WWP1: a versatile ubiquitin E3 ligase in signaling and diseases

WW Domain-containing E3 Ubiquitin Protein Ligase 1 (WWP1) Delays Cellular Senescence by Promoting p27Kip1Degradation in Human Diploid Fibroblasts

(2011) Xiaoxiao Cao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Estrogen Regulates Tumor Growth Through a Nonclassical Pathway that Includes the Transcription Factors ER  and KLF5

(2011) Y. Nakajima et al.   Science Signaling

Tumor necrosis factor inhibits mesenchymal stem cell differentiation into osteoblasts via the ubiquitin E3 ligase Wwp1

(2011) Lan Zhao et al.   STEM CELLS

The E3 ubiquitin ligase WWP1 regulates ΔNp63-dependent transcription through Lys63 linkages

(2010) Angelo Peschiaroli et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The Fbw7 Tumor Suppressor Targets KLF5 for Ubiquitin-Mediated Degradation and Suppresses Breast Cell Proliferation

(2010) Dong Zhao et al.   CANCER RESEARCH

Calcium Activates Nedd4 E3 Ubiquitin Ligases by Releasing the C2 Domain-mediated Auto-inhibition

(2010) Jian Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Multiple Interactions between the ESCRT Machinery and Arrestin-Related Proteins: Implications for PPXY-Dependent Budding

(2010) S. Rauch et al.   JOURNAL OF VIROLOGY

WWP-1 Is a Novel Modulator of the DAF-2 Insulin-Like Signaling Network Involved in Pore-Forming Toxin Cellular Defenses in Caenorhabditis elegans

(2010) Chang-Shi Chen et al.   PLoS One

Endogenous spartin (SPG20) is recruited to endosomes and lipid droplets and interacts with the ubiquitin E3 ligases AIP4 and AIP5

(2009) Thomas L. Edwards et al.   BIOCHEMICAL JOURNAL

Essential role of KLF5 transcription factor in cell proliferation and differentiation and its implications for human diseases

(2009) Jin-Tang Dong et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Overexpression of WWP1 is associated with the estrogen receptor and insulin-like growth factor receptor 1 in breast carcinoma

(2009) Ceshi Chen et al.   INTERNATIONAL JOURNAL OF CANCER

A role for ubiquitin ligases and Spartin/SPG20 in lipid droplet turnover

(2009) Scott W. Eastman et al.   JOURNAL OF CELL BIOLOGY

WW domain containing E3 ubiquitin protein ligase 1 targets the full-length ErbB4 for ubiquitin-mediated degradation in breast cancer

(2009) Y Li et al.   ONCOGENE

Identification and Structural Mechanism for a Novel Interaction between a Ubiquitin Ligase WWP1 and Nogo-A, a Key Inhibitor for Central Nervous System Regeneration†‡

(2008) Haina Qin et al.   BIOCHEMISTRY

WW domain-containing E3 ubiquitin protein ligase 1 targets p63 transcription factor for ubiquitin-mediated proteasomal degradation and regulates apoptosis

(2008) Y Li et al.   CELL DEATH AND DIFFERENTIATION

CHIP promotes Runx2 degradation and negatively regulates osteoblast differentiation

(2008) Xueni Li et al.   JOURNAL OF CELL BIOLOGY

Tumour-promoting activity of altered WWP1 expression in breast cancer and its utility as a prognostic indicator

(2008) NS Nguyen Huu et al.   JOURNAL OF PATHOLOGY

The E3 Ubiquitin Ligase WWP1 Selectively Targets HER4 and Its Proteolytically Derived Signaling Isoforms for Degradation

(2008) S.-M. Feng et al.   MOLECULAR AND CELLULAR BIOLOGY

The WW domain containing E3 ubiquitin protein ligase 1 upregulates ErbB2 and EGFR through RING finger protein 11

(2008) C Chen et al.   ONCOGENE