Human γδ TCR Repertoires in Health and Disease

γδ T Cells Kill Plasmodium falciparum in a Granzyme- and Granulysin-Dependent Mechanism during the Late Blood Stage

(2020) Maria Andrea Hernández-Castañeda et al.   JOURNAL OF IMMUNOLOGY

TCR repertoire analysis reveals phosphoantigen‐induced polyclonal proliferation of Vγ9Vδ2 T cells in neonates and adults

(2020) Alina S Fichtner et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Butyrophilin 2A1 is essential for phosphoantigen reactivity by γδ T cells

(2020) Marc Rigau et al.   SCIENCE

A class of γδ T cell receptors recognize the underside of the antigen-presenting molecule MR1

(2020) Jérôme Le Nours et al.   SCIENCE

Regulation of γδ T Cell Effector Diversification in the Thymus

(2020) Morgan E. Parker et al.   Frontiers in Immunology

Butyrophilin-2A1 Directly Binds Germline-Encoded Regions of the Vγ9Vδ2 TCR and Is Essential for Phosphoantigen Sensing

(2020) Mohindar M. Karunakaran et al.   IMMUNITY

Chronic Inflammation Permanently Reshapes Tissue-Resident Immunity in Celiac Disease

(2019) Toufic Mayassi et al.   CELL

High-throughput analysis of the human thymic Vδ1+ T cell receptor repertoire

(2019) Biagio Di Lorenzo et al.   Scientific Data

TCR Sequencing Reveals the Distinct Development of Fetal and Adult Human Vγ9Vδ2 T Cells

(2019) Maria Papadopoulou et al.   JOURNAL OF IMMUNOLOGY

Butyrophilin-like 3 Directly Binds a Human Vγ4+ T Cell Receptor Using a Modality Distinct from Clonally-Restricted Antigen

(2019) Carrie R. Willcox et al.   IMMUNITY

Differential skewing of donor-unrestricted and γδ T cell repertoires in tuberculosis-infected human lungs

(2019) Paul Ogongo et al.   JOURNAL OF CLINICAL INVESTIGATION

Single-cell TCR sequencing of gut intraepithelial γδ T cells reveals a vast and diverse repertoire in celiac disease

(2019) Linn M. Eggesbø et al.   Mucosal Immunology

An innate-like Vδ1+ γδ T cell compartment in the human breast is associated with remission in triple-negative breast cancer

(2019) Yin Wu et al.   Science Translational Medicine

The human fetal thymus generates invariant effector γδ T cells

(2019) Paola Tieppo et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Activation of TCR Vδ1+ and Vδ1−Vδ2− γδ T Cells upon Controlled Infection with Plasmodium falciparum in Tanzanian Volunteers

(2019) Tobias Rutishauser et al.   JOURNAL OF IMMUNOLOGY

CD8+γδ T Cells Are More Frequent in CMV Seropositive Bone Marrow Grafts and Display Phenotype of an Adaptive Immune Response

(2019) Ahmed Gaballa et al.   Stem Cells International

Human liver infiltrating γδ T cells are composed of clonally expanded circulating and tissue-resident populations

(2018) Stuart Hunter et al.   JOURNAL OF HEPATOLOGY

Heteromeric interactions regulate butyrophilin (BTN) and BTN-like molecules governing γδ T cell biology

(2018) Pierre Vantourout et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The human Vδ2+ T-cell compartment comprises distinct innate-like Vγ9+ and adaptive Vγ9- subsets

(2018) Martin S. Davey et al.   Nature Communications

Protective Role of γδ T Cells in Different Pathogen Infections and Its Potential Clinical Application

(2018) Yueshui Zhao et al.   Journal of Immunology Research

Human γδ T Cell Receptor Repertoires in Peripheral Blood Remain Stable Despite Clearance of Persistent Hepatitis C Virus Infection by Direct-Acting Antiviral Drug Therapy

(2018) Sarina Ravens et al.   Frontiers in Immunology

Next-Generation Sequencing Analysis of the Human TCRγδ+ T-Cell Repertoire Reveals Shifts in Vγ- and Vδ-Usage in Memory Populations upon Aging

(2018) Martine J. Kallemeijn et al.   Frontiers in Immunology

Development and Selection of the Human Vγ9Vδ2+ T-Cell Repertoire

(2018) Carrie R. Willcox et al.   Frontiers in Immunology

Vδ2+ T Cells—Two Subsets for the Price of One

(2018) Martin S. Davey et al.   Frontiers in Immunology

Interleukin-17-Producing γδ T Cells Originate from SOX13+ Progenitors that Are Independent of γδTCR Signaling

(2018) Nicholas A. Spidale et al.   IMMUNITY

The γδTCR combines innate immunity with adaptive immunity by utilizing spatially distinct regions for agonist selection and antigen responsiveness

(2018) Daisy Melandri et al.   NATURE IMMUNOLOGY

γδ T Cells in Antimalarial Immunity: New Insights Into Their Diverse Functions in Protection and Tolerance

(2018) Kathleen W. Dantzler et al.   Frontiers in Immunology

γδ T Lymphocytes: An Effector Cell in Autoimmunity and Infection

(2018) Carolina Maiumi Shiromizu et al.   Frontiers in Immunology

Human Vγ9Vδ2 T Lymphocytes in the Immune Response to P. falciparum Infection

(2018) Jennifer Howard et al.   Frontiers in Immunology

Gamma/Delta T Cells and Their Role in Protection Against Malaria

(2018) Katrien Deroost et al.   Frontiers in Immunology

Sensing of cell stress by human γδ TCR-dependent recognition of annexin A2

(2017) Romain Marlin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Clonal selection in the human Vδ1 T cell repertoire indicates γδ TCR-dependent adaptive immune surveillance

(2017) Martin S. Davey et al.   Nature Communications

Key Features of Gamma-Delta T-Cell Subsets in Human Diseases and Their Immunotherapeutic Implications

(2017) Myriam Lawand et al.   Frontiers in Immunology

Dysregulated signaling, proliferation and apoptosis impact on the pathogenesis of TCRγδ+ T cell large granular lymphocyte leukemia

(2017) Martine J. Kallemeijn et al.   PLoS One

Epithelia Use Butyrophilin-like Molecules to Shape Organ-Specific γδ T Cell Compartments

(2016) Rafael Di Marco Barros et al.   CELL

Evolution and function of the TCR Vgamma9 chain repertoire: It’s good to be public

(2015) C. David Pauza et al.   CELLULAR IMMUNOLOGY

Early innate responses to pathogens: pattern recognition by unconventional human T-cells

(2015) Anna Rita Liuzzi et al.   CURRENT OPINION IN IMMUNOLOGY

Effector Vγ9Vδ2 T cells dominate the human fetal γδ T-cell repertoire

(2015) Tanya Dimova et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A clonotypic Vγ4Jγ1/Vδ5Dδ2Jδ1 innate γδ T-cell population restricted to the CCR6+CD27− subset

(2015) Elham Kashani et al.   Nature Communications

Vγ9Vδ2 TCR-activation by phosphorylated antigens requires butyrophilin 3 A1 (BTN3A1) and additional genes on human chromosome 6

(2014) Felipe Riaño et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

The Intracellular B30.2 Domain of Butyrophilin 3A1 Binds Phosphoantigens to Mediate Activation of Human Vγ9Vδ2 T Cells

(2014) Andrew Sandstrom et al.   IMMUNITY

Human    Thymocytes Are Functionally Immature and Differentiate into Cytotoxic Type 1 Effector T Cells upon IL-2/IL-15 Signaling

(2014) J. C. Ribot et al.   JOURNAL OF IMMUNOLOGY

Ontogeny of Innate T Lymphocytes – Some Innate Lymphocytes are More Innate than Others

(2014) David Vermijlen et al.   Frontiers in Immunology

The γδ T-cell receptor repertoire is reconstituted in HIV patients after prolonged antiretroviral therapy

(2013) Suchita Chaudhry et al.   AIDS

Depletion and dysfunction of Vγ2Vδ2 T cells in HIV disease: mechanisms, impacts and therapeutic implications

(2013) Haishan Li et al.   Cellular & Molecular Immunology

Functional development of γδ T cells

(2013) Immo Prinz et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Butyrophilin 3A1 Plays an Essential Role in Prenyl Pyrophosphate Stimulation of Human V 2V 2 T Cells

(2013) H. Wang et al.   JOURNAL OF IMMUNOLOGY

Cord Blood Vγ2Vδ2 T Cells Provide a Molecular Marker for the Influence of Pregnancy-Associated Malaria on Neonatal Immunity

(2013) Cristiana Cairo et al.   JOURNAL OF INFECTIOUS DISEASES

CD1d-lipid antigen recognition by the γδ TCR

(2013) Adam P Uldrich et al.   NATURE IMMUNOLOGY

Butyrophilin 3A1 binds phosphorylated antigens and stimulates human γδ T cells

(2013) Stefano Vavassori et al.   NATURE IMMUNOLOGY

Anergic Pulmonary Tuberculosis Is Associated with Contraction of the Vd2+T Cell Population, Apoptosis and Enhanced Inhibitory Cytokine Production

(2013) Liping Yan et al.   PLoS One

Key implication of CD277/butyrophilin-3 (BTN3A) in cellular stress sensing by a major human    T-cell subset

(2012) C. Harly et al.   BLOOD

γδ-T cells: an unpolished sword in human anti-infection immunity

(2012) Jian Zheng et al.   Cellular & Molecular Immunology

Development of Interleukin-17-Producing γδ T Cells Is Restricted to a Functional Embryonic Wave

(2012) Jan D. Haas et al.   IMMUNITY

Cytomegalovirus and tumor stress surveillance by binding of a human γδ T cell antigen receptor to endothelial protein C receptor

(2012) Carrie R Willcox et al.   NATURE IMMUNOLOGY

HIV envelope-mediated, CCR5/ 4 7-dependent killing of CD4-negative    T cells which are lost during progression to AIDS

(2011) H. Li et al.   BLOOD

Type 1 Responses of Human V 9V 2 T Cells to Influenza A Viruses

(2011) G. Qin et al.   JOURNAL OF VIROLOGY

Deep Sequencing of the Human TCR  and TCR  Repertoires Suggests that TCR  Rearranges After    and    T Cell Commitment

(2011) A. M. Sherwood et al.   Science Translational Medicine

Mechanisms underlying    T-cell subset perturbations in SIV-infected Asian rhesus macaques

(2010) L. D. Harris et al.   BLOOD

Human cytomegalovirus elicits fetal γδ T cell responses in utero

(2010) David Vermijlen et al.   JOURNAL OF EXPERIMENTAL MEDICINE

V 2V 2 T Cell Receptor Recognition of Prenyl Pyrophosphates Is Dependent on All CDRs

(2010) H. Wang et al.   JOURNAL OF IMMUNOLOGY

Phosphoantigen‐Expanded Human γδ T Cells Display Potent Cytotoxicity against Monocyte‐Derived Macrophages Infected with Human and Avian Influenza Viruses

(2009) Gang Qin et al.   JOURNAL OF INFECTIOUS DISEASES

Altered cord blood γδ T cell repertoire in Nigeria: Possible impacts of environmental factors on neonatal immunity

(2008) Cristiana Cairo et al.   MOLECULAR IMMUNOLOGY