MUC1-C oncoprotein as a target in breast cancer: activation of signaling pathways and therapeutic approaches

Randomized Phase II Trial of Letrozole plus Anti-MUC1 Antibody AS1402 in Hormone Receptor-Positive Locally Advanced or Metastatic Breast Cancer

(2011) N. K. Ibrahim et al.   CLINICAL CANCER RESEARCH

A Pilot Study of MUC-1/CEA/TRICOM Poxviral-Based Vaccine in Patients with Metastatic Breast and Ovarian Cancer

(2011) M. Mohebtash et al.   CLINICAL CANCER RESEARCH

Targeted therapies for breast cancer

(2011) Michaela J. Higgins et al.   JOURNAL OF CLINICAL INVESTIGATION

Overexpression of MUC1 Enhances Proangiogenic Activity of Non-Small-Cell Lung Cancer Cells Through Activation of Akt and Extracellular Signal-regulated Kinase Pathways

(2011) Mengying Yao et al.   LUNG

Dependence on the MUC1-C Oncoprotein in Non-Small Cell Lung Cancer Cells

(2011) D. Raina et al.   MOLECULAR CANCER THERAPEUTICS

Mucin 1 C-Terminal Subunit Oncoprotein Is a Target for Small-Molecule Inhibitors

(2011) Y. Zhou et al.   MOLECULAR PHARMACOLOGY

Galectin-3 regulates MUC1 and EGFR cellular distribution and EGFR downstream pathways in pancreatic cancer cells

(2011) J Merlin et al.   ONCOGENE

The Cytoplasmic Domain of MUC1 Induces Hyperplasia in the Mammary Gland and Correlates with Nuclear Accumulation of β-Catenin

(2011) Yuan Li et al.   PLoS One

MUC1-C Oncoprotein Regulates Glycolysis and Pyruvate Kinase m2 Activity in Cancer Cells

(2011) Michio Kosugi et al.   PLoS One

MUC1-C Oncoprotein Promotes STAT3 Activation in an Autoinductive Regulatory Loop

(2011) R. Ahmad et al.   Science Signaling

Functional targeting of the MUC1 oncogene in human cancers

(2010) Donald W. Kufe   CANCER BIOLOGY & THERAPY

MUC1 oncogene amplification correlates with protein overexpression in invasive breast carcinoma cells

(2010) E. Lacunza et al.   CANCER GENETICS AND CYTOGENETICS

MUC1 regulates nuclear localization and function of the epidermal growth factor receptor

(2010) B. G. Bitler et al.   JOURNAL OF CELL SCIENCE

MUC1-C Oncoprotein Functions as a Direct Activator of the Nuclear Factor- B p65 Transcription Factor

(2009) R. Ahmad et al.   CANCER RESEARCH

MUC1-Induced Transcriptional Programs Associated with Tumorigenesis Predict Outcome in Breast and Lung Cancer

(2009) N. N. Khodarev et al.   CANCER RESEARCH

Direct Targeting of the Mucin 1 Oncoprotein Blocks Survival and Tumorigenicity of Human Breast Carcinoma Cells

(2009) D. Raina et al.   CANCER RESEARCH

MicroRNA-145 Suppresses Cell Invasion and Metastasis by Directly Targeting Mucin 1

(2009) M. Sachdeva et al.   CANCER RESEARCH

Wnt/β-Catenin Signaling: Components, Mechanisms, and Diseases

(2009) Bryan T. MacDonald et al.   DEVELOPMENTAL CELL

ERK and PI3K regulate different aspects of the epithelial to mesenchymal transition of mammary tumor cells induced by truncated MUC1

(2009) Galit Horn et al.   EXPERIMENTAL CELL RESEARCH

MUC1 oncoprotein is a druggable target in human prostate cancer cells

(2009) M. D. Joshi et al.   MOLECULAR CANCER THERAPEUTICS

Targeting the phosphoinositide 3-kinase pathway in cancer

(2009) Pixu Liu et al.   NATURE REVIEWS DRUG DISCOVERY

Cooperativity of the MUC1 oncoprotein and STAT1 pathway in poor prognosis human breast cancer

(2009) N Khodarev et al.   ONCOGENE

MUC1-induced alterations in a lipid metabolic gene network predict response of human breast cancers to tamoxifen treatment

(2009) S. P. Pitroda et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Shared Principles in NF-κB Signaling

(2008) Matthew S. Hayden et al.   CELL

Pilot Study of Vaccination with Recombinant CEA-MUC-1-TRICOM Poxviral-Based Vaccines in Patients with Metastatic Carcinoma

(2008) J. L. Gulley et al.   CLINICAL CANCER RESEARCH

Phosphorylation of MUC1 by Met Modulates Interaction with p53 and MMP1 Expression

(2008) Pankaj K. Singh et al.   JOURNAL OF BIOLOGICAL CHEMISTRY