The Dual Roles of Human γδ T Cells: Anti-Tumor or Tumor-Promoting

Butyrophilin 2A1 is essential for phosphoantigen reactivity by γδ T cells

(2020) Marc Rigau et al.   SCIENCE

Butyrophilin-2A1 Directly Binds Germline-Encoded Regions of the Vγ9Vδ2 TCR and Is Essential for Phosphoantigen Sensing

(2020) Mohindar M. Karunakaran et al.   IMMUNITY

Potent Bidirectional Cross-Talk Between Plasmacytoid Dendritic Cells and γδT Cells Through BTN3A, Type I/II IFNs and Immune Checkpoints

(2020) Pauline Girard et al.   Frontiers in Immunology

Human γδ TCR Repertoires in Health and Disease

(2020) Alina Suzann Fichtner et al.   Cells

Allogenic Vγ9Vδ2 T cell as new potential immunotherapy drug for solid tumor: a case study for cholangiocarcinoma

(2019) Mohammed Alnaggar et al.   Journal for ImmunoTherapy of Cancer

Broad Cytotoxic Targeting of Acute Myeloid Leukemia by Polyclonal Delta One T Cells

(2019) Biagio Di Lorenzo et al.   Cancer Immunology Research

A Structural Change in Butyrophilin upon Phosphoantigen Binding Underlies Phosphoantigen-Mediated Vγ9Vδ2 T Cell Activation

(2019) Yunyun Yang et al.   IMMUNITY

IL-21-mediated expansion of Vγ9Vδ2 T cells is limited by the Tim-3 pathway

(2019) Kangni Wu et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

γδ T cells in hepatocellular carcinoma patients present cytotoxic activity but are reduced in potency due to IL-2 and IL-21 pathways

(2019) Hang Jiang et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Distribution and functions of γδ T cells infiltrated in the ovarian cancer microenvironment

(2019) Xian Chen et al.   Journal of Translational Medicine

The M476W/Q482H mutation of procaspase-8 restored caspase-8-mediated apoptosis

(2019) Ming Li et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Vitamin C promotes the proliferation and effector functions of human γδ T cells

(2019) Léonce Kouakanou et al.   Cellular & Molecular Immunology

Diminished cytolytic activity of γδ T cells with reduced DNAM-1 expression in neuroblastoma patients

(2019) Xiaolin Wang et al.   CLINICAL IMMUNOLOGY

An imbalance between stellate cells and γδT cells contributes to hepatocellular carcinoma aggressiveness and recurrence

(2019) Bao-Yong Zhou et al.   Hepatology International

NK cells switch from granzyme B to death receptor–mediated cytotoxicity during serial killing

(2019) Isabel Prager et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Clinical Relevance and Immunosuppressive Pattern of Circulating and Infiltrating Subsets of Myeloid-Derived Suppressor Cells (MDSCs) in Epithelial Ovarian Cancer

(2019) Karolina Okła et al.   Frontiers in Immunology

Interleukin‐17 is associated with expression of programmed cell death 1 ligand 1 in ovarian carcinoma

(2019) Aeri Aotsuka et al.   CANCER SCIENCE

Translating gammadelta (γδ) T cells and their receptors into cancer cell therapies

(2019) Zsolt Sebestyen et al.   NATURE REVIEWS DRUG DISCOVERY

TRAIL-Receptor 4 Modulates γδ T Cell-Cytotoxicity Toward Cancer Cells

(2019) Doaa Tawfik et al.   Frontiers in Immunology

Chitosan Nanoparticles Strengthen Vγ9Vδ2 T-Cell Cytotoxicity Through Upregulation Of Killing Molecules And Cytoskeleton Polarization

(2019) Li Lin et al.   International Journal of Nanomedicine

An innate-like Vδ1+ γδ T cell compartment in the human breast is associated with remission in triple-negative breast cancer

(2019) Yin Wu et al.   Science Translational Medicine

Tim-3 suppresses the killing effect of Vγ9Vδ2 T cells on colon cancer cells by reducing perforin and granzyme B expression

(2019) Xiaomi Li et al.   EXPERIMENTAL CELL RESEARCH

Bispecific antibodies enhance tumor‐infiltrating T cell cytotoxicity against autologous HER‐2‐expressing high‐grade ovarian tumors

(2019) Hans‐Heinrich Oberg et al.   JOURNAL OF LEUKOCYTE BIOLOGY

NKG2D and its ligands in cancer

(2018) Payal Dhar et al.   CURRENT OPINION IN IMMUNOLOGY

PMN-MDSC and arginase are increased in myeloma and may contribute to resistance to therapy

(2018) Alessandra Romano et al.   EXPERT REVIEW OF MOLECULAR DIAGNOSTICS

Human Vδ3 + γδ T cells induce maturation and IgM secretion by B cells

(2018) Andreea Petrasca et al.   IMMUNOLOGY LETTERS

HMGN2

(2018) Jiao Chen et al.   JOURNAL OF IMMUNOTHERAPY

IL-21 Increases the Reactivity of Allogeneic Human Vγ9Vδ2 T Cells Against Primary Glioblastoma Tumors

(2018) Noémie Joalland et al.   JOURNAL OF IMMUNOTHERAPY

Gamma-delta (γδ) T cells: friend or foe in cancer development?

(2018) Yijing Zhao et al.   Journal of Translational Medicine

Chimeric Antigen Receptor-Engineered Human Gamma Delta T Cells: Enhanced Cytotoxicity with Retention of Cross Presentation

(2018) Anna Capsomidis et al.   MOLECULAR THERAPY

K6 linked polyubiquitylation of FADD by CHIP prevents death inducing signaling complex formation suppressing cell death

(2018) Jinho Seo et al.   ONCOGENE

Heteromeric interactions regulate butyrophilin (BTN) and BTN-like molecules governing γδ T cell biology

(2018) Pierre Vantourout et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Low-Density Lipoprotein Uptake Inhibits the Activation and Antitumor Functions of Human Vγ9Vδ2 T Cells

(2018) Neidy V. Rodrigues et al.   Cancer Immunology Research

Working in “NK Mode”: Natural Killer Group 2 Member D and Natural Cytotoxicity Receptors in Stress-Surveillance by γδ T Cells

(2018) Bruno Silva-Santos et al.   Frontiers in Immunology

Decitabine Enhances Vγ9Vδ2 T Cell-Mediated Cytotoxic Effects on Osteosarcoma Cells via the NKG2DL–NKG2D Axis

(2018) Zhan Wang et al.   Frontiers in Immunology

Improving the Efficiency of Vγ9Vδ2 T-Cell Immunotherapy in Cancer

(2018) Timm Hoeres et al.   Frontiers in Immunology

Myeloid-Derived Suppressor Cells Specifically Suppress IFN-γ Production and Antitumor Cytotoxic Activity of Vδ2 T Cells

(2018) Alessandra Sacchi et al.   Frontiers in Immunology

GMP-Grade Manufacturing of T Cells Engineered to Express a Defined γδTCR

(2018) Trudy Straetemans et al.   Frontiers in Immunology

Valproic Acid Combined with Zoledronate Enhance γδ T Cell-Mediated Cytotoxicity against Osteosarcoma Cells via the Accumulation of Mevalonate Pathway Intermediates

(2018) Shengdong Wang et al.   Frontiers in Immunology

Cellular immunotherapy on primary multiple myeloma expanded in a 3D bone marrow niche model

(2018) Maaike V. J. Braham et al.   OncoImmunology

Quantification and phenotypic characterization of peripheral blood Vδ1 + T cells in chronic lymphocytic leukemia and monoclonal B cell lymphocytosis

(2018) Catarina Simões et al.   CYTOMETRY PART B-CLINICAL CYTOMETRY

Antigen-Presenting Cell Characteristics of Human γδ T Lymphocytes in Chronic Myeloid Leukemia

(2018) Piamsiri Sawaisorn et al.   IMMUNOLOGICAL INVESTIGATIONS

Targeting the crosstalk between cytokine-induced killer cells and myeloid-derived suppressor cells in hepatocellular carcinoma

(2018) Su Jong Yu et al.   JOURNAL OF HEPATOLOGY

Boosting γδ T cell-mediated antibody-dependent cellular cytotoxicity by PD-1 blockade in follicular lymphoma

(2018) Cédric Rossi et al.   OncoImmunology

The butyrophilin 3A1 intracellular domain undergoes a conformational change involving the juxtamembrane region

(2017) Khiem Nguyen et al.   FASEB JOURNAL

Synergistic targeting of breast cancer stem-like cells by human γδ T cells and CD8+ T cells

(2017) Hung-Chang Chen et al.   IMMUNOLOGY AND CELL BIOLOGY

The Juxtamembrane Domain of Butyrophilin BTN3A1 Controls Phosphoantigen-Mediated Activation of Human Vγ9Vδ2 T Cells

(2017) Cassie-Marie Peigné et al.   JOURNAL OF IMMUNOLOGY

Increased frequencies of circulating and tumor-resident Vδ1+ T cells in patients with diffuse large B-cell lymphoma

(2017) Emilie Reboursiere et al.   LEUKEMIA & LYMPHOMA

Avoidance of On-Target Off-Tumor Activation Using a Co-stimulation-Only Chimeric Antigen Receptor

(2017) Jonathan Fisher et al.   MOLECULAR THERAPY

Human papillomavirus oncoproteins induce a reorganization of epithelial-associated γδ T cells promoting tumor formation

(2017) Dorien Van hede et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Phosphoantigen-induced conformational change of butyrophilin 3A1 (BTN3A1) and its implication on Vγ9Vδ2 T cell activation

(2017) Siyi Gu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

CD20-Specific Immunoligands Engaging NKG2D Enhance γδ T Cell-Mediated Lysis of Lymphoma Cells

(2017) M. Peipp et al.   SCANDINAVIAN JOURNAL OF IMMUNOLOGY

Zerumbone modulates CD1d expression and lipid antigen presentation pathway in breast cancer cells

(2017) Ritis K. Shyanti et al.   TOXICOLOGY IN VITRO

The Ambiguous Role of γδ T Lymphocytes in Antitumor Immunity

(2017) Guranda Chitadze et al.   TRENDS IN IMMUNOLOGY

The ATP-binding cassette transporter A1 regulates phosphoantigen release and Vγ9Vδ2 T cell activation by dendritic cells

(2017) Barbara Castella et al.   Nature Communications

Squamous Cell Tumors Recruit γδ T Cells Producing either IL17 or IFNγ Depending on the Tumor Stage

(2017) Elena Lo Presti et al.   Cancer Immunology Research

Distinctive features of tumor-infiltrating γδ T lymphocytes in human colorectal cancer

(2017) S. Meraviglia et al.   OncoImmunology

Expansion and functions of myeloid-derived suppressor cells in the tumor microenvironment

(2016) Peng Qu et al.   CANCER LETTERS

γδ T Cells Support Pancreatic Oncogenesis by Restraining αβ T Cell Activation

(2016) Donnele Daley et al.   CELL

Human γδT-cell subsets and their involvement in tumor immunity

(2016) Dang Wu et al.   Cellular & Molecular Immunology

Delta One T Cells for Immunotherapy of Chronic Lymphocytic Leukemia: Clinical-Grade Expansion/Differentiation and Preclinical Proof of Concept

(2016) A. R. Almeida et al.   CLINICAL CANCER RESEARCH

Proportions of blood-borne Vδ1+ and Vδ2+ T-cells are associated with overall survival of melanoma patients treated with ipilimumab

(2016) Kilian Wistuba-Hamprecht et al.   EUROPEAN JOURNAL OF CANCER

IL17 producing γδT cells induce angiogenesis and are associated with poor survival in gallbladder cancer patients

(2016) Rushikesh Sudam Patil et al.   INTERNATIONAL JOURNAL OF CANCER

Interleukin-15 enhances the proliferation, stimulatory phenotype, and antitumor effector functions of human gamma delta T cells

(2016) Heleen H. Van Acker et al.   Journal of Hematology & Oncology

In vivo expansion and activation of γδ T cells as immunotherapy for refractory neuroblastoma

(2016) Joseph G. Pressey et al.   MEDICINE

Pediatric Primitive Neuroectodermal Tumors of the Central Nervous System Differentially Express Granzyme Inhibitors

(2016) Jeroen F. Vermeulen et al.   PLoS One

Analysis of tumor-infiltrating gamma delta T cells in rectal cancer

(2016) Liang Rong et al.   WORLD JOURNAL OF GASTROENTEROLOGY

In vitro analysis of the proliferative capacity and cytotoxic effects of ex vivo induced natural killer cells, cytokine-induced killer cells, and gamma-delta T cells

(2015) Chao Niu et al.   BMC IMMUNOLOGY

Myeloid molecular characteristics of human γδ T cells support their acquisition of tumor antigen-presenting capacity

(2015) Masato Muto et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

The Emerging Protumor Role of    T Lymphocytes: Implications for Cancer Immunotherapy

(2015) M. Rei et al.   CANCER RESEARCH

γδ T cell activation by bispecific antibodies

(2015) Hans-Heinrich Oberg et al.   CELLULAR IMMUNOLOGY

Human gamma delta T cells: Evolution and ligand recognition

(2015) Erin J. Adams et al.   CELLULAR IMMUNOLOGY

Phenotypic characterization and prognostic impact of circulating γδ and αβ T-cells in metastatic malignant melanoma

(2015) Kilian Wistuba-Hamprecht et al.   INTERNATIONAL JOURNAL OF CANCER

TCRVγ9 γδ T Cell Response to IL-33: A CD4 T Cell–Dependent Mechanism

(2015) Caroline Duault et al.   JOURNAL OF IMMUNOLOGY

Sensor Function for Butyrophilin 3A1 in Prenyl Pyrophosphate Stimulation of Human Vγ2Vδ2 T Cells

(2015) Hong Wang et al.   JOURNAL OF IMMUNOLOGY

Interleukin-17 Could Promote Breast Cancer Progression at Several Stages of the Disease

(2015) Thomas Welte et al.   MEDIATORS OF INFLAMMATION

IL-17 promotes tumor angiogenesis through Stat3 pathway mediated upregulation of VEGF in gastric cancer

(2015) Xiaoqin Wu et al.   TUMOR BIOLOGY

Sensing of Pyrophosphate Metabolites by Vγ9Vδ2 T Cells

(2015) Siyi Gu et al.   Frontiers in Immunology

Ex vivoexpanded human circulating Vδ1 γδT cells exhibit favorable therapeutic potential for colon cancer

(2015) Dang Wu et al.   OncoImmunology

Interleukin-17 promotes angiogenesis by stimulating VEGF production of cancer cells via the STAT3/GIV signaling pathway in non-small-cell lung cancer

(2015) Bo Pan et al.   Scientific Reports

Multicentric neoadjuvant phase II study of panitumumab combined with an anthracycline/taxane-based chemotherapy in operable triple-negative breast cancer: identification of biologically defined signatures predicting treatment impact

(2014) J. M. Nabholtz et al.   ANNALS OF ONCOLOGY

γδT Cells: First Line of Defense and Beyond

(2014) Yueh-hsiu Chien et al.   Annual Review of Immunology

Novel Bispecific Antibodies Increase    T-Cell Cytotoxicity against Pancreatic Cancer Cells

(2014) H.-H. Oberg et al.   CANCER RESEARCH

Activating and Propagating Polyclonal Gamma Delta T Cells with Broad Specificity for Malignancies

(2014) D. C. Deniger et al.   CLINICAL CANCER RESEARCH

Neuroblastoma Killing Properties of V 2 and V 2-Negative   T Cells Following Expansion by Artificial Antigen-Presenting Cells

(2014) J. P. H. Fisher et al.   CLINICAL CANCER RESEARCH

γδT17 Cells Promote the Accumulation and Expansion of Myeloid-Derived Suppressor Cells in Human Colorectal Cancer

(2014) Pin Wu et al.   IMMUNITY

The Intracellular B30.2 Domain of Butyrophilin 3A1 Binds Phosphoantigens to Mediate Activation of Human Vγ9Vδ2 T Cells

(2014) Andrew Sandstrom et al.   IMMUNITY

Definition of APC Presentation of Phosphoantigen (E)-4-Hydroxy-3-methyl-but-2-enyl Pyrophosphate to V 2V 2 TCR

(2014) H. Wei et al.   JOURNAL OF IMMUNOLOGY

A Comprehensive Analysis of Primary Acute Myeloid Leukemia Identifies Biomarkers Predicting Susceptibility to Human Allogeneic Vγ9Vδ2 T Cells

(2014) Stefan Gundermann et al.   JOURNAL OF IMMUNOTHERAPY

γδ T cell surveillance via CD1 molecules

(2014) Adrienne M. Luoma et al.   TRENDS IN IMMUNOLOGY

Intraperitoneal injection of in vitro expanded Vγ9Vδ2 T cells together with zoledronate for the treatment of malignant ascites due to gastric cancer

(2014) Ikuo Wada et al.   Cancer Medicine

Tumor-ActivatedTCRγδ+T Cells from Gastric Cancer Patients Induce the Antitumor Immune Response ofTCRαβ+T Cells via Their Antigen-Presenting Cell-Like Effects

(2014) Chaoming Mao et al.   Journal of Immunology Research

γδ T Lymphocytes as a First Line of Immune Defense: Old and New Ways of Antigen Recognition and Implications for Cancer Immunotherapy

(2014) Alessandro Poggi et al.   Frontiers in Immunology

Expanded Human Blood-Derived γδT Cells Display Potent Antigen-Presentation Functions

(2014) Mohd Wajid A. Khan et al.   Frontiers in Immunology

Plasticity of γδ T Cells: Impact on the Anti-Tumor Response

(2014) Virginie Lafont et al.   Frontiers in Immunology

Innate γδT17 cells convert cancer-elicited inflammation into immunosuppression through myeloid-derived suppressor cells

(2014) Jun Yan et al.   OncoImmunology

Proteasomal regulation of caspase-8 in cancer cell apoptosis

(2013) Michael V. Fiandalo et al.   APOPTOSIS

Specific Recruitment of    Regulatory T Cells in Human Breast Cancer

(2013) J. Ye et al.   CANCER RESEARCH

NKG2D regulates production of soluble TRAIL by ex vivo expanded human γδ T cells

(2013) Pouneh Dokouhaki et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Crystal Structure of Vδ1 T Cell Receptor in Complex with CD1d-Sulfatide Shows MHC-like Recognition of a Self-Lipid by Human γδ T Cells

(2013) Adrienne M. Luoma et al.   IMMUNITY

Cutting Edge: CD1d Restriction and Th1/Th2/Th17 Cytokine Secretion by Human V 3 T Cells

(2013) B. A. Mangan et al.   JOURNAL OF IMMUNOLOGY

Tumor-Derived    Regulatory T Cells Suppress Innate and Adaptive Immunity through the Induction of Immunosenescence

(2013) J. Ye et al.   JOURNAL OF IMMUNOLOGY

Mechanisms of the Antitumor Activity of Human Vγ9Vδ2 T Cells in Combination With Zoledronic Acid in a Preclinical Model of Neuroblastoma

(2013) Emma Di Carlo et al.   MOLECULAR THERAPY

Butyrophilin 3A1 binds phosphorylated antigens and stimulates human γδ T cells

(2013) Stefano Vavassori et al.   NATURE IMMUNOLOGY

CMV-Independent Lysis of Glioblastoma by Ex Vivo Expanded/Activated Vδ1+ γδ T Cells

(2013) Andrea Knight et al.   PLoS One

Natural Cytotoxicity Receptors: Broader Expression Patterns and Functions in Innate and Adaptive Immune Cells

(2013) Kelly Hudspeth et al.   Frontiers in Immunology

Tumor cell recognition by γδ T lymphocytes

(2013) Daniel V. Correia et al.   OncoImmunology

 9 and  2CDR3 domains regulate functional avidity of T cells harboring  9 2TCRs

(2012) C. Grunder et al.   BLOOD

CD277 takes the lead in human    T-cell activation

(2012) D. Kabelitz   BLOOD

Human Vdelta1 gamma-delta T cells exert potent specific cytotoxicity against primary multiple myeloma cells

(2012) Andrea Knight et al.   CYTOTHERAPY

Understanding the complexity of γδ T-cell subsets in mouse and human

(2012) Dick J. Pang et al.   IMMUNOLOGY

Human cord blood γδ T cells expressing public Vγ2 chains dominate the response to bisphosphonate plus interleukin-15

(2012) Cristiana Cairo et al.   IMMUNOLOGY

Ectopically Expressed Human Tumor Biomarker MutS Homologue 2 Is a Novel Endogenous Ligand That Is Recognized by Human γδ T Cells to Induce Innate Anti-tumor/Virus Immunity

(2012) Yumei Dai et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Human V 9V 2 T Cells Specifically Recognize and Kill Acute Myeloid Leukemic Blasts

(2012) J. Gertner-Dardenne et al.   JOURNAL OF IMMUNOLOGY

Human    T Lymphocytes Are Licensed for Professional Antigen Presentation by Interaction with Opsonized Target Cells

(2012) N. Himoudi et al.   JOURNAL OF IMMUNOLOGY

Tumor-promoting Versus Tumor-antagonizing Roles of γδ T Cells in Cancer Immunotherapy

(2012) Volker Kunzmann et al.   JOURNAL OF IMMUNOTHERAPY

Zoledronate Sensitizes Neuroblastoma-derived Tumor-initiating Cells to Cytolysis Mediated by Human γδ T Cells

(2012) Nobuhiro Nishio et al.   JOURNAL OF IMMUNOTHERAPY

Phenotypic and Functional Characterization of Human γδ T-Cell Subsets in Response to Influenza A Viruses

(2012) Gang Qin et al.   JOURNAL OF INFECTIOUS DISEASES

The activity of γδ T cells against paediatric liver tumour cells and spheroids in cell culture

(2012) Alexander Hoh et al.   LIVER INTERNATIONAL

EPCR: a stress trigger for γδ T cells

(2012) Deborah A Witherden et al.   NATURE IMMUNOLOGY

Cytomegalovirus and tumor stress surveillance by binding of a human γδ T cell antigen receptor to endothelial protein C receptor

(2012) Carrie R Willcox et al.   NATURE IMMUNOLOGY

Cleavage of Notch1 by granzyme B disables its transcriptional activity

(2011) Geert van Tetering et al.   BIOCHEMICAL JOURNAL

Redirecting   T cells against cancer cells by transfer of a broadly tumor-reactive   T-cell receptor

(2011) V. Marcu-Malina et al.   BLOOD

Differentiation of human peripheral blood V 1+ T cells expressing the natural cytotoxicity receptor NKp30 for recognition of lymphoid leukemia cells

(2011) D. V. Correia et al.   BLOOD

Clinical evaluation of autologous gamma delta T cell-based immunotherapy for metastatic solid tumours

(2011) A J Nicol et al.   BRITISH JOURNAL OF CANCER

Phase I/II study of adoptive transfer of γδ T cells in combination with zoledronic acid and IL-2 to patients with advanced renal cell carcinoma

(2011) Hirohito Kobayashi et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Pilot trial of interleukin-2 and zoledronic acid to augment γδ T cells as treatment for patients with refractory renal cell carcinoma

(2011) Joshua M. Lang et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Human ovarian cancer stem-like cells can be efficiently killed by γδ T lymphocytes

(2011) Dongmei Lai et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Anti-γδ TCR antibody-expanded γδ T cells: a better choice for the adoptive immunotherapy of lymphoid malignancies

(2011) Jianhua Zhou et al.   Cellular & Molecular Immunology

Human Vδ1 γδ T cells expanded from peripheral blood exhibit specific cytotoxicity against B-cell chronic lymphocytic leukemia-derived cells

(2011) Gabrielle M. Siegers et al.   CYTOTHERAPY

IFN-γ enhances HOS and U2OS cell lines susceptibility to γδ T cell-mediated killing through the Fas/Fas ligand pathway

(2011) Zhaoxu Li et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Stimulated    T Cells Increase the In Vivo Efficacy of Trastuzumab in HER-2+ Breast Cancer

(2011) A.-H. Capietto et al.   JOURNAL OF IMMUNOLOGY

Indirect Stimulation of Human Vγ2Vδ2 T Cells through Alterations in Isoprenoid Metabolism

(2011) Hong Wang et al.   JOURNAL OF IMMUNOLOGY

Adoptive Immunotherapy for Advanced Non-small CellLung Cancer Using Zoledronate-expanded γδTCells

(2011) Miki Sakamoto et al.   JOURNAL OF IMMUNOTHERAPY

Sensitization of human osteosarcoma cells to Vγ9Vδ2 T-cell-mediated cytotoxicity by zoledronate

(2011) Zhaoxu Li et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

Human Ovarian Tumor Cells Escape γδ T Cell Recognition Partly by Down Regulating Surface Expression of MICA and Limiting Cell Cycle Related Molecules

(2011) Jingwei Lu et al.   PLoS One

Crystal structure of a    T-cell receptor specific for the human MHC class I homolog MICA

(2011) B. Xu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Expansion of Human Peripheral Blood γδ T Cells using Zoledronate

(2011) Makoto Kondo et al.   Jove-Journal of Visualized Experiments

TRAIL-induced apoptosis of human melanoma cells involves activation of caspase-4

(2010) Zhi Gang Mao et al.   APOPTOSIS

Human    T lymphocytes induce robust NK cell-mediated antitumor cytotoxicity through CD137 engagement

(2010) A. Maniar et al.   BLOOD

Phase I study of bromohydrin pyrophosphate (BrHPP, IPH 1101), a Vγ9Vδ2 T lymphocyte agonist in patients with solid tumors

(2010) Jaafar Bennouna et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

In vivo manipulation of Vγ9Vδ2 T cells with zoledronate and low-dose interleukin-2 for immunotherapy of advanced breast cancer patients

(2010) S. Meraviglia et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Optimizing Tumor-Reactive γδT Cells for Antibody-Based Cancer Immunotherapy

(2010) S. Meraviglia et al.   CURRENT MOLECULAR MEDICINE

A phase I study of adoptive immunotherapy for recurrent non-small-cell lung cancer patients with autologous γδ T cells☆☆☆

(2010) Jun Nakajima et al.   EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY

Immunotherapy targeting colon cancer stem cells

(2010) Flora Iovino et al.   Immunotherapy

Human Perforin Employs Different Avenues to Damage Membranes

(2010) Tilen Praper et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

F1-Adenosine Triphosphatase Displays Properties Characteristic of an Antigen Presentation Molecule for V 9V 2 T Cells

(2010) J. Mookerjee-Basu et al.   JOURNAL OF IMMUNOLOGY

Defective NKT Cell Activation by CD1d+ TRAMP Prostate Tumor Cells Is Corrected by Interleukin-12 with alpha-Galactosylceramide

(2010) Michael Nowak et al.   PLoS One

Bromohydrin pyrophosphate enhances antibody-dependent cell-mediated cytotoxicity induced by therapeutic antibodies

(2009) J. Gertner-Dardenne et al.   BLOOD

The NKG2D ligand ULBP4 binds to TCR 9/ 2 and induces cytotoxicity to tumor cells through both TCR   and NKG2D

(2009) Y. Kong et al.   BLOOD

DNAX accessory molecule-1 (CD226) promotes human hepatocellular carcinoma cell lysis by Vγ9Vδ2 T cells

(2009) Olivier Toutirais et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Clinical and immunological evaluation of zoledronate-activated Vγ9γδ T-cell-based immunotherapy for patients with multiple myeloma

(2009) Yu Abe et al.   EXPERIMENTAL HEMATOLOGY

Human peripheral γδ T cells possess regulatory potential

(2009) Anja A. Kühl et al.   IMMUNOLOGY

Efficient Killing of Human Colon Cancer Stem Cells by    T Lymphocytes

(2009) M. Todaro et al.   JOURNAL OF IMMUNOLOGY

Phase-I study of Innacell γδ™, an autologous cell-therapy product highly enriched in γ9δ2 T lymphocytes, in combination with IL-2, in patients with metastatic renal cell carcinoma

(2008) Jaafar Bennouna et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Isopentenyl Pyrophosphate-Activated CD56+    T Lymphocytes Display Potent Antitumor Activity toward Human Squamous Cell Carcinoma

(2008) A. A.Z. Alexander et al.   CLINICAL CANCER RESEARCH

Vγ9Vδ2 T cell cytotoxicity against tumor cells is enhanced by monoclonal antibody drugs—Rituximab and trastuzumab

(2008) Hirotake Tokuyama et al.   INTERNATIONAL JOURNAL OF CANCER

Identification of Human T Cell Receptor γδ-recognized Epitopes/Proteins via CDR3δ Peptide-based Immunobiochemical Strategy

(2008) Hui Chen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY