Longitudinal transcriptomics define the stages of myeloid activation in the living human brain after intracerebral hemorrhage

Transcriptional profiling of human microglia reveals grey–white matter heterogeneity and multiple sclerosis-associated changes

(2019) Marlijn van der Poel et al.   Nature Communications

Efficacy and safety of minimally invasive surgery with thrombolysis in intracerebral haemorrhage evacuation (MISTIE III): a randomised, controlled, open-label, blinded endpoint phase 3 trial

(2019) Daniel F Hanley et al.   LANCET

A single-cell atlas of mouse brain macrophages reveals unique transcriptional identities shaped by ontogeny and tissue environment

(2019) Hannah Van Hove et al.   NATURE NEUROSCIENCE

The Healing Power of Neutrophils

(2019) Mia Phillipson et al.   TRENDS IN IMMUNOLOGY

Macrophage-Derived Extracellular Succinate Licenses Neural Stem Cells to Suppress Chronic Neuroinflammation

(2018) Luca Peruzzotti-Jametti et al.   Cell Stem Cell

The Janus Face of VEGF in Stroke

(2018) Samuel Geiseler et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Distinct myeloid cell subsets promote meningeal remodeling and vascular repair after mild traumatic brain injury

(2018) Matthew V. Russo et al.   NATURE IMMUNOLOGY

Beneficial Role of Neutrophils Through Function of Lactoferrin After Intracerebral Hemorrhage

(2018) Xiurong Zhao et al.   STROKE

Protective Effects of L-902,688, a Prostanoid EP4 Receptor Agonist, against Acute Blood-Brain Barrier Damage in Experimental Ischemic Stroke

(2018) Kelly M. DeMars et al.   Frontiers in Neuroscience

Role of SLC7A5 in Metabolic Reprogramming of Human Monocyte/Macrophage Immune Responses

(2018) Bo Ruem Yoon et al.   Frontiers in Immunology

Four Key Steps Control Glycolytic Flux in Mammalian Cells

(2018) Lukas Bahati Tanner et al.   Cell Systems

PGE2 production at sites of tissue injury promotes an anti-inflammatory neutrophil phenotype and determines the outcome of inflammation resolution in vivo

(2018) Catherine A. Loynes et al.   Science Advances

N-acetylcysteine targets 5 lipoxygenase-derived, toxic lipids and can synergize with prostaglandin E2 to inhibit ferroptosis and improve outcomes following hemorrhagic stroke in mice

(2018) Saravanan S. Karuppagounder et al.   ANNALS OF NEUROLOGY

Blood handling and leukocyte isolation methods impact the global transcriptome of immune cells

(2018) Brittany A. Goods et al.   BMC IMMUNOLOGY

Metabolism as a guiding force for immunity

(2018) Jonathan Jung et al.   NATURE CELL BIOLOGY

A Defective Pentose Phosphate Pathway Reduces Inflammatory Macrophage Responses during Hypercholesterolemia

(2018) Jeroen Baardman et al.   Cell Reports

Peripherally derived macrophages modulate microglial function to reduce inflammation after CNS injury

(2018) Andrew D. Greenhalgh et al.   PLOS BIOLOGY

Erythrocyte efferocytosis modulates macrophages towards recovery after intracerebral hemorrhage

(2017) Che-Feng Chang et al.   JOURNAL OF CLINICAL INVESTIGATION

Prostaglandin E2 facilitates neurite outgrowth in a motor neuron-like cell line, NSC-34

(2017) Hiroshi Nango et al.   JOURNAL OF PHARMACOLOGICAL SCIENCES

Neuroimmunology of Traumatic Brain Injury: Time for a Paradigm Shift

(2017) Yasir N. Jassam et al.   NEURON

Diverse Requirements for Microglial Survival, Specification, and Function Revealed by Defined-Medium Cultures

(2017) Christopher J. Bohlen et al.   NEURON

An environment-dependent transcriptional network specifies human microglia identity

(2017) David Gosselin et al.   SCIENCE

Single-cell RNA-seq reveals new types of human blood dendritic cells, monocytes, and progenitors

(2017) Alexandra-Chloé Villani et al.   SCIENCE

Macrophage Immunometabolism: Where Are We (Going)?

(2017) Jan Van den Bossche et al.   TRENDS IN IMMUNOLOGY

Prostaglandin E2 Impairs P2Y2/P2Y4 Receptor Signaling in Cerebellar Astrocytes via EP3 Receptors

(2017) Lucía Paniagua-Herranz et al.   Frontiers in Pharmacology

Macrophage responses to lipopolysaccharide are modulated by a feedback loop involving prostaglandin E2, dual specificity phosphatase 1 and tristetraprolin

(2017) Tina Tang et al.   Scientific Reports

HIF1α and metabolic reprogramming in inflammation

(2016) Sarah E. Corcoran et al.   JOURNAL OF CLINICAL INVESTIGATION

Balancing the immune response in the brain: IL-10 and its regulation

(2016) Diogo Lobo-Silva et al.   Journal of Neuroinflammation

Brain trauma elicits non-canonical macrophage activation states

(2016) Charles C. Kim et al.   Journal of Neuroinflammation

Monocyte-Derived Macrophages Contribute to Spontaneous Long-Term Functional Recovery after Stroke in Mice

(2016) S. Wattananit et al.   JOURNAL OF NEUROSCIENCE

Broad defects in the energy metabolism of leukocytes underlie immunoparalysis in sepsis

(2016) Shih-Chin Cheng et al.   NATURE IMMUNOLOGY

Origin, fate and dynamics of macrophages at central nervous system interfaces

(2016) Tobias Goldmann et al.   NATURE IMMUNOLOGY

GAM: a web-service for integrated transcriptional and metabolic network analysis

(2016) Alexey A. Sergushichev et al.   NUCLEIC ACIDS RESEARCH

Enrichr: a comprehensive gene set enrichment analysis web server 2016 update

(2016) Maxim V. Kuleshov et al.   NUCLEIC ACIDS RESEARCH

Integrating immunometabolism and macrophage diversity

(2016) Maxim N. Artyomov et al.   SEMINARS IN IMMUNOLOGY

Reduced nuclear protein 1 expression improves insulin sensitivity and protects against diet-induced glucose intolerance through up-regulation of heat shock protein 70

(2015) H.C. Barbosa-Sampaio et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Network Integration of Parallel Metabolic and Transcriptional Data Reveals Metabolic Modules that Regulate Macrophage Polarization

(2015) Abhishek K. Jha et al.   IMMUNITY

Myeloid HIFs Are Dispensable for Resolution of Inflammation during Skeletal Muscle Regeneration

(2015) Julien Gondin et al.   JOURNAL OF IMMUNOLOGY

limma powers differential expression analyses for RNA-sequencing and microarray studies

(2015) Matthew E. Ritchie et al.   NUCLEIC ACIDS RESEARCH

The Molecular Signatures Database Hallmark Gene Set Collection

(2015) Arthur Liberzon et al.   Cell Systems

Environment Drives Selection and Function of Enhancers Controlling Tissue-Specific Macrophage Identities

(2014) David Gosselin et al.   CELL

Proresolving Lipid Mediators and Mechanisms in the Resolution of Acute Inflammation

(2014) Christopher D. Buckley et al.   IMMUNITY

Transcriptome-Based Network Analysis Reveals a Spectrum Model of Human Macrophage Activation

(2014) Jia Xue et al.   IMMUNITY

Macrophage heterogeneity in tissues: phenotypic diversity and functions

(2014) Siamon Gordon et al.   IMMUNOLOGICAL REVIEWS

TLR-driven early glycolytic reprogramming via the kinases TBK1-IKKɛ supports the anabolic demands of dendritic cell activation

(2014) Bart Everts et al.   NATURE IMMUNOLOGY

mTOR- and HIF-1 -mediated aerobic glycolysis as metabolic basis for trained immunity

(2014) S.-C. Cheng et al.   SCIENCE

Enrichr: interactive and collaborative HTML5 gene list enrichment analysis tool

(2013) Edward Y Chen et al.   BMC BIOINFORMATICS

Succinate is an inflammatory signal that induces IL-1β through HIF-1α

(2013) G. M. Tannahill et al.   NATURE

Control of amino-acid transport by antigen receptors coordinates the metabolic reprogramming essential for T cell differentiation

(2013) Linda V Sinclair et al.   NATURE IMMUNOLOGY

Inflammatory monocytes regulate pathologic responses to commensals during acute gastrointestinal infection

(2013) John R Grainger et al.   NATURE MEDICINE

Smart-seq2 for sensitive full-length transcriptome profiling in single cells

(2013) Simone Picelli et al.   NATURE METHODS

Human housekeeping genes, revisited

(2013) Eli Eisenberg et al.   TRENDS IN GENETICS

Commitment to glycolysis sustains survival of NO-producing inflammatory dendritic cells

(2012) B. Everts et al.   BLOOD

Nupr1-Aurora Kinase A Pathway Provides Protection against Metabolic Stress-Mediated Autophagic-Associated Cell Death

(2012) T. Hamidi et al.   CLINICAL CANCER RESEARCH

Intracerebral haemorrhage: mechanisms of injury and therapeutic targets

(2012) Richard F Keep et al.   LANCET NEUROLOGY

Gene-expression profiles and transcriptional regulatory pathways that underlie the identity and diversity of mouse tissue macrophages

(2012) Emmanuel L Gautier et al.   NATURE IMMUNOLOGY

Prostaglandin E2 induces glutamate release from subventricular zone astrocytes

(2011) Kathleen A. Dave et al.   Neuron Glia Biology

Mechanisms of Cell Protection by Heme Oxygenase-1

(2010) Raffaella Gozzelino et al.   Annual Review of Pharmacology and Toxicology

The COX-2 inhibitors, meloxicam and nimesulide, suppress neurogenesis in the adult mouse brain

(2010) Maria Beatriz Goncalves et al.   BRITISH JOURNAL OF PHARMACOLOGY

Vascular Endothelial Growth Factor Increases Neurogenesis after Traumatic Brain Injury

(2010) Orli Thau-Zuchman et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Activation of a Metabolic Gene Regulatory Network Downstream of mTOR Complex 1

(2010) Katrin Düvel et al.   MOLECULAR CELL

A scaling normalization method for differential expression analysis of RNA-seq data

(2010) Mark D Robinson et al.   GENOME BIOLOGY