TLR4 (toll-like receptor 4) activation suppresses autophagy through inhibition of FOXO3 and impairs phagocytic capacity of microglia

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Deficient autophagy in microglia impairs synaptic pruning and causes social behavioral defects

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Autophagy Beyond Intracellular MHC Class II Antigen Presentation

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FoxO1-mediated autophagy is required for NK cell development and innate immunity

(2016) Shuo Wang et al.   Nature Communications

Systematic Analysis of Translocator Protein 18 kDa (TSPO) Ligands on Toll-like Receptors-mediated Pro-inflammatory Responses in Microglia and Astrocytes

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PI(5)P Regulates Autophagosome Biogenesis

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Rubicon swaps autophagy for LAP

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Immune attack: the role of inflammation in Alzheimer disease

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miR-Let7A Modulates Autophagy Induction in LPS-Activated Microglia

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Coordinated Expression of Phosphoinositide Metabolic Genes during Development and Aging of Human Dorsolateral Prefrontal Cortex

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Signaling pathway of autophagy associated with innate immunity

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Lipidation of the autophagy proteins LC3 and GABARAP is a membrane-curvature dependent process

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Autophagy in microglia degrades extracellular β-amyloid fibrils and regulates the NLRP3 inflammasome

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Translocator Protein 18 kDa Negatively Regulates Inflammation in Microglia

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Impairment of autophagy in the central nervous system during lipopolysaccharide-induced inflammatory stress in mice

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TLR4 enhances histamine-mediated pruritus by potentiating TRPV1 activity

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Toll-Like Receptor Signaling Pathways

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Activation of Autophagy Pathway Suppresses the Expression of iNOS, IL6 and Cell Death of LPS-Stimulated Microglia Cells

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Lipopolysaccharide (LPS)-induced autophagy is involved in the restriction of Escherichia coli in peritoneal mesothelial cells

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Autophagy failure in Alzheimer's disease and the role of defective lysosomal acidification

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FOXO3A directs a protective autophagy program in haematopoietic stem cells

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CD33 Alzheimer's disease locus: altered monocyte function and amyloid biology

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Microglial Beclin 1 Regulates Retromer Trafficking and Phagocytosis and Is Impaired in Alzheimer’s Disease

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Functional Impairment of Microglia Coincides with Beta-Amyloid Deposition in Mice with Alzheimer-Like Pathology

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MTORC1 functions as a transcriptional regulator of autophagy by preventing nuclear transport of TFEB

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A lysosome-to-nucleus signalling mechanism senses and regulates the lysosome via mTOR and TFEB

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Systemic immune challenges trigger and drive Alzheimer-like neuropathology in mice

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Activation of autophagy by inflammatory signals limits IL-1β production by targeting ubiquitinated inflammasomes for destruction

(2012) Chong-Shan Shi et al.   NATURE IMMUNOLOGY

PI3K signalling: the path to discovery and understanding

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Variant of TREM2 Associated with the Risk of Alzheimer's Disease

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In vivo, Pikfyve generates PI(3,5)P2, which serves as both a signaling lipid and the major precursor for PI5P

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Therapeutic effects of remediating autophagy failure in a mouse model of Alzheimer disease by enhancing lysosomal proteolysis

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Lipopolysaccaride induces autophagic signaling in macrophages via a TLR4, heme oxygenase-1 dependent pathway

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Autophagy and cytokines

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Autophagy-based unconventional secretory pathway for extracellular delivery of IL-1β

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Inflammasome-Independent Modulation of Cytokine Response by Autophagy in Human Cells

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Microtubule-associated protein 1 light chain 3 alpha (LC3)-associated phagocytosis is required for the efficient clearance of dead cells

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TFEB Links Autophagy to Lysosomal Biogenesis

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Mechanisms Underlying Inflammation in Neurodegeneration

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Autophagy requires endoplasmic reticulum targeting of the PI3-kinase complex via Atg14L

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Autophagy proteins regulate innate immune responses by inhibiting the release of mitochondrial DNA mediated by the NALP3 inflammasome

(2010) Kiichi Nakahira et al.   NATURE IMMUNOLOGY

The emerging mechanisms of isoform-specific PI3K signalling

(2010) Bart Vanhaesebroeck et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

A Method for Generation of Bone Marrow-Derived Macrophages from Cryopreserved Mouse Bone Marrow Cells

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Decreased Clearance of CNS  -Amyloid in Alzheimer's Disease

(2010) K. G. Mawuenyega et al.   SCIENCE

FoxO Transcription Factors Promote Autophagy in Cardiomyocytes

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NOD2 stimulation induces autophagy in dendritic cells influencing bacterial handling and antigen presentation

(2009) Rachel Cooney et al.   NATURE MEDICINE

LPS-induced autophagy is mediated by oxidative signaling in cardiomyocytes and is associated with cytoprotection

(2008) Hua Yuan et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Toll-like receptors control autophagy

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Autophagosome formation from membrane compartments enriched in phosphatidylinositol 3-phosphate and dynamically connected to the endoplasmic reticulum

(2008) Elizabeth L. Axe et al.   JOURNAL OF CELL BIOLOGY

Microglial Dysfunction and Defective  -Amyloid Clearance Pathways in Aging Alzheimer's Disease Mice

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Loss of the autophagy protein Atg16L1 enhances endotoxin-induced IL-1β production

(2008) Tatsuya Saitoh et al.   NATURE