Specialized Pro-Resolving Mediators as Potential Regulators of Inflammatory Macrophage Responses in COVID-19

Characteristics of and Important Lessons From the Coronavirus Disease 2019 (COVID-19) Outbreak in China

(2020) Zunyou Wu et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China

(2020) Chaolin Huang et al.   LANCET

A Novel Coronavirus from Patients with Pneumonia in China, 2019

(2020) Na Zhu et al.   NEW ENGLAND JOURNAL OF MEDICINE

Should we stimulate or suppress immune responses in COVID-19? Cytokine and anti-cytokine interventions

(2020) Yvan Jamilloux et al.   AUTOIMMUNITY REVIEWS

Inflammation resolution: a dual-pronged approach to averting cytokine storms in COVID-19?

(2020) Dipak Panigrahy et al.   CANCER AND METASTASIS REVIEWS

Imbalanced Host Response to SARS-CoV-2 Drives Development of COVID-19

(2020) Daniel Blanco-Melo et al.   CELL

Plasma IP-10 and MCP-3 levels are highly associated with disease severity and predict the progression of COVID-19

(2020) Yang Yang et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study

(2020) Fei Zhou et al.   LANCET

Bioinformatic analysis and identification of single-stranded RNA sequences recognized by TLR7/8 in the SARS-CoV-2, SARS-CoV, and MERS-CoV genomes

(2020) Mario Adán Moreno-Eutimio et al.   MICROBES AND INFECTION

Single-cell landscape of bronchoalveolar immune cells in patients with COVID-19

(2020) Mingfeng Liao et al.   NATURE MEDICINE

Beyond the CNS: The many peripheral roles of APOE

(2020) Ana B. Martínez-Martínez et al.   NEUROBIOLOGY OF DISEASE

Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Infection in Children and Adolescents

(2020) Riccardo Castagnoli et al.   JAMA Pediatrics

Phagocytosis of Apoptotic Cells in Resolution of Inflammation

(2020) Ioannis Kourtzelis et al.   Frontiers in Immunology

The Role of Cytokines including Interleukin-6 in COVID-19 induced Pneumonia and Macrophage Activation Syndrome-Like Disease

(2020) Dennis McGonagle et al.   AUTOIMMUNITY REVIEWS

COVID‐19—Associated dyslipidemia: Implications for mechanism of impaired resolution and novel therapeutic approaches

(2020) Alexander V. Sorokin et al.   FASEB JOURNAL

Presence of Genetic Variants Among Young Men With Severe COVID-19

(2020) Caspar I. van der Made et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Clinical characteristics of coronavirus disease 2019 (COVID-19) in China: A systematic review and meta-analysis

(2020) Leiwen Fu et al.   JOURNAL OF INFECTION

Serum Amyloid A is a biomarker of severe Coronavirus Disease and poor prognosis

(2020) Huan Li et al.   JOURNAL OF INFECTION

COVID-19 severity correlates with airway epithelium–immune cell interactions identified by single-cell analysis

(2020) Robert Lorenz Chua et al.   NATURE BIOTECHNOLOGY

Impaired type I interferon activity and inflammatory responses in severe COVID-19 patients

(2020) Jérôme Hadjadj et al.   SCIENCE

Resolution of Pulmonary Inflammation Induced by Carbon Nanotubes and Fullerenes in Mice: Role of Macrophage Polarization

(2020) Chol Seung Lim et al.   Frontiers in Immunology

Cytokine Storm in COVID-19: The Current Evidence and Treatment Strategies

(2020) Yujun Tang et al.   Frontiers in Immunology

Dexamethasone, pro‐resolving lipid mediators and resolution of inflammation in COVID‐19

(2020) Evangelos Andreakos et al.   ALLERGY

Specialized pro-resolving mediator network: an update on production and actions

(2020) Nan Chiang et al.   Essays in Biochemistry

Covid-19 management with inflammation resolving mediators? Perspectives and potential

(2020) Pedro-Antonio Regidor   MEDICAL HYPOTHESES

Is macrophages heterogeneity important in determining COVID-19 lethality?

(2020) Pasquale Pagliaro   MEDICAL HYPOTHESES

SARS-CoV-2 infection pathogenesis is related to oxidative stress as a response to aggression

(2020) Rubens Cecchini et al.   MEDICAL HYPOTHESES

Trained Innate Immunity, Epigenetics, and Covid-19

(2020) Alberto Mantovani et al.   NEW ENGLAND JOURNAL OF MEDICINE

Pro resolving inflammatory effects of the lipid mediators of omega 3 fatty acids and its implication in SARS COVID-19

(2020) Pedro-Antonio Regidor et al.   MEDICAL HYPOTHESES

MAFB and MAF Transcription Factors as Macrophage Checkpoints for COVID-19 Severity

(2020) Miguel A. Vega et al.   Frontiers in Immunology

Reference-based analysis of lung single-cell sequencing reveals a transitional profibrotic macrophage

(2019) Dvir Aran et al.   NATURE IMMUNOLOGY

Beyond leukotriene formation – the noncanonical functions of 5-lipoxygenase

(2019) Ann-Kathrin Häfner et al.   PROSTAGLANDINS & OTHER LIPID MEDIATORS

Aspirin-triggered proresolving mediators stimulate resolution in cancer

(2019) Molly M. Gilligan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Dynamic changes to lipid mediators support transitions among macrophage subtypes during muscle regeneration

(2019) Nikolas Giannakis et al.   NATURE IMMUNOLOGY

Resolvin D4 attenuates the severity of pathological thrombosis in mice

(2019) Deya Cherpokova et al.   BLOOD

Proresolving Lipid Mediators: Endogenous Modulators of Oxidative Stress

(2019) Alessandro Leuti et al.   Oxidative Medicine and Cellular Longevity

Resolution metabolomes activated by hypoxic environment

(2019) Paul C. Norris et al.   Science Advances

Identification and Complete Stereochemical Assignments of the New Resolvin Conjugates in Tissue Regeneration in Human Tissues that Stimulate Proresolving Phagocyte Functions and Tissue Regeneration

(2018) Xavier de la Rosa et al.   AMERICAN JOURNAL OF PATHOLOGY

Resolvins in inflammation: emergence of the pro-resolving superfamily of mediators

(2018) Charles N. Serhan et al.   JOURNAL OF CLINICAL INVESTIGATION

Human macrophages differentially produce specific resolvin or leukotriene signals that depend on bacterial pathogenicity

(2018) Oliver Werz et al.   Nature Communications

Immune responsive resolvin D1 programs peritoneal macrophages and cardiac fibroblast phenotypes in diversified metabolic microenvironment

(2018) Vasundhara Kain et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Resolvin D1 decreases abdominal aortic aneurysm formation by inhibiting NETosis in a mouse model

(2018) Michael Spinosa et al.   JOURNAL OF VASCULAR SURGERY

Monocyte-derived alveolar macrophages drive lung fibrosis and persist in the lung over the life span

(2017) Alexander V. Misharin et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Efferocytosis Signaling in the Regulation of Macrophage Inflammatory Responses

(2017) Michael R. Elliott et al.   JOURNAL OF IMMUNOLOGY

Prevention of Chronic Post-Thoracotomy Pain in Rats By Intrathecal Resolvin D1 and D2: Effectiveness of Perioperative and Delayed Drug Delivery

(2017) Jeffery Chi-Fei Wang et al.   JOURNAL OF PAIN

Pro-Resolving Mediators in Regulating and Conferring Macrophage Function

(2017) Jesmond Dalli et al.   Frontiers in Immunology

Dysregulated Type I Interferon and Inflammatory Monocyte-Macrophage Responses Cause Lethal Pneumonia in SARS-CoV-Infected Mice

(2016) Rudragouda Channappanavar et al.   Cell Host & Microbe

Macrophages: sentinels and regulators of the immune system

(2016) Lars Franken et al.   CELLULAR MICROBIOLOGY

Specialized proresolving lipid mediators in patients with coronary artery disease and their potential for clot remodeling

(2016) Tarec K. Elajami et al.   FASEB JOURNAL

Resolvin D1, resolvin D2 and maresin 1 activate the GSK3β anti-inflammatory axis in TLR4-engaged human monocytes

(2016) Zhen Gu et al.   Innate Immunity

Addition of aspirin to a fish oil-rich diet decreases inflammation and atherosclerosis in ApoE-null mice

(2016) Alexander V. Sorokin et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Trained immunity: A program of innate immune memory in health and disease

(2016) M. G. Netea et al.   SCIENCE

An imbalance between specialized pro-resolving lipid mediators and pro-inflammatory leukotrienes promotes instability of atherosclerotic plaques

(2016) Gabrielle Fredman et al.   Nature Communications

Resolvins Attenuate Inflammation and Promote Resolution in Cigarette Smoke-Exposed Human Macrophages

(2015) Amanda Croasdell et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

ChemR23, the Receptor for Chemerin and Resolvin E1, Is Expressed and Functional on M1 but Not on M2 Macrophages

(2015) Magdalena Herová et al.   JOURNAL OF IMMUNOLOGY

The resolution code of acute inflammation: Novel pro-resolving lipid mediators in resolution

(2015) Charles N. Serhan et al.   SEMINARS IN IMMUNOLOGY

Macrophage Activation and Polarization: Nomenclature and Experimental Guidelines

(2014) Peter J. Murray et al.   IMMUNITY

The Specialized Proresolving Mediator 17-HDHA Enhances the Antibody-Mediated Immune Response against Influenza Virus: A New Class of Adjuvant?

(2014) Sesquile Ramon et al.   JOURNAL OF IMMUNOLOGY

Resolvin D1 limits 5-lipoxygenase nuclear localization and leukotriene B4synthesis by inhibiting a calcium-activated kinase pathway

(2014) Gabrielle Fredman et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Lipid Mediator Protectin D1 Inhibits Influenza Virus Replication and Improves Severe Influenza

(2013) Masayuki Morita et al.   CELL

Impaired Local Production of Proresolving Lipid Mediators in Obesity and 17-HDHA as a Potential Treatment for Obesity-Associated Inflammation

(2013) A. Neuhofer et al.   DIABETES

Toll-like receptor 7 stimulates production of specialized pro-resolving lipid mediators and promotes resolution of airway inflammation

(2013) Ourania Koltsida et al.   EMBO Molecular Medicine

The novel 13S,14S-epoxy-maresin is converted by human macrophages to maresin 1 (MaR1), inhibits leukotriene A4 hydrolase (LTA4H), and shifts macrophage phenotype

(2013) Jesmond Dalli et al.   FASEB JOURNAL

Plasticity of Leukocytic Exudates in Resolving Acute Inflammation Is Regulated by MicroRNA and Proresolving Mediators

(2013) Yongsheng Li et al.   IMMUNITY

Biasing the lipoxin A4/formyl peptide receptor 2 pushes inflammatory resolution

(2013) J. G. Filep   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Lipidomic profiling of bioactive lipids by mass spectrometry during microbial infections

(2013) Vincent C. Tam   SEMINARS IN IMMUNOLOGY

Specific lipid mediator signatures of human phagocytes: microparticles stimulate macrophage efferocytosis and pro-resolving mediators

(2012) J. Dalli et al.   BLOOD

Macrophage proresolving mediator maresin 1 stimulates tissue regeneration and controls pain

(2012) Charles N. Serhan et al.   FASEB JOURNAL

Sensing of RNA Viruses: a Review of Innate Immune Receptors Involved in Recognizing RNA Virus Invasion

(2012) S. Jensen et al.   JOURNAL OF VIROLOGY

Microfluidic chambers for monitoring leukocyte trafficking and humanized nano-proresolving medicines interactions

(2012) C. N. Jones et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Serum amyloid A opposes lipoxin A4 to mediate glucocorticoid refractory lung inflammation in chronic obstructive pulmonary disease

(2012) S. Bozinovski et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Autacoid 14S,21R-Dihydroxy-Docosahexaenoic Acid Counteracts Diabetic Impairment of Macrophage Prohealing Functions

(2011) Haibin Tian et al.   AMERICAN JOURNAL OF PATHOLOGY

Lipoxin A4 and benzo-lipoxin A4 attenuate experimental renal fibrosis

(2011) Emma Börgeson et al.   FASEB JOURNAL

14S,21R-dihydroxy-docosahexaenoic Acid Treatment Enhances Mesenchymal Stem Cell Amelioration of Renal Ischemia/Reperfusion Injury

(2011) Haibin Tian et al.   STEM CELLS AND DEVELOPMENT

Control of Macrophage Activation and Function by PPARs

(2010) Ajay Chawla   CIRCULATION RESEARCH

Controlling Herpes Simplex Virus-Induced Ocular Inflammatory Lesions with the Lipid-Derived Mediator Resolvin E1

(2010) N. K. Rajasagi et al.   JOURNAL OF IMMUNOLOGY

Macrophage plasticity and interaction with lymphocyte subsets: cancer as a paradigm

(2010) Subhra K Biswas et al.   NATURE IMMUNOLOGY

ATLa, an Aspirin-Triggered Lipoxin A4 Synthetic Analog, Prevents the Inflammatory and Fibrotic Effects of Bleomycin-Induced Pulmonary Fibrosis

(2009) V. Martins et al.   JOURNAL OF IMMUNOLOGY

Coronaviruses post-SARS: update on replication and pathogenesis

(2009) Stanley Perlman et al.   NATURE REVIEWS MICROBIOLOGY

Resolvin E1, an EPA-derived mediator in whole blood, selectively counterregulates leukocytes and platelets

(2008) M. Dona et al.   BLOOD

Maresins: novel macrophage mediators with potent antiinflammatory and proresolving actions

(2008) Charles N. Serhan et al.   JOURNAL OF EXPERIMENTAL MEDICINE