Knockdown of AKT3 Activates HER2 and DDR Kinases in Bone-Seeking Breast Cancer Cells, Promotes Metastasis In Vivo and Attenuates the TGFβ/CTGF Axis

Cell-Autonomous versus Systemic Akt Isoform Deletions Uncovered New Roles for Akt1 and Akt2 in Breast Cancer

(2020) Xinyu Chen et al.   MOLECULAR CELL

High Sensitivity of Circulating Tumor Cells Derived from a Colorectal Cancer Patient for Dual Inhibition with AKT and mTOR Inhibitors

(2020) Daniel J. Smit et al.   Cells

Combination treatment with a PI3K/Akt/mTOR pathway inhibitor overcomes resistance to anti-HER2 therapy in PIK3CA-mutant HER2-positive breast cancer cells

(2020) Yumi Fujimoto et al.   Scientific Reports

Cancer statistics, 2019

(2019) Rebecca L. Siegel et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Targeting the PI3-kinase pathway in triple-negative breast cancer

(2019) J Pascual et al.   ANNALS OF ONCOLOGY

HER2 Upregulates ATF4 to Promote Cell Migration via Activation of ZEB1 and Downregulation of E-Cadherin

(2019) Peng Zeng et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

A CTGF‐RUNX2‐RANKL Axis in Breast and Prostate Cancer cells Promotes Tumor Progression in Bone

(2019) Bongjun Kim et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Distinct functions of AKT isoforms in breast cancer: a comprehensive review

(2019) Nico Hinz et al.   Cell Communication and Signaling

Understanding the Progression of Bone Metastases to Identify Novel Therapeutic Targets

(2018) Annie Schmid-Alliana et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Bone metastasis pattern in initial metastatic breast cancer: a population-based study

(2018) Zhenchong Xiong et al.   Cancer Management and Research

The next generation of PI3K-Akt-mTOR pathway inhibitors in breast cancer cohorts

(2018) Michael Mc Kenna et al.   BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER

Exploring the molecular mechanism associated with breast cancer bone metastasis using bioinformatic analysis and microarray genetic interaction network

(2018) Xinhua Chen et al.   MEDICINE

Signaling by Discoidin Domain Receptor 1 in Cancer Metastasis

(2018) Mayur Gadiya et al.   Cell Adhesion & Migration

Akt1 inhibition promotes breast cancer metastasis through EGFR-mediated β-catenin nuclear accumulation

(2018) Wei Li et al.   Cell Communication and Signaling

Breast cancer subtypes predict the preferential site of distant metastases: a SEER based study

(2017) Qi Wu et al.   Oncotarget

AKT1 and AKT2 isoforms play distinct roles during breast cancer progression through the regulation of specific downstream proteins

(2017) Marina Riggio et al.   Scientific Reports

Multi-organ Site Metastatic Reactivation Mediated by Non-canonical Discoidin Domain Receptor 1 Signaling

(2016) Hua Gao et al.   CELL

Matrix metalloproteinase-2 regulates MDA-MB-231 breast cancer cell invasion induced by active mammalian diaphanous-related formin 1

(2016) DAEHWAN KIM et al.   Molecular Medicine Reports

Downregulation of AKT3 Increases Migration and Metastasis in Triple Negative Breast Cancer Cells by Upregulating S100A4

(2016) Astrid Grottke et al.   PLoS One

Non-Smad Signaling Pathways of the TGF-β Family

(2016) Ying E. Zhang   Cold Spring Harbor Perspectives in Biology

Dual Targeting of Akt and mTORC1 Impairs Repair of DNA Double-Strand Breaks and Increases Radiation Sensitivity of Human Tumor Cells

(2016) Marina Holler et al.   PLoS One

NSG Mice Provide a Better Spontaneous Model of Breast Cancer Metastasis than Athymic (Nude) Mice

(2016) Madhavi Puchalapalli et al.   PLoS One

CCN2 enhances RANKL-induced osteoclast differentiation via direct binding to RANK and OPG

(2015) Eriko Aoyama et al.   BONE

Genomically amplified Akt3 activates DNA repair pathway and promotes glioma progression

(2015) Kristen M. Turner et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

IGF-I induces upregulation of DDR1 collagen receptor in breast cancer cells by suppressing MIR-199a-5p through the PI3K/AKT pathway

(2015) Roberta Matà et al.   Oncotarget

TRAIL-R2 promotes skeletal metastasis in a breast cancer xenograft mouse model

(2015) Hendrik Fritsche et al.   Oncotarget

Akt1 and Akt3 Exert Opposing Roles in the Regulation of Vascular Tumor Growth

(2014) T. L. Phung et al.   CANCER RESEARCH

Different molecular profiles are associated with breast cancer cell homing compared with colonisation of bone: evidence using a novel bone-seeking cell line

(2014) Faith Nutter et al.   ENDOCRINE-RELATED CANCER

Antagonism of EGFR and HER3 Enhances the Response to Inhibitors of the PI3K-Akt Pathway in Triple-Negative Breast Cancer

(2014) J. J. Tao et al.   Science Signaling

Targeting Akt3 Signaling in Triple-Negative Breast Cancer

(2013) Y. R. Chin et al.   CANCER RESEARCH

Investigation of molecular alterations ofAKT-3in triple-negative breast cancer

(2013) Gillian O'Hurley et al.   HISTOPATHOLOGY

Combined targeting of AKT and mTOR using MK-2206 and RAD001 is synergistic in the treatment of cholangiocarcinoma

(2013) Florian Ewald et al.   INTERNATIONAL JOURNAL OF CANCER

Canonical Wnt signaling inhibits osteoclastogenesis independent of osteoprotegerin

(2013) Joachim Albers et al.   JOURNAL OF CELL BIOLOGY

The collagen receptor discoidin domain receptor 2 stabilizes SNAIL1 to facilitate breast cancer metastasis

(2013) Kun Zhang et al.   NATURE CELL BIOLOGY

AKT Facilitates EGFR Trafficking and Degradation by Phosphorylating and Activating PIKfyve

(2013) E. E. Er et al.   Science Signaling

Signaling interplay between transforming growth factor-β receptor and PI3K/AKT pathways in cancer

(2013) Long Zhang et al.   TRENDS IN BIOCHEMICAL SCIENCES

CCN2: a master regulator of the genesis of bone and cartilage

(2013) Masaharu Takigawa   Journal of Cell Communication and Signaling

Involvement of epidermal growth factor receptor overexpression in the promotion of breast cancer brain metastasis

(2012) Fang Nie et al.   CANCER

Mouse models of breast cancer metastasis to bone

(2012) Kelsi L. Kretschmann et al.   CANCER AND METASTASIS REVIEWS

Bone-Derived IGF Mediates Crosstalk between Bone and Breast Cancer Cells in Bony Metastases

(2012) Toru Hiraga et al.   CANCER RESEARCH

Incidence and Patterns of Distant Metastases for Patients With Early-Stage Breast Cancer After Breast Conservation Treatment

(2012) Abigail T. Berman et al.   Clinical Breast Cancer

N-cadherin regulates mammary tumor cell migration through Akt3 suppression

(2012) S Chung et al.   ONCOGENE

Decreased Autocrine EGFR Signaling in Metastatic Breast Cancer Cells Inhibits Tumor Growth in Bone and Mammary Fat Pad

(2012) Nicole K. Nickerson et al.   PLoS One

Strategies for subtypes—dealing with the diversity of breast cancer: highlights of the St Gallen International Expert Consensus on the Primary Therapy of Early Breast Cancer 2011

(2011) A. Goldhirsch et al.   ANNALS OF ONCOLOGY

AKT Inhibition Relieves Feedback Suppression of Receptor Tyrosine Kinase Expression and Activity

(2011) Sarat Chandarlapaty et al.   CANCER CELL

Everolimus in Postmenopausal Hormone-Receptor–Positive Advanced Breast Cancer

(2011) José Baselga et al.   NEW ENGLAND JOURNAL OF MEDICINE

Ablation of Akt2 Induces Autophagy through Cell Cycle Arrest, the Downregulation of p70S6K, and the Deregulation of Mitochondria in MDA-MB231 Cells

(2011) Stacey A. Santi et al.   PLoS One

C-Src-mediated RANKL-induced breast cancer cell migration by activation of the ERK and Akt pathway

(2011) LINGYUN ZHANG et al.   Oncology Letters

The phosphatidyl inositol 3-kinase/AKT signaling pathway in breast cancer

(2010) Carlos A. Castaneda et al.   CANCER AND METASTASIS REVIEWS

Metastatic Behavior of Breast Cancer Subtypes

(2010) Hagen Kennecke et al.   JOURNAL OF CLINICAL ONCOLOGY

The Actin-Bundling Protein Palladin Is an Akt1-Specific Substrate that Regulates Breast Cancer Cell Migration

(2010) Y. Rebecca Chin et al.   MOLECULAR CELL

EGFR signaling in breast cancer: Bad to the bone

(2010) John Foley et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

TGFβ in Cancer

(2008) Joan Massagué   CELL

Osteoblasts-derived TGF-β1 enhance motility and integrin upregulation through Akt, ERK, and NF-κB-dependent pathway in human breast cancer cells

(2007) Ying-Ying Wei et al.   MOLECULAR CARCINOGENESIS