Bacteria‐Based Cancer Immunotherapy

In Situ Photocatalyzed Oxygen Generation with Photosynthetic Bacteria to Enable Robust Immunogenic Photodynamic Therapy in Triple‐Negative Breast Cancer

(2020) Lanlan Liu et al.   ADVANCED FUNCTIONAL MATERIALS

A Size‐Changeable Collagenase‐Modified Nanoscavenger for Increasing Penetration and Retention of Nanomedicine in Deep Tumor Tissue

(2020) Funeng Xu et al.   ADVANCED MATERIALS

A Hybrid Eukaryotic-Prokaryotic Nanoplatform with Photothermal Modality for Enhanced Antitumor Vaccination

(2020) Qi Chen et al.   ADVANCED MATERIALS

Bioengineered smart bacterial carriers for combinational targeted therapy of solid tumors

(2020) Siamak Alizadeh et al.   JOURNAL OF DRUG TARGETING

Intratumoral accumulation of gut microbiota facilitates CD47-based immunotherapy via STING signaling

(2020) Yaoyao Shi et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Engineered probiotics for local tumor delivery of checkpoint blockade nanobodies

(2020) Candice R. Gurbatri et al.   Science Translational Medicine

Chemotaxis-driven delivery of nano-pathogenoids for complete eradication of tumors post-phototherapy

(2020) Min Li et al.   Nature Communications

Recent Progress of Potentiating Immune Checkpoint Blockade with External Stimuli—an Industry Perspective

(2020) Jun Xu et al.   Advanced Science

Melanoma Cell Membrane Biomimetic Versatile CuS Nanoprobes for Homologous Targeting Photoacoustic Imaging and Photothermal Chemotherapy

(2020) Minliang Wu et al.   ACS Applied Materials & Interfaces

Current Status of Epidemiology, Diagnosis, Therapeutics, and Vaccines for Novel Coronavirus Disease 2019 (COVID-19)

(2020) Dae-Gyun Ahn et al.   JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY

The human tumor microbiome is composed of tumor type–specific intracellular bacteria

(2020) Deborah Nejman et al.   SCIENCE

Immunotherapy with engineered bacteria by targeting the STING pathway for anti-tumor immunity

(2020) Daniel S. Leventhal et al.   Nature Communications

Nanomaterials/microorganism-integrated microbiotic nanomedicine

(2020) Minfeng Huo et al.   Nano Today

Development of a pH-responsive polymersome inducing endoplasmic reticulum stress and autophagy blockade

(2020) Funeng Xu et al.   Science Advances

Endosomolytic polymersomes increase the activity of cyclic dinucleotide STING agonists to enhance cancer immunotherapy

(2019) Daniel Shae et al.   Nature Nanotechnology

Second-generation IL-2 receptor-targeted diphtheria fusion toxin exhibits antitumor activity and synergy with anti–PD-1 in melanoma

(2019) Laurene S. Cheung et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Stimuli-responsive nitric oxide generator for light-triggered synergistic cancer photothermal/gas therapy

(2019) Xuehui Huang et al.   Nano Research

Regulatory T (Treg) cells in cancer: can Treg cells be a new therapeutic target?

(2019) Yoshihiro Ohue et al.   CANCER SCIENCE

Therapeutic bacteria to combat cancer; current advances, challenges, and opportunities

(2019) Mansour Sedighi et al.   Cancer Medicine

Cancer nanomedicine for combination cancer immunotherapy

(2019) Jutaek Nam et al.   Nature Reviews Materials

Fenton reaction assisted photodynamic therapy for cancer with multifunctional magnetic nanoparticles

(2019) Huabo Hou et al.   ACS Applied Materials & Interfaces

Recent advances with Treg depleting fusion protein toxins for cancer immunotherapy

(2019) Pankaj Kumar et al.   Immunotherapy

Programmable bacteria induce durable tumor regression and systemic antitumor immunity

(2019) Sreyan Chowdhury et al.   NATURE MEDICINE

TCF1 and LEF1 Control Treg Competitive Survival and Tfr Development to Prevent Autoimmune Diseases

(2019) Bi-Huei Yang et al.   Cell Reports

Probiotics Lactobacillus reuteri Abrogates Immune Checkpoint Blockade-Associated Colitis by Inhibiting Group 3 Innate Lymphoid Cells

(2019) Tingting Wang et al.   Frontiers in Immunology

Tumor microenvironment targeted nanotherapeutics for cancer therapy and diagnosis: A review

(2019) Shreya Thakkar et al.   Acta Biomaterialia

Development of an In Situ Cancer Vaccine via Combinational Radiation and Bacterial‐Membrane‐Coated Nanoparticles

(2019) Ravi B. Patel et al.   ADVANCED MATERIALS

Tumour Hypoxia

(2019) C.M. West et al.   CLINICAL ONCOLOGY

Combination of Bacterial‐Photothermal Therapy with an Anti‐PD‐1 Peptide Depot for Enhanced Immunity against Advanced Cancer

(2019) Wenfei Chen et al.   ADVANCED FUNCTIONAL MATERIALS

Visualization and In Situ Ablation of Intracellular Bacterial Pathogens through Metabolic Labeling

(2019) Fang Hu et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

The role of bacterial toxins and spores in cancer therapy

(2019) Lihini Ranesha Weerakkody et al.   LIFE SCIENCES

Targeted Diphtheria Toxin-Based Therapy: A Review Article

(2019) Fatemeh Shafiee et al.   Frontiers in Microbiology

Targeted cancer immunotherapy with genetically engineered oncolytic Salmonella typhimurium

(2019) Yanxia Guo et al.   CANCER LETTERS

Bioengineering Bacterial Vesicle-Coated Polymeric Nanomedicine for Enhanced Cancer Immunotherapy and Metastasis Prevention

(2019) Qi Chen et al.   NANO LETTERS

Nanotechnology intervention of the microbiome for cancer therapy

(2019) Wantong Song et al.   Nature Nanotechnology

Multifunctional nanoplatforms for subcellular delivery of drugs in cancer therapy

(2019) Xing Guo et al.   PROGRESS IN MATERIALS SCIENCE

Bacteria-Driven Hypoxia Targeting for Combined Biotherapy and Photothermal Therapy

(2018) Wenfei Chen et al.   ACS Nano

Biodegradable STING agonist nanoparticles for enhanced cancer immunotherapy

(2018) David R. Wilson et al.   Nanomedicine-Nanotechnology Biology and Medicine

Understanding the tumor immune microenvironment (TIME) for effective therapy

(2018) Mikhail Binnewies et al.   NATURE MEDICINE

Immune-Related Adverse Events Associated with Immune Checkpoint Blockade

(2018) Michael A. Postow et al.   NEW ENGLAND JOURNAL OF MEDICINE

Optically-controlled bacterial metabolite for cancer therapy

(2018) Di-Wei Zheng et al.   Nature Communications

Hypoxia-tropic Protein Nanocages for Modulation of Tumor- and Chemotherapy-Associated Hypoxia

(2018) Xinglu Huang et al.   ACS Nano

Trapping of Lipopolysaccharide to Promote Immunotherapy against Colorectal Cancer and Attenuate Liver Metastasis

(2018) Wantong Song et al.   ADVANCED MATERIALS

Cutting Edge: Activation of STING in T Cells Induces Type I IFN Responses and Cell Death

(2017) Bridget Larkin et al.   JOURNAL OF IMMUNOLOGY

Two-step enhanced cancer immunotherapy with engineeredSalmonella typhimuriumsecreting heterologous flagellin

(2017) Jin Hai Zheng et al.   Science Translational Medicine

Bacterial outer membrane vesicles suppress tumor by interferon-γ-mediated antitumor response

(2017) Oh Youn Kim et al.   Nature Communications

The Escherichia coli Serogroup O1 and O2 Lipopolysaccharides Are Encoded by Multiple O-antigen Gene Clusters

(2017) Sabine Delannoy et al.   Frontiers in Cellular and Infection Microbiology

Outer Membrane Vesicles (OMVs) of Gram-negative Bacteria: A Perspective Update

(2017) Arif Tasleem Jan   Frontiers in Microbiology

Engineered Salmonella enterica serovar Typhimurium overcomes limitations of anti-bacterial immunity in bacteria-mediated tumor therapy

(2017) Sebastian Felgner et al.   OncoImmunology

Rethinking cancer nanotheranostics

(2017) Hongmin Chen et al.   Nature Reviews Materials

An innovative biologic system for photon-powered myocardium in the ischemic heart

(2017) Jeffrey E. Cohen et al.   Science Advances

Cancer Cell Membrane–Biomimetic Nanoparticles for Homologous-Targeting Dual-Modal Imaging and Photothermal Therapy

(2016) Ze Chen et al.   ACS Nano

Suppression of pancreatic ductal adenocarcinoma growth by intratumoral delivery of attenuatedSalmonella typhimuriumusing a dual fluorescent live tracking system

(2016) Sujin Zhou et al.   CANCER BIOLOGY & THERAPY

Microbiome and Anticancer Immunosurveillance

(2016) Laurence Zitvogel et al.   CELL

Regulatory T cells in cancer immunotherapy

(2016) Atsushi Tanaka et al.   CELL RESEARCH

Microbiota—myeloid cell crosstalk beyond the gut

(2016) Sayeh Gorjifard et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Characterization of a re-engineered, mesothelin-targeted Pseudomonas exotoxin fusion protein for lung cancer therapy

(2016) Frieder Bauss et al.   Molecular Oncology

Synchronized cycles of bacterial lysis for in vivo delivery

(2016) M. Omar Din et al.   NATURE

A novel mechanism for the biogenesis of outer membrane vesicles in Gram-negative bacteria

(2016) Sandro Roier et al.   Nature Communications

Analysis of nanoparticle delivery to tumours

(2016) Stefan Wilhelm et al.   Nature Reviews Materials

Adverse Events Associated with Immune Checkpoint Blockade in Patients with Cancer: A Systematic Review of Case Reports

(2016) Noha Abdel-Wahab et al.   PLoS One

Immunoconjugates in the management of hairy cell leukemia

(2015) Robert J. Kreitman et al.   BEST PRACTICE & RESEARCH CLINICAL HAEMATOLOGY

TLR5 Ligand-Secreting T Cells Reshape the Tumor Microenvironment and Enhance Antitumor Activity

(2015) D. Geng et al.   CANCER RESEARCH

Activation of inflammasome by attenuatedSalmonella typhimuriumin bacteria-mediated cancer therapy

(2015) Thuy Xuan Phan et al.   MICROBIOLOGY AND IMMUNOLOGY

Engineering Nanoparticle-Coated Bacteria as Oral DNA Vaccines for Cancer Immunotherapy

(2015) Qinglian Hu et al.   NANO LETTERS

Outer-membrane vesicles from Gram-negative bacteria: biogenesis and functions

(2015) Carmen Schwechheimer et al.   NATURE REVIEWS MICROBIOLOGY

Immunological mechanisms of the antitumor effects of supplemental oxygenation

(2015) Stephen M. Hatfield et al.   Science Translational Medicine

STING agonist formulated cancer vaccines can cure established tumors resistant to PD-1 blockade

(2015) Juan Fu et al.   Science Translational Medicine

Salmonella typhimurium Suppresses Tumor Growth via the Pro-Inflammatory Cytokine Interleukin-1β

(2015) Jung-Eun Kim et al.   Theranostics

NlpI-mediated modulation of outer membrane vesicle production through peptidoglycan dynamics inEscherichia coli

(2015) Carmen Schwechheimer et al.   MicrobiologyOpen

Flagellin is a strong vaginal adjuvant of a therapeutic vaccine for genital cancer

(2015) Shee Eun Lee et al.   OncoImmunology

Spores of Clostridium engineered for clinical efficacy and safety cause regression and cure of tumors in vivo

(2015) John T. Heap et al.   Oncotarget

Bioengineered Bacterial Outer Membrane Vesicles as Cell-Specific Drug-Delivery Vehicles for Cancer Therapy

(2014) Vipul Gujrati et al.   ACS Nano

Modulation of bacterial outer membrane vesicle production by envelope structure and content

(2014) Carmen Schwechheimer et al.   BMC MICROBIOLOGY

Immune Escape Mechanisms as a Guide for Cancer Immunotherapy

(2014) G. L. Beatty et al.   CLINICAL CANCER RESEARCH

Biogenesis and multifaceted roles of outer membrane vesicles from Gram-negative bacteria

(2014) H. M. Kulkarni et al.   MICROBIOLOGY-SGM

Localization and expression of heat shock protein 70 with rat myocardial cell damage induced by heat stress in vitro and in vivo

(2014) HONGBO CHEN et al.   Molecular Medicine Reports

Cancer Cell Membrane-Coated Nanoparticles for Anticancer Vaccination and Drug Delivery

(2014) Ronnie H. Fang et al.   NANO LETTERS

In Vivo IFN-γ Secretion by NK Cells in Response to Salmonella Typhimurium Requires NLRC4 Inflammasomes

(2014) Andreas Kupz et al.   PLoS One

Engineering of bacterial strains and their products for cancer therapy

(2013) Nuno Bernardes et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Correlation between Supercoiling and Conformational Motions of the Bacterial Flagellar Filament

(2013) Andreas M. Stadler et al.   BIOPHYSICAL JOURNAL

Myeloid-derived suppressor cells have a central role in attenuated Listeria monocytogenes-based immunotherapy against metastatic breast cancer in young and old mice

(2013) D Chandra et al.   BRITISH JOURNAL OF CANCER

A Multifunctional Chimeric Chaperone Serves as a Novel Immune Modulator Inducing Therapeutic Antitumor Immunity

(2013) X. Yu et al.   CANCER RESEARCH

Live-attenuated bacteria as a cancer vaccine vector

(2013) Bertrand Toussaint et al.   Expert Review of Vaccines

Salmonella enhance chemosensitivity in tumor through connexin 43 upregulation

(2013) Wen-Wei Chang et al.   INTERNATIONAL JOURNAL OF CANCER

Clostridium butyricum MIYAIRI 588 shows antitumor effects by enhancing the release of TRAIL from neutrophils through MMP-8

(2013) MASAHIDE SHINNOH et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

The Role of FOXP3 in Regulating Immune Responses

(2013) Jens Vent-Schmidt et al.   INTERNATIONAL REVIEWS OF IMMUNOLOGY

Potentiating antibacterial activity by predictably enhancing endogenous microbial ROS production

(2013) Mark P Brynildsen et al.   NATURE BIOTECHNOLOGY

A novel peptide therapeutic targeting PD1 immune checkpoint with equipotent antagonism of both ligands and a potential for better management of immune-related adverse events

(2013) Pottayil Sasikumar et al.   Journal for ImmunoTherapy of Cancer

Bacterial vectors for imaging and cancer gene therapy: a review

(2012) M Cronin et al.   CANCER GENE THERAPY

The effects of ROS-mediating oxygen tension on human CD34+CD38− cells induced into mature dendritic cells

(2012) Jinli Fan et al.   JOURNAL OF BIOTECHNOLOGY

Engineering bacteria toward tumor targeting for cancer treatment: current state and perspectives

(2011) Che-Hsin Lee   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

How to improve the immunogenicity of chemotherapy and radiotherapy

(2011) Yuting Ma et al.   CANCER AND METASTASIS REVIEWS

Tumour hypoxia promotes tolerance and angiogenesis via CCL28 and Treg cells

(2011) Andrea Facciabene et al.   NATURE

Biological Functions and Biogenesis of Secreted Bacterial Outer Membrane Vesicles

(2010) Adam Kulp et al.   Annual Review of Microbiology

Targeting solid tumors with non-pathogenic obligate anaerobic bacteria

(2010) Shun’ichiro Taniguchi et al.   CANCER SCIENCE

The Tumor-Immune Microenvironment and Response to Radiation Therapy

(2010) Stephen L. Shiao et al.   JOURNAL OF MAMMARY GLAND BIOLOGY AND NEOPLASIA

Bacteria-Induced Gap Junctions in Tumors Favor Antigen Cross-Presentation and Antitumor Immunity

(2010) F. Saccheri et al.   Science Translational Medicine

High Efficacy of a Listeria-Based Vaccine against Metastatic Breast Cancer Reveals a Dual Mode of Action

(2009) S. H. Kim et al.   CANCER RESEARCH

STAT3 tyrosine phosphorylation is critical for interleukin 1 beta and interleukin-6 production in response to lipopolysaccharide and live bacteria

(2009) Lobelia Samavati et al.   MOLECULAR IMMUNOLOGY

Flagellin: key target of mucosal innate immunity

(2009) M Vijay-Kumar et al.   Mucosal Immunology

STING regulates intracellular DNA-mediated, type I interferon-dependent innate immunity

(2009) Hiroki Ishikawa et al.   NATURE

Tumor Invasion of Salmonella enterica Serovar Typhimurium Is Accompanied by Strong Hemorrhage Promoted by TNF-α

(2009) Sara Leschner et al.   PLoS One

IL-18-producing Salmonella inhibit tumor growth

(2008) M Loeffler et al.   CANCER GENE THERAPY

Toll-Like Receptor 5-Deficient Mice Have Dysregulated Intestinal Gene Expression and Nonspecific Resistance to Salmonella-Induced Typhoid-Like Disease

(2008) M. Vijay-Kumar et al.   INFECTION AND IMMUNITY

Proteomics in gram-negative bacterial outer membrane vesicles

(2008) Eun-Young Lee et al.   MASS SPECTROMETRY REVIEWS

STING is an endoplasmic reticulum adaptor that facilitates innate immune signalling

(2008) Hiroki Ishikawa et al.   NATURE