A high-throughput Galectin-9 imaging assay for quantifying nanoparticle uptake, endosomal escape and functional RNA delivery

mTOR at the nexus of nutrition, growth, ageing and disease

(2020) Grace Y. Liu et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Naturally-occurring cholesterol analogues in lipid nanoparticles induce polymorphic shape and enhance intracellular delivery of mRNA

(2020) Siddharth Patel et al.   Nature Communications

Cationic Amphiphilic Drugs Boost the Lysosomal Escape of Small Nucleic Acid Therapeutics in a Nanocarrier-Dependent Manner

(2020) Thijs Van de Vyver et al.   ACS Nano

Endocytosis of Extracellular Vesicles and Release of Their Cargo from Endosomes

(2020) Bhagyashree S. Joshi et al.   ACS Nano

Deconvoluting Lipid Nanoparticle Structure for Messenger RNA Delivery

(2020) Yulia Eygeris et al.   NANO LETTERS

Imaging small molecule-induced endosomal escape of siRNA

(2020) Hampus Du Rietz et al.   Nature Communications

Recent advances in siRNA delivery mediated by lipid-based nanoparticles

(2020) Sei Yonezawa et al.   ADVANCED DRUG DELIVERY REVIEWS

Galectins in Intra- and Extracellular Vesicles

(2020) Sebastian Bänfer et al.   Biomolecules

Nanoparticles Containing Oxidized Cholesterol Deliver mRNA to the Liver Microenvironment at Clinically Relevant Doses

(2019) Kalina Paunovska et al.   ADVANCED MATERIALS

Endocytic Profiling of Cancer Cell Models Reveals Critical Factors Influencing LNP-Mediated mRNA Delivery and Protein Expression

(2019) Edward J. Sayers et al.   MOLECULAR THERAPY

The Endosomal Escape of Nanoparticles: Toward More Efficient Cellular Delivery

(2018) Samuel A. Smith et al.   BIOCONJUGATE CHEMISTRY

FDA-Approved Oligonucleotide Therapies in 2017

(2017) Cy A. Stein et al.   MOLECULAR THERAPY

Overcoming cellular barriers for RNA therapeutics

(2017) Steven F Dowdy   NATURE BIOTECHNOLOGY

Lysosomal cholesterol activates mTORC1 via an SLC38A9–Niemann-Pick C1 signaling complex

(2017) Brian M. Castellano et al.   SCIENCE

Surface De-PEGylation Controls Nanoparticle-Mediated siRNA Delivery In Vitro and In Vivo

(2017) Xi Zhu et al.   Theranostics

Advances in the delivery of RNA therapeutics: from concept to clinical reality

(2017) James C. Kaczmarek et al.   Genome Medicine

Materials for non-viral intracellular delivery of messenger RNA therapeutics

(2016) Kevin J. Kauffman et al.   JOURNAL OF CONTROLLED RELEASE

Optimization of Lipid Nanoparticle Formulations for mRNA Delivery in Vivo with Fractional Factorial and Definitive Screening Designs

(2015) Kevin J. Kauffman et al.   NANO LETTERS

Visualizing lipid-formulated siRNA release from endosomes and target gene knockdown

(2015) Anders Wittrup et al.   NATURE BIOTECHNOLOGY

High-throughput screening identifies small molecules that enhance the pharmacological effects of oligonucleotides

(2015) B. Yang et al.   NUCLEIC ACIDS RESEARCH

Degradable lipid nanoparticles with predictable in vivo siRNA delivery activity

(2014) Kathryn A. Whitehead et al.   Nature Communications

Image-based analysis of lipid nanoparticle–mediated siRNA delivery, intracellular trafficking and endosomal escape

(2013) Jerome Gilleron et al.   NATURE BIOTECHNOLOGY

Maximizing the Potency of siRNA Lipid Nanoparticles for Hepatic Gene Silencing In Vivo

(2012) Muthusamy Jayaraman et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Obligate Ligation-Gated Recombination (ObLiGaRe): Custom-designed nuclease-mediated targeted integration through nonhomologous end joining

(2012) M. Maresca et al.   GENOME RESEARCH

Spatiotemporal Dynamics of Adenovirus Membrane Rupture and Endosomal Escape

(2012) O. Maier et al.   JOURNAL OF VIROLOGY

Galectin 8 targets damaged vesicles for autophagy to defend cells against bacterial invasion

(2012) Teresa L. M. Thurston et al.   NATURE

Diblock copolymers with tunable pH transitions for gene delivery

(2011) Matthew J. Manganiello et al.   BIOMATERIALS

Targeted Delivery of RNAi Therapeutics With Endogenous and Exogenous Ligand-Based Mechanisms

(2010) Akin Akinc et al.   MOLECULAR THERAPY

Rational design of cationic lipids for siRNA delivery

(2010) Sean C Semple et al.   NATURE BIOTECHNOLOGY

Ku-0063794 is a specific inhibitor of the mammalian target of rapamycin (mTOR)

(2009) Juan M. García-Martínez et al.   BIOCHEMICAL JOURNAL

Galectin-3, a marker for vacuole lysis by invasive pathogens

(2009) Irit Paz et al.   CELLULAR MICROBIOLOGY

An ATP-competitive Mammalian Target of Rapamycin Inhibitor Reveals Rapamycin-resistant Functions of mTORC1

(2009) Carson C. Thoreen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY