proteins through Insertion of Cell-Penetrating Motifs into Surface Loops

(2020) Kuangyu Chen et al.   ACS Chemical Biology

Impact of the endosomal escape activity of cell-penetrating peptides on the endocytic pathway

(2020) Helena M. Kondow-McConaghy et al.   ACS Chemical Biology

Application of advances in endocytosis and membrane trafficking to drug delivery

(2020) Yaping Ju et al.   ADVANCED DRUG DELIVERY REVIEWS

Optimizing charge switching in membrane lytic peptides for endosomal release of biomacromolecules

(2020) Kentarou Sakamoto et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Cytosolic delivery of peptidic STAT3 SH2 domain inhibitors

(2020) Robert A. Cerulli et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Peptide-Assisted Intracellular Delivery of Biomacromolecules

(2020) Shiroh Futaki et al.   CHEMISTRY LETTERS

Non-viral strategies for delivering genome editing enzymes

(2020) Jie Li et al.   ADVANCED DRUG DELIVERY REVIEWS

Targeted Subcellular Protein Delivery Using Cleavable Cyclic Cell-Penetrating Peptides

(2019) Anselm F. L. Schneider et al.   BIOCONJUGATE CHEMISTRY

pH-Lemon, a fluorescent protein-based pH reporter for acidic compartments

(2019) Sandra Burgstaller et al.   ACS Sensors

An Oligoarginine-Bearing Tandem Repeat Penetration-Accelerating Sequence Delivers Protein to the Cytosol via Caveolae-Mediated Endocytosis

(2019) Akiko Okuda et al.   BIOMACROMOLECULES

Trapped! A critical evaluation of methods for measuring total cellular uptake versus cytosolic localization

(2019) Kirsten Deprey et al.   BIOCONJUGATE CHEMISTRY

Contemporary approaches to site-selective protein modification

(2019) Emily A. Hoyt et al.   Nature Reviews Chemistry

Split Green Fluorescent Proteins: Scope, Limitations, and Outlook

(2019) Matthew G. Romei et al.   Annual Review of Biophysics

Understanding Cell Penetration of Cyclic Peptides

(2019) Patrick G. Dougherty et al.   CHEMICAL REVIEWS

Inducible Membrane Permeabilization by Attenuated Lytic Peptides: A New Concept for Accessing Cell Interiors through Ruffled Membranes

(2019) Misao Akishiba et al.   MOLECULAR PHARMACEUTICS

Cyclic Cell-Penetrating Peptides As Efficient Intracellular Drug Delivery Tools

(2019) Shang Eun Park et al.   MOLECULAR PHARMACEUTICS

Cell-penetrating peptide sequence and modification dependent uptake and subcellular distribution of green florescent protein in different cell lines

(2019) Sanjay G. Patel et al.   Scientific Reports

Cytosolic Delivery of Macromolecules in Live Human Cells Using the Combined Endosomal Escape Activities of a Small Molecule and Cell Penetrating Peptides

(2019) Jason Allen et al.   ACS Chemical Biology

Polymers for cytosolic protein delivery

(2019) Jia Lv et al.   BIOMATERIALS

Considerations on the Rational Design of Covalently Conjugated Cell-Penetrating Peptides (CPPs) for Intracellular Delivery of Proteins: A Guide to CPP Selection Using Glucarpidase as the Model Cargo Molecule

(2019) Behzadipour et al.   MOLECULES

Assessing the Cell Permeability of Bivalent Chemical Degraders Using the Chloroalkane Penetration Assay

(2019) Caroline A. Foley et al.   ACS Chemical Biology

A Coordinative Dendrimer Achieves Excellent Efficiency in Cytosolic Protein and Peptide Delivery

(2019) Lanfang Ren et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Intracellular delivery of therapeutic antibodies into specific cells using antibody-peptide fusions

(2019) Julie Gaston et al.   Scientific Reports

Protein delivery into cells using inorganic nanoparticle–protein supramolecular assemblies

(2018) Federica Scaletti et al.   CHEMICAL SOCIETY REVIEWS

Recent developments in intracellular protein delivery

(2018) Yumiao Zhang et al.   CURRENT OPINION IN BIOTECHNOLOGY

Fluorescent Proteins for Investigating Biological Events in Acidic Environments

(2018) Hajime Shinoda et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Efficient cell delivery mediated by lipid-specific endosomal escape of supercharged branched peptides

(2018) Dakota J. Brock et al.   TRAFFIC

The fluorination effect of fluoroamphiphiles in cytosolic protein delivery

(2018) Zhenjing Zhang et al.   Nature Communications

Where in the cell is our cargo? Current methods to study intracellular cytosolic localization.

(2018) Alejandro Méndez Ardoy et al.   CHEMBIOCHEM

Cell Penetration Profiling Using the Chloroalkane Penetration Assay

(2018) Leila Peraro et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Lysosomal membrane permeabilization and cell death

(2018) Fengjuan Wang et al.   TRAFFIC

Fluorescence Correlation Spectroscopy Reveals Efficient Cytosolic Delivery of Protein Cargo by Cell-Permeant Miniature Proteins

(2018) Rebecca F. Wissner et al.   ACS Central Science

Bypassing Endocytosis: Direct Cytosolic Delivery of Proteins

(2018) Shubo Du et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

pH-Triggered, Macromolecule-Sized Poration of Lipid Bilayers by Synthetically Evolved Peptides

(2017) Gregory Wiedman et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Diversity-Oriented Stapling Yields Intrinsically Cell-Penetrant Inducers of Autophagy

(2017) Leila Peraro et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Cell-Penetrating Peptides: Design Strategies beyond Primary Structure and Amphipathicity

(2017) Daniela Kalafatovic et al.   MOLECULES

Cytosolic delivery: Just passing through

(2017) Macarena Sánchez-Navarro et al.   Nature Chemistry

Cytosolic antibody delivery by lipid-sensitive endosomolytic peptide

(2017) Misao Akishiba et al.   Nature Chemistry

Cell-permeable nanobodies for targeted immunolabelling and antigen manipulation in living cells

(2017) Henry D. Herce et al.   Nature Chemistry

In vitro and in vivo delivery of therapeutic proteins using cell penetrating peptides

(2017) Azam Bolhassani et al.   PEPTIDES

Peptide/Cas9 nanostructures for ribonucleoprotein cell membrane transport and gene edition

(2017) Irene Lostalé-Seijo et al.   Chemical Science

A quantitative comparison of cytosolic delivery via different protein uptake systems

(2017) Wouter P. R. Verdurmen et al.   Scientific Reports

Transduction Methods for Cytosolic Delivery of Proteins and Bioconjugates into Living Cells

(2017) Manuela Chiper et al.   Advanced Healthcare Materials

Syndecan-4 Is a Receptor for Clathrin-Mediated Endocytosis of Arginine-Rich Cell-Penetrating Peptides

(2016) Yoshimasa Kawaguchi et al.   BIOCONJUGATE CHEMISTRY

Coiled-Coil-Mediated Activation of Oligoarginine Cell-Penetrating Peptides

(2016) Saskia A. Bode et al.   CHEMBIOCHEM

Cre Recombinase and Other Tyrosine Recombinases

(2016) Gretchen Meinke et al.   CHEMICAL REVIEWS

Exosome engineering for efficient intracellular delivery of soluble proteins using optically reversible protein–protein interaction module

(2016) Nambin Yim et al.   Nature Communications

NanoLuc Complementation Reporter Optimized for Accurate Measurement of Protein Interactions in Cells

(2015) Andrew S. Dixon et al.   ACS Chemical Biology

Delivery of therapeutic oligonucleotides with cell penetrating peptides

(2015) Prisca Boisguérin et al.   ADVANCED DRUG DELIVERY REVIEWS

Preparation of cell-permeable Cre recombinase by expressed protein ligation

(2015) Soo Lyu et al.   BMC BIOTECHNOLOGY

Advances in Chemical Protein Modification

(2015) Omar Boutureira et al.   CHEMICAL REVIEWS

A bacterial type III secretion-based protein delivery tool for broad applications in cell biology

(2015) Simon J. Ittig et al.   JOURNAL OF CELL BIOLOGY

A fusogenic peptide from a sea urchin fertilization protein promotes intracellular delivery of biomacromolecules by facilitating endosomal escape

(2015) Keisuke Niikura et al.   JOURNAL OF CONTROLLED RELEASE

Fluorescence Correlation Spectroscopy Reveals Highly Efficient Cytosolic Delivery of Certain Penta-Arg Proteins and Stapled Peptides

(2015) Jonathan R. LaRochelle et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Discovery and Characterization of a Peptide That Enhances Endosomal Escape of Delivered Proteins in Vitro and in Vivo

(2015) Margie Li et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Intracellular antigens as targets for antibody based immunotherapy of malignant diseases

(2015) Yangyang Wang et al.   Molecular Oncology

Mechanism Matters: A Taxonomy of Cell Penetrating Peptides

(2015) W. Berkeley Kauffman et al.   TRENDS IN BIOCHEMICAL SCIENCES

GFP-complementation assay to detect functional CPP and protein delivery into living cells

(2015) Nadia Milech et al.   Scientific Reports

Covalent Attachment of Cyclic TAT Peptides to GFP Results in Protein Delivery into Live Cells with Immediate Bioavailability

(2014) Nicole Nischan et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Electroporation-Based Technologies for Medicine: Principles, Applications, and Challenges

(2014) Martin L. Yarmush et al.   Annual Review of Biomedical Engineering

Early Endosomal Escape of a Cyclic Cell-Penetrating Peptide Allows Effective Cytosolic Cargo Delivery

(2014) Ziqing Qian et al.   BIOCHEMISTRY

Genomic DNA recombination with cell-penetrating peptide-tagged cre protein in mouse skeletal and cardiac muscle

(2014) Wei-Ming Chien et al.   GENESIS

Gene disruption by cell-penetrating peptide-mediated delivery of Cas9 protein and guide RNA

(2014) S. Ramakrishna et al.   GENOME RESEARCH

pHuji, a pH-sensitive red fluorescent protein for imaging of exo- and endocytosis

(2014) Yi Shen et al.   JOURNAL OF CELL BIOLOGY

Protein delivery into live cells by incubation with an endosomolytic agent

(2014) Alfredo Erazo-Oliveras et al.   NATURE METHODS

Cell-Penetrating Peptide-Mediated Delivery of TALEN Proteins via Bioconjugation for Genome Engineering

(2014) Jia Liu et al.   PLoS One

Selective chemical protein modification

(2014) Christopher D. Spicer et al.   Nature Communications

Improved Assays for Determining the Cytosolic Access of Peptides, Proteins, and Their Mimetics

(2013) Justin M. Holub et al.   BIOCHEMISTRY

Activation of cell-penetrating peptides by disulfide bridge formation of truncated precursors

(2013) Saskia A. Bode et al.   CHEMICAL COMMUNICATIONS

Tapping the treasure of intracellular oncotargets with immunotherapy

(2013) Cheng William Hong et al.   FEBS LETTERS

A New Protein-Protein Interaction Sensor Based on Tripartite Split-GFP Association

(2013) Stéphanie Cabantous et al.   Scientific Reports

Efficient Delivery of Cyclic Peptides into Mammalian Cells with Short Sequence Motifs

(2012) Ziqing Qian et al.   ACS Chemical Biology

Engineered Luciferase Reporter from a Deep Sea Shrimp Utilizing a Novel Imidazopyrazinone Substrate

(2012) Mary P. Hall et al.   ACS Chemical Biology

Arginine Topology Controls Escape of Minimally Cationic Proteins from Early Endosomes to the Cytoplasm

(2012) Jacob S. Appelbaum et al.   CHEMISTRY & BIOLOGY

Cell-penetrating peptides: classes, origin, and current landscape

(2012) Francesca Milletti   DRUG DISCOVERY TODAY

Macropinocytosis: an endocytic pathway for internalising large gulps

(2011) Jet Phey Lim et al.   IMMUNOLOGY AND CELL BIOLOGY

At the Crossroads of Chemistry and Cell Biology: Inhibiting Membrane Traffic by Small Molecules

(2011) Lisa Kleist et al.   TRAFFIC

Backbone rigidity and static presentation of guanidinium groups increases cellular uptake of arginine-rich cell-penetrating peptides

(2011) Gisela Lättig-Tünnemann et al.   Nature Communications

Peptide-mediated protein delivery—Which pathways are penetrable?

(2010) Helin Räägel et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Expressed protein ligation for the preparation of fusion proteins with cell penetrating peptides for endotoxin removal and intracellular delivery

(2010) Hao-Hsin Yu et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Cell-penetrating peptides: Nanocarrier for macromolecule delivery in living cells

(2010) Archana Chugh et al.   IUBMB LIFE

Genetic engineering of mammalian cells by direct delivery of FLP recombinase protein

(2010) Christoph Patsch et al.   METHODS

Cytosolic Targeting of Macromolecules Using a pH-Dependent Fusogenic Peptide in Combination with Cationic Liposomes

(2009) Sachiko Kobayashi et al.   BIOCONJUGATE CHEMISTRY

Twenty years of cell-penetrating peptides: from molecular mechanisms to therapeutics

(2009) Frederic Heitz et al.   BRITISH JOURNAL OF PHARMACOLOGY

Delivery of Macromolecules into Live Cells by Simple Co-incubation with a Peptide

(2009) Ya-Jung Lee et al.   CHEMBIOCHEM

HaloTag: A Novel Protein Labeling Technology for Cell Imaging and Protein Analysis

(2008) Georgyi V. Los et al.   ACS Chemical Biology

Comparison of Cellular Uptake Using 22 CPPs in 4 Different Cell Lines

(2008) Judith Mueller et al.   BIOCONJUGATE CHEMISTRY

Intracellular delivery of peptides via association with ubiquitin or SUMO-1 coupled to protein transduction domains

(2008) Anne-Laure Vitte et al.   BMC BIOTECHNOLOGY

Real-Time Fluorescence Detection of Protein Transduction into Live Cells

(2008) Ya-Jung Lee et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Proline-rich, amphipathic cell-penetrating peptides

(2007) Sílvia Pujals et al.   ADVANCED DRUG DELIVERY REVIEWS

Delivery of proteins and nucleic acids using a non-covalent peptide-based strategy

(2007) Sébastien Deshayes et al.   ADVANCED DRUG DELIVERY REVIEWS