Article
Plant Sciences
Giovanna Salbitani, Angela Perrone, Luigi Rosati, Carmen Laezza, Simona Carfagna
Summary: This study investigates the effects of sulfur deprivation on Galdieria sulphuraria and reveals that it leads to a decrease in total protein content and an increase in soluble protein fraction. The glutathione content in Galdieria sulphuraria remains high even under sulfur deprivation.
Article
Environmental Sciences
Manuela D. Machado, Eduardo V. Soares
Summary: This study revealed that the herbicide MET had negative effects on the redox homeostasis of the freshwater green alga Pseudokirchneriella subcapitata, leading to an increase in reactive oxygen species and a decrease in antioxidant molecules and enzyme activity. The imbalance caused oxidative damage to the cell membrane, highlighting the importance of toxicological studies in assessing the impact of herbicides in freshwater environments.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2021)
Article
Biochemistry & Molecular Biology
Jing Wang, Xingyu Zhao, Jiawei Zheng, Daniela D. Herrera-Balandrano, Xiaoxiao Zhang, Wuyang Huang, Zhongquan Sui
Summary: Blueberries are rich in anthocyanins which have positive concentration-dependent antioxidant activity in mice. They improve antioxidant defense by increasing total antioxidant capacity, reducing oxidative stress marker levels, and enhancing enzyme activity and mRNA levels.
JOURNAL OF ZHEJIANG UNIVERSITY-SCIENCE B
(2023)
Article
Biochemistry & Molecular Biology
Kenji Watanabe, Shuichi Shibuya, Yusuke Ozawa, Toshihiko Toda, Takahiko Shimizu
Summary: The study showed that p53 regulated ROS-mediated apoptotic cell death and tumorigenesis, but did not affect ROS-mediated tissue degeneration in SOD-deficient models.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Gita Kholghi, Vahide Alipour, Maede Rezaie, Mohammad-Reza Zarrindast, Salar Vaseghi
Summary: Sleep deprivation has negative effects on cognitive functions, but some studies suggest it may improve cognitive functions. This study investigated the effects of 4-hour and 24-hour sleep deprivation, as well as mild short-term and moderate long-term treadmill exercise, on spatial memory performance and oxidative and antioxidant markers in rats. The results showed that 24-hour sleep deprivation and long-term moderate treadmill exercise had negative effects on memory and oxidative status. However, both treadmill exercise protocols reversed the negative effects of sleep deprivation on memory and oxidative stress.
NEUROCHEMICAL RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Edurne Tellechea, Aaron C. Asensio, Paula Ciaurriz, Javier Buezo, Pedro Lopez-Gomez, Marina Urra, Jose F. Moran
Summary: This study investigates the characteristics of the recombinant cowpea FeSOD immobilized onto gold nanoparticles (AuNPs) and the effects of NP surface chemistry and biofunctionalization methods on enzyme activity. The results highlight the importance of the biomolecule and AuNP interaction for the functionality of the hybrid and demonstrate the potential of these strategies in biomedical applications.
Review
Biochemistry & Molecular Biology
Mi Yang, Xiaofei Zhou, Xi Tan, Xincheng Huang, Lu Yuan, Zipeng Zhang, Yan Yang, Min Xu, Ying Wan, Zezhi Li
Summary: Alcohol dependence leads to oxidative stress in the body, as evident from the changes observed in the levels of oxidative stress biomarkers. This meta-analysis highlights the decreased activities of superoxide dismutase (SOD) and glutathione peroxidase (GPx) enzymes and lower levels of albumin, along with increased levels of malondialdehyde (MDA), vitamin B12, homocysteine, and bilirubin in patients with alcohol dependence.
Article
Plant Sciences
Alka Sagar, R. Z. Sayyed, Pramod W. Ramteke, Wusirika Ramakrishna, Peter Poczai, Sami Al Obaid, Mohammad Javed Ansari
Summary: This study evaluated the plant growth-promoting potential of a bacterial isolate PR19 (Azotobacter nigricans) obtained from organic farm soil and found that it could be combined with inorganic fertilizer for maize cultivation, resulting in improved growth and yield.
FRONTIERS IN PLANT SCIENCE
(2022)
Article
Multidisciplinary Sciences
Noorah Saleh Al-Sowayan, Reema Mohammad AL-Sallali
Summary: The anti-diabetic and antioxidant effects of aloin were examined in this study. Results showed that aloin significantly decreased blood glucose levels and increased insulin levels, while reducing malondialdehyde levels in the liver and kidneys and increasing the levels of catalase, superoxide dismutase, and glutathione. Histological assessment of the pancreas was also performed. Therefore, aloin has potential as an anti-diabetic and antioxidant agent at a dose of 30 mg/kg body weight for 30 days.
JOURNAL OF KING SAUD UNIVERSITY SCIENCE
(2023)
Review
Biochemistry & Molecular Biology
Vlad Sever Neculicioiu, Ioana Alina Colosi, Carmen Costache, Dan Alexandru Toc, Alexandra Sevastre-Berghian, Horatiu Alexandru Colosi, Simona Clichici
Summary: Sleep deprivation is a widespread issue in modern society, with unclear effects on oxidative stress. This review analyzed experimental data from studies on rat models conducted between 2015 and 2022, and found that sleep deprivation appears to affect oxidative stress parameters, indicating a potential antioxidant role of sleep. The effects of sleep deprivation were observed in different protocols and rat strains, and extended beyond the central nervous system to other body sites. Sleep recovery exhibited variability, with some parameters normalizing and others showing long-lasting changes. The presence of a stress response following sleep deprivation was also noted, but its origin and impact remain unclear.
Article
Chemistry, Medicinal
Ya Wu, Jing Hu, Xingyao Long, Yanni Pan, Jianfei Mu, Kun-Young Park, Xin Zhao
Summary: LP-ZS62 can effectively alleviate alcohol-induced gastric injury by regulating antioxidant capacity, suggesting its potential therapeutic value in treating alcoholic gastric injury.
DRUG DESIGN DEVELOPMENT AND THERAPY
(2021)
Article
Food Science & Technology
Nan Zhang, Yuan Tian, Yu Wang, Yuling Fan, Yue Zhang, Xinyue Xing, Bo Nan, Zhiyi Ai, Xia Li, Yuhua Wang
Summary: This study found that Lactobacillus plantarum Lp2 has antioxidant properties and can alleviate liver injury caused by cyclophosphamide. It improves CTX-induced oxidative damage and hepatocyte apoptosis by inhibiting the MAPKs pathway and strengthening the Nrf2/HO-1/NQO1 antioxidant defense system.
FOOD AND CHEMICAL TOXICOLOGY
(2022)
Article
Multidisciplinary Sciences
Nurkhasanah Mahfudh, Nanik Sulistyani, Asiilah Fatihatul Khoirot, Tsanawiyah Indah Safira, Fezah Othman, Zainul Amiruddin Zakaria
Summary: This study investigated the effect of the ethanol extract of purple sweet potato leaves on the endogenous antioxidant activity in hyperlipidemic rats. The results showed that the extract significantly increased the activities of SOD, CAT, and GSH-Px, and lowered the MDA level.
Review
Chemistry, Multidisciplinary
Namrata Singh, G. R. Sherin, Govindasamy Mugesh
Summary: Nanozymes, nanomaterials with enzyme-mimicking activity, have attracted significant interest in biomedical applications, particularly in oxidative stress-mediated disorders. The challenge lies in designing nanozymes that can selectively differentiate between physiological oxidative stress and pathological oxidative stress and mediate appropriate redox reactions in cells, tissues, and organs. This review summarizes the advancements in redox-active nanozymes and their therapeutic significance in various disease models, such as cancer, neurodegeneration, and cardiovascular diseases. It also discusses the future prospects and challenges associated with the biomedical applications of nanozymes.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Nutrition & Dietetics
Yi Gan, Jin Tong, Xianrong Zhou, Xingyao Long, Yanni Pan, Weiwei Liu, Xin Zhao
Summary: The study found that the bacterial strain Lactobacillus plantarum HFY09 exhibited significant liver protective effects in mice with ethanol-induced liver injury, improving liver function by regulating various physiological indicators as well as gene expression levels.
FRONTIERS IN NUTRITION
(2021)
Article
Agriculture, Multidisciplinary
I-Chen Li, Shan Lin, Yueh-Ting Tsai, Jui-Hsia Hsu, Yen-Lien Chen, Wen-Hsin Lin, Chin-Chu Chen
JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE
(2019)
Article
Food Science & Technology
Shyang-Chwen Sheu, Po-Chuan Tsou, Yi-Yang Lien, Meng-Shiou Lee
EUROPEAN FOOD RESEARCH AND TECHNOLOGY
(2020)
Article
Food Science & Technology
Shyang-Chwen Sheu, Jhong-Yong Huang, Yi-Yang Lien, Meng-Shiou Lee
JOURNAL OF FOOD SCIENCE AND TECHNOLOGY-MYSORE
(2020)
Article
Nutrition & Dietetics
Li-Chan Yang, Shih-Wei Lin, I-Chen Li, Yen-Po Chen, Shih-Yang Tzu, Wei Chou, Chin-Chu Chen, Wen-Chuan Lin, Yen-Lien Chen, Wen-Hsin Lin
Article
Chemistry, Medicinal
Hui-Chi Huang, Wen-Te Chang, Meng-Shiou Lee, Hsing-Yu Chen, Yu-Hua Chen, Chi-Chen Lin, Ming-Kuem Lin
Summary: The study demonstrated that bufadienolides isolated from Kalanchoe tubiflora did not induce apoptosis but rather activated an autophagy pathway in highly metastatic human lung cancer cells. These bufadienolides induced autophagy was linked to the down-regulation of p-mTOR and the up-regulation of various proteins, providing evidence of their potential therapeutic strategy for lung cancer.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2021)
Article
Chemistry, Applied
Shyang-Chwen Sheu, Min-Tse Yu, Yi-Yang Lien, Meng-Shiou Lee
Article
Biochemistry & Molecular Biology
Shan-Ling Hsu, Wen-Yi Chou, Chieh-Cheng Hsu, Jih-Yang Ko, Shun-Wun Jhan, Ching-Jen Wang, Meng-Shiou Lee, Tsai-Chin Hsu, Jai-Hong Cheng
Article
Integrative & Complementary Medicine
Shih-Wei Lin, You-Shan Tsai, Yen-Lien Chen, Ming-Fu Wang, Chin-Chu Chen, Wen-Hsin Lin, Tony J. Fang
Summary: Probiotics GKS6 and GKK2 demonstrated antioxidative effects in delaying aging and preventing age-related muscle loss in SAMP8 mice.
EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
(2021)
Article
Nutrition & Dietetics
Shih-Wei Lin, You-Shan Tsai, Yen-Lien Chen, Ming-Fu Wang, Chin-Chu Chen, Wen-Hsin Lin, Tony J. Fang
Summary: The study revealed that the probiotic Lactobacillus plantarum GKM3 has significant effects in delaying aging, alleviating age-related cognitive impairment, and reducing oxidative stress.
Article
Agricultural Engineering
Hui-Chi Huang, Wen-Te Chang, Yi-Hsuan Wu, Bo-Cheng Yang, Mo-Rong Xu, Ming-Kuem Lin, Hsi-Jien Chen, Jai-Hong Cheng, Meng-Shiou Lee
Summary: In this study, microbial fermentation of Hibiscus sabdariffa L. calyx extract was used to enhance its phytochemical constituents and biological activity, resulting in increased antioxidant activity and phenolic content, especially with Galactomyces geotrichum inoculation. The optimized fermentation conditions included 1% eHS addition and static culture method. High performance liquid chromatography (HPLC) and enzymatic activity analysis showed that the improved biological activities of fermented eHS were mainly due to increased levels of phenolic compounds, flavonoids, anthocyanin and its aglycone derivatives. This is the first report to demonstrate the use of microbial fermentation to improve the biological functionalities of fermented eHS.
INDUSTRIAL CROPS AND PRODUCTS
(2022)
Article
Medicine, General & Internal
Jai-Hong Cheng, Wen-Yi Chou, Ching-Jen Wang, Ka-Kit Siu, Jei-Ming Peng, Yi-No Wu, Meng-Shiou Lee, Chien-Yiu Huang, Jih-Yang Ko, Shun-Wun Jhan
Summary: This study demonstrated the effects of extracorporeal shockwave therapy (ESWT) on rat knee osteoarthritis (OA) and its associated pathological changes. The results revealed that ESWT had better outcomes in the medial group compared to the lateral group. The study also identified correlations between the modified Mankin score, tidemark roughness, and calcified cartilage thickness.
INTERNATIONAL JOURNAL OF MEDICAL SCIENCES
(2022)
Article
Biology
Shyang-Chwen Sheu, Yi-Cheng Wu, Yi-Yang Lien, Meng-Shiou Lee
Summary: A loop-mediated isothermal amplification (LAMP) method was developed for detecting C. longa DNA, allowing rapid and accurate identification of turmeric and prevention of adulteration, with a sensitivity 10 times higher than PCR.
SAUDI JOURNAL OF BIOLOGICAL SCIENCES
(2021)
Article
Food Science & Technology
Priya Rana, Shu-Yi Liaw, Meng-Shiou Lee, Shyang-Chwen Sheu
Summary: A new method was developed to discriminate four Cinnamomum species using physico-functional properties and chemometric techniques. The principal component analysis and multiclass discriminant analysis showed significant separation of the different species. The model proved to be valid and reliable with a 100% prediction rate upon testing.
Article
Oncology
Chia-Cheng Yu, Lih-Chyang Chen, Wen-Hsin Lin, Victor C. Lin, Chao-Yuan Huang, Te-Ling Lu, Cheng-Hsueh Lee, Shu-Pin Huang, Bo-Ying Bao
CANCER GENOMICS & PROTEOMICS
(2020)
Article
Integrative & Complementary Medicine
Chun-Hsien Chen, Hsin-Chun Chen, Wen-Te Chang, Meng-Shiou Lee, Yi-Chen Liu, Ming-Kuem Lin
AMERICAN JOURNAL OF CHINESE MEDICINE
(2020)