Article
Developmental Biology
Lila Gannoun, Catalina De Schrevel, Morgane Belle, Nicolas Dauguet, Younes Achouri, Axelle Loriot, Christophe Vanderaa, Sabine Cordi, Alexandra Dili, Yves Heremans, Ilse Rooman, Isabelle A. Leclercq, Patrick Jacquemin, Laurent Gatto, Frederic P. Lemaigre
Summary: This study identifies new regulators in liver development and explores their functions in both health and liver regeneration. Experimental evidence demonstrates the significance of specific signaling pathways in portal area development and maturation of vascular smooth muscle cells in the hepatic artery.
Review
Chemistry, Medicinal
Jiaojiao Guo, Zhouling Xie, Wei Ruan, Qidong Tang, Dan Qiao, Wufu Zhu
Summary: The overuse of antibiotics has led to the emergence of antibiotic resistance, especially in Methicillin-resistant Staphylococcus aureus (MRSA), which is a common and virulent bacterium in clinical practice. Researchers have focused on developing new candidate drugs, particularly thiazole derivatives, that can effectively overcome MRSA resistance with reduced toxicity.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2023)
Article
Biology
Carter J. Barger, Linda Chee, Mustafa Albahrani, Catalina Munoz-Trujillo, Lidia Boghean, Connor Branick, Kunle Odunsi, Ronny Drapkin, Lee Zou, Adam R. Karpf
Summary: FOXM1 and RHNO1 are co-amplified and co-expressed in high-grade serous carcinoma, and their bidirectional promoter may serve as a potential therapeutic target for ovarian and other cancers. Their oncogenic properties in HGSC cells highlight the significance of targeting the FOXM1/RHNO1 gene pair in cancer therapy.
Article
Engineering, Environmental
Zhao Cheng, Daheng Ren, Shaolin Yang, Longkai Qiao, Yanchen Liu, Xia Huang
Summary: This study investigated the removal profiles of antibiotics and antibiotic resistance genes (ARGs) during urine nitritation. The results showed that sulfamethoxazole and roxithromycin were effectively eliminated, while trimethoprim and chloramphenicol had low removal efficiency. Ammonia oxidation bacteria and heterotrophic bacteria played important roles in sulfamethoxazole degradation.
JOURNAL OF HAZARDOUS MATERIALS
(2022)
Article
Biochemistry & Molecular Biology
Xiao Wang, Xiao Wang, Ning Dou, Jialin Wang, Yi Zhang, Yandong Li, Yong Gao
Summary: The study revealed that FOXM1 activates miR-552 to promote pancreatic cancer progression and cell migration. Additionally, miR-552 also influences pancreatic cancer development by downregulating tumor suppressor genes like DACH1, PCDH10, and SMAD4.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2021)
Review
Environmental Sciences
Ranjith Kumar Manoharan, Fahmida Ishaque, Young-Ho Ahn
Summary: This paper discusses the emergence of antibiotic-resistant bacteria and antibiotic-resistant genes in aquatic environments, as well as the methods for their removal. Different treatment methods are analyzed and discussed. The advantages and disadvantages of various integrated technologies are also presented, along with possible solutions to reduce the discharge of antibiotic-resistant genes.
Article
Chemistry, Medicinal
Juan Xia, Liang Xin, Jingyi Li, Lei Tian, Kangxiong Wu, Shaojun Zhang, Wenjing Yan, Han Li, Qianqian Zhao, Chengyuan Liang
Summary: The design, synthesis, antibacterial activities, and structure-activity relationships of quaternary amine C-14 side chain-containing pleuromutilin derivatives were investigated. Most of these derivatives exhibited broad-spectrum antibacterial activity. Among them, 10b showed excellent antibacterial activity against MRSA and remarkable antimycoplasma activity, rapid bactericidal effects, and a strong ability to damage bacterial biofilms. Further mechanistic studies revealed that 10b exerted its antibacterial effects through the destruction of bacterial cell membranes.
JOURNAL OF MEDICINAL CHEMISTRY
(2023)
Article
Zoology
Dan Jin, Binda Sun, Wenqi Zhao, Jincheng Ma, Qiuyue Zhou, Xuemeng Han, Yalin Mei, Yanhua Fan, Yan Pei
Summary: A mutant with decreased conidial production and hyphal growth in Beauveria bassiana was identified, linked to disruption in thiamine biosynthesis genes Bbthi and Bbpyr. This disruption significantly reduced thiamine content, affecting conidial production and hyphal growth, without impacting the virulence of B. bassiana. These findings emphasize the importance of thiamine biosynthesis in conidiation of entomopathogenic fungi for biocontrol of insect pests.
JOURNAL OF INVERTEBRATE PATHOLOGY
(2021)
Review
Environmental Sciences
Ting-ting Zhu, Zhong-xian Su, Wen-xia Lai, Yao-bin Zhang, Yi-wen Liu
Summary: This review discusses the fate of antibiotics and ARGs in wastewater treatment plants, highlighting the importance of biological treatment technologies and combined processes. It emphasizes that adsorption and biodegradation are the major removal pathways for antibiotics, and suggests further investigation into combined technologies for future application prospects.
SCIENCE OF THE TOTAL ENVIRONMENT
(2021)
Article
Cell Biology
Jerry Hung-Hao Lo, Miguel Edwards, Justin Langerman, Rupa Sridharan, Kathrin Plath, Stephen T. Smale
Summary: By examining dynamic ranges of gene expression, the authors found that Oct4 and Sox2 binding is enriched near genes with large dynamic ranges of expression. Their results suggest that Oct4 and Sox2 directly establish both active and silent transcriptional states in pluripotent cells at a large number of genes subject to dynamic regulation.
GENES & DEVELOPMENT
(2022)
Article
Multidisciplinary Sciences
Chen Dong, Shuhua Fu, Rowan M. Karvas, Brian Chew, Laura A. Fischer, Xiaoyun Xing, Jessica K. Harrison, Pooja Popli, Ramakrishna Kommagani, Ting Wang, Bo Zhang, Thorold W. Theunissen
Summary: The authors systematically identify and characterize essential and growth-restricting genes in human trophoblast cells through a genome-wide CRISPR-Cas9 knockout screen. They reveal TEAD1 as a key regulator modulating chromatin architecture and gene expression to play a crucial role in the specification, maintenance, and differentiation of the human trophoblast lineage.
NATURE COMMUNICATIONS
(2022)
Article
Multidisciplinary Sciences
Chao Liu, Lingang Sun, Yijun Tan, Qi Wang, Tao Luo, Chenlu Li, Nan Yao, Yuting Xie, Xiao Yi, Yi Zhu, Tiannan Guo, Junfeng Ji
Summary: USP7 plays an important role in maintaining the identity of mouse embryonic stem cells (mESCs) by regulating the transcriptional network. It represses lineage differentiation genes through both catalytic activity-dependent and -independent mechanisms, and stabilizes the transcription factor SOX2 to suppress the expression of mesoendodermal lineage genes. Additionally, it contributes to Polycomb chromatin-mediated repression of lineage genes.
Review
Environmental Sciences
Rui Zhang, Shu Yang, Yuwei An, Yangqing Wang, Yu Lei, Liyan Song
Summary: Landfill serves as important reservoirs for antibiotics and antibiotic resistance genes, with risks of transferring to the local environment. Studies have shown complex linkages among antibiotics, ARGs, and bacterial communities, highlighting the need for further research.
SCIENCE OF THE TOTAL ENVIRONMENT
(2022)
Article
Biochemistry & Molecular Biology
Zongshuai Li, Yina Li, Qiran Zhang, Wenbo Ge, Yong Zhang, Xingxu Zhao, Junjie Hu, Ligang Yuan, Wangdong Zhang
Summary: In this study, Bactrian camel induced pluripotent stem cells (bciPSCs) were successfully generated by transferring four mouse genes into Bactrian camel fetal fibroblasts. The pluripotency of the bciPSCs was confirmed through various analyses, although late formation of stem cell clones was observed. The identification of potential unique pluripotent genes in Bactrian camels provides valuable information for future bciPSC production.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Engineering, Environmental
Nian-Si Fan, Jin-Jin Fu, Dong-Qi Huang, Yuan-Long Ma, Zheng-Yang Lu, Ren-Cun Jin, Ping Zheng
Summary: High concentrations of antibiotics ETC and SMZ had significant inhibitory effects on the nitrogen removal performance of the anammox process, with the combined inhibitory effect being more significant. The anammox process was able to quickly recover from deterioration, possibly attributed to the increase in ARGs and secretion of EPS.
Letter
Gastroenterology & Hepatology
Hazel O'Sullivan, Fergal C. Kelleher, Maire Lavelle, Brianan McGovern, Jean Murphy, Niall Swan, Ray McDermott
Article
Gastroenterology & Hepatology
Fergal C. Kelleher, Grainne Callaghan, Catriona Gallagher, Hazel O'Sullivan
WORLD JOURNAL OF GASTROENTEROLOGY
(2017)
Review
Oncology
Fergal C. Kelleher, Hazel O'Sullivan
JOURNAL OF ADOLESCENT AND YOUNG ADULT ONCOLOGY
(2017)
Editorial Material
Oncology
Mary Clare McKenna, Kevin Molloy, Stephen Crowther, John Feeney, Amy Gillis, Maureen Connolly, Fergal Kelleher
JOURNAL OF ONCOLOGY PRACTICE
(2018)
Review
Oncology
Fergal C. Kelleher, Jeska Kroes, Jeremy Lewin
Article
Health Care Sciences & Services
Ciaran Kenny, Julie Regan, Lucy Balding, Stephen Higgins, Norma O'Leary, Fergal Kelleher, Ray McDermott, John Armstrong, Alina Mihai, Eoin Tiernan, Jennifer Westrup, Pierre Thirion, Declan Walsh
JOURNAL OF PAIN AND SYMPTOM MANAGEMENT
(2019)
Article
Medicine, Research & Experimental
Sinead Toomey, Aoife Carr, Mateusz Janusz Mezynski, Yasir Elamin, Shereen Rafee, Mattia Cremona, Clare Morgan, Stephen Madden, Khairun I. Abdul-Jalil, Kathy Gately, Angela Farrelly, Elaine W. Kay, Susan Kennedy, Kenneth O'Byrne, Liam Grogan, Oscar Breathnach, Patrick G. Morris, Alexander J. Eustace, Joanna Fay, Robert Cummins, Anthony O'Grady, Roshni Kalachand, Norma O'Donovan, Fergal Kelleher, Aine O'Reilly, Mark Doherty, John Crown, Bryan T. Hennessy
JOURNAL OF TRANSLATIONAL MEDICINE
(2020)
Review
Health Care Sciences & Services
Victoria Mallett, Anna Linehan, Orla Burke, Laura Healy, Sara Picardo, Catherine M. Kelly, John McCaffrey, Des Carney, Ray McDermott, Janice Walshe, Fergal Kelleher, Stephen Higgins, Karen Ryan, Michaela J. Higgins
Summary: This study found that patients who received chemotherapy at the end-of-life in Ireland were more likely to be admitted to hospital, undergo invasive procedures, and die in the hospital. They were also less likely to be referred early to specialist palliative care services.
AMERICAN JOURNAL OF HOSPICE & PALLIATIVE MEDICINE
(2021)
Article
Oncology
Juliette E. Hamilton, Michael Alexander, Fergal C. Kelleher
CLINICAL SARCOMA RESEARCH
(2020)
Article
Oncology
Diya M. Sabu, Jeska Kroes, Charles Gilham, Ann Fleming, Fergal C. Kelleher
Summary: Basal cell carcinomas are common in Caucasian populations, with the Hedgehog pathway playing a significant role in their development. This case highlights the dramatic response of an elderly patient with untreated sporadic Basal cell carcinoma to the Hedgehog pathway inhibitor Vismodegib, enabling definitive treatment to be pursued.
CURRENT PROBLEMS IN CANCER
(2021)
Meeting Abstract
Medicine, General & Internal
M. Quinn, M. L. Healy, F. Kelleher, A. Pazderska
IRISH JOURNAL OF MEDICAL SCIENCE
(2019)
Meeting Abstract
Dermatology
L. Nestor, J. Aird, R. Coleman, P. Ormond, N. Leonard, C. Healy, E. Calonje, D. Gallagher, F. Kelleher, M. McMenamin
BRITISH JOURNAL OF DERMATOLOGY
(2018)
Meeting Abstract
Gastroenterology & Hepatology
G. M. Callaghan, F. C. Kelleher, P. F. Ridgway, B. M. Ryan
Article
Oncology
Dermot O'Sullivan, Paul Dowling, Helena Joyce, Edel McAuley, Andrew McCann, Michael Henry, Brianan McGovern, Paul Barham, Fergal C. Kelleher, Jean Murphy, Susan Kennedy, Niall Swan, Michael Moriarty, Martin Clynes, Annemarie Larkin
BRITISH JOURNAL OF CANCER
(2017)
Meeting Abstract
Medicine, General & Internal
C. Anderson, S. McKenna, A. Santos, J. Westrup, F. Kelleher, M. Griffin
IRISH JOURNAL OF MEDICAL SCIENCE
(2017)