Optimize Prime/Boost Vaccine Strategies: Trained Immunity as a New Player in the Game

Safety and efficacy of an rAd26 and rAd5 vector-based heterologous prime-boost COVID-19 vaccine: an interim analysis of a randomised controlled phase 3 trial in Russia

(2021) Denis Y Logunov et al.   LANCET

Innate immune memory of tissue‐resident macrophages and trained innate immunity: Re‐vamping vaccine concept and strategies

(2020) Zhou Xing et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Prevention of tuberculosis in macaques after intravenous BCG immunization

(2020) Patricia A. Darrah et al.   NATURE

Myeloid Cell-Mediated Trained Innate Immunity in Mucosal AIDS Vaccine Development

(2020) Yongjun Sui et al.   Frontiers in Immunology

C/EBPβ-Dependent Epigenetic Memory Induces Trained Immunity in Hematopoietic Stem Cells

(2020) Bérengère de Laval et al.   Cell Stem Cell

Development of SARS-CoV-2 vaccines: should we focus on mucosal immunity?

(2020) Leticia Moreno-Fierros et al.   EXPERT OPINION ON BIOLOGICAL THERAPY

New live attenuated tuberculosis vaccine MTBVAC induces trained immunity and confers protection against experimental lethal pneumonia

(2020) Raquel Tarancón et al.   PLoS Pathogens

Virus-Induced T Cell-Mediated Heterologous Immunity and Vaccine Development

(2020) Kathrin Balz et al.   Frontiers in Immunology

Innate and secondary humoral responses are improved by increasing the time between MVA vaccine immunizations

(2020) Jean-Louis Palgen et al.   npj Vaccines

BCG Vaccination in Humans Elicits Trained Immunity via the Hematopoietic Progenitor Compartment

(2020) Branko Cirovic et al.   Cell Host & Microbe

Combinatorial Single-Cell Analyses of Granulocyte-Monocyte Progenitor Heterogeneity Reveals an Early Uni-potent Neutrophil Progenitor

(2020) Immanuel Kwok et al.   IMMUNITY

Trained Immunity Based-Vaccines as a Prophylactic Strategy in Common Variable Immunodeficiency. A Proof of Concept Study

(2020) Kissy Guevara-Hoyer et al.   Biomedicines

Activate: Randomized Clinical Trial of BCG Vaccination against Infection in the Elderly

(2020) Evangelos J. Giamarellos-Bourboulis et al.   CELL

Airway Macrophages Mediate Mucosal Vaccine–Induced Trained Innate Immunity against Mycobacterium tuberculosis in Early Stages of Infection

(2020) Michael R. D’Agostino et al.   JOURNAL OF IMMUNOLOGY

Using BCG vaccine to enhance non-specific protection of health care workers during the COVID-19 pandemic: A structured summary of a study protocol for a randomised controlled trial in Denmark

(2020) Anne Marie Rosendahl Madsen et al.   Trials

BCG vaccination history associates with decreased SARS-CoV-2 seroprevalence across a diverse cohort of health care workers

(2020) Magali Noval Rivas et al.   JOURNAL OF CLINICAL INVESTIGATION

Designing the Next Generation of Vaccines: Relevance for Future Pandemics

(2020) Jorge Domínguez-Andrés et al.   mBio

Anti-viral protective capacity of tissue resident memory T cells

(2020) Daniel H Paik et al.   Current Opinion in Virology

Prevention of tuberculosis infection and disease by local BCG in repeatedly exposed rhesus macaques

(2019) Karin Dijkman et al.   NATURE MEDICINE

Trained Immunity Carried by Non-immune Cells

(2019) Attoumani Hamada et al.   Frontiers in Microbiology

NK cell immune responses differ after prime and boost vaccination

(2019) Jean-Louis Palgen et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Factors That Influence the Immune Response to Vaccination

(2019) Petra Zimmermann et al.   CLINICAL MICROBIOLOGY REVIEWS

INTERACTING NON-SPECIFIC IMMUNOLOGICAL EFFECTS OF BCG AND Tdapf VACCINATIONS: AN EXPLORATIVE RANDOMIZED TRIAL

(2019) Bastiaan A Blok et al.   CLINICAL INFECTIOUS DISEASES

Tissue-Resident T Cells and Other Resident Leukocytes

(2019) David Masopust et al.   Annual Review of Immunology

Induction of memory-like dendritic cell responses in vivo

(2019) Camaron R. Hole et al.   Nature Communications

Anti-inflammatory Trained Immunity Mediated by Helminth Products Attenuates the Induction of T Cell-Mediated Autoimmune Disease

(2019) Shauna M. Quinn et al.   Frontiers in Immunology

Targeting innate immunity for tuberculosis vaccination

(2019) Shabaana A. Khader et al.   JOURNAL OF CLINICAL INVESTIGATION

Human and translational immunology in the third millennium: progress, challenges and opportunities

(2019) Ioanna E. Galani et al.   NATURE IMMUNOLOGY

BCG-Induced Cross-Protection and Development of Trained Immunity: Implication for Vaccine Design

(2019) Camila Covián et al.   Frontiers in Immunology

Trained Immunity Confers Broad-Spectrum Protection Against Bacterial Infections

(2019) Eleonora Ciarlo et al.   JOURNAL OF INFECTIOUS DISEASES

Bystander Activation of Pulmonary Trm Cells Attenuates the Severity of Bacterial Pneumonia by Enhancing Neutrophil Recruitment

(2019) Chenghao Ge et al.   Cell Reports

Epigenetic stabilization of DC and DC precursor classical activation by TNFα contributes to protective T cell polarization

(2019) Alison J. Eastman et al.   Science Advances

Modulation of Myelopoiesis Progenitors Is an Integral Component of Trained Immunity

(2018) Ioannis Mitroulis et al.   CELL

BCG Educates Hematopoietic Stem Cells to Generate Protective Innate Immunity against Tuberculosis

(2018) Eva Kaufmann et al.   CELL

BCG Vaccination Protects against Experimental Viral Infection in Humans through the Induction of Cytokines Associated with Trained Immunity

(2018) Rob J.W. Arts et al.   Cell Host & Microbe

Developmental Analysis of Bone Marrow Neutrophils Reveals Populations Specialized in Expansion, Trafficking, and Effector Functions

(2018) Maximilien Evrard et al.   IMMUNITY

Trained Memory of Human Uterine NK Cells Enhances Their Function in Subsequent Pregnancies

(2018) Moriya Gamliel et al.   IMMUNITY

Non-specific effects of vaccines: Current evidence and potential implications

(2018) Charlotte L.C.J. de Bree et al.   SEMINARS IN IMMUNOLOGY

Prime and Boost Vaccination Elicit a Distinct Innate Myeloid Cell Immune Response

(2018) Jean-Louis Palgen et al.   Scientific Reports

Neutrophil Vaccination Dynamics and Their Capacity To Mediate B Cell Help in Rhesus Macaques

(2018) Thomas Musich et al.   JOURNAL OF IMMUNOLOGY

Identification of an Early Unipotent Neutrophil Progenitor with Pro-tumoral Activity in Mouse and Human Bone Marrow

(2018) Yanfang Peipei Zhu et al.   Cell Reports

Induction of Autonomous Memory Alveolar Macrophages Requires T Cell Help and Is Critical to Trained Immunity

(2018) Yushi Yao et al.   CELL

Targeting SHIP-1 in Myeloid Cells Enhances Trained Immunity and Boosts Response to Infection

(2018) Paula Saz-Leal et al.   Cell Reports

Trained Immunity-Based Vaccines: A New Paradigm for the Development of Broad-Spectrum Anti-infectious Formulations

(2018) Silvia Sánchez-Ramón et al.   Frontiers in Immunology

Non-specific Effects of Live Attenuated Pertussis Vaccine Against Heterologous Infectious and Inflammatory Diseases

(2018) Stéphane Cauchi et al.   Frontiers in Immunology

Identification of a Human Clonogenic Progenitor with Strict Monocyte Differentiation Potential: A Counterpart of Mouse cMoPs

(2017) Shunsuke Kawamura et al.   IMMUNITY

Fcγ Receptor Function and the Design of Vaccination Strategies

(2017) Stylianos Bournazos et al.   IMMUNITY

Evaluation of trained immunity by β-1, 3 (d )-glucan on murine monocytes in vitro and duration of response in vivo

(2017) Pablo Garcia-Valtanen et al.   IMMUNOLOGY AND CELL BIOLOGY

Redefining Memory: Building the Case for Adaptive NK Cells

(2017) Silke Paust et al.   JOURNAL OF VIROLOGY

Do Memory B Cells Form Secondary Germinal Centers?

(2017) Louise J. McHeyzer-Williams et al.   Cold Spring Harbor Perspectives in Biology

Granulocytes: New Members of the Antigen-Presenting Cell Family

(2017) Ang Lin et al.   Frontiers in Immunology

The Effect of Smallpox and Bacillus Calmette-Guérin Vaccination on the Risk of Human Immunodeficiency Virus-1 Infection in Guinea-Bissau and Denmark

(2017) Andreas Rieckmann et al.   Open Forum Infectious Diseases

Anti-mycobacterial activity correlates with altered DNA methylation pattern in immune cells from BCG-vaccinated subjects

(2017) Deepti Verma et al.   Scientific Reports

Glutaminolysis and Fumarate Accumulation Integrate Immunometabolic and Epigenetic Programs in Trained Immunity

(2016) Rob J.W. Arts et al.   Cell Metabolism

In VitroExperimental Model of Trained Innate Immunity in Human Primary Monocytes

(2016) Siroon Bekkering et al.   Clinical and Vaccine Immunology

Development and maturation of natural killer cells

(2016) Theresa L Geiger et al.   CURRENT OPINION IN IMMUNOLOGY

Allergen-Experienced Group 2 Innate Lymphoid Cells Acquire Memory-like Properties and Enhance Allergic Lung Inflammation

(2016) Itziar Martinez-Gonzalez et al.   IMMUNITY

Fungal Chitin Induces Trained Immunity in Human Monocytes during Cross-talk of the Host withSaccharomyces cerevisiae

(2016) Lisa Rizzetto et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Innate cell communication kick-starts pathogen-specific immunity

(2016) Amariliz Rivera et al.   NATURE IMMUNOLOGY

The Effect of Oral Polio Vaccine at Birth on Infant Mortality: A Randomized Trial

(2015) Najaaraq Lund et al.   CLINICAL INFECTIOUS DISEASES

Editorial Commentary: Different Strains of Bacillus Calmette–Guérin Vaccine Have Very Different Effects on Tuberculosis and on Unrelated Infections

(2015) Frank Shann   CLINICAL INFECTIOUS DISEASES

Cytomegalovirus Infection Drives Adaptive Epigenetic Diversification of NK Cells with Altered Signaling and Effector Function

(2015) Heinrich Schlums et al.   IMMUNITY

Natural Killer Cell Memory

(2015) Timothy E. O’Sullivan et al.   IMMUNITY

Mouse and human FcR effector functions

(2015) Pierre Bruhns et al.   IMMUNOLOGICAL REVIEWS

BCG Vaccination Enhances the Immunogenicity of Subsequent Influenza Vaccination in Healthy Volunteers: A Randomized, Placebo-Controlled Pilot Study

(2015) Jenneke Leentjens et al.   JOURNAL OF INFECTIOUS DISEASES

Ready to benefit from training: heterologous effects of early life immunization

(2015) O. Levy et al.   TRANSACTIONS OF THE ROYAL SOCIETY OF TROPICAL MEDICINE AND HYGIENE

BCG-induced trained immunity in NK cells: Role for non-specific protection to infection

(2014) Johanneke Kleinnijenhuis et al.   CLINICAL IMMUNOLOGY

Memory-T-Cell-Derived Interferon-γ Instructs Potent Innate Cell Activation for Protective Immunity

(2014) Saïdi M’Homa Soudja et al.   IMMUNITY

Immune activation alters cellular and humoral responses to yellow fever 17D vaccine

(2014) Enoch Muyanja et al.   JOURNAL OF CLINICAL INVESTIGATION

Resident memory CD8 T cells trigger protective innate and adaptive immune responses

(2014) J. M. Schenkel et al.   SCIENCE

mTOR- and HIF-1 -mediated aerobic glycolysis as metabolic basis for trained immunity

(2014) S.-C. Cheng et al.   SCIENCE

Long-Lasting Effects of BCG Vaccination on Both Heterologous Th1/Th17 Responses and Innate Trained Immunity

(2013) Johanneke Kleinnijenhuis et al.   Journal of Innate Immunity

Natural killer cells: walking three paths down memory lane

(2013) Gundula Min-Oo et al.   TRENDS IN IMMUNOLOGY

Non-specific effect of Bacille Calmette-Guérin vaccine on the immune response to routine immunisations

(2013) Nicole Ritz et al.   VACCINE

Candida albicans Infection Affords Protection against Reinfection via Functional Reprogramming of Monocytes

(2012) Jessica Quintin et al.   Cell Host & Microbe

Bacille Calmette-Guerin induces NOD2-dependent nonspecific protection from reinfection via epigenetic reprogramming of monocytes

(2012) J. Kleinnijenhuis et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Testing the hypothesis that diphtheria–tetanus–pertussis vaccine has negative non-specific and sex-differential effects on child survival in high-mortality countries

(2012) Peter Aaby et al.   BMJ Open

Trained Immunity: A Memory for Innate Host Defense

(2011) Mihai G. Netea et al.   Cell Host & Microbe

Immunological mechanisms of vaccination

(2011) Bali Pulendran et al.   NATURE IMMUNOLOGY

Inflammatory Monocytes and Neutrophils Are Licensed to Kill during Memory Responses In Vivo

(2011) Emilie Narni-Mancinelli et al.   PLoS Pathogens

Repetitive Antigen Stimulation Induces Stepwise Transcriptome Diversification but Preserves a Core Signature of Memory CD8+ T Cell Differentiation

(2010) Thomas C. Wirth et al.   IMMUNITY

From Vaccines to Memory and Back

(2010) Federica Sallusto et al.   IMMUNITY

Memory CD4 T cells: generation, reactivation and re-assignment

(2010) Megan K.L. MacLeod et al.   IMMUNOLOGY

Long-Lasting Protective Antiviral Immunity Induced by Passive Immunotherapies Requires both Neutralizing and Effector Functions of the Administered Monoclonal Antibody

(2010) R. Nasser et al.   JOURNAL OF VIROLOGY

Memory CD4+ T cells induce innate responses independently of pathogen

(2010) Tara M Strutt et al.   NATURE MEDICINE

Polyfunctional CD4+ T-Cell Induction in Neutralizing Antibody-Triggered Control of Simian Immunodeficiency Virus Infection

(2009) T. Yamamoto et al.   JOURNAL OF VIROLOGY