Maternal antibodies facilitate Amyloid-β clearance by activating Fc-receptor-Syk-mediated phagocytosis

Maternal gatekeepers: How maternal antibody Fc characteristics influence passive transfer and infant protection

(2020) Stephanie N. Langel et al.   PLoS Pathogens

Translating genetic risk of Alzheimer’s disease into mechanistic insight and drug targets

(2020) Annerieke Sierksma et al.   SCIENCE

Plasma amyloid and tau as dementia biomarkers in Down syndrome: Systematic review and meta‐analyses

(2019) Falah Alhajraf et al.   Developmental Neurobiology

Distinct Signaling Pathways Regulate TREM2 Phagocytic and NFκB Antagonistic Activities

(2019) Hailan Yao et al.   Frontiers in Cellular Neuroscience

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(2018) Frances K Wiseman et al.   BRAIN

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Erythromyeloid-Derived TREM2: A Major Determinant of Alzheimer’s Disease Pathology in Down Syndrome

(2018) Ruma Raha-Chowdhury et al.   JOURNAL OF ALZHEIMERS DISEASE

Intradermal active full-length DNA Aβ42 immunization via electroporation leads to high anti-Aβ antibody levels in wild-type mice

(2018) Roger N. Rosenberg et al.   JOURNAL OF NEUROIMMUNOLOGY

Germ Line IgM Is Sufficient, but Not Required, for Antibody-Mediated Alphavirus Clearance from the Central Nervous System

(2018) Voraphoj Nilaratanakul et al.   JOURNAL OF VIROLOGY

ACOG Committee Opinion No. 741

(2018)   OBSTETRICS AND GYNECOLOGY

Structural basis for cofilin binding and actin filament disassembly

(2018) Kotaro Tanaka et al.   Nature Communications

Alzheimer's Prevention Initiative: A Plan to Accelerate the Evaluation of Presymptomatic Treatments

(2018) Eric M. Reiman et al.   JOURNAL OF ALZHEIMERS DISEASE

TREM2 — a key player in microglial biology and Alzheimer disease

(2018) Tyler K. Ulland et al.   Nature Reviews Neurology

Restoring microglial and astroglial homeostasis using DNA immunization in a Down Syndrome mouse model

(2018) Tomer Illouz et al.   BRAIN BEHAVIOR AND IMMUNITY

New insights into the role of TREM2 in Alzheimer’s disease

(2018) Maud Gratuze et al.   Molecular Neurodegeneration

Intranasal rapamycin ameliorates Alzheimer-like cognitive decline in a mouse model of Down syndrome

(2018) Antonella Tramutola et al.   Translational Neurodegeneration

HNE-modified proteins in Down syndrome: Involvement in development of Alzheimer disease neuropathology

(2017) Eugenio Barone et al.   FREE RADICAL BIOLOGY AND MEDICINE

The TREM2-APOE Pathway Drives the Transcriptional Phenotype of Dysfunctional Microglia in Neurodegenerative Diseases

(2017) Susanne Krasemann et al.   IMMUNITY

Distribution of FcRn Across Species and Tissues

(2017) Sari Latvala et al.   JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY

A protocol for quantitative analysis of murine and human amyloid-β 1-40 and 1-42

(2017) Tomer Illouz et al.   JOURNAL OF NEUROSCIENCE METHODS

Early-Onset Alzheimer Disease

(2017) Mario F. Mendez   NEUROLOGIC CLINICS

HBcAg produced in transgenic tobacco triggers Th1 and Th2 response when intramuscularly delivered

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TREM2/DAP12 Complex Regulates Inflammatory Responses in Microglia via the JNK Signaling Pathway

(2017) Li Zhong et al.   Frontiers in Aging Neuroscience

Novel Object Recognition Test for the Investigation of Learning and Memory in Mice

(2017) Lindsay M. Lueptow   Jove-Journal of Visualized Experiments

TREM2 deficiency reduces the efficacy of immunotherapeutic amyloid clearance

(2016) Xianyuan Xiang et al.   EMBO Molecular Medicine

Cellular functions of the ADF/cofilin family at a glance

(2016) Georgios Kanellos et al.   JOURNAL OF CELL SCIENCE

CD68/macrosialin: not just a histochemical marker

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Mouse models of Down syndrome: gene content and consequences

(2016) Meenal Gupta et al.   MAMMALIAN GENOME

Placental antibody transfer efficiency and maternal levels: specific for measles, coxsackievirus A16, enterovirus 71, poliomyelitis I-III and HIV-1 antibodies

(2016) Chuanxi Fu et al.   Scientific Reports

Mouse and human FcR effector functions

(2015) Pierre Bruhns et al.   IMMUNOLOGICAL REVIEWS

A genetic cause of Alzheimer disease: mechanistic insights from Down syndrome

(2015) Frances K. Wiseman et al.   NATURE REVIEWS NEUROSCIENCE

Dissecting Alzheimer disease in Down syndrome using mouse models

(2015) Xun Yu Choong et al.   Frontiers in Behavioral Neuroscience

Use of the Open Field Maze to Measure Locomotor and Anxiety-like Behavior in Mice

(2015) Michael L. Seibenhener et al.   Jove-Journal of Visualized Experiments

Actin Cytoskeleton Reorganization by Syk Regulates Fcγ Receptor Responsiveness by Increasing Its Lateral Mobility and Clustering

(2014) Valentin Jaumouillé et al.   DEVELOPMENTAL CELL

Phagocytosis of Microglia in the Central Nervous System Diseases

(2014) Ruying Fu et al.   MOLECULAR NEUROBIOLOGY

Maternal Antibodies: Clinical Significance, Mechanism of Interference with Immune Responses, and Possible Vaccination Strategies

(2014) Stefan Niewiesk   Frontiers in Immunology

Current Estimate of Down Syndrome Population Prevalence in the United States

(2013) Angela P. Presson et al.   JOURNAL OF PEDIATRICS

Object recognition test in mice

(2013) Marianne Leger et al.   Nature Protocols

Massively Parallel Sequencing Reveals the Complex Structure of an Irradiated Human Chromosome on a Mouse Background in the Tc1 Model of Down Syndrome

(2013) Susan M. Gribble et al.   PLoS One

Stopping Alzheimer's Before It Starts

(2012) G. Miller   SCIENCE

DNA immunization with HBsAg-based particles expressing a B cell epitope of amyloid β-peptide attenuates disease progression and prolongs survival in a mouse model of Alzheimer's disease

(2012) Purevdorj B. Olkhanud et al.   VACCINE

Mouse Models of Down Syndrome as a Tool to Unravel the Causes of Mental Disabilities

(2012) Noemí Rueda et al.   NEURAL PLASTICITY

Electroporation delivery of DNA vaccines: prospects for success

(2011) Niranjan Y Sardesai et al.   CURRENT OPINION IN IMMUNOLOGY

A new method to isolate microglia from adult mice and culture them for an extended period of time

(2010) Simon Moussaud et al.   JOURNAL OF NEUROSCIENCE METHODS

The genetic architecture of Down syndrome phenotypes revealed by high-resolution analysis of human segmental trisomies

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