Regulation of p53 by E3s

The landscape of viral associations in human cancers

(2020) Marc Zapatka et al.   NATURE GENETICS

Role of the COP1 protein in cancer development and therapy

(2020) Yizuo Song et al.   SEMINARS IN CANCER BIOLOGY

Ubiquitination of P53 by E3 ligase MKRN2 promotes melanoma cell proliferation

(2020) Yiling Zhang et al.   Oncology Letters

P53: A Guardian of Immunity Becomes Its Saboteur through Mutation

(2020) Arjelle Decasa Agupitan et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

MDM2-C Functions as an E3 Ubiquitin Ligase

(2020) Jun Yeob Kim et al.   Cancer Management and Research

TRIM69 inhibits cataractogenesis by negatively regulating p53

(2019) Xianfang Rong et al.   Redox Biology

Ubiquitin ligase TRIM71 suppresses ovarian tumorigenesis by degrading mutant p53

(2019) Yajie Chen et al.   Cell Death & Disease

Isoforms of RNF128 Regulate the Stability of Mutant P53 in Barrett's Esophageal Cells

(2019) Dipankar Ray et al.   GASTROENTEROLOGY

Stepwise multipolyubiquitination of p53 by the E6AP-E6 ubiquitin ligase complex

(2019) Yuji Masuda et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Ring1 promotes the transformation of hepatic progenitor cells into cancer stem cells through the Wnt/β‐catenin signaling pathway

(2019) Kai Zhu et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

TRIM59 predicts poor prognosis and promotes pancreatic cancer progression via the PI3K/AKT/mTOR‐glycolysis signaling axis

(2019) Rongkun Li et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

E3 ubiquitin ligase CHIP attenuates cellular proliferation and invasion abilities in triple-negative breast cancer cells

(2019) Jingjing Xu et al.   CLINICAL AND EXPERIMENTAL MEDICINE

Structural mechanisms of HECT-type ubiquitin ligases

(2018) Sonja Lorenz   BIOLOGICAL CHEMISTRY

Regulating the human HECT E3 ligases

(2018) Jasper Sluimer et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

CHIP promotes autophagy-mediated degradation of aggregating mutant p53 in hypoxic conditions

(2018) Meenu Maan et al.   FEBS Journal

CHIP functions as an oncogene by promoting colorectal cancer metastasis via activation of MAPK and AKT signaling and suppression of E-cadherin

(2018) Jingjing Xu et al.   Journal of Translational Medicine

De novo mutation inRING1with epigenetic effects on neurodevelopment

(2018) Sarah B. Pierce et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

TRIM32 promotes proliferation and confers chemoresistance to breast cancer cells through activation of the NF-κB pathway

(2018) Ting-Ting Zhao et al.   Journal of Cancer

40 Years of Research Put p53 in Translation

(2018) Virginie Marcel et al.   Cancers

TRIM59 overexpression correlates with poor prognosis and contributes to breast cancer progression through AKT signaling pathway

(2018) Yunxiao Liu et al.   MOLECULAR CARCINOGENESIS

Identification and monitoring of atypical PML/RARA fusion transcripts in acute promyelocytic leukemia

(2018) Licia Iaccarino et al.   GENES CHROMOSOMES & CANCER

Efp promotes in vitro and in vivo growth of endometrial cancer cells along with the activation of nuclear factor-κB signaling

(2018) Wataru Sato et al.   PLoS One

TRIM32 overexpression improves chemoresistance through regulation of mitochondrial function in non-small-cell lung cancers

(2018) Yaming Du et al.   OncoTargets and Therapy

TRIM59 promotes breast cancer motility by suppressing p62-selective autophagic degradation of PDCD10

(2018) Peng Tan et al.   PLOS BIOLOGY

Cytoplasmic E3 ubiquitin ligase CUL9 controls cell proliferation, senescence, apoptosis and genome integrity through p53

(2017) Z Li et al.   ONCOGENE

TRIM59 facilitates the proliferation of colorectal cancer and promotes metastasis via the PI3K/AKT pathway

(2017) Ye Sun et al.   ONCOLOGY REPORTS

DNA damage induces expression of WWP1 to target ΔNp63α to degradation

(2017) Ji Chen et al.   PLoS One

Reduced abundance of the E3 ubiquitin ligase E6AP contributes to decreased expression of theINK4/ARFlocus in non–small cell lung cancer

(2017) Cristina Gamell et al.   Science Signaling

The Ubiquitin Code in the Ubiquitin-Proteasome System and Autophagy

(2017) Yong Tae Kwon et al.   TRENDS IN BIOCHEMICAL SCIENCES

E6AP promotes prostate cancer by reducing p27 expression

(2017) Dinesh Raghu et al.   Oncotarget

Protein SUMOylation modification and its associations with disease

(2017) Yanfang Yang et al.   Open Biology

Reduced abundance of the E3 ubiquitin ligase E6AP contributes to decreased expression of theINK4/ARFlocus in non–small cell lung cancer

(2017) Cristina Gamell et al.   Science Signaling

Long story short: p53 mediates innate immunity

(2016) Jessica Miciak et al.   BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER

Commentary on “Participation of p53 Protein in the Cellular Response to DNA Damage”

(2016) Michael B. Kastan   CANCER RESEARCH

Ubiquitin modifications

(2016) Kirby N Swatek et al.   CELL RESEARCH

TRIM32 ubiquitin E3 ligase, one enzyme for several pathologies: From muscular dystrophy to tumours

(2016) Elisa Lazzari et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

KAP1 is overexpressed in hepatocellular carcinoma and its clinical significance

(2016) Yanying Wang et al.   International Journal of Clinical Oncology

Mechanisms of HBV-induced hepatocellular carcinoma

(2016) Massimo Levrero et al.   JOURNAL OF HEPATOLOGY

System-Wide Modulation of HECT E3 Ligases with Selective Ubiquitin Variant Probes

(2016) Wei Zhang et al.   MOLECULAR CELL

A novel TRIM family member, Trim69, regulates zebrafish development through p53-mediated apoptosis

(2016) Ruiqin Han et al.   MOLECULAR REPRODUCTION AND DEVELOPMENT

Overexpression of TRIM25 in Lung Cancer Regulates Tumor Cell Progression

(2016) Ying Qin et al.   TECHNOLOGY IN CANCER RESEARCH & TREATMENT

The ubiquitin ligase TRIM25 targets ERG for degradation in prostate cancer

(2016) Shan Wang et al.   Oncotarget

TRIM25 blockade by RNA interference inhibited migration and invasion of gastric cancer cells through TGF-β signaling

(2016) Zhenya Zhu et al.   Scientific Reports

The Paradox of p53: What, How, and Why?

(2016) Yael Aylon et al.   Cold Spring Harbor Perspectives in Medicine

The Regulation of Cellular Functions by the p53 Protein: Cellular Senescence

(2016) Crystal A. Tonnessen-Murray et al.   Cold Spring Harbor Perspectives in Medicine

Downregulation of RNF128 Predicts Progression and Poor Prognosis in Patients with Urothelial Carcinoma of the Upper Tract and Urinary Bladder

(2016) Yi-Ying Lee et al.   Journal of Cancer

Regulation of the Mdm2-p53 signaling axis in the DNA damage response and tumorigenesis

(2016) Michael I. Carr et al.   Translational Cancer Research

The ubiquitin ligase CHIP inactivates NF-κB signaling and impairs the ability of migration and invasion in gastric cancer cells

(2015) FEI LIU et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

TRIM24 suppresses development of spontaneous hepatic lipid accumulation and hepatocellular carcinoma in mice

(2015) Shiming Jiang et al.   JOURNAL OF HEPATOLOGY

TRIM28 as an independent prognostic marker plays critical roles in glioma progression

(2015) Zeng-Xin Qi et al.   JOURNAL OF NEURO-ONCOLOGY

Expression and prognostic role of ubiquitination factor E4B in primary hepatocellular carcinoma

(2015) Xiao-Fei Zhang et al.   MOLECULAR CARCINOGENESIS

TRIM25 has a dual function in the p53/Mdm2 circuit

(2015) P Zhang et al.   ONCOGENE

Src phosphorylation converts Mdm2 from a ubiquitinating to a neddylating E3 ligase

(2015) Christopher N. Batuello et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Clinical significance and biological roles of TRIM24 in human bladder carcinoma

(2015) Dongwei Xue et al.   TUMOR BIOLOGY

TRIM24 is upregulated in human gastric cancer and promotes gastric cancer cell growth and chemoresistance

(2015) Zhi-Feng Miao et al.   VIRCHOWS ARCHIV

p53 is active in murine stem cells and alters the transcriptome in a manner that is reminiscent of mutant p53

(2015) H Yan et al.   Cell Death & Disease

Dual Roles of RNF2 in Melanoma Progression

(2015) K. Rai et al.   Cancer Discovery

UBE4B targets phosphorylated p53 at serines 15 and 392 for degradation

(2015) Cheng Du et al.   Oncotarget

Knockdown of WWP1 inhibits growth and induces apoptosis in hepatoma carcinoma cells through the activation of caspase3 and p53

(2014) Qian Cheng et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

RBR E3 ubiquitin ligases: new structures, new insights, new questions

(2014) Donald E. Spratt et al.   BIOCHEMICAL JOURNAL

KAP1 Promotes Proliferation and Metastatic Progression of Breast Cancer Cells

(2014) J. B. Addison et al.   CANCER RESEARCH

Trim32 Facilitates Degradation of MYCN on Spindle Poles and Induces Asymmetric Cell Division in Human Neuroblastoma Cells

(2014) H. Izumi et al.   CANCER RESEARCH

E3 ubiquitin ligase TRIM32 negatively regulates tumor suppressor p53 to promote tumorigenesis

(2014) Ju Liu et al.   CELL DEATH AND DIFFERENTIATION

TRIM59 Is Up-regulated in Gastric Tumors, Promoting Ubiquitination and Degradation of p53

(2014) Zhicheng Zhou et al.   GASTROENTEROLOGY

TRIM24 Is a p53-Induced E3-Ubiquitin Ligase That Undergoes ATM-Mediated Phosphorylation and Autodegradation during DNA Damage

(2014) A. K. Jain et al.   MOLECULAR AND CELLULAR BIOLOGY

TRIM24 promotes glioma progression and enhances chemoresistance through activation of the PI3K/Akt signaling pathway

(2014) L-H Zhang et al.   ONCOGENE

Polycomb Group Oncogene RING1 is Over-expressed in Non-Small Cell Lung Cancer

(2014) Yiqun Zhou et al.   PATHOLOGY & ONCOLOGY RESEARCH

Overexpression of TRIM24 Is Associated with the Onset and Progress of Human Hepatocellular Carcinoma

(2014) Xiao Liu et al.   PLoS One

Arsenic Trioxide Reactivates Proteasome-Dependent Degradation of Mutant p53 Protein in Cancer Cells in Part via Enhanced Expression of Pirh2 E3 Ligase

(2014) Wensheng Yan et al.   PLoS One

Peptide and small molecule inhibitors of HECT-type ubiquitin ligases

(2014) Thomas Mund et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Prion-like aggregation of mutant p53 in cancer

(2014) Jerson L. Silva et al.   TRENDS IN BIOCHEMICAL SCIENCES

Autophagic degradation of the inhibitory p53 isoform Δ133p53α as a regulatory mechanism for p53-mediated senescence

(2014) Izumi Horikawa et al.   Nature Communications

Metastatic Lymph Node CHIP Expression is a Potential Prognostic Marker for Resected Esophageal Squamous Cell Carcinoma Patients

(2013) Jing Wen et al.   ANNALS OF SURGICAL ONCOLOGY

RNF38 encodes a nuclear ubiquitin protein ligase that modifies p53

(2013) Jamie E. Sheren et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

MDM2 is a useful prognostic biomarker for resectable gastric cancer

(2013) Yang Ye et al.   CANCER SCIENCE

CHIP/Stub1 functions as a tumor suppressor and represses NF- B-mediated signaling in colorectal cancer

(2013) Y. Wang et al.   CARCINOGENESIS

Grail as a molecular determinant for the functions of the tumor suppressor p53 in tumorigenesis

(2013) Y-C Chen et al.   CELL DEATH AND DIFFERENTIATION

Chaperone-mediated autophagy degrades mutant p53

(2013) H. Vakifahmetoglu-Norberg et al.   GENES & DEVELOPMENT

Knockdown of RNF2 induces apoptosis by regulating MDM2 and p53 stability

(2013) W Wen et al.   ONCOGENE

Loss of COP1 expression determines poor prognosis in patients with gastric cancer

(2013) GENTA SAWADA et al.   ONCOLOGY REPORTS

TRIM24 Overexpression Is Common in Locally Advanced Head and Neck Squamous Cell Carcinoma and Correlates with Aggressive Malignant Phenotypes

(2013) Zhibin Cui et al.   PLoS One

Msl2 Is a Novel Component of the Vertebrate DNA Damage Response

(2013) Zheng Lai et al.   PLoS One

RNF2/Ring1b negatively regulates p53 expression in selective cancer cell types to promote tumor development

(2013) W.-j. Su et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Integrative Analysis of Complex Cancer Genomics and Clinical Profiles Using the cBioPortal

(2013) J. Gao et al.   Science Signaling

Characterisation of human RING finger protein TRIM69, a novel testis E3 ubiquitin ligase and its subcellular localisation

(2012) Yongqing Han et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

E6AP ubiquitin ligase regulates PML-induced senescence in Myc-driven lymphomagenesis

(2012) K. Wolyniec et al.   BLOOD

The p53 isoforms are differentially modified by Mdm2

(2012) Suzanne Camus et al.   CELL CYCLE

Natural Product MDM2 Inhibitors: Anticancer Activity and Mechanisms of Action

(2012) J.-J. Qin et al.   CURRENT MEDICINAL CHEMISTRY

CHIP functions as a novel suppressor of tumour angiogenesis with prognostic significance in human gastric cancer

(2012) Shouyu Wang et al.   GUT

Liver-specific ablation of Krüppel-associated box-associated protein 1 in mice leads to male-predominant hepatosteatosis and development of liver adenoma

(2012) Karolina Bojkowska et al.   HEPATOLOGY

High Level of COP1 Expression is Associated with Poor Prognosis in Primary Gastric Cancer

(2012) Yuan-fang Li et al.   International Journal of Biological Sciences

UBE4B: A Promising Regulatory Molecule in Neuronal Death and Survival

(2012) Rami Zeinab et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Tripartite Motif Containing 28 (Trim28) Can Regulate Cell Proliferation by Bridging HDAC1/E2F Interactions

(2012) Lu Chen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Trim39 ubiquitin ligase inhibits APC/CCdh1-mediated degradation of the Bax activator MOAP-1

(2012) Nai-Jia Huang et al.   JOURNAL OF CELL BIOLOGY

p53 mutations in cancer

(2012) Patricia A. J. Muller et al.   NATURE CELL BIOLOGY

Androgen receptor degradation by the E3 ligase CHIP modulates mitotic arrest in prostate cancer cells

(2012) S Sarkar et al.   ONCOGENE

TRIM32 Regulates Skeletal Muscle Stem Cell Differentiation and Is Necessary for Normal Adult Muscle Regeneration

(2012) Sarah Nicklas et al.   PLoS One

Overexpression of TRIM24 Correlates with Tumor Progression in Non-Small Cell Lung Cancer

(2012) Haiying Li et al.   PLoS One

Ubiquitylation of p53 by the APC/C inhibitor Trim39

(2012) L. Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The double life of MULE in preeclamptic and IUGR placentae

(2012) A Rolfo et al.   Cell Death & Disease

Ginsenosides as anticancer agents: In vitro and in vivo activities, structure–activity relationships, and molecular mechanisms of action

(2012) Subhasree Ashok Nag   Frontiers in Pharmacology

Prognostic Significance of TRIM24/TIF-1α Gene Expression in Breast Cancer

(2011) Monique Chambon et al.   AMERICAN JOURNAL OF PATHOLOGY

Hoiamide D, a marine cyanobacteria-derived inhibitor of p53/MDM2 interaction

(2011) Karla L. Malloy et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Overexpression of ligase defective E6-associated protein, E6-AP, results in mammary tumorigenesis

(2011) Sivapriya Ramamoorthy et al.   BREAST CANCER RESEARCH AND TREATMENT

Cytoplasmic CUL9/PARC Ubiquitin Ligase Is a Tumor Suppressor and Promotes p53-Dependent Apoptosis

(2011) X.-H. Pei et al.   CANCER RESEARCH

MDM2 promotes SUMO-2/3 modification of p53 to modulate transcriptional activity

(2011) Maren H. Stindt et al.   CELL CYCLE

UBE4B, a ubiquitin chain assembly factor, is required for MDM2-mediated p53 polyubiquitination and degradation

(2011) Hong Wu et al.   CELL CYCLE

SAHA shows preferential cytotoxicity in mutant p53 cancer cells by destabilizing mutant p53 through inhibition of the HDAC6-Hsp90 chaperone axis

(2011) D Li et al.   CELL DEATH AND DIFFERENTIATION

WWP1: a versatile ubiquitin E3 ligase in signaling and diseases

(2011) Xu Zhi et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Inactivation ofarf-bp1Induces p53 Activation and Diabetic Phenotypes in Mice

(2011) Ning Kon et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

TRIM32 Protein Sensitizes Cells to Tumor Necrosis Factor (TNFα)-induced Apoptosis via Its RING Domain-dependent E3 Ligase Activity against X-linked Inhibitor of Apoptosis (XIAP)

(2011) Yeung Sook Ryu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mutant p53 Protein Is Targeted by Arsenic for Degradation and Plays a Role in Arsenic-mediated Growth Suppression

(2011) Wensheng Yan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

CHIP E3 ligase regulates mammalian senescence by modulating the levels of oxidized proteins

(2011) Christina Sisoula et al.   MECHANISMS OF AGEING AND DEVELOPMENT

Functional Inactivation of Endogenous MDM2 and CHIP by HSP90 Causes Aberrant Stabilization of Mutant p53 in Human Cancer Cells

(2011) D. Li et al.   MOLECULAR CANCER RESEARCH

PGC-1α, a Key Modulator of p53, Promotes Cell Survival upon Metabolic Stress

(2011) Nirmalya Sen et al.   MOLECULAR CELL

UBE4B promotes Hdm2-mediated degradation of the tumor suppressor p53

(2011) Hong Wu et al.   NATURE MEDICINE

Role of Pirh2 in Mediating the Regulation of p53 and c-Myc

(2011) Anne Hakem et al.   PLoS Genetics

The cullin protein family

(2011) Antonio Sarikas et al.   GENOME BIOLOGY

E3 ubiquitin protein ligase, E6-associated protein (E6-AP) regulates PI3K-Akt signaling and prostate cell growth

(2010) Sathish Srinivasan et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Deficiency of the dual ubiquitin/SUMO ligase Topors results in genetic instability and an increased rate of malignancy in mice

(2010) Henderson Marshall et al.   BMC MOLECULAR BIOLOGY

Knockdown of Efp by DNA-modified small interfering RNA inhibits breast cancer cell proliferation and in vivo tumor growth

(2010) K Ueyama et al.   CANCER GENE THERAPY

Definition of Ubiquitination Modulator COP1 as a Novel Therapeutic Target in Human Hepatocellular Carcinoma

(2010) Y.-H. Lee et al.   CANCER RESEARCH

14-3-3  Exerts Tumor-Suppressor Activity Mediated by Regulation of COP1 Stability

(2010) C.-H. Su et al.   CANCER RESEARCH

Degradation of MDM2 by the Interaction between Berberine and DAXX Leads to Potent Apoptosis in MDM2-Overexpressing Cancer Cells

(2010) X. Zhang et al.   CANCER RESEARCH

CARPs enhance p53 turnover by degrading 14-3-3σ and stabilizing MDM2

(2010) Wensheng Yang et al.   CELL CYCLE

p53-Ubl fusions as models of ubiquitination, sumoylation and neddylation of p53

(2010) Stephanie A. Carter et al.   CELL CYCLE

The adenovirus E1B-55K oncoprotein induces SUMO modification of p53

(2010) Stefan Muller et al.   CELL CYCLE

First International p53 Isoforms Meeting: ‘p53 isoforms through evolution: from identification to biological function’

(2010) V Marcel et al.   CELL DEATH AND DIFFERENTIATION

CHIP-dependent p53 regulation occurs specifically during cellular senescence

(2010) Christina Sisoula et al.   FREE RADICAL BIOLOGY AND MEDICINE

The essence of senescence

(2010) T. Kuilman et al.   GENES & DEVELOPMENT

Substrate Phosphorylation and Feedback Regulation in JFK-promoted p53 Destabilization

(2010) Luyang Sun et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structural and Functional Comparison of the RING Domains of Two p53 E3 Ligases, Mdm2 and Pirh2

(2010) Jonathan Shloush et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Adenovirus E1B 55-Kilodalton Protein Is a p53-SUMO1 E3 Ligase That Represses p53 and Stimulates Its Nuclear Export through Interactions with Promyelocytic Leukemia Nuclear Bodies

(2010) M. A. Pennella et al.   JOURNAL OF VIROLOGY

A genome-scale protein interaction profile of Drosophila p53 uncovers additional nodes of the human p53 network

(2010) A. Lunardi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

PML Nuclear Bodies

(2010) V. Lallemand-Breitenbach et al.   Cold Spring Harbor Perspectives in Biology

KAP1 Is Associated With Peritoneal Carcinomatosis in Gastric Cancer

(2009) Takeshi Yokoe et al.   ANNALS OF SURGICAL ONCOLOGY

RING Domain E3 Ubiquitin Ligases

(2009) Raymond J. Deshaies et al.   Annual Review of Biochemistry

p53-induced RING-H2 protein, a novel marker for poor survival in hepatocellular carcinoma after hepatic resection

(2009) Xiao-Min Wang et al.   CANCER

High expression of Pirh2, an E3 ligase for p27, is associated with low expression of p27 and poor prognosis in head and neck cancers

(2009) Mai Shimada et al.   CANCER SCIENCE

E6AP promotes the degradation of the PML tumor suppressor

(2009) I Louria-Hayon et al.   CELL DEATH AND DIFFERENTIATION

Regulation of p53 - insights into a complex process

(2009) Karen A Boehme et al.   CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY

Regulation of p53 family members by the ubiquitin-like SUMO system

(2009) Per Stehmeier et al.   DNA REPAIR

Differential regulation of p53 and p21 by MKRN1 E3 ligase controls cell cycle arrest and apoptosis

(2009) Eun-Woo Lee et al.   EMBO JOURNAL

Identification and Characterization of Two Novel Isoforms of Pirh2 Ubiquitin Ligase That Negatively Regulate p53 Independent of RING Finger Domains

(2009) Chad A. Corcoran et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Plk1-mediated Phosphorylation of Topors Regulates p53 Stability

(2009) Xiaoming Yang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Parthenolide promotes the ubiquitination of MDM2 and activates p53 cellular functions

(2009) Y.N. V. Gopal et al.   MOLECULAR CANCER THERAPEUTICS

Involvement of p53 in oroxylin A-induced apoptosis in cancer cells

(2009) Rong Mu et al.   MOLECULAR CARCINOGENESIS

JFK, a Kelch domain-containing F-box protein, links the SCF complex to p53 regulation

(2009) L. Sun et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Trim24 targets endogenous p53 for degradation

(2009) Kendra Allton et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Isoforms of the p53 Protein

(2009) M. P. Khoury et al.   Cold Spring Harbor Perspectives in Biology

Structural Biology of the Tumor Suppressor p53

(2008) Andreas C. Joerger et al.   Annual Review of Biochemistry

Discovery of new pyridoacridine alkaloids from Lissoclinum cf. badium that inhibit the ubiquitin ligase activity of Hdm2 and stabilize p53

(2008) Jason A. Clement et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Concepts of epigenetics in prostate cancer development

(2008) C S Cooper et al.   BRITISH JOURNAL OF CANCER

Tripartite Motif Protein 32 Facilitates Cell Growth and Migration via Degradation of Abl-Interactor 2

(2008) S. Kano et al.   CANCER RESEARCH

Regulation of turnover of tumor suppressor p53 and cell growth by E6-AP, a ubiquitin protein ligase mutated in Angelman mental retardation syndrome

(2008) A. Mishra et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

MDM2-A, a common Mdm2 splice variant, causes perinatal lethality, reduced longevity and enhanced senescence

(2008) E. L. Volk et al.   Disease Models & Mechanisms

Function and regulation of protein neddylation. ‘Protein Modifications: Beyond the Usual Suspects’ Review Series

(2008) Gwénaël Rabut et al.   EMBO REPORTS

MSL2 Promotes Mdm2-independent Cytoplasmic Localization of p53

(2008) Jan-Philipp Kruse et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Gambogic acid mediates apoptosis as a p53 inducer through down-regulation of mdm2 in wild-type p53-expressing cancer cells

(2008) Hongyan Gu et al.   MOLECULAR CANCER THERAPEUTICS

Genome-Wide and Functional Annotation of Human E3 Ubiquitin Ligases Identifies MULAN, a Mitochondrial E3 that Regulates the Organelle's Dynamics and Signaling

(2008) Wei Li et al.   PLoS One

p53 stabilization in response to DNA damage requires Akt/PKB and DNA-PK

(2008) K. A. Boehme et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA