Gamma-delta (γδ) T cells: friend or foe in cancer development?

Synergistic targeting of breast cancer stem-like cells by human γδ T cells and CD8+ T cells

(2017) Hung-Chang Chen et al.   IMMUNOLOGY AND CELL BIOLOGY

LAG-3 Protein Expression in Non–Small Cell Lung Cancer and Its Relationship with PD-1/PD-L1 and Tumor-Infiltrating Lymphocytes

(2017) Yayi He et al.   Journal of Thoracic Oncology

Squamous Cell Tumors Recruit γδ T Cells Producing either IL17 or IFNγ Depending on the Tumor Stage

(2017) Elena Lo Presti et al.   Cancer Immunology Research

Expansion and functions of myeloid-derived suppressor cells in the tumor microenvironment

(2016) Peng Qu et al.   CANCER LETTERS

IL-17A-producing CD30+Vδ1 T cells drive inflammation-induced cancer progression

(2016) Yoshitaka Kimura et al.   CANCER SCIENCE

γδ T Cells Support Pancreatic Oncogenesis by Restraining αβ T Cell Activation

(2016) Donnele Daley et al.   CELL

Human γδT-cell subsets and their involvement in tumor immunity

(2016) Dang Wu et al.   Cellular & Molecular Immunology

Delta One T Cells for Immunotherapy of Chronic Lymphocytic Leukemia: Clinical-Grade Expansion/Differentiation and Preclinical Proof of Concept

(2016) A. R. Almeida et al.   CLINICAL CANCER RESEARCH

Proportions of blood-borne Vδ1+ and Vδ2+ T-cells are associated with overall survival of melanoma patients treated with ipilimumab

(2016) Kilian Wistuba-Hamprecht et al.   EUROPEAN JOURNAL OF CANCER

IL-21 inhibits IL-17A-producing γδ T-cell response after infection with Bacillus Calmette-Guérin via induction of apoptosis

(2016) Yinxia Huang et al.   Innate Immunity

IL17 producing γδT cells induce angiogenesis and are associated with poor survival in gallbladder cancer patients

(2016) Rushikesh Sudam Patil et al.   INTERNATIONAL JOURNAL OF CANCER

Interleukin-15 enhances the proliferation, stimulatory phenotype, and antitumor effector functions of human gamma delta T cells

(2016) Heleen H. Van Acker et al.   Journal of Hematology & Oncology

Immune checkpoint proteins PD-1 and TIM-3 are both highly expressed in liver tissues and correlate with their gene polymorphisms in patients with HBV-related hepatocellular carcinoma

(2016) Zhu Li et al.   MEDICINE

Analysis of tumor-infiltrating gamma delta T cells in rectal cancer

(2016) Liang Rong et al.   WORLD JOURNAL OF GASTROENTEROLOGY

Immunosuppressive γδ T cells foster pancreatic carcinogenesis

(2016) Laura Mondragón et al.   OncoImmunology

Co-Expansion of Cytokine-Induced Killer Cells and Vγ9Vδ2 T Cells for CAR T-Cell Therapy

(2016) Shou-Hui Du et al.   PLoS One

In vitro analysis of the proliferative capacity and cytotoxic effects of ex vivo induced natural killer cells, cytokine-induced killer cells, and gamma-delta T cells

(2015) Chao Niu et al.   BMC IMMUNOLOGY

IL-36γ Transforms the Tumor Microenvironment and Promotes Type 1 Lymphocyte-Mediated Antitumor Immune Responses

(2015) Xuefeng Wang et al.   CANCER CELL

Myeloid molecular characteristics of human γδ T cells support their acquisition of tumor antigen-presenting capacity

(2015) Masato Muto et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Carbonic Anhydrase IX Promotes Myeloid-Derived Suppressor Cell Mobilization and Establishment of a Metastatic Niche by Stimulating G-CSF Production

(2015) S. C. Chafe et al.   CANCER RESEARCH

CD38-Expressing Myeloid-Derived Suppressor Cells Promote Tumor Growth in a Murine Model of Esophageal Cancer

(2015) T. A. Karakasheva et al.   CANCER RESEARCH

The Emerging Protumor Role of    T Lymphocytes: Implications for Cancer Immunotherapy

(2015) M. Rei et al.   CANCER RESEARCH

A new effect of IL-4 on human γδ T cells: promoting regulatory Vδ1 T cells via IL-10 production and inhibiting function of Vδ2 T cells

(2015) Yujia Mao et al.   Cellular & Molecular Immunology

Chicago 2014 – 30years of γδ T cells

(2015) Marc Bonneville et al.   CELLULAR IMMUNOLOGY

All hands on DE(T)C: Epithelial-resident γδ T cells respond to tissue injury

(2015) Kevin Ramirez et al.   CELLULAR IMMUNOLOGY

Human gamma delta T cells: Evolution and ligand recognition

(2015) Erin J. Adams et al.   CELLULAR IMMUNOLOGY

Phenotypic characterization and prognostic impact of circulating γδ and αβ T-cells in metastatic malignant melanoma

(2015) Kilian Wistuba-Hamprecht et al.   INTERNATIONAL JOURNAL OF CANCER

γδ T Cells Shape Preimmune Peripheral B Cell Populations

(2015) Yafei Huang et al.   JOURNAL OF IMMUNOLOGY

Interleukin-17 Could Promote Breast Cancer Progression at Several Stages of the Disease

(2015) Thomas Welte et al.   MEDIATORS OF INFLAMMATION

IL-17-producing γδ T cells and neutrophils conspire to promote breast cancer metastasis

(2015) Seth B. Coffelt et al.   NATURE

Effector Vγ9Vδ2 T cells dominate the human fetal γδ T-cell repertoire

(2015) Tanya Dimova et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

IL-17 promotes tumor angiogenesis through Stat3 pathway mediated upregulation of VEGF in gastric cancer

(2015) Xiaoqin Wu et al.   TUMOR BIOLOGY

Empowering gamma delta T cells with antitumor immunity by dendritic cell-based immunotherapy

(2015) Heleen H Van Acker et al.   OncoImmunology

Interleukin-17 promotes angiogenesis by stimulating VEGF production of cancer cells via the STAT3/GIV signaling pathway in non-small-cell lung cancer

(2015) Bo Pan et al.   Scientific Reports

Indoleamine 2,3-dioxygenase pathways of pathogenic inflammation and immune escape in cancer

(2014) George C. Prendergast et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

VISTA Is an Immune Checkpoint Molecule for Human T Cells

(2014) J. L. Lines et al.   CANCER RESEARCH

Neuroblastoma Killing Properties of V 2 and V 2-Negative   T Cells Following Expansion by Artificial Antigen-Presenting Cells

(2014) J. P. H. Fisher et al.   CLINICAL CANCER RESEARCH

IL-12 and IL-18 induce interferon-γ production and de novo CD2 expression in porcine γδ T cells

(2014) Corinna Sedlak et al.   DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY

γδT17 Cells Promote the Accumulation and Expansion of Myeloid-Derived Suppressor Cells in Human Colorectal Cancer

(2014) Pin Wu et al.   IMMUNITY

IL-7 Receptor Blockade Inhibits IL-17-Producing γδ Cells and Suppresses Melanoma Development

(2014) Jun Li et al.   INFLAMMATION

TNF-  Is a Positive Regulatory Factor for Human V 2V 2 T Cells

(2014) H. Li et al.   JOURNAL OF IMMUNOLOGY

γδT Cells Drive Myeloid-Derived Suppressor Cell–Mediated CD8+T Cell Exhaustion in Hepatitis B Virus–Induced Immunotolerance

(2014) Xiaohui Kong et al.   JOURNAL OF IMMUNOLOGY

Successful adoptive transfer and in vivo expansion of haploidentical γδ T cells

(2014) Martin Wilhelm et al.   Journal of Translational Medicine

Cytotoxic and Regulatory Properties of Circulating Vδ1+ γδ T Cells: A New Player on the Cell Therapy Field?

(2014) Gabrielle M Siegers et al.   MOLECULAR THERAPY

Murine CD27(-) V 6(+)    T cells producing IL-17A promote ovarian cancer growth via mobilization of protumor small peritoneal macrophages

(2014) M. Rei et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Human Gamma Delta T Regulatory Cells in Cancer: Fact or Fiction?

(2014) Daniela Wesch et al.   Frontiers in Immunology

Plasticity of γδ T Cells: Impact on the Anti-Tumor Response

(2014) Virginie Lafont et al.   Frontiers in Immunology

Tumor-Infiltrating γδ T Lymphocytes: Pathogenic Role, Clinical Significance, and Differential Programing in the Tumor Microenvironment

(2014) Elena Lo Presti et al.   Frontiers in Immunology

Innate γδT17 cells convert cancer-elicited inflammation into immunosuppression through myeloid-derived suppressor cells

(2014) Jun Yan et al.   OncoImmunology

Anti-metastatic potential of human Vδ1+ γδ T cells in an orthotopic mouse xenograft model of colon carcinoma

(2013) Christel Devaud et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Specific Recruitment of    Regulatory T Cells in Human Breast Cancer

(2013) J. Ye et al.   CANCER RESEARCH

Ex vivo characterization of γδ T-cell repertoire in patients after adoptive transfer of Vγ9Vδ2 T cells expressing the interleukin-2 receptor β-chain and the common γ-chain

(2013) Takamichi Izumi et al.   CYTOTHERAPY

Neutrophils suppress γδ T-cell function

(2013) Florencia Sabbione et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

NKG2D regulates production of soluble TRAIL by ex vivo expanded human γδ T cells

(2013) Pouneh Dokouhaki et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Cutting Edge: CD1d Restriction and Th1/Th2/Th17 Cytokine Secretion by Human V 3 T Cells

(2013) B. A. Mangan et al.   JOURNAL OF IMMUNOLOGY

Tumor-Derived    Regulatory T Cells Suppress Innate and Adaptive Immunity through the Induction of Immunosenescence

(2013) J. Ye et al.   JOURNAL OF IMMUNOLOGY

Mechanisms of the Antitumor Activity of Human Vγ9Vδ2 T Cells in Combination With Zoledronic Acid in a Preclinical Model of Neuroblastoma

(2013) Emma Di Carlo et al.   MOLECULAR THERAPY

Anti-tumour immunotherapy with Vγ9Vδ2 T lymphocytes: from the bench to the bedside

(2012) Mounia S. Braza et al.   BRITISH JOURNAL OF HAEMATOLOGY

What lessons can be learned from γδ T cell-based cancer immunotherapy trials?

(2012) Jean-Jacques Fournié et al.   Cellular & Molecular Immunology

Tumor-promoting Versus Tumor-antagonizing Roles of γδ T Cells in Cancer Immunotherapy

(2012) Volker Kunzmann et al.   JOURNAL OF IMMUNOTHERAPY

Complex Role of γδ T-Cell-Derived Cytokines and Growth Factors in Cancer

(2012) Andrew G. Ramstead et al.   JOURNAL OF INTERFERON AND CYTOKINE RESEARCH

Cytomegalovirus and tumor stress surveillance by binding of a human γδ T cell antigen receptor to endothelial protein C receptor

(2012) Carrie R Willcox et al.   NATURE IMMUNOLOGY

IL-21 Regulates the Differentiation of a Human γδ T Cell Subset Equipped with B Cell Helper Activity

(2012) Nadia Caccamo et al.   PLoS One

Differentiation of human peripheral blood V 1+ T cells expressing the natural cytotoxicity receptor NKp30 for recognition of lymphoid leukemia cells

(2011) D. V. Correia et al.   BLOOD

Antibody-dependent anti-cytomegalovirus activity of human    T cells expressing CD16 (Fc RIIIa)

(2011) L. Couzi et al.   BLOOD

Differentiation, phenotype, and function of interleukin-17-producing human V 9V 2 T cells

(2011) N. Caccamo et al.   BLOOD

Phase I/II study of adoptive transfer of γδ T cells in combination with zoledronic acid and IL-2 to patients with advanced renal cell carcinoma

(2011) Hirohito Kobayashi et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Pilot trial of interleukin-2 and zoledronic acid to augment γδ T cells as treatment for patients with refractory renal cell carcinoma

(2011) Joshua M. Lang et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

γδ T-APCs: a novel tool for immunotherapy?

(2011) Bernhard Moser et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Human Vδ1 γδ T cells expanded from peripheral blood exhibit specific cytotoxicity against B-cell chronic lymphocytic leukemia-derived cells

(2011) Gabrielle M. Siegers et al.   CYTOTHERAPY

IL-21 enhances the potential of human γδ T cells to provide B-cell help

(2011) Raj R. Bansal et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

IFN-γ enhances HOS and U2OS cell lines susceptibility to γδ T cell-mediated killing through the Fas/Fas ligand pathway

(2011) Zhaoxu Li et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Adoptive Immunotherapy for Advanced Non-small CellLung Cancer Using Zoledronate-expanded γδTCells

(2011) Miki Sakamoto et al.   JOURNAL OF IMMUNOTHERAPY

Human    T lymphocytes induce robust NK cell-mediated antitumor cytotoxicity through CD137 engagement

(2010) A. Maniar et al.   BLOOD

Zoledronate-activated Vγ9γδ T cell-based immunotherapy is feasible and restores the impairment of γδ T cells in patients with solid tumors

(2010) Atsutaka Noguchi et al.   CYTOTHERAPY

A phase I study of adoptive immunotherapy for recurrent non-small-cell lung cancer patients with autologous γδ T cells☆☆☆

(2010) Jun Nakajima et al.   EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY

Promoting angiogenesis within the tumor microenvironment: The secret life of murine lymphoid IL-17-producing γδ T cells

(2010) Bruno Silva-Santos   EUROPEAN JOURNAL OF IMMUNOLOGY

Tumor-infiltrating IL-17-producing γδ T cells support the progression of tumor by promoting angiogenesis

(2010) Daiko Wakita et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Identification of a panel of ten cell surface protein antigens associated with immunotargeting of leukemias and lymphomas by peripheral blood    T cells

(2010) A. Q. Gomes et al.   HAEMATOLOGICA

Cytokine Requirements for the Differentiation and Expansion of IL-17A- and IL-22-Producing Human V 2V 2 T Cells

(2010) K. J. Ness-Schwickerath et al.   JOURNAL OF IMMUNOLOGY

Effect of IL-18 on Expansion of γδ T Cells Stimulated by Zoledronate and IL-2

(2010) Wen Li et al.   JOURNAL OF IMMUNOTHERAPY

Human peripheral γδ T cells possess regulatory potential

(2009) Anja A. Kühl et al.   IMMUNOLOGY

Efficient Killing of Human Colon Cancer Stem Cells by    T Lymphocytes

(2009) M. Todaro et al.   JOURNAL OF IMMUNOLOGY

Cutting Edge: TGF- 1 and IL-15 Induce FOXP3+    Regulatory T Cells in the Presence of Antigen Stimulation

(2009) R. Casetti et al.   JOURNAL OF IMMUNOLOGY

Modulation of innate immunity by IL-18

(2009) Wen Li et al.   JOURNAL OF REPRODUCTIVE IMMUNOLOGY

Phase-I study of Innacell γδ™, an autologous cell-therapy product highly enriched in γ9δ2 T lymphocytes, in combination with IL-2, in patients with metastatic renal cell carcinoma

(2008) Jaafar Bennouna et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Isopentenyl Pyrophosphate-Activated CD56+    T Lymphocytes Display Potent Antitumor Activity toward Human Squamous Cell Carcinoma

(2008) A. A.Z. Alexander et al.   CLINICAL CANCER RESEARCH

Epithelial-Mesenchymal Transition: At the Crossroads of Development and Tumor Metastasis

(2008) Jing Yang et al.   DEVELOPMENTAL CELL