Conformational Landscape of the PRKACA-DNAJB1 Chimeric Kinase, the Driver for Fibrolamellar Hepatocellular Carcinoma

Mutation of a kinase allosteric node uncouples dynamics linked to phosphotransfer

(2017) Lalima G. Ahuja et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

OPLS3: A Force Field Providing Broad Coverage of Drug-like Small Molecules and Proteins

(2015) Edward Harder et al.   Journal of Chemical Theory and Computation

Transcriptomic characterization of fibrolamellar hepatocellular carcinoma

(2015) Elana P. Simon et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural insights into mis-regulation of protein kinase A in human tumors

(2015) Jonah Cheung et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

An Isoform-Specific Myristylation Switch Targets Type II PKA Holoenzymes to Membranes

(2015) Ping Zhang et al.   STRUCTURE

Dynamics-Driven Allostery in Protein Kinases

(2015) Alexandr P. Kornev et al.   TRENDS IN BIOCHEMICAL SCIENCES

The genomic landscape of fibrolamellar hepatocellular carcinoma: whole genome sequencing of ten patients

(2015) David G. Darcy et al.   Oncotarget

Structure and Function of Human DnaJ Homologue Subfamily A Member 1 (DNAJA1) and Its Relationship to Pancreatic Cancer

(2014) Jaime L. Stark et al.   BIOCHEMISTRY

Detection of a Recurrent DNAJB1-PRKACA Chimeric Transcript in Fibrolamellar Hepatocellular Carcinoma

(2014) J. N. Honeyman et al.   SCIENCE

Synchronous Opening and Closing Motions Are Essential for cAMP-Dependent Protein Kinase A Signaling

(2014) Atul K. Srivastava et al.   STRUCTURE

Fibrolamellar variant of hepatocellular carcinoma does not have a better survival than conventional hepatocellular carcinoma – Results and treatment recommendations from the Childhood Liver Tumour Strategy Group (SIOPEL) experience

(2013) V.B. Weeda et al.   EUROPEAN JOURNAL OF CANCER

Conformational Equilibrium of N-Myristoylated cAMP-Dependent Protein Kinase A by Molecular Dynamics Simulations

(2012) Alessandro Cembran et al.   BIOCHEMISTRY

Role of N-Terminal Myristylation in the Structure and Regulation of cAMP-Dependent Protein Kinase

(2012) Adam C. Bastidas et al.   JOURNAL OF MOLECULAR BIOLOGY

Structure and Allostery of the PKA RII  Tetrameric Holoenzyme

(2012) P. Zhang et al.   SCIENCE

A Myristoyl/Phosphoserine Switch Controls cAMP-Dependent Protein Kinase Association to Membranes

(2011) Ece C. Gaffarogullari et al.   JOURNAL OF MOLECULAR BIOLOGY

Dynamically committed, uncommitted, and quenched states encoded in protein kinase A revealed by NMR spectroscopy

(2011) L. R. Masterson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Dynamics connect substrate recognition to catalysis in protein kinase A

(2010) Larry R Masterson et al.   Nature Chemical Biology