Phosphorylation of Microglial IRF5 and IRF4 by IRAK4 Regulates Inflammatory Responses to Ischemia

Microglial IRF5-IRF4 regulatory axis regulates neuroinflammation after cerebral ischemia and impacts stroke outcomes

(2020) Abdullah Al Mamun et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The kinase IRAK4 promotes endosomal TLR and immune complex signaling in B cells and plasmacytoid dendritic cells

(2020) Cesar A. Corzo et al.   Science Signaling

Free radical-decellularized tissue promotes enhanced antioxidant and anti-inflammatory macrophage response

(2019) St Lopresti et al.   BIOMATERIALS

Targeting IRAK4 disrupts inflammatory pathways and delays tumor development in chronic lymphocytic leukemia

(2019) Neus Giménez et al.   LEUKEMIA

Interferon regulatory factor 4/5 signaling impacts on microglial activation after ischemic stroke in mice

(2018) Abdullah Al Mamun et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Immune responses in stroke: how the immune system contributes to damage and healing after stroke and how this knowledge could be translated to better cures?

(2018) Aditya Rayasam et al.   IMMUNOLOGY

Regulation and role of the transcription factor IRF5 in innate immune responses and systemic lupus erythematosus

(2018) Tatsuma Ban et al.   INTERNATIONAL IMMUNOLOGY

Epigenetic and transcriptional regulation of IL4-induced CCL17 production in human monocytes and murine macrophages

(2018) Amy T. Hsu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Advances and challenges in targeting IRF5, a key regulator of inflammation

(2018) Hannah Almuttaqi et al.   FEBS Journal

How to reprogram microglia toward beneficial functions

(2018) Marta Fumagalli et al.   GLIA

Interleukin-1 receptor–associated kinase 4 (IRAK4) plays a dual role in myddosome formation and Toll-like receptor signaling

(2018) Dominic De Nardo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Understanding early TLR signaling through the Myddosome

(2018) Katherine R. Balka et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Microglia Responses to Pro-inflammatory Stimuli (LPS, IFNγ+TNFα) and Reprogramming by Resolving Cytokines (IL-4, IL-10)

(2018) Starlee Lively et al.   Frontiers in Cellular Neuroscience

A Hyperfluorinated Hydrophilic Molecule for Aqueous 19F MRI Contrast Media

(2018) Eric A. Tanifum et al.   Contrast Media & Molecular Imaging

Microglia in Neurological Diseases: A Road Map to Brain-Disease Dependent-Inflammatory Response

(2018) Sara Bachiller et al.   Frontiers in Cellular Neuroscience

IRAK4 kinase activity controls Toll-like receptor–induced inflammation through the transcription factor IRF5 in primary human monocytes

(2017) Leah Cushing et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Microglial Function during Glucose Deprivation: Inflammatory and Neuropsychiatric Implications

(2017) Matthew A. Churchward et al.   MOLECULAR NEUROBIOLOGY

The biphasic function of microglia in ischemic stroke

(2017) Yuanyuan Ma et al.   PROGRESS IN NEUROBIOLOGY

NOSH-NBP, a Novel Nitric Oxide and Hydrogen Sulfide- Releasing Hybrid, Attenuates Ischemic Stroke-Induced Neuroinflammatory Injury by Modulating Microglia Polarization

(2017) Jing Ji et al.   Frontiers in Cellular Neuroscience

Microglia preconditioned by oxygen-glucose deprivation promote functional recovery in ischemic rats

(2017) Masato Kanazawa et al.   Scientific Reports

Nafamostat mesilate improves function recovery after stroke by inhibiting neuroinflammation in rats

(2016) Chenhui Li et al.   BRAIN BEHAVIOR AND IMMUNITY

Lyn Kinase Suppresses the Transcriptional Activity of IRF5 in the TLR-MyD88 Pathway to Restrain the Development of Autoimmunity

(2016) Tatsuma Ban et al.   IMMUNITY

Microglial M1/M2 polarization and metabolic states

(2015) Ruben Orihuela et al.   BRITISH JOURNAL OF PHARMACOLOGY

The subpopulation of microglia sensitive to neurotransmitters/neurohormones is modulated by stimulation with LPS, interferon-γ, and IL-4

(2014) Maria Pannell et al.   GLIA

Interleukin 1/Toll-like Receptor-induced Autophosphorylation Activates Interleukin 1 Receptor-associated Kinase 4 and Controls Cytokine Induction in a Cell Type-specific Manner

(2014) Leah Cushing et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A novel cell line from spontaneously immortalized murine microglia

(2014) Kumi Nagamoto-Combs et al.   JOURNAL OF NEUROSCIENCE METHODS

Phagocytic activity of LPS tolerant macrophages

(2014) Thais Martins de Lima et al.   MOLECULAR IMMUNOLOGY

IKKβ is an IRF5 kinase that instigates inflammation

(2014) Junyao Ren et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Protein kinase IKKβ-catalyzed phosphorylation of IRF5 at Ser462 induces its dimerization and nuclear translocation in myeloid cells

(2014) Marta Lopez-Pelaez et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

IRF5, IRF8, and IRF7 in human pDCs - the good, the bad, and the insignificant?

(2013) Karin Pelka et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Microglia and macrophages differentially modulate cell death after brain injury caused by oxygen-glucose deprivation in organotypic brain slices

(2013) Sylvie Girard et al.   GLIA

Interferon-Regulatory Factors Determine Macrophage Phenotype Polarization

(2013) Roman Günthner et al.   MEDIATORS OF INFLAMMATION

Identification of a unique TGF-β–dependent molecular and functional signature in microglia

(2013) Oleg Butovsky et al.   NATURE NEUROSCIENCE

Microglia Actively Regulate the Number of Functional Synapses

(2013) Kyungmin Ji et al.   PLoS One

RNF168 ubiquitylates 53BP1 and controls its response to DNA double-strand breaks

(2013) M. Bohgaki et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Minocycline selectively inhibits M1 polarization of microglia

(2013) K Kobayashi et al.   Cell Death & Disease

Microglial Cell Activation is a Source of Metalloproteinase Generation during Hemorrhagic Transformation

(2012) Gregory J del Zoppo et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Complete Dependence on IRAK4 Kinase Activity in TLR2, but Not TLR4, Signaling Pathways Underlies Decreased Cytokine Production and Increased Susceptibility to Streptococcus pneumoniae Infection in IRAK4 Kinase-Inactive Mice

(2012) M. E. Pennini et al.   JOURNAL OF IMMUNOLOGY

The voltage-gated proton channel Hv1 enhances brain damage from ischemic stroke

(2012) Long-Jun Wu et al.   NATURE NEUROSCIENCE

In Vitro Generation of Monocyte-Derived Macrophages under Serum-Free Conditions Improves Their Tumor Promoting Functions

(2012) Flora Rey-Giraud et al.   PLoS One

Microglia/Macrophage Polarization Dynamics Reveal Novel Mechanism of Injury Expansion After Focal Cerebral Ischemia

(2012) Xiaoming Hu et al.   STROKE

Interferon regulatory factor 5 activation in monocytes of systemic lupus erythematosus patients is triggered by circulating autoantigens independent of type I interferons

(2011) Rivka C. Stone et al.   ARTHRITIS AND RHEUMATISM

Microglial Cells Contribute to Endogenous Brain Defenses after Acute Neonatal Focal Stroke

(2011) J. V. Faustino et al.   JOURNAL OF NEUROSCIENCE

What the Myddosome structure tells us about the initiation of innate immunity

(2011) Nicholas J. Gay et al.   TRENDS IN IMMUNOLOGY

Phosphorylation of IRF4 by ROCK2 regulates IL-17 and IL-21 production and the development of autoimmunity in mice

(2010) Partha S. Biswas et al.   JOURNAL OF CLINICAL INVESTIGATION

Helical assembly in the MyD88–IRAK4–IRAK2 complex in TLR/IL-1R signalling

(2010) Su-Chang Lin et al.   NATURE

The Jmjd3-Irf4 axis regulates M2 macrophage polarization and host responses against helminth infection

(2010) Takashi Satoh et al.   NATURE IMMUNOLOGY

An Oligomeric Signaling Platform Formed by the Toll-like Receptor Signal Transducers MyD88 and IRAK-4

(2009) Precious G. Motshwene et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Stimulated nuclear translocation of NF-κB and shuttling differentially depend on dynein and the dynactin complex

(2009) Cynthia K. Shrum et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Interferon regulatory factor family of transcription factors and regulation of oncogenesis

(2008) Akinori Takaoka et al.   CANCER SCIENCE

Responses of Endothelial Cell and Astrocyte Matrix-Integrin Receptors to Ischemia Mimic Those Observed in the Neurovascular Unit

(2007) Richard Milner et al.   STROKE