Live-attenuated bacteria as a cancer vaccine vector

Live-attenuatedListeria-based immunotherapy

(2013) John Rothman et al.   Expert Review of Vaccines

A Safe Bacterial Microsyringe for In Vivo Antigen Delivery and Immunotherapy

(2013) Audrey Le Gouëllec et al.   MOLECULAR THERAPY

Double-blind, placebo-controlled first in human study to investigate an oral vaccine aimed to elicit an immune reaction against the VEGF-Receptor 2 in patients with stage IV and locally advanced pancreatic cancer

(2012) Andreas G Niethammer et al.   BMC CANCER

Combined immunotherapy with Listeria monocytogenes-based PSA vaccine and radiation therapy leads to a therapeutic response in a murine model of prostate cancer

(2012) Raquibul Hannan et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Killed but metabolically active vaccines

(2012) Thomas W Dubensky et al.   CURRENT OPINION IN BIOTECHNOLOGY

Evaluation of Salmonella enterica Type III Secretion System Effector Proteins as Carriers for Heterologous Vaccine Antigens

(2012) Wael Abdel Halim Hegazy et al.   INFECTION AND IMMUNITY

Optimization of Antitumor Immunotherapy Mediated by Type III Secretion System-based Live Attenuated Bacterial Vectors

(2012) Yan Wang et al.   JOURNAL OF IMMUNOTHERAPY

Cancer exome analysis reveals a T-cell-dependent mechanism of cancer immunoediting

(2012) Hirokazu Matsushita et al.   NATURE

CD8 T-Cell Induction against Vascular Endothelial Growth Factor Receptor 2 by Salmonella for Vaccination Purposes against a Murine Melanoma

(2012) Stefan Jellbauer et al.   PLoS One

Bacterial vectors for active immunotherapy reach clinical and industrial stages

(2012) Audrey Le Gouëllec et al.   Human Vaccines & Immunotherapeutics

Targeting tumor vasculature with novel Listeria-based vaccines directed against CD105

(2011) Laurence M. Wood et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

The ubiquitin-like protein, ISG15, is a novel tumor-associated antigen for cancer immunotherapy

(2011) Laurence M. Wood et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

MTDH/AEG-1-based DNA vaccine suppresses lung metastasis and enhances chemosensitivity to doxorubicin in breast cancer

(2011) Ben-Jiang Qian et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

A Live-Attenuated Listeria Vaccine (ANZ-100) and a Live-Attenuated Listeria Vaccine Expressing Mesothelin (CRS-207) for Advanced Cancers: Phase I Studies of Safety and Immune Induction

(2011) D. T. Le et al.   CLINICAL CANCER RESEARCH

Cancer immunotherapy using recombinantListeria monocytogenes: Transition from bench to clinic

(2011) Reshma Singh et al.   Human vaccines & immunotherapeutics

Live Attenuated Salmonella Vaccines against Mycobacterium tuberculosis with Antigen Delivery via the Type III Secretion System

(2011) María Dolores Juárez-Rodríguez et al.   INFECTION AND IMMUNITY

Induction of Effective Antitumor Response After Mucosal Bacterial Vector Mediated DNA Vaccination With Endogenous Prostate Cancer Specific Antigen

(2011) Sarfraz Ahmad et al.   JOURNAL OF UROLOGY

Listeria monocytogenes engineered to activate the Nlrc4 inflammasome are severely attenuated and are poor inducers of protective immunity

(2011) J.-D. Sauer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Oral Delivery of the Sj23LHD-GST Antigen by Salmonella typhimurium Type III Secretion System Protects against Schistosoma japonicum Infection in Mice

(2011) Guo Chen et al.   PLoS Neglected Tropical Diseases

Orally Administered DNA Vaccine Delivery by Attenuated Salmonella typhimurium Targeting Fetal Liver Kinase 1 Inhibits Murine Lewis Lung Carcinoma Growth and Metastasis

(2010) Shu Guang Zuo et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

A comparative study of gene vaccines encoding different extracellular domains of the vascular endothelial growth factor receptor 2 in the mouse model of colon adenocarcinoma CT-26

(2010) Jian Dong et al.   CANCER BIOLOGY & THERAPY

Development of a live and highly attenuated Listeria monocytogenes-based vaccine for the treatment of Her2/neu-overexpressing cancers in human

(2010) V Shahabi et al.   CANCER GENE THERAPY

Invasion and destruction of a murine fibrosarcoma by Salmonella-induced effector CD8 T cells as a therapeutic intervention against cancer

(2010) Elisabeth Roider et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Tumor antigen delivered by Salmonella III secretion protein fused with heat shock protein 70 induces protection and eradication against murine melanoma

(2010) Xiangying Zhu et al.   CANCER SCIENCE

Immunomodulation using genetically engineered bacteria for type III-mediated delivery of heterologous antigens and cytokines: Potential application in vaccine and therapeutical developments

(2010) Mustapha Chamekh   IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY

Listeria and Salmonella bacterial vectors of tumor-associated antigens for cancer immunotherapy

(2010) Yvonne Paterson et al.   SEMINARS IN IMMUNOLOGY

A Novel Human Her-2/neu Chimeric Molecule Expressed by Listeria monocytogenes Can Elicit Potent HLA-A2 Restricted CD8-positive T cell Responses and Impact the Growth and Spread of Her-2/neu-positive Breast Tumors

(2009) M. M. Seavey et al.   CLINICAL CANCER RESEARCH

Salmonella enterica serovar Typhi live vector vaccines finally come of age

(2009) James E Galen et al.   IMMUNOLOGY AND CELL BIOLOGY

Survivin minigene DNA vaccination is effective against neuroblastoma

(2009) Stefan Fest et al.   INTERNATIONAL JOURNAL OF CANCER

The type III secretion system of Pseudomonas aeruginosa: infection by injection

(2009) Alan R. Hauser   NATURE REVIEWS MICROBIOLOGY

The first clinical use of a live-attenuated Listeria monocytogenes vaccine: A Phase I safety study of Lm-LLO-E7 in patients with advanced carcinoma of the cervix

(2009) Paulo Cesar Maciag et al.   VACCINE

Listeria monocytogenes Delivery of HPV-16 Major Capsid Protein L1 Induces Systemic and Mucosal Cell-Mediated CD4+ and CD8+ T-Cell Responses After Oral Immunization

(2009) Waleed Mustafa et al.   VIRAL IMMUNOLOGY

Mage-b vaccine delivered by recombinant Listeria monocytogenes is highly effective against breast cancer metastases

(2008) S H Kim et al.   BRITISH JOURNAL OF CANCER

Development of a Listeria monocytogenes based vaccine against prostate cancer

(2008) Vafa Shahabi et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Two oral HBx vaccines delivered by live attenuated Salmonella: Both eliciting effective anti-tumor immunity

(2008) Ye-Jun Wang et al.   CANCER LETTERS

Cancer Immunotherapy Targeting the High Molecular Weight Melanoma-Associated Antigen Protein Results in a Broad Antitumor Response and Reduction of Pericytes in the Tumor Vasculature

(2008) P. C. Maciag et al.   CANCER RESEARCH

Construction and Characterization of an Attenuated Listeria monocytogenes Strain for Clinical Use in Cancer Immunotherapy

(2008) A. Wallecha et al.   Clinical and Vaccine Immunology

Promises and challenges for the development ofListeria monocytogenes-based immunotherapies

(2008) Dirk G Brockstedt et al.   Expert Review of Vaccines

Synergistic antitumoral effects of human telomerase reverse transcriptase-mediated dual-apoptosis-related gene vector delivered by orally attenuatedSalmonella enterica Serovar Typhimurium in murine tumor models

(2008) Wei Fu et al.   JOURNAL OF GENE MEDICINE

A rationally designed tyrosine hydroxylase DNA vaccine induces specific antineuroblastoma immunity

(2008) N. Huebener et al.   MOLECULAR CANCER THERAPEUTICS

The enhanced anti-angiogenic and antitumor effects of combining flk1-based DNA vaccine and IP-10

(2008) Xiao-ling Lu et al.   VACCINE

Listeria monocytogenes as novel carrier system for the development of live vaccines

(2007) Christoph Schoen et al.   INTERNATIONAL JOURNAL OF MEDICAL MICROBIOLOGY