CCN2: a master regulator of the genesis of bone and cartilage

Cartilage–Specific Over-Expression of CCN Family Member 2/Connective Tissue Growth Factor (CCN2/CTGF) Stimulates Insulin-Like Growth Factor Expression and Bone Growth

(2013) Nao Tomita et al.   PLoS One

Roles of heterotypic CCN2/CTGF-CCN3/NOV and homotypic CCN2-CCN2 interactions in expression of the differentiated phenotype of chondrocytes

(2012) Mitsuhiro Hoshijima et al.   FEBS Journal

CCN2/CTGF binds to fibroblast growth factor receptor 2 and modulates its signaling

(2012) Eriko Aoyama et al.   FEBS LETTERS

Role of LRP1 in transport of CCN2 protein in chondrocytes

(2012) Kazumi Kawata et al.   JOURNAL OF CELL SCIENCE

Differential roles of CCN family proteins during osteoblast differentiation: Involvement of Smad and MAPK signaling pathways

(2011) Harumi Kawaki et al.   BONE

Effect of CCN2 on FGF2-Induced Proliferation and MMP9 and MMP13 Productions by Chondrocytes

(2011) Takashi Nishida et al.   ENDOCRINOLOGY

Decorin Interacts with Connective Tissue Growth Factor (CTGF)/CCN2 by LRR12 Inhibiting Its Biological Activity

(2011) Cecilia Vial et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Taking aim at the extracellular matrix: CCN proteins as emerging therapeutic targets

(2011) Joon-Il Jun et al.   NATURE REVIEWS DRUG DISCOVERY

The role of CCN2 in cartilage and bone development

(2011) Satoshi Kubota et al.   Journal of Cell Communication and Signaling

CCN family 2/connective tissue growth factor (CCN2/CTGF) promotes osteoclastogenesis via induction of and interaction with dendritic cell-specific transmembrane protein (DC-STAMP)

(2010) Takashi Nishida et al.   JOURNAL OF BONE AND MINERAL RESEARCH

N-terminal domains of CCN family 2/connective tissue growth factor bind to aggrecan

(2009) Eriko Aoyama et al.   BIOCHEMICAL JOURNAL

CCN2/CTGF has anti-aging effects to protect articular cartilage from age-related degenerative changes

(2009) S. Itoh et al.   BONE

Role of the low-density lipoprotein receptor-related protein-1 in regulation of chondrocyte differentiation

(2009) Kazumi Kawata et al.   JOURNAL OF CELLULAR PHYSIOLOGY

CCN Family 2/Connective Tissue Growth Factor Modulates BMP Signalling as a Signal Conductor, Which Action Regulates the Proliferation and Differentiation of Chondrocytes

(2008) A. Maeda et al.   JOURNAL OF BIOCHEMISTRY

Cooperative Regulation of Chondrocyte Differentiation by CCN2 and CCN3 Shown by a Comprehensive Analysis of the CCN Family Proteins in Cartilage

(2008) Harumi Kawaki et al.   JOURNAL OF BONE AND MINERAL RESEARCH

CCN family 2/connective tissue growth factor (CCN2/CTGF) stimulates proliferation and differentiation of auricular chondrocytes

(2008) T. Fujisawa et al.   OSTEOARTHRITIS AND CARTILAGE

Promotion of Bone Regeneration by CCN2 Incorporated into Gelatin Hydrogel

(2008) Takeshi Kikuchi et al.   TISSUE ENGINEERING PART A

Functional requirement of CCN2 for intramembranous bone formation in embryonic mice

(2007) Harumi Kawaki et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Berberine inhibits RANKL-induced osteoclast formation and survival through suppressing the NF-κB and Akt pathways

(2007) Jin-Ping Hu et al.   EUROPEAN JOURNAL OF PHARMACOLOGY